Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02

AUTHORS

Anastasia Dielmann, Anne Letsch, Anika Nonnenmacher, Kurt Miller, Ulrich Keilholz, Antonia Busse

ABSTRACT

T-box transcription factors, T-box expressed in T cells (T-bet) encoded by Tbx21 and Eomesodermin (Eomes), drive the differentiation of effector/memory T cell lineages and NK cells. The aim of the study was to determine the prognostic influence of the expression of these transcription factors in peripheral blood (pB) in a cohort of 41 metastatic (m) RCC patients before receiving sorafenib treatment and to analyze their association with the immunophenotype in pB. In contrast to Tbx21, in the multivariate analysis including clinical features, Eomes mRNA expression was identified as an independent good prognostic factor for progression-free survival (PFS, p = 0.042) and overall survival (OS, p = 0.001) in addition to a favorable ECOG performance status (p = 0.01 and p = 0.008, respectively). Eomes expression correlated positively not only with expression of Tbx21 and TGFβ1 mRNA, but also with mRNA expression of the activation marker ICOS, and with in vivo activated HLA-DR(+) T cells. Eomes expression was negatively associated with TNFα-producing T cells. On protein level, Eomes was mainly expressed by CD56(+)CD3(-) NK cells in pB. In conclusion, we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib. More... »

PAGES

181-192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-015-1786-1

DOI

http://dx.doi.org/10.1007/s00262-015-1786-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047610804

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26753694


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