A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08

AUTHORS

Dhifaf Sarhan, Erik Wennerberg, Padraig D’Arcy, Deepthy Gurajada, Stig Linder, Andreas Lundqvist

ABSTRACT

The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of proteasome deubiquitinating activity, sensitizes tumors to both NK and T cell-mediated killing. Exposure to b-AP15 significantly increased the susceptibility of tumor cell lines of various origins to NK (p < 0.0002) and T cell (p = 0.02)-mediated cytotoxicity. Treatment with b-AP15 resulted in increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 expression (p = 0.03) and decreased cFLIP expression in tumor cells in vitro. In tumor-bearing SCID/Beige mice, treatment with b-AP15 followed by infusion of either human NK cells or tumor-specific T cells resulted in a significantly delayed tumor progression compared with mice treated with NK cells (p = 0.006), T cells (p < 0.0001) or b-AP15 alone (p = 0.003). Combined infusion of NK and T cells in tumor-bearing BALB/c mice following treatment with b-AP15 resulted in a significantly prolonged long-term survival compared with mice treated with b-AP15 and NK or T cells (p ≤ 0.01). Our findings show that b-AP15-induced sensitization to TRAIL-mediated apoptosis could be used as a novel strategy to augment the anticancer effects of adoptively infused NK and T cells in patients with cancer. More... »

PAGES

1359-1368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-013-1439-1

DOI

http://dx.doi.org/10.1007/s00262-013-1439-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005191255

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23689729


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxicity, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HCT116 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy, Adoptive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "K562 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Killer Cells, Natural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MCF-7 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperidones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protease Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteasome Endopeptidase Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarhan", 
        "givenName": "Dhifaf", 
        "id": "sg:person.01001263611.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001263611.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wennerberg", 
        "givenName": "Erik", 
        "id": "sg:person.01047377011.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047377011.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u2019Arcy", 
        "givenName": "Padraig", 
        "id": "sg:person.0771447570.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771447570.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gurajada", 
        "givenName": "Deepthy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linder", 
        "givenName": "Stig", 
        "id": "sg:person.01050565740.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lundqvist", 
        "givenName": "Andreas", 
        "id": "sg:person.01256031631.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256031631.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002033675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cji.0000158855.92792.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002151888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cji.0000158855.92792.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002151888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-05-283770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002749297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003070665", 
          "https://doi.org/10.1038/nm.2536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003070665", 
          "https://doi.org/10.1038/nm.2536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3858/emm.2011.43.1.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003733204", 
          "https://doi.org/10.3858/emm.2011.43.1.003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2006.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005479285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60911-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006515864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-05-158253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009148838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-11-0814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013312775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016113094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023405417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023405417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024356780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.12.040194.003511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025354667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027647191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-4621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031336464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-4274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034546747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034962577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-222190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-05-222190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2008.07570.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037067227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.2009.02227.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037640308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-0996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037885040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.25.4847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041441843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.leukres.2007.05.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043589163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.21.7422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047557806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1988.tb00749.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052322219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.3858/emm.2011.43.3.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052766665", 
          "https://doi.org/10.3858/emm.2011.43.3.016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.10.6.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071529019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.5.12.3352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.174.8.4590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077034528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.1.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077537198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0902856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078026736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078386258", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08", 
    "datePublishedReg": "2013-08-01", 
    "description": "The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of proteasome deubiquitinating activity, sensitizes tumors to both NK and T cell-mediated killing. Exposure to b-AP15 significantly increased the susceptibility of tumor cell lines of various origins to NK (p < 0.0002) and T cell (p = 0.02)-mediated cytotoxicity. Treatment with b-AP15 resulted in increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 expression (p = 0.03) and decreased cFLIP expression in tumor cells in vitro. In tumor-bearing SCID/Beige mice, treatment with b-AP15 followed by infusion of either human NK cells or tumor-specific T cells resulted in a significantly delayed tumor progression compared with mice treated with NK cells (p = 0.006), T cells (p < 0.0001) or b-AP15 alone (p = 0.003). Combined infusion of NK and T cells in tumor-bearing BALB/c mice following treatment with b-AP15 resulted in a significantly prolonged long-term survival compared with mice treated with b-AP15 and NK or T cells (p \u2264 0.01). Our findings show that b-AP15-induced sensitization to TRAIL-mediated apoptosis could be used as a novel strategy to augment the anticancer effects of adoptively infused NK and T cells in patients with cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-013-1439-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "62"
      }
    ], 
    "name": "A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells", 
    "pagination": "1359-1368", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "18bb871f42598dd1da69f17512fc0f93bf6a55d1027409059fa9bd26685becfc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23689729"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-013-1439-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005191255"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-013-1439-1", 
      "https://app.dimensions.ai/details/publication/pub.1005191255"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000530.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-013-1439-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-013-1439-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-013-1439-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-013-1439-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-013-1439-1'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      87 URIs      47 LITERALS      35 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-013-1439-1 schema:about N0976495f83e54cffb954fe6f2419784c
2 N0980eaeb6d9d4ae798745c77468e7338
3 N0cea292355534043a4cf77e7f0e78d5a
4 N0d030e6c5c1744d0803fba9355cb9c53
5 N16fd85cdc9b24d21a8a75201a8f03177
6 N31a15dde788549e9bec76bac8003bcc1
7 N31c6dea2c4ef4b11a0aa4900a520719c
8 N3a0cd39abc5547128faf66337fc2cb01
9 N44fd255a1dec4389bccda9c8e4f1316f
10 N455011c2340d4d01b67151ef0b3b31a4
11 N611980a09ded45079e2ba525a7abda56
12 N61374a830a534e75884a4f4f4796764b
13 N63f3507dfcf14e219f2281328ad71f53
14 N746d6e219af94b30b9f3a1a9f6e051e0
15 N8e87c6c6377e464daff33bbbc4dba705
16 N96d1eef871fc4b0d9e7a86fb55fdf95b
17 N9c4d10f8f79d4d999a3a5aea55751c3b
18 Na81eb695da5847478a5dcae8f283120a
19 Nd06591a2622d4b9ba5f3cfbe0f6ce5c6
20 Nd96fa9773f8747fea8af3413b22d7243
21 Nd99cc5c4954e40d2bfd88579671ef8c6
22 Ne8ae91d0511b464789f0d33fac7117e9
23 Nec9b89fc84b745b0bfa7351e850780c8
24 Necef0a4c57984a3ebb050cc42c1fdcca
25 Nefb837f04efb436da92546f98af085c2
26 Nf9670106851a44e5b9ede50fed15b9c2
27 anzsrc-for:11
28 anzsrc-for:1107
29 schema:author N48279daf53ab40acb8e09d0492c1d893
30 schema:citation sg:pub.10.1038/nm.2536
31 sg:pub.10.3858/emm.2011.43.1.003
32 sg:pub.10.3858/emm.2011.43.3.016
33 https://app.dimensions.ai/details/publication/pub.1078386258
34 https://doi.org/10.1002/hep.20807
35 https://doi.org/10.1016/j.ejca.2006.03.018
36 https://doi.org/10.1016/j.leukres.2007.05.024
37 https://doi.org/10.1016/s0065-2776(08)60911-6
38 https://doi.org/10.1093/jnci/djn113
39 https://doi.org/10.1097/01.cji.0000158855.92792.7a
40 https://doi.org/10.1111/j.1365-2141.2008.07570.x
41 https://doi.org/10.1111/j.1365-3083.2009.02227.x
42 https://doi.org/10.1111/j.1600-065x.1988.tb00749.x
43 https://doi.org/10.1146/annurev.iy.12.040194.003511
44 https://doi.org/10.1158/0008-5472.can-04-4621
45 https://doi.org/10.1158/0008-5472.can-06-0680
46 https://doi.org/10.1158/0008-5472.can-06-4274
47 https://doi.org/10.1158/1078-0432.ccr-09-0996
48 https://doi.org/10.1158/1078-0432.ccr-11-0116
49 https://doi.org/10.1158/1078-0432.ccr-11-1347
50 https://doi.org/10.1158/1535-7163.mct-11-0814
51 https://doi.org/10.1172/jci32446
52 https://doi.org/10.1182/blood-2008-05-158253
53 https://doi.org/10.1182/blood-2009-05-222190
54 https://doi.org/10.1182/blood-2010-05-283770
55 https://doi.org/10.1200/jco.2008.21.7422
56 https://doi.org/10.1200/jco.2009.25.4847
57 https://doi.org/10.3892/or.10.6.2005
58 https://doi.org/10.4049/jimmunol.0902856
59 https://doi.org/10.4049/jimmunol.174.8.4590
60 https://doi.org/10.4049/jimmunol.180.1.163
61 https://doi.org/10.4161/cbt.5.12.3352
62 schema:datePublished 2013-08
63 schema:datePublishedReg 2013-08-01
64 schema:description The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of proteasome deubiquitinating activity, sensitizes tumors to both NK and T cell-mediated killing. Exposure to b-AP15 significantly increased the susceptibility of tumor cell lines of various origins to NK (p < 0.0002) and T cell (p = 0.02)-mediated cytotoxicity. Treatment with b-AP15 resulted in increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 expression (p = 0.03) and decreased cFLIP expression in tumor cells in vitro. In tumor-bearing SCID/Beige mice, treatment with b-AP15 followed by infusion of either human NK cells or tumor-specific T cells resulted in a significantly delayed tumor progression compared with mice treated with NK cells (p = 0.006), T cells (p < 0.0001) or b-AP15 alone (p = 0.003). Combined infusion of NK and T cells in tumor-bearing BALB/c mice following treatment with b-AP15 resulted in a significantly prolonged long-term survival compared with mice treated with b-AP15 and NK or T cells (p ≤ 0.01). Our findings show that b-AP15-induced sensitization to TRAIL-mediated apoptosis could be used as a novel strategy to augment the anticancer effects of adoptively infused NK and T cells in patients with cancer.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree false
68 schema:isPartOf Na64b23619b0b4bd3a275941f9476a123
69 Ne74e794bd92f43bb9add347423239da9
70 sg:journal.1096240
71 schema:name A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
72 schema:pagination 1359-1368
73 schema:productId N0abca52d728e4e1e9599a089382b3211
74 N21f75c2340b64227b073c43c3cde88d4
75 N25012b3328b942a789edd8dc8494ba76
76 N3cd1f9ece18a416fbc6347d6c0d0fde7
77 N7a7b2648fca14738b2cf2bce1996fe0e
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005191255
79 https://doi.org/10.1007/s00262-013-1439-1
80 schema:sdDatePublished 2019-04-10T20:00
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Nc1837c9ba2a94e509d17d3fe3140affe
83 schema:url http://link.springer.com/10.1007%2Fs00262-013-1439-1
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0976495f83e54cffb954fe6f2419784c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Blotting, Western
89 rdf:type schema:DefinedTerm
90 N0980eaeb6d9d4ae798745c77468e7338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Humans
92 rdf:type schema:DefinedTerm
93 N0abca52d728e4e1e9599a089382b3211 schema:name readcube_id
94 schema:value 18bb871f42598dd1da69f17512fc0f93bf6a55d1027409059fa9bd26685becfc
95 rdf:type schema:PropertyValue
96 N0cea292355534043a4cf77e7f0e78d5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cytokines
98 rdf:type schema:DefinedTerm
99 N0d030e6c5c1744d0803fba9355cb9c53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Xenograft Model Antitumor Assays
101 rdf:type schema:DefinedTerm
102 N16fd85cdc9b24d21a8a75201a8f03177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Protease Inhibitors
104 rdf:type schema:DefinedTerm
105 N1b3e6ba7285f4399811545cbfdbef066 rdf:first sg:person.0771447570.17
106 rdf:rest N7739cab017ac43b885f8f5638e0ce22a
107 N21f75c2340b64227b073c43c3cde88d4 schema:name nlm_unique_id
108 schema:value 8605732
109 rdf:type schema:PropertyValue
110 N25012b3328b942a789edd8dc8494ba76 schema:name doi
111 schema:value 10.1007/s00262-013-1439-1
112 rdf:type schema:PropertyValue
113 N31a15dde788549e9bec76bac8003bcc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name TNF-Related Apoptosis-Inducing Ligand
115 rdf:type schema:DefinedTerm
116 N31c6dea2c4ef4b11a0aa4900a520719c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Animals
118 rdf:type schema:DefinedTerm
119 N3a0cd39abc5547128faf66337fc2cb01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cells, Cultured
121 rdf:type schema:DefinedTerm
122 N3cd1f9ece18a416fbc6347d6c0d0fde7 schema:name pubmed_id
123 schema:value 23689729
124 rdf:type schema:PropertyValue
125 N44fd255a1dec4389bccda9c8e4f1316f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice, SCID
127 rdf:type schema:DefinedTerm
128 N455011c2340d4d01b67151ef0b3b31a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Apoptosis
130 rdf:type schema:DefinedTerm
131 N48279daf53ab40acb8e09d0492c1d893 rdf:first sg:person.01001263611.37
132 rdf:rest Nb16ccce57ea44ded84355bd5844dd011
133 N611980a09ded45079e2ba525a7abda56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cytotoxicity, Immunologic
135 rdf:type schema:DefinedTerm
136 N61374a830a534e75884a4f4f4796764b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Immunotherapy, Adoptive
138 rdf:type schema:DefinedTerm
139 N63f3507dfcf14e219f2281328ad71f53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice
141 rdf:type schema:DefinedTerm
142 N7243966dae64499cbec3bcdb0372581d rdf:first sg:person.01050565740.93
143 rdf:rest Nc3fb7fbade9d4b6b9060c55ffb32dc59
144 N746d6e219af94b30b9f3a1a9f6e051e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Neoplasms
146 rdf:type schema:DefinedTerm
147 N7739cab017ac43b885f8f5638e0ce22a rdf:first Ndf9ab437b5124246b3e756c5e416060b
148 rdf:rest N7243966dae64499cbec3bcdb0372581d
149 N7a7b2648fca14738b2cf2bce1996fe0e schema:name dimensions_id
150 schema:value pub.1005191255
151 rdf:type schema:PropertyValue
152 N8e87c6c6377e464daff33bbbc4dba705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Ubiquitination
154 rdf:type schema:DefinedTerm
155 N96d1eef871fc4b0d9e7a86fb55fdf95b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice, Inbred BALB C
157 rdf:type schema:DefinedTerm
158 N9c4d10f8f79d4d999a3a5aea55751c3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name K562 Cells
160 rdf:type schema:DefinedTerm
161 Na64b23619b0b4bd3a275941f9476a123 schema:volumeNumber 62
162 rdf:type schema:PublicationVolume
163 Na81eb695da5847478a5dcae8f283120a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name T-Lymphocytes
165 rdf:type schema:DefinedTerm
166 Nb16ccce57ea44ded84355bd5844dd011 rdf:first sg:person.01047377011.72
167 rdf:rest N1b3e6ba7285f4399811545cbfdbef066
168 Nc1837c9ba2a94e509d17d3fe3140affe schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 Nc3fb7fbade9d4b6b9060c55ffb32dc59 rdf:first sg:person.01256031631.99
171 rdf:rest rdf:nil
172 Nd06591a2622d4b9ba5f3cfbe0f6ce5c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Piperidones
174 rdf:type schema:DefinedTerm
175 Nd96fa9773f8747fea8af3413b22d7243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name HeLa Cells
177 rdf:type schema:DefinedTerm
178 Nd99cc5c4954e40d2bfd88579671ef8c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Killer Cells, Natural
180 rdf:type schema:DefinedTerm
181 Ndf9ab437b5124246b3e756c5e416060b schema:affiliation https://www.grid.ac/institutes/grid.4714.6
182 schema:familyName Gurajada
183 schema:givenName Deepthy
184 rdf:type schema:Person
185 Ne74e794bd92f43bb9add347423239da9 schema:issueNumber 8
186 rdf:type schema:PublicationIssue
187 Ne8ae91d0511b464789f0d33fac7117e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Proteasome Endopeptidase Complex
189 rdf:type schema:DefinedTerm
190 Nec9b89fc84b745b0bfa7351e850780c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Cell Line, Tumor
192 rdf:type schema:DefinedTerm
193 Necef0a4c57984a3ebb050cc42c1fdcca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name MCF-7 Cells
195 rdf:type schema:DefinedTerm
196 Nefb837f04efb436da92546f98af085c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Combined Modality Therapy
198 rdf:type schema:DefinedTerm
199 Nf9670106851a44e5b9ede50fed15b9c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name HCT116 Cells
201 rdf:type schema:DefinedTerm
202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical and Health Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
206 schema:name Immunology
207 rdf:type schema:DefinedTerm
208 sg:journal.1096240 schema:issn 0340-7004
209 1432-0851
210 schema:name Cancer Immunology, Immunotherapy
211 rdf:type schema:Periodical
212 sg:person.01001263611.37 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
213 schema:familyName Sarhan
214 schema:givenName Dhifaf
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001263611.37
216 rdf:type schema:Person
217 sg:person.01047377011.72 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
218 schema:familyName Wennerberg
219 schema:givenName Erik
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047377011.72
221 rdf:type schema:Person
222 sg:person.01050565740.93 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
223 schema:familyName Linder
224 schema:givenName Stig
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93
226 rdf:type schema:Person
227 sg:person.01256031631.99 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
228 schema:familyName Lundqvist
229 schema:givenName Andreas
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256031631.99
231 rdf:type schema:Person
232 sg:person.0771447570.17 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
233 schema:familyName D’Arcy
234 schema:givenName Padraig
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771447570.17
236 rdf:type schema:Person
237 sg:pub.10.1038/nm.2536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003070665
238 https://doi.org/10.1038/nm.2536
239 rdf:type schema:CreativeWork
240 sg:pub.10.3858/emm.2011.43.1.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003733204
241 https://doi.org/10.3858/emm.2011.43.1.003
242 rdf:type schema:CreativeWork
243 sg:pub.10.3858/emm.2011.43.3.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052766665
244 https://doi.org/10.3858/emm.2011.43.3.016
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1078386258 schema:CreativeWork
247 https://doi.org/10.1002/hep.20807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023405417
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.ejca.2006.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005479285
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.leukres.2007.05.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043589163
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0065-2776(08)60911-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006515864
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1093/jnci/djn113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016113094
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/01.cji.0000158855.92792.7a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002151888
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1365-2141.2008.07570.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037067227
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1365-3083.2009.02227.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037640308
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1600-065x.1988.tb00749.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052322219
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1146/annurev.iy.12.040194.003511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025354667
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1158/0008-5472.can-04-4621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031336464
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1158/0008-5472.can-06-0680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002033675
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1158/0008-5472.can-06-4274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034546747
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1158/1078-0432.ccr-09-0996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037885040
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1158/1078-0432.ccr-11-0116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034962577
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1158/1078-0432.ccr-11-1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024356780
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/1535-7163.mct-11-0814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013312775
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1172/jci32446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027647191
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1182/blood-2008-05-158253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009148838
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1182/blood-2009-05-222190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035527613
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1182/blood-2010-05-283770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002749297
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.2008.21.7422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047557806
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1200/jco.2009.25.4847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041441843
292 rdf:type schema:CreativeWork
293 https://doi.org/10.3892/or.10.6.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071529019
294 rdf:type schema:CreativeWork
295 https://doi.org/10.4049/jimmunol.0902856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078026736
296 rdf:type schema:CreativeWork
297 https://doi.org/10.4049/jimmunol.174.8.4590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077034528
298 rdf:type schema:CreativeWork
299 https://doi.org/10.4049/jimmunol.180.1.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077537198
300 rdf:type schema:CreativeWork
301 https://doi.org/10.4161/cbt.5.12.3352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293993
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
304 schema:name Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...