Ontology type: schema:ScholarlyArticle
2011-12
AUTHORSShinichirou Izawa, Koji Kono, Kousaku Mimura, Yoshihiko Kawaguchi, Mitsuaki Watanabe, Takanori Maruyama, Hideki Fujii
ABSTRACTHuman NK cells can be divided into two subsets, CD56(dim)CD16(+)NK and CD56(bright)CD16(-)NK cells, based on their expression of CD56 and CD16. In the present study, we analyzed the relationship between CD56(dim)/CD56(bright) NK cells and H₂O₂ in tumor-infiltrating NK cells in patients with gastric (n = 50) and esophageal (n = 35) cancer. The ratio of CD56(dim) NK cells infiltrating tumors gradually decreased according to disease progression. H₂O₂ was abundantly produced within tumor microenvironments, and there was an inverse correlation between CD56(dim) NK cell infiltration and H₂O₂ production. CD56(dim) NK cells are more sensitive to apoptosis induced by physiological levels of H₂O₂ than CD56(bright) NK cells. Furthermore, the exposure of NK cells to H₂O₂ resulted in the impairment of ADCC activity. In conclusion, H₂O₂ produced within tumor microenvironments inversely correlated with the infiltration of CD56(dim) NK cells, possibly due to their preferentially induced cell death. These observations may explain one of the mechanisms behind NK cell dysfunction frequently observed in tumor microenvironments. More... »
PAGES1801-1810
http://scigraph.springernature.com/pub.10.1007/s00262-011-1082-7
DOIhttp://dx.doi.org/10.1007/s00262-011-1082-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017870949
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21811786
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CD56 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Squamous Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Separation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Esophageal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Flow Cytometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydrogen Peroxide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Killer Cells, Natural",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Subsets",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes, Tumor-Infiltrating",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stomach Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Microenvironment",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Izawa",
"givenName": "Shinichirou",
"id": "sg:person.01032310467.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032310467.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Kono",
"givenName": "Koji",
"id": "sg:person.01362133435.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362133435.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Mimura",
"givenName": "Kousaku",
"id": "sg:person.01033220160.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033220160.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Kawaguchi",
"givenName": "Yoshihiko",
"id": "sg:person.0636527335.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636527335.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Watanabe",
"givenName": "Mitsuaki",
"id": "sg:person.01251041175.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251041175.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Maruyama",
"givenName": "Takanori",
"id": "sg:person.01020364175.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020364175.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Yamanashi",
"id": "https://www.grid.ac/institutes/grid.267500.6",
"name": [
"First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898, Chuo-city, Yamanashi, Japan"
],
"type": "Organization"
},
"familyName": "Fujii",
"givenName": "Hideki",
"id": "sg:person.014173406752.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014173406752.52"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0891-5849(99)00087-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004885588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.179.7.4513",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014694953"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.freeradbiomed.2004.05.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016176635"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2090",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016255227",
"https://doi.org/10.1038/nrc2090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpcell.00496.2001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016305518"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-05-0857",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016717835"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-4144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018143652"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.8957",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019255637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.00349.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019750396"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-2476",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020241992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020837704"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.2910610605",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022670634"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2249.1997.4771375.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025609621"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.10973",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029932238"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20010659",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030015772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm200103153441101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031768583"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.22370",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033051252"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.immunol.15.1.323",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033355295"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/cimm.1999.1586",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034460990"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/eji.1830260620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034978148"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa033025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035161767"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036295371"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10585-006-9043-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038621216",
"https://doi.org/10.1007/s10585-006-9043-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10585-006-9043-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038621216",
"https://doi.org/10.1007/s10585-006-9043-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0003-9861(03)00283-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040381357"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0003-9861(03)00283-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040381357"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/immu.200390014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041606830"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2006.08.8021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042832378"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2008.10.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044735212"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m105660200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045369037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-3083.2005.01692.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047430185"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-3083.2005.01692.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047430185"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1471-4906(01)02060-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052990106"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075175865",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.172.12.7335",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076850126"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.173.11.6547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076969423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.175.10.6852",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077137403"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077645853",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083347622",
"type": "CreativeWork"
}
],
"datePublished": "2011-12",
"datePublishedReg": "2011-12-01",
"description": "Human NK cells can be divided into two subsets, CD56(dim)CD16(+)NK and CD56(bright)CD16(-)NK cells, based on their expression of CD56 and CD16. In the present study, we analyzed the relationship between CD56(dim)/CD56(bright) NK cells and H\u2082O\u2082 in tumor-infiltrating NK cells in patients with gastric (n = 50) and esophageal (n = 35) cancer. The ratio of CD56(dim) NK cells infiltrating tumors gradually decreased according to disease progression. H\u2082O\u2082 was abundantly produced within tumor microenvironments, and there was an inverse correlation between CD56(dim) NK cell infiltration and H\u2082O\u2082 production. CD56(dim) NK cells are more sensitive to apoptosis induced by physiological levels of H\u2082O\u2082 than CD56(bright) NK cells. Furthermore, the exposure of NK cells to H\u2082O\u2082 resulted in the impairment of ADCC activity. In conclusion, H\u2082O\u2082 produced within tumor microenvironments inversely correlated with the infiltration of CD56(dim) NK cells, possibly due to their preferentially induced cell death. These observations may explain one of the mechanisms behind NK cell dysfunction frequently observed in tumor microenvironments.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00262-011-1082-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.6049688",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6067445",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1096240",
"issn": [
"0340-7004",
"1432-0851"
],
"name": "Cancer Immunology, Immunotherapy",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "60"
}
],
"name": "H2O2 production within tumor microenvironment inversely correlated with infiltration of CD56dim NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction",
"pagination": "1801-1810",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"552633d46a23e3762e6536c959c90a3b90d514f71558691e423d83cb74d33650"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21811786"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8605732"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00262-011-1082-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017870949"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00262-011-1082-7",
"https://app.dimensions.ai/details/publication/pub.1017870949"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T23:28",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000531.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00262-011-1082-7"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-1082-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-1082-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-1082-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-1082-7'
This table displays all metadata directly associated to this object as RDF triples.
290 TRIPLES
21 PREDICATES
82 URIs
38 LITERALS
26 BLANK NODES