Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07

AUTHORS

Ester Simeone, Giusy Gentilcore, Diana Giannarelli, Antonio M. Grimaldi, Corrado Caracò, Marcello Curvietto, Assunta Esposito, Miriam Paone, Marco Palla, Ernesta Cavalcanti, Fabio Sandomenico, Antonella Petrillo, Gerardo Botti, Franco Fulciniti, Giuseppe Palmieri, Paola Queirolo, Paolo Marchetti, Virginia Ferraresi, Gaetana Rinaldi, Maria Pia Pistillo, Gennaro Ciliberto, Nicola Mozzillo, Paolo A. Ascierto

ABSTRACT

BACKGROUND: Ipilimumab can induce durable disease control and long-term survival in patients with metastatic melanoma. Identification of a biomarker that correlates with clinical benefit and potentially provides an early marker of response is an active area of research. PATIENTS AND METHODS: Ipilimumab was available upon physician request for patients aged ≥16 years with stage III (unresectable) or IV cutaneous, ocular or mucosal melanoma, who had failed or did not tolerate previous treatments and had no other therapeutic option available. Patients received ipilimumab 3 mg/kg every 3 weeks for four doses. Tumour assessments were conducted at baseline, Week 12 and Week 24 using immune-related response criteria. Patients were monitored continuously for adverse events (AEs), including immune-related AEs. Candidate immunological markers were evaluated in peripheral blood and sera samples collected at baseline and Weeks 4, 7, 10 and 12. RESULTS: Among 95 patients treated with ipilimumab 3 mg/kg, the immune-related disease control rate at Week 24 was 38 %. With a median follow-up of 24 months, median overall survival was 9.6 months. Both disease control and survival were significantly associated with decreasing levels of lactate dehydrogenase, C-reactive protein and FoxP3/regulatory T cells, and increasing absolute lymphocyte count, between baseline and the end of dosing (Week 12). CONCLUSION: Ipilimumab is a feasible treatment option for heavily pretreated patients with metastatic melanoma. Changes in some immunological markers between baseline and the fourth ipilimumab infusion appear to be associated with disease control and survival, but verification in prospective clinical trials is required. More... »

PAGES

675-683

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-014-1545-8

DOI

http://dx.doi.org/10.1007/s00262-014-1545-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041405474

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24695951


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eye Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ipilimumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simeone", 
        "givenName": "Ester", 
        "id": "sg:person.01127536021.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127536021.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gentilcore", 
        "givenName": "Giusy", 
        "id": "sg:person.01201301337.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201301337.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituti Fisioterapici Ospitalieri", 
          "id": "https://www.grid.ac/institutes/grid.417520.5", 
          "name": [
            "Regina Elena National Cancer Institute, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giannarelli", 
        "givenName": "Diana", 
        "id": "sg:person.01125770034.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125770034.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grimaldi", 
        "givenName": "Antonio M.", 
        "id": "sg:person.0762462504.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762462504.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carac\u00f2", 
        "givenName": "Corrado", 
        "id": "sg:person.016255602354.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016255602354.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Curvietto", 
        "givenName": "Marcello", 
        "id": "sg:person.01253353754.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253353754.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Esposito", 
        "givenName": "Assunta", 
        "id": "sg:person.01321467154.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321467154.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paone", 
        "givenName": "Miriam", 
        "id": "sg:person.016663134461.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016663134461.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palla", 
        "givenName": "Marco", 
        "id": "sg:person.01343700266.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343700266.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cavalcanti", 
        "givenName": "Ernesta", 
        "id": "sg:person.0743654734.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743654734.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sandomenico", 
        "givenName": "Fabio", 
        "id": "sg:person.01044277041.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044277041.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petrillo", 
        "givenName": "Antonella", 
        "id": "sg:person.013047011360.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013047011360.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Botti", 
        "givenName": "Gerardo", 
        "id": "sg:person.01142725140.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142725140.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fulciniti", 
        "givenName": "Franco", 
        "id": "sg:person.01131161075.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131161075.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Research Council", 
          "id": "https://www.grid.ac/institutes/grid.5326.2", 
          "name": [
            "National Research Council, Sassari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palmieri", 
        "givenName": "Giuseppe", 
        "id": "sg:person.0762206722.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762206722.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "San Martino Hospital, National Institute for Cancer Research, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Queirolo", 
        "givenName": "Paola", 
        "id": "sg:person.01102114523.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102114523.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Dermopathic Institute of the Immaculate IDI-IRCCS, Rome, Italy", 
            "Sant\u2019Andrea Hospital, University Sapienza, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchetti", 
        "givenName": "Paolo", 
        "id": "sg:person.0641150074.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641150074.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituti Fisioterapici Ospitalieri", 
          "id": "https://www.grid.ac/institutes/grid.417520.5", 
          "name": [
            "Regina Elena National Cancer Institute, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferraresi", 
        "givenName": "Virginia", 
        "id": "sg:person.0624523022.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624523022.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "\u201cPaolo Giaccone\u201d Polyclinic University Hospital, Palermo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rinaldi", 
        "givenName": "Gaetana", 
        "id": "sg:person.01177215722.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177215722.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "San Martino Hospital, National Institute for Cancer Research, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pistillo", 
        "givenName": "Maria Pia", 
        "id": "sg:person.0650360120.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650360120.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciliberto", 
        "givenName": "Gennaro", 
        "id": "sg:person.01275000143.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275000143.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mozzillo", 
        "givenName": "Nicola", 
        "id": "sg:person.0752035543.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752035543.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione \u201cG. Pascale\u201d, Via Mariano Semmola, 80131, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ascierto", 
        "givenName": "Paolo A.", 
        "id": "sg:person.01212502023.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001223166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001896079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-9-204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002969174", 
          "https://doi.org/10.1186/1479-5876-9-204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60868-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003772891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-9-214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006168982", 
          "https://doi.org/10.1186/1479-5876-9-214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1110814108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008211321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008750772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010268280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.4799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013277178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018207285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018207285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-10-146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018588583", 
          "https://doi.org/10.1186/1479-5876-10-146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-011-1046-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019792264", 
          "https://doi.org/10.1007/s00262-011-1046-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-4797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019812323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e31828eed39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020023591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e31828eed39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020023591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e31817fd8f3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023122482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e31817fd8f3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023122482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028571226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-013-1418-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029173312", 
          "https://doi.org/10.1007/s00262-013-1418-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1067/mcp.2001.113989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032912526", 
          "https://doi.org/10.1067/mcp.2001.113989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-8-76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034028817", 
          "https://doi.org/10.1186/1479-5876-8-76"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.43.5966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035149915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039926565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.7837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046075678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70024-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051396936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1003466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052212829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.5.1697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082882846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.2609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083942874"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-07", 
    "datePublishedReg": "2014-07-01", 
    "description": "BACKGROUND: Ipilimumab can induce durable disease control and long-term survival in patients with metastatic melanoma. Identification of a biomarker that correlates with clinical benefit and potentially provides an early marker of response is an active area of research.\nPATIENTS AND METHODS: Ipilimumab was available upon physician request for patients aged \u226516 years with stage III (unresectable) or IV cutaneous, ocular or mucosal melanoma, who had failed or did not tolerate previous treatments and had no other therapeutic option available. Patients received ipilimumab 3 mg/kg every 3 weeks for four doses. Tumour assessments were conducted at baseline, Week 12 and Week 24 using immune-related response criteria. Patients were monitored continuously for adverse events (AEs), including immune-related AEs. Candidate immunological markers were evaluated in peripheral blood and sera samples collected at baseline and Weeks 4, 7, 10 and 12.\nRESULTS: Among 95 patients treated with ipilimumab 3 mg/kg, the immune-related disease control rate at Week 24 was 38 %. With a median follow-up of 24 months, median overall survival was 9.6 months. Both disease control and survival were significantly associated with decreasing levels of lactate dehydrogenase, C-reactive protein and FoxP3/regulatory T cells, and increasing absolute lymphocyte count, between baseline and the end of dosing (Week 12).\nCONCLUSION: Ipilimumab is a feasible treatment option for heavily pretreated patients with metastatic melanoma. Changes in some immunological markers between baseline and the fourth ipilimumab infusion appear to be associated with disease control and survival, but verification in prospective clinical trials is required.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-014-1545-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma", 
    "pagination": "675-683", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c53e47894c23b13170e0d8f028b0ee6107746b79067c645a03a0ed2c3ea880a2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24695951"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-014-1545-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041405474"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-014-1545-8", 
      "https://app.dimensions.ai/details/publication/pub.1041405474"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-014-1545-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-014-1545-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-014-1545-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-014-1545-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-014-1545-8'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      72 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-014-1545-8 schema:about N122fb5a079244343bd2ef7a3ac35fb56
2 N14121ad8f92146c080118fa47f55ec1d
3 N14f1417d804742e88603ff765641784b
4 N32b5da30cc68418e9d710fdd9dc9e98b
5 N42478e6a995c48029c3398dea71bc6e6
6 N59a76c656df1446ab056deeb3384386f
7 N5e155ebb3d124dfe9f9edc8c6c881b17
8 N60ae59990f6346699a2e7e84d5ae37b8
9 N666b4e4f983941b58422e4d19d704f6c
10 N66ec1cc7ad6c4bc69bdd477ed6eb4890
11 Nacd532d631344af0983cad702934a767
12 Naddb7dcf509547829a79ccd3ea086848
13 Nb4eb90c1fc574d90abdf7777647c9ef9
14 Ncae1386359c54e2ab03fcc8bf0fa9b35
15 Nd7c55d3acaf5475dae176da2b210294f
16 Neab913de9be141daa217767bd5b0b0e9
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author Nd1949f5629fb44ac850dd45441c1b442
20 schema:citation sg:pub.10.1007/s00262-011-1046-y
21 sg:pub.10.1007/s00262-013-1418-6
22 sg:pub.10.1067/mcp.2001.113989
23 sg:pub.10.1186/1479-5876-10-146
24 sg:pub.10.1186/1479-5876-8-76
25 sg:pub.10.1186/1479-5876-9-204
26 sg:pub.10.1186/1479-5876-9-214
27 https://doi.org/10.1002/cncr.24951
28 https://doi.org/10.1016/j.ejca.2008.03.006
29 https://doi.org/10.1016/s0140-6736(12)60868-x
30 https://doi.org/10.1016/s1470-2045(13)70024-x
31 https://doi.org/10.1056/nejmoa1003466
32 https://doi.org/10.1056/nejmoa1103782
33 https://doi.org/10.1073/pnas.1110814108
34 https://doi.org/10.1093/annonc/mdt027
35 https://doi.org/10.1097/cji.0b013e31817fd8f3
36 https://doi.org/10.1097/cji.0b013e31828eed39
37 https://doi.org/10.1158/1078-0432.ccr-07-4797
38 https://doi.org/10.1158/1078-0432.ccr-09-1624
39 https://doi.org/10.1158/1078-0432.ccr-10-2463
40 https://doi.org/10.1158/1078-0432.ccr-11-1823
41 https://doi.org/10.1158/1078-0432.ccr-12-2982
42 https://doi.org/10.1200/jco.1996.14.5.1697
43 https://doi.org/10.1200/jco.2007.12.7837
44 https://doi.org/10.1200/jco.2009.23.4799
45 https://doi.org/10.1200/jco.2010.28.15_suppl.2609
46 https://doi.org/10.1200/jco.2012.43.5966
47 schema:datePublished 2014-07
48 schema:datePublishedReg 2014-07-01
49 schema:description BACKGROUND: Ipilimumab can induce durable disease control and long-term survival in patients with metastatic melanoma. Identification of a biomarker that correlates with clinical benefit and potentially provides an early marker of response is an active area of research. PATIENTS AND METHODS: Ipilimumab was available upon physician request for patients aged ≥16 years with stage III (unresectable) or IV cutaneous, ocular or mucosal melanoma, who had failed or did not tolerate previous treatments and had no other therapeutic option available. Patients received ipilimumab 3 mg/kg every 3 weeks for four doses. Tumour assessments were conducted at baseline, Week 12 and Week 24 using immune-related response criteria. Patients were monitored continuously for adverse events (AEs), including immune-related AEs. Candidate immunological markers were evaluated in peripheral blood and sera samples collected at baseline and Weeks 4, 7, 10 and 12. RESULTS: Among 95 patients treated with ipilimumab 3 mg/kg, the immune-related disease control rate at Week 24 was 38 %. With a median follow-up of 24 months, median overall survival was 9.6 months. Both disease control and survival were significantly associated with decreasing levels of lactate dehydrogenase, C-reactive protein and FoxP3/regulatory T cells, and increasing absolute lymphocyte count, between baseline and the end of dosing (Week 12). CONCLUSION: Ipilimumab is a feasible treatment option for heavily pretreated patients with metastatic melanoma. Changes in some immunological markers between baseline and the fourth ipilimumab infusion appear to be associated with disease control and survival, but verification in prospective clinical trials is required.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N16427bd31841405083df931b49cf312f
54 N53e7ce325a94442887bf0829ec99bc82
55 sg:journal.1096240
56 schema:name Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma
57 schema:pagination 675-683
58 schema:productId N15a4f89644e54288a3691a1fd19c3b1f
59 N3f23ecf1a0fe47df814e50e7bdc55ca4
60 N650ce899063f409f9824eea29fba8e3d
61 N74b2b25dc7c943099184d4af75cf7d3c
62 Neaa66481ea924cc4b6cce84d05ed9506
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041405474
64 https://doi.org/10.1007/s00262-014-1545-8
65 schema:sdDatePublished 2019-04-10T20:51
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N73289f0ffa4e4d65ae9b2e7cbbf42de6
68 schema:url http://link.springer.com/10.1007%2Fs00262-014-1545-8
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N0202d9e4d7224e8ab47f36090dbccaff schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
73 rdf:type schema:Organization
74 N09de9f615d4147a99b308729ccee0e76 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
75 rdf:type schema:Organization
76 N0d4f64642c3e43e3b6abd272cd0ed280 rdf:first sg:person.01321467154.56
77 rdf:rest N11786f67dc6c4d3fa01d9ad1db3dcb86
78 N0e4633dde11c40ac95c81e13bd419826 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
79 rdf:type schema:Organization
80 N11786f67dc6c4d3fa01d9ad1db3dcb86 rdf:first sg:person.016663134461.13
81 rdf:rest N31283052263b45388d09b1d298b0ccd9
82 N11879006ae7e4da3a3ec30942c6d529c rdf:first sg:person.0650360120.09
83 rdf:rest Nf77eb7e9505f4accbe842e952d502b59
84 N122fb5a079244343bd2ef7a3ac35fb56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Eye Neoplasms
86 rdf:type schema:DefinedTerm
87 N14121ad8f92146c080118fa47f55ec1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Female
89 rdf:type schema:DefinedTerm
90 N14f1417d804742e88603ff765641784b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Male
92 rdf:type schema:DefinedTerm
93 N15a4f89644e54288a3691a1fd19c3b1f schema:name pubmed_id
94 schema:value 24695951
95 rdf:type schema:PropertyValue
96 N16427bd31841405083df931b49cf312f schema:issueNumber 7
97 rdf:type schema:PublicationIssue
98 N1e2bc267e51e4155bba7a3ce08de08f2 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
99 rdf:type schema:Organization
100 N27c6cb27c8e14d2aae1f43d9afb8108c schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
101 rdf:type schema:Organization
102 N296354674ab546ce8f7bf7e16957f2b8 rdf:first sg:person.0762462504.03
103 rdf:rest Ndae31b1deeff4c10a78a2ce4b2d7967f
104 N31283052263b45388d09b1d298b0ccd9 rdf:first sg:person.01343700266.04
105 rdf:rest Neddf1da4facc44b99347624d900057f4
106 N32b5da30cc68418e9d710fdd9dc9e98b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Young Adult
108 rdf:type schema:DefinedTerm
109 N3a7fd181836b435ab3dc9beb2f54db27 rdf:first sg:person.0624523022.47
110 rdf:rest Nab82aecd68444b9ca20ad482073ad2fe
111 N3b84fd7ff36443e6bd5f9420965ab81a rdf:first sg:person.01212502023.44
112 rdf:rest rdf:nil
113 N3c33226f211a4770a081cb9f258cf159 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
114 rdf:type schema:Organization
115 N3f23ecf1a0fe47df814e50e7bdc55ca4 schema:name readcube_id
116 schema:value c53e47894c23b13170e0d8f028b0ee6107746b79067c645a03a0ed2c3ea880a2
117 rdf:type schema:PropertyValue
118 N42478e6a995c48029c3398dea71bc6e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Adult
120 rdf:type schema:DefinedTerm
121 N48c4a00384d04530b8693ec9fefbc662 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
122 rdf:type schema:Organization
123 N4f765d6088dd4f1e894e07b3972399d7 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
124 rdf:type schema:Organization
125 N53e7ce325a94442887bf0829ec99bc82 schema:volumeNumber 63
126 rdf:type schema:PublicationVolume
127 N59a76c656df1446ab056deeb3384386f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N5c122a3515d64f2096496ee77733a4c5 rdf:first sg:person.0752035543.31
131 rdf:rest N3b84fd7ff36443e6bd5f9420965ab81a
132 N5e155ebb3d124dfe9f9edc8c6c881b17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Aged, 80 and over
134 rdf:type schema:DefinedTerm
135 N5ee57a013e324e218e384819a95d79d0 schema:name “Paolo Giaccone” Polyclinic University Hospital, Palermo, Italy
136 rdf:type schema:Organization
137 N60ae59990f6346699a2e7e84d5ae37b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Treatment Outcome
139 rdf:type schema:DefinedTerm
140 N64870d44b48e4871998d7cfa9c1609fb schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
141 rdf:type schema:Organization
142 N650ce899063f409f9824eea29fba8e3d schema:name nlm_unique_id
143 schema:value 8605732
144 rdf:type schema:PropertyValue
145 N666b4e4f983941b58422e4d19d704f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Antibodies, Monoclonal
147 rdf:type schema:DefinedTerm
148 N66ec1cc7ad6c4bc69bdd477ed6eb4890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adolescent
150 rdf:type schema:DefinedTerm
151 N675c63616c3044b59f15706b74d0d7cd rdf:first sg:person.01131161075.02
152 rdf:rest Nc64cd050699f42d1963ce37b130b64fd
153 N73289f0ffa4e4d65ae9b2e7cbbf42de6 schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 N74b2b25dc7c943099184d4af75cf7d3c schema:name dimensions_id
156 schema:value pub.1041405474
157 rdf:type schema:PropertyValue
158 N74ea2e3c9ec5408995547be151c57a16 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
159 rdf:type schema:Organization
160 N7b491420d5a648c7b8f9096808879938 rdf:first sg:person.01201301337.59
161 rdf:rest N85fa297c738d474c977cd23d5cb1978f
162 N811677138bf443e7b11a61e94c9dd16f schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
163 rdf:type schema:Organization
164 N85fa297c738d474c977cd23d5cb1978f rdf:first sg:person.01125770034.23
165 rdf:rest N296354674ab546ce8f7bf7e16957f2b8
166 N89994cc2e8344b52acb50e3182c21d11 rdf:first sg:person.01142725140.44
167 rdf:rest N675c63616c3044b59f15706b74d0d7cd
168 N99afe11e109a4f24be73aa02a8563ab0 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
169 rdf:type schema:Organization
170 Nab82aecd68444b9ca20ad482073ad2fe rdf:first sg:person.01177215722.45
171 rdf:rest N11879006ae7e4da3a3ec30942c6d529c
172 Nacd532d631344af0983cad702934a767 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Middle Aged
174 rdf:type schema:DefinedTerm
175 Naddb7dcf509547829a79ccd3ea086848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Survival Analysis
177 rdf:type schema:DefinedTerm
178 Nb213dca6efe042d1a75fee3628fa4fb1 rdf:first sg:person.01044277041.02
179 rdf:rest Nc288bfe1f1274c5ba01d6685c93d9dd9
180 Nb4eb90c1fc574d90abdf7777647c9ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Skin Neoplasms
182 rdf:type schema:DefinedTerm
183 Nc288bfe1f1274c5ba01d6685c93d9dd9 rdf:first sg:person.013047011360.26
184 rdf:rest N89994cc2e8344b52acb50e3182c21d11
185 Nc3ee4f1878b9492d94450c8c4cc20e98 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
186 rdf:type schema:Organization
187 Nc5987f9c4a084a899c3a1e4996f13c44 rdf:first sg:person.0641150074.04
188 rdf:rest N3a7fd181836b435ab3dc9beb2f54db27
189 Nc64cd050699f42d1963ce37b130b64fd rdf:first sg:person.0762206722.62
190 rdf:rest Nfddbb3584b154071b6bc9ff87ade111c
191 Nc6af9f8de99d425d83e6e4de7642d270 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
192 rdf:type schema:Organization
193 Ncae1386359c54e2ab03fcc8bf0fa9b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Ipilimumab
195 rdf:type schema:DefinedTerm
196 Nd1949f5629fb44ac850dd45441c1b442 rdf:first sg:person.01127536021.40
197 rdf:rest N7b491420d5a648c7b8f9096808879938
198 Nd7c55d3acaf5475dae176da2b210294f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Melanoma
200 rdf:type schema:DefinedTerm
201 Ndae31b1deeff4c10a78a2ce4b2d7967f rdf:first sg:person.016255602354.24
202 rdf:rest Ndd91e29f90d64015aec0b10f0eac38c9
203 Ndd91e29f90d64015aec0b10f0eac38c9 rdf:first sg:person.01253353754.22
204 rdf:rest N0d4f64642c3e43e3b6abd272cd0ed280
205 Nddb0d6b89c7f4e8a8efbd0d843b69e93 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
206 rdf:type schema:Organization
207 Neaa66481ea924cc4b6cce84d05ed9506 schema:name doi
208 schema:value 10.1007/s00262-014-1545-8
209 rdf:type schema:PropertyValue
210 Neab913de9be141daa217767bd5b0b0e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Aged
212 rdf:type schema:DefinedTerm
213 Neddf1da4facc44b99347624d900057f4 rdf:first sg:person.0743654734.22
214 rdf:rest Nb213dca6efe042d1a75fee3628fa4fb1
215 Nf77eb7e9505f4accbe842e952d502b59 rdf:first sg:person.01275000143.77
216 rdf:rest N5c122a3515d64f2096496ee77733a4c5
217 Nf7962301fd214316b0a3a9a99d988095 schema:name Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, IRCCS, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
218 rdf:type schema:Organization
219 Nfddbb3584b154071b6bc9ff87ade111c rdf:first sg:person.01102114523.12
220 rdf:rest Nc5987f9c4a084a899c3a1e4996f13c44
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
225 schema:name Immunology
226 rdf:type schema:DefinedTerm
227 sg:journal.1096240 schema:issn 0340-7004
228 1432-0851
229 schema:name Cancer Immunology, Immunotherapy
230 rdf:type schema:Periodical
231 sg:person.01044277041.02 schema:affiliation N48c4a00384d04530b8693ec9fefbc662
232 schema:familyName Sandomenico
233 schema:givenName Fabio
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044277041.02
235 rdf:type schema:Person
236 sg:person.01102114523.12 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
237 schema:familyName Queirolo
238 schema:givenName Paola
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102114523.12
240 rdf:type schema:Person
241 sg:person.01125770034.23 schema:affiliation https://www.grid.ac/institutes/grid.417520.5
242 schema:familyName Giannarelli
243 schema:givenName Diana
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125770034.23
245 rdf:type schema:Person
246 sg:person.01127536021.40 schema:affiliation N3c33226f211a4770a081cb9f258cf159
247 schema:familyName Simeone
248 schema:givenName Ester
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127536021.40
250 rdf:type schema:Person
251 sg:person.01131161075.02 schema:affiliation N811677138bf443e7b11a61e94c9dd16f
252 schema:familyName Fulciniti
253 schema:givenName Franco
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131161075.02
255 rdf:type schema:Person
256 sg:person.01142725140.44 schema:affiliation N64870d44b48e4871998d7cfa9c1609fb
257 schema:familyName Botti
258 schema:givenName Gerardo
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142725140.44
260 rdf:type schema:Person
261 sg:person.01177215722.45 schema:affiliation N5ee57a013e324e218e384819a95d79d0
262 schema:familyName Rinaldi
263 schema:givenName Gaetana
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177215722.45
265 rdf:type schema:Person
266 sg:person.01201301337.59 schema:affiliation N09de9f615d4147a99b308729ccee0e76
267 schema:familyName Gentilcore
268 schema:givenName Giusy
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201301337.59
270 rdf:type schema:Person
271 sg:person.01212502023.44 schema:affiliation N74ea2e3c9ec5408995547be151c57a16
272 schema:familyName Ascierto
273 schema:givenName Paolo A.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44
275 rdf:type schema:Person
276 sg:person.01253353754.22 schema:affiliation N4f765d6088dd4f1e894e07b3972399d7
277 schema:familyName Curvietto
278 schema:givenName Marcello
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253353754.22
280 rdf:type schema:Person
281 sg:person.01275000143.77 schema:affiliation N27c6cb27c8e14d2aae1f43d9afb8108c
282 schema:familyName Ciliberto
283 schema:givenName Gennaro
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275000143.77
285 rdf:type schema:Person
286 sg:person.013047011360.26 schema:affiliation Nc3ee4f1878b9492d94450c8c4cc20e98
287 schema:familyName Petrillo
288 schema:givenName Antonella
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013047011360.26
290 rdf:type schema:Person
291 sg:person.01321467154.56 schema:affiliation N1e2bc267e51e4155bba7a3ce08de08f2
292 schema:familyName Esposito
293 schema:givenName Assunta
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321467154.56
295 rdf:type schema:Person
296 sg:person.01343700266.04 schema:affiliation N99afe11e109a4f24be73aa02a8563ab0
297 schema:familyName Palla
298 schema:givenName Marco
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343700266.04
300 rdf:type schema:Person
301 sg:person.016255602354.24 schema:affiliation Nc6af9f8de99d425d83e6e4de7642d270
302 schema:familyName Caracò
303 schema:givenName Corrado
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016255602354.24
305 rdf:type schema:Person
306 sg:person.016663134461.13 schema:affiliation N0202d9e4d7224e8ab47f36090dbccaff
307 schema:familyName Paone
308 schema:givenName Miriam
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016663134461.13
310 rdf:type schema:Person
311 sg:person.0624523022.47 schema:affiliation https://www.grid.ac/institutes/grid.417520.5
312 schema:familyName Ferraresi
313 schema:givenName Virginia
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624523022.47
315 rdf:type schema:Person
316 sg:person.0641150074.04 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
317 schema:familyName Marchetti
318 schema:givenName Paolo
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641150074.04
320 rdf:type schema:Person
321 sg:person.0650360120.09 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
322 schema:familyName Pistillo
323 schema:givenName Maria Pia
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650360120.09
325 rdf:type schema:Person
326 sg:person.0743654734.22 schema:affiliation N0e4633dde11c40ac95c81e13bd419826
327 schema:familyName Cavalcanti
328 schema:givenName Ernesta
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743654734.22
330 rdf:type schema:Person
331 sg:person.0752035543.31 schema:affiliation Nddb0d6b89c7f4e8a8efbd0d843b69e93
332 schema:familyName Mozzillo
333 schema:givenName Nicola
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752035543.31
335 rdf:type schema:Person
336 sg:person.0762206722.62 schema:affiliation https://www.grid.ac/institutes/grid.5326.2
337 schema:familyName Palmieri
338 schema:givenName Giuseppe
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762206722.62
340 rdf:type schema:Person
341 sg:person.0762462504.03 schema:affiliation Nf7962301fd214316b0a3a9a99d988095
342 schema:familyName Grimaldi
343 schema:givenName Antonio M.
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762462504.03
345 rdf:type schema:Person
346 sg:pub.10.1007/s00262-011-1046-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019792264
347 https://doi.org/10.1007/s00262-011-1046-y
348 rdf:type schema:CreativeWork
349 sg:pub.10.1007/s00262-013-1418-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029173312
350 https://doi.org/10.1007/s00262-013-1418-6
351 rdf:type schema:CreativeWork
352 sg:pub.10.1067/mcp.2001.113989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032912526
353 https://doi.org/10.1067/mcp.2001.113989
354 rdf:type schema:CreativeWork
355 sg:pub.10.1186/1479-5876-10-146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018588583
356 https://doi.org/10.1186/1479-5876-10-146
357 rdf:type schema:CreativeWork
358 sg:pub.10.1186/1479-5876-8-76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034028817
359 https://doi.org/10.1186/1479-5876-8-76
360 rdf:type schema:CreativeWork
361 sg:pub.10.1186/1479-5876-9-204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002969174
362 https://doi.org/10.1186/1479-5876-9-204
363 rdf:type schema:CreativeWork
364 sg:pub.10.1186/1479-5876-9-214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006168982
365 https://doi.org/10.1186/1479-5876-9-214
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1002/cncr.24951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018207285
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/j.ejca.2008.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039926565
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/s0140-6736(12)60868-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003772891
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/s1470-2045(13)70024-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051396936
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1073/pnas.1110814108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008211321
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/annonc/mdt027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008750772
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1097/cji.0b013e31817fd8f3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023122482
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1097/cji.0b013e31828eed39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020023591
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1158/1078-0432.ccr-07-4797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019812323
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1158/1078-0432.ccr-09-1624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028571226
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1158/1078-0432.ccr-10-2463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001896079
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1158/1078-0432.ccr-11-1823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010268280
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1158/1078-0432.ccr-12-2982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001223166
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1200/jco.1996.14.5.1697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082882846
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1200/jco.2007.12.7837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046075678
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1200/jco.2009.23.4799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013277178
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1200/jco.2010.28.15_suppl.2609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083942874
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1200/jco.2012.43.5966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035149915
406 rdf:type schema:CreativeWork
407 https://www.grid.ac/institutes/grid.410345.7 schema:alternateName Ospedale San Martino
408 schema:name San Martino Hospital, National Institute for Cancer Research, Genoa, Italy
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.417520.5 schema:alternateName Istituti Fisioterapici Ospitalieri
411 schema:name Regina Elena National Cancer Institute, Rome, Italy
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.5326.2 schema:alternateName National Research Council
414 schema:name National Research Council, Sassari, Italy
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.7841.a schema:alternateName Sapienza University of Rome
417 schema:name Dermopathic Institute of the Immaculate IDI-IRCCS, Rome, Italy
418 Sant’Andrea Hospital, University Sapienza, Rome, Italy
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...