Optimized adoptive T-cell therapy for the treatment of residual mantle cell lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Corey M. Munger, Ganapati V. Hegde, Dennis D. Weisenburger, Julie M. Vose, Shantaram S. Joshi

ABSTRACT

Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm with few patients achieving long-term survival with current treatment regimens. High-dose therapy is effective in reducing the tumor burden; however, patients eventually relapse due to minimal residual disease. Having demonstrated efficacy in other malignancies, the effectiveness of dendritic cell-based immunotherapy for minimal residual MCL was examined. We demonstrated that dendritic cells (DC) primed with MCL antigens stimulated the activation of MCL-specific T cells that recognized and destroyed both MCL cell lines and primary MCL in vitro. In addition, in vivo studies demonstrated that adoptively transferred MCL-specific T cells were able to significantly inhibit tumor growth in mice with minimal residual MCL. Subsequently, when combined with CHOP chemotherapy, adoptive T-cell therapy was able to significantly extend the survival of the mice by further reducing the tumor burden. These results clearly show that MCL-specific cellular immunotherapy is effective in treating minimal residual MCL, paving the way for future clinical studies. More... »

PAGES

1819-1832

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-012-1229-1

DOI

http://dx.doi.org/10.1007/s00262-012-1229-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000682251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22441656


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