Impact of minimal tumor burden on antibody response to vaccination View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Soo-Kie Kim, Xiaohong Wu, Govind Ragupathi, John Gathuru, Fusataka Koide, Nai-Kong Cheung, Katherine Panageas, Philip O. Livingston

ABSTRACT

Four randomized phase III trials conducted recently in melanoma patients in the adjuvant setting have been based in part on the correlation between antibody responses in immunized patients and improved survival. Each of these randomized trials demonstrated no clinical benefit, although again there was a significant correlation between antibody response after vaccination and disease free and overall survival. To better understand this paradox, we established a surgical adjuvant model targeting GD2 ganglioside on EL4 lymphoma cells injected into the foot pad followed by amputation at variable intervals. Our findings are (1) comparable strong therapeutic benefit resulted from treatment of mice after amputation with a GD2-KLH conjugate vaccine or with anti-GD2 monoclonal antibody 3F8. (2) The strongest correlation was between antibody induction in response to vaccination and prolonged survival. (3) Antibody titers in response to vaccination in tumor challenged mice as compared to unchallenged mice were far lower despite the absence of detectable recurrences at the time. (4) The half life of administered 3F8 monoclonal antibody (but not control antibody) in challenged mice administered was significantly shorter than the half life of 3F8 antibody in unchallenged controls. The correlation between vaccine-induced antibody titers and prolonged survival may reflect, at least in part, increased tumor burden in antibody-negative mice. Absorption of vaccine-induced antibodies by increased, although not detected tumor burden may also explain the correlation between vaccine-induced antibody titers and survival in the adjuvant clinical trials described above. More... »

PAGES

621-627

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-011-0975-9

DOI

http://dx.doi.org/10.1007/s00262-011-0975-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033129010

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21267719


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adjuvants, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody-Dependent Cell Cytotoxicity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cancer Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gangliosides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemocyanins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Conjugate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Soo-Kie", 
        "id": "sg:person.01021553146.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021553146.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Xiaohong", 
        "id": "sg:person.01124126357.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124126357.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ragupathi", 
        "givenName": "Govind", 
        "id": "sg:person.015714470407.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015714470407.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VaxInnate (United States)", 
          "id": "https://www.grid.ac/institutes/grid.438933.6", 
          "name": [
            "Vaxinnate Corporation, 08512, Cranbury, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gathuru", 
        "givenName": "John", 
        "id": "sg:person.0616564346.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616564346.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Nabi Biopharmaceuticals, 20852, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koide", 
        "givenName": "Fusataka", 
        "id": "sg:person.0733012746.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733012746.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheung", 
        "givenName": "Nai-Kong", 
        "id": "sg:person.011122030077.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122030077.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panageas", 
        "givenName": "Katherine", 
        "id": "sg:person.01356724235.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356724235.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Livingston", 
        "givenName": "Philip O.", 
        "id": "sg:person.011221226737.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011221226737.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00008390-199708001-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000149786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-199708001-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000149786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-199708001-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000149786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.79.24.7629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005040851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01741326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006900227", 
          "https://doi.org/10.1007/bf01741326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01741326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006900227", 
          "https://doi.org/10.1007/bf01741326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(99)00316-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007433020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-007-0289-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012898059", 
          "https://doi.org/10.1007/s00262-007-0289-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-007-0289-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012898059", 
          "https://doi.org/10.1007/s00262-007-0289-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199210000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015014754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199210000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015014754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1963.tb08933.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018174403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2007.06.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023711291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.182.5.1609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025282267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-199601000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029664280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-199601000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029664280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.182.1.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030300143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.17.1777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034639576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034865923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038445109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)92398-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041139747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)92398-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041139747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970926)73:1<42::aid-ijc8>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041156481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950115)75:2<495::aid-cncr2820750212>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041500559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(00)00195-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043872284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-1103-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044850066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(94)90065-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053186033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4439(94)90065-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053186033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.24.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.22.4189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074954332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076064065", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076596038", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077039504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077977586", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079061452", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079273692", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079783288", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/66.2.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082049833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082727127", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083290317", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347511", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.8505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083944531"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-05", 
    "datePublishedReg": "2011-05-01", 
    "description": "Four randomized phase III trials conducted recently in melanoma patients in the adjuvant setting have been based in part on the correlation between antibody responses in immunized patients and improved survival. Each of these randomized trials demonstrated no clinical benefit, although again there was a significant correlation between antibody response after vaccination and disease free and overall survival. To better understand this paradox, we established a surgical adjuvant model targeting GD2 ganglioside on EL4 lymphoma cells injected into the foot pad followed by amputation at variable intervals. Our findings are (1) comparable strong therapeutic benefit resulted from treatment of mice after amputation with a GD2-KLH conjugate vaccine or with anti-GD2 monoclonal antibody 3F8. (2) The strongest correlation was between antibody induction in response to vaccination and prolonged survival. (3) Antibody titers in response to vaccination in tumor challenged mice as compared to unchallenged mice were far lower despite the absence of detectable recurrences at the time. (4) The half life of administered 3F8 monoclonal antibody (but not control antibody) in challenged mice administered was significantly shorter than the half life of 3F8 antibody in unchallenged controls. The correlation between vaccine-induced antibody titers and prolonged survival may reflect, at least in part, increased tumor burden in antibody-negative mice. Absorption of vaccine-induced antibodies by increased, although not detected tumor burden may also explain the correlation between vaccine-induced antibody titers and survival in the adjuvant clinical trials described above.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-011-0975-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435475", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "60"
      }
    ], 
    "name": "Impact of minimal tumor burden on antibody response to vaccination", 
    "pagination": "621-627", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9dd244e717e62a913904d6c8d04d6d356669dee4f6471f71fb2085bc8742d940"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21267719"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-011-0975-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033129010"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-011-0975-9", 
      "https://app.dimensions.ai/details/publication/pub.1033129010"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-011-0975-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-0975-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-0975-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-0975-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-011-0975-9'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      82 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-011-0975-9 schema:about N00e31a8b16a945538298a642d409ed90
2 N073db544d76d43b08f9603f0dbd8ff6c
3 N3d80b66cbdca491da7c6b78d7077eed4
4 N45be17ed0779449a950cba900243ce0a
5 N498625fbd75e483fbc7f0876955f8bb7
6 N5a9eacd0276f4e36a3db4c81a87bcb1d
7 N5c9bac5b972b47bbb2bc9c7ad5040090
8 N5f449f6aff374d078b06675c00f366e7
9 N6d5f57deb4954ba4ba668fa03b26edd5
10 N749ce3c185c64c2a96d0a5513813170c
11 N878681a6183543839045a0ce36abc6fe
12 N91c840566a1640698b19c35f734f6ea6
13 Na02774f57bc6480bac9e298b321643a7
14 Nad44bdd738b54a28b84d81981589cf03
15 Nb0b0c8a3a8d54270a6894a40745b4e48
16 Nb5d128e8ebd94bc88c6b744e592cb8c9
17 Nb909d6149b4a4d1ea1274b1dfa166a58
18 Nf456cfcc720e4434b44795473e63af96
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author N2217f2a8c3024184aa5fdb51b34df05b
22 schema:citation sg:pub.10.1007/bf01741326
23 sg:pub.10.1007/s00262-007-0289-0
24 https://app.dimensions.ai/details/publication/pub.1076064065
25 https://app.dimensions.ai/details/publication/pub.1076596038
26 https://app.dimensions.ai/details/publication/pub.1077977586
27 https://app.dimensions.ai/details/publication/pub.1079061452
28 https://app.dimensions.ai/details/publication/pub.1079273692
29 https://app.dimensions.ai/details/publication/pub.1079783288
30 https://app.dimensions.ai/details/publication/pub.1082727127
31 https://app.dimensions.ai/details/publication/pub.1083290317
32 https://app.dimensions.ai/details/publication/pub.1083347511
33 https://doi.org/10.1002/(sici)1097-0215(19970926)73:1<42::aid-ijc8>3.0.co;2-1
34 https://doi.org/10.1002/1097-0142(19950115)75:2<495::aid-cncr2820750212>3.0.co;2-s
35 https://doi.org/10.1016/0925-4439(94)90065-5
36 https://doi.org/10.1016/j.vaccine.2007.06.033
37 https://doi.org/10.1016/s0140-6736(94)92398-1
38 https://doi.org/10.1016/s0264-410x(00)00195-x
39 https://doi.org/10.1016/s0264-410x(99)00316-3
40 https://doi.org/10.1056/nejmoa052122
41 https://doi.org/10.1073/pnas.79.24.7629
42 https://doi.org/10.1084/jem.182.1.67
43 https://doi.org/10.1084/jem.182.5.1609
44 https://doi.org/10.1093/jnci/66.2.249
45 https://doi.org/10.1093/jnci/85.24.2012
46 https://doi.org/10.1097/00000658-199210000-00010
47 https://doi.org/10.1097/00002371-199601000-00007
48 https://doi.org/10.1097/00008390-199708001-00024
49 https://doi.org/10.1111/j.1471-4159.1963.tb08933.x
50 https://doi.org/10.1158/0008-5472.can-04-2164
51 https://doi.org/10.1158/0008-5472.can-05-1894
52 https://doi.org/10.1158/0008-5472.can-06-1158
53 https://doi.org/10.1158/1078-0432.ccr-1103-3
54 https://doi.org/10.1200/jco.2001.19.22.4189
55 https://doi.org/10.1200/jco.2008.17.1777
56 https://doi.org/10.1200/jco.2010.28.15_suppl.8505
57 schema:datePublished 2011-05
58 schema:datePublishedReg 2011-05-01
59 schema:description Four randomized phase III trials conducted recently in melanoma patients in the adjuvant setting have been based in part on the correlation between antibody responses in immunized patients and improved survival. Each of these randomized trials demonstrated no clinical benefit, although again there was a significant correlation between antibody response after vaccination and disease free and overall survival. To better understand this paradox, we established a surgical adjuvant model targeting GD2 ganglioside on EL4 lymphoma cells injected into the foot pad followed by amputation at variable intervals. Our findings are (1) comparable strong therapeutic benefit resulted from treatment of mice after amputation with a GD2-KLH conjugate vaccine or with anti-GD2 monoclonal antibody 3F8. (2) The strongest correlation was between antibody induction in response to vaccination and prolonged survival. (3) Antibody titers in response to vaccination in tumor challenged mice as compared to unchallenged mice were far lower despite the absence of detectable recurrences at the time. (4) The half life of administered 3F8 monoclonal antibody (but not control antibody) in challenged mice administered was significantly shorter than the half life of 3F8 antibody in unchallenged controls. The correlation between vaccine-induced antibody titers and prolonged survival may reflect, at least in part, increased tumor burden in antibody-negative mice. Absorption of vaccine-induced antibodies by increased, although not detected tumor burden may also explain the correlation between vaccine-induced antibody titers and survival in the adjuvant clinical trials described above.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N36e75cd1920b43ec9e950734744ac840
64 Nd79dadb0deba451193fec1e71f4c1f60
65 sg:journal.1096240
66 schema:name Impact of minimal tumor burden on antibody response to vaccination
67 schema:pagination 621-627
68 schema:productId N1daaa39c08b643519b9f7bbae93d303c
69 N6970d5815fb14e929f1ed80536944cf9
70 N6ba9ca4380654f0492127d5234940663
71 Ndc1bcea7f63348ad8809a51db618c8be
72 Ne56b4f5cfd80426cb8edc8da4019d5ed
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033129010
74 https://doi.org/10.1007/s00262-011-0975-9
75 schema:sdDatePublished 2019-04-10T16:46
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N4706b9c6244a4b0ca2975bce30cd8553
78 schema:url http://link.springer.com/10.1007%2Fs00262-011-0975-9
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N00e31a8b16a945538298a642d409ed90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Adjuvants, Immunologic
84 rdf:type schema:DefinedTerm
85 N073db544d76d43b08f9603f0dbd8ff6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Hemocyanins
87 rdf:type schema:DefinedTerm
88 N147bdcc2df2b4b7082efd66907c6d965 rdf:first sg:person.015714470407.71
89 rdf:rest N1e65d40240f8436eba25630a2566f6a0
90 N1ba5caa7e07b485db6395b6bac46e3b2 rdf:first sg:person.011221226737.23
91 rdf:rest rdf:nil
92 N1daaa39c08b643519b9f7bbae93d303c schema:name dimensions_id
93 schema:value pub.1033129010
94 rdf:type schema:PropertyValue
95 N1e65d40240f8436eba25630a2566f6a0 rdf:first sg:person.0616564346.53
96 rdf:rest Nf5cc44ec95e14493b0156e24ae8b43c5
97 N2217f2a8c3024184aa5fdb51b34df05b rdf:first sg:person.01021553146.18
98 rdf:rest N2df8c1881a0d4a7db91104c8c810d8a2
99 N2df8c1881a0d4a7db91104c8c810d8a2 rdf:first sg:person.01124126357.64
100 rdf:rest N147bdcc2df2b4b7082efd66907c6d965
101 N36e75cd1920b43ec9e950734744ac840 schema:issueNumber 5
102 rdf:type schema:PublicationIssue
103 N3d80b66cbdca491da7c6b78d7077eed4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Gangliosides
105 rdf:type schema:DefinedTerm
106 N412786ae528749d29c5b27e979e61218 rdf:first sg:person.011122030077.73
107 rdf:rest N76b1cdb91c9d4b81aa16db0be2190723
108 N45be17ed0779449a950cba900243ce0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice, Inbred C57BL
110 rdf:type schema:DefinedTerm
111 N4706b9c6244a4b0ca2975bce30cd8553 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N498625fbd75e483fbc7f0876955f8bb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Antibody-Dependent Cell Cytotoxicity
115 rdf:type schema:DefinedTerm
116 N5a9eacd0276f4e36a3db4c81a87bcb1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Enzyme-Linked Immunosorbent Assay
118 rdf:type schema:DefinedTerm
119 N5c9bac5b972b47bbb2bc9c7ad5040090 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Vaccines, Conjugate
121 rdf:type schema:DefinedTerm
122 N5f449f6aff374d078b06675c00f366e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antibodies, Monoclonal
124 rdf:type schema:DefinedTerm
125 N6970d5815fb14e929f1ed80536944cf9 schema:name nlm_unique_id
126 schema:value 8605732
127 rdf:type schema:PropertyValue
128 N6ba9ca4380654f0492127d5234940663 schema:name pubmed_id
129 schema:value 21267719
130 rdf:type schema:PropertyValue
131 N6d5f57deb4954ba4ba668fa03b26edd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Disease-Free Survival
133 rdf:type schema:DefinedTerm
134 N749ce3c185c64c2a96d0a5513813170c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Antibodies, Neoplasm
136 rdf:type schema:DefinedTerm
137 N76b1cdb91c9d4b81aa16db0be2190723 rdf:first sg:person.01356724235.54
138 rdf:rest N1ba5caa7e07b485db6395b6bac46e3b2
139 N878681a6183543839045a0ce36abc6fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cell Line, Tumor
141 rdf:type schema:DefinedTerm
142 N91c840566a1640698b19c35f734f6ea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mice
144 rdf:type schema:DefinedTerm
145 N95751ef02dde47d2b27035f1dccc879b schema:name Nabi Biopharmaceuticals, 20852, Rockville, MD, USA
146 rdf:type schema:Organization
147 Na02774f57bc6480bac9e298b321643a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Immunoglobulin G
149 rdf:type schema:DefinedTerm
150 Nad44bdd738b54a28b84d81981589cf03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Lymphoma
152 rdf:type schema:DefinedTerm
153 Nb0b0c8a3a8d54270a6894a40745b4e48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Vaccination
155 rdf:type schema:DefinedTerm
156 Nb5d128e8ebd94bc88c6b744e592cb8c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Tumor Burden
158 rdf:type schema:DefinedTerm
159 Nb909d6149b4a4d1ea1274b1dfa166a58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Animals
161 rdf:type schema:DefinedTerm
162 Nd79dadb0deba451193fec1e71f4c1f60 schema:volumeNumber 60
163 rdf:type schema:PublicationVolume
164 Ndc1bcea7f63348ad8809a51db618c8be schema:name doi
165 schema:value 10.1007/s00262-011-0975-9
166 rdf:type schema:PropertyValue
167 Ne56b4f5cfd80426cb8edc8da4019d5ed schema:name readcube_id
168 schema:value 9dd244e717e62a913904d6c8d04d6d356669dee4f6471f71fb2085bc8742d940
169 rdf:type schema:PropertyValue
170 Nf456cfcc720e4434b44795473e63af96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cancer Vaccines
172 rdf:type schema:DefinedTerm
173 Nf5cc44ec95e14493b0156e24ae8b43c5 rdf:first sg:person.0733012746.00
174 rdf:rest N412786ae528749d29c5b27e979e61218
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
179 schema:name Immunology
180 rdf:type schema:DefinedTerm
181 sg:grant.2435475 http://pending.schema.org/fundedItem sg:pub.10.1007/s00262-011-0975-9
182 rdf:type schema:MonetaryGrant
183 sg:journal.1096240 schema:issn 0340-7004
184 1432-0851
185 schema:name Cancer Immunology, Immunotherapy
186 rdf:type schema:Periodical
187 sg:person.01021553146.18 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
188 schema:familyName Kim
189 schema:givenName Soo-Kie
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021553146.18
191 rdf:type schema:Person
192 sg:person.011122030077.73 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
193 schema:familyName Cheung
194 schema:givenName Nai-Kong
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011122030077.73
196 rdf:type schema:Person
197 sg:person.011221226737.23 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
198 schema:familyName Livingston
199 schema:givenName Philip O.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011221226737.23
201 rdf:type schema:Person
202 sg:person.01124126357.64 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
203 schema:familyName Wu
204 schema:givenName Xiaohong
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124126357.64
206 rdf:type schema:Person
207 sg:person.01356724235.54 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
208 schema:familyName Panageas
209 schema:givenName Katherine
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356724235.54
211 rdf:type schema:Person
212 sg:person.015714470407.71 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
213 schema:familyName Ragupathi
214 schema:givenName Govind
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015714470407.71
216 rdf:type schema:Person
217 sg:person.0616564346.53 schema:affiliation https://www.grid.ac/institutes/grid.438933.6
218 schema:familyName Gathuru
219 schema:givenName John
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616564346.53
221 rdf:type schema:Person
222 sg:person.0733012746.00 schema:affiliation N95751ef02dde47d2b27035f1dccc879b
223 schema:familyName Koide
224 schema:givenName Fusataka
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733012746.00
226 rdf:type schema:Person
227 sg:pub.10.1007/bf01741326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006900227
228 https://doi.org/10.1007/bf01741326
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s00262-007-0289-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012898059
231 https://doi.org/10.1007/s00262-007-0289-0
232 rdf:type schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1076064065 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1076596038 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1077977586 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1079061452 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1079273692 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079783288 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1082727127 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1083290317 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1083347511 schema:CreativeWork
242 https://doi.org/10.1002/(sici)1097-0215(19970926)73:1<42::aid-ijc8>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041156481
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/1097-0142(19950115)75:2<495::aid-cncr2820750212>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1041500559
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0925-4439(94)90065-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053186033
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.vaccine.2007.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023711291
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0140-6736(94)92398-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041139747
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0264-410x(00)00195-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043872284
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0264-410x(99)00316-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007433020
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1056/nejmoa052122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035589584
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1073/pnas.79.24.7629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005040851
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1084/jem.182.1.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030300143
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1084/jem.182.5.1609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025282267
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/jnci/66.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082049833
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1093/jnci/85.24.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818361
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/00000658-199210000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015014754
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/00002371-199601000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029664280
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1097/00008390-199708001-00024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000149786
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1471-4159.1963.tb08933.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018174403
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1158/0008-5472.can-04-2164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077039504
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1158/0008-5472.can-05-1894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038445109
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1158/0008-5472.can-06-1158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034865923
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1158/1078-0432.ccr-1103-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044850066
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1200/jco.2001.19.22.4189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074954332
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1200/jco.2008.17.1777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034639576
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1200/jco.2010.28.15_suppl.8505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083944531
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.438933.6 schema:alternateName VaxInnate (United States)
291 schema:name Vaxinnate Corporation, 08512, Cranbury, NJ, USA
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
294 schema:name Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA
295 Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA
296 Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA
297 Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...