CTLA4 blockade in mesothelioma: finally a competing strategy over cytotoxic/target therapy? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Luana Calabrò, Giovanni Luca Ceresoli, Alessandra di Pietro, Ornella Cutaia, Aldo Morra, Ramy Ibrahim, Michele Maio

ABSTRACT

No second-line treatment significantly prolongs the survival of malignant mesothelioma patients who have a high unmet medical need. Here, we comment on the therapeutic potential of cytotoxic T-lymphocyte-associated protein (CTLA)4-blockade by the anti-CTLA4 monoclonal antibody (mAb) tremelimumab of refractory malignant mesothelioma patients. We also focus on the critical role of an accurate tumor assessment in the course of treatment with immunomodulating mAb. Finally, treatment with potentially effective, second-generation checkpoint(s) inhibiting mAb, as well future combination strategies in this deadly disease, will be discussed. More... »

PAGES

105-112

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-014-1609-9

DOI

http://dx.doi.org/10.1007/s00262-014-1609-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010683088

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25233793


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