Local expression of interferon-alpha and interferon receptors in cervical intraepithelial neoplasia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04-18

AUTHORS

Nelson R. Tirone, Bethanea C. Peghini, Ana Cristina M. Barcelos, Eddie F. C. Murta, Marcia A. Michelin

ABSTRACT

PurposeThe present study evaluated mRNA expression of interferon-alpha (IFN-α), IFN-α receptor subunits (IFNAR-1 and IFNAR-2) and an IFN-stimulated gene encoding the enzyme 2′,5′-oligoadenylate synthetase (2′5′OAS) in biopsies on patients with varying grades of cervical intraepithelial neoplasia (CIN I, II and III).MethodsUterine cervix biopsies were collected from women with CIN I, II and III (n = 28) and controls without CIN lesions or human papilloma virus (HPV) infection (n = 17). The presence of high and low-risk HPV DNA was determined using hybrid capture. The mRNA levels of IFNAR-1, IFNAR-2, IFN-α and 2′5′OAS were determined by RT-PCR with specific primers.ResultsThe control group exhibited a greater frequency of IFNAR-1 expression (10/17; 58.3%) than the CIN samples (4/28; 14.2%) (P = 0.0018), while, the expression of IFNAR-2 was also greater in the control samples (11/17; 64.7%) than in the patients with lesions (2/28; 7.1%) (P = 0.0018). Importantly, simultaneous expression of both receptors was observed only in the control group (8/17; 47.0%) (P = 0.0001). Among the CIN samples, there was one case of low expression of mRNA of IFNAR-1 and IFNAR-2. IFN-α was present in 14.2% (4/28) of the CIN samples but was not expressed in the control group. mRNA 2′5′OAS were expressed in 28.5% (8/28) of the CIN samples and 11.7% (2/17) of the control samples (not statistically significant). Fifty percent (14/28) of the CIN samples were positive for HPV DNA.ConclusionsCervical biopsy samples from control women or those without neoplasia or HPV infection displayed higher IFN-α receptor expression than those with CIN, while simultaneous expression of both IFN-α receptor subunits was found only in the control group. There was no significant difference in mRNA expression of IFN-α and 2′5′OAS between the control and CIN groups. Then we concluded that the samples obtained from patients with CIN present low levels of the IFN-α receptor mRNA. More... »

PAGES

2003-2010

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-009-0707-6

DOI

http://dx.doi.org/10.1007/s00262-009-0707-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001909086

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19381629


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