Intratumoral interferon-α gene transfer enhances tumor immunity after allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07

AUTHORS

Hidehiko Hara, Akihiko Kobayashi, Kenta Narumi, Atsushi Kondoh, Kimiko Yoshida, Takeshi Nishimoto, Masaki Ohashi, Eiji Higashihara, Shumpei Ohnami, Teruhiko Yoshida, Kazunori Aoki

ABSTRACT

One of the major challenges in the treatment of solid cancers by allogenic hematopoietic stem cell transfer (alloHSCT) is the specific enhancement of antitumor immunity. Interferon (IFN) is a cytokine with pleiotropic biological functions including an immunomoduration, and our preclinical studies have shown that an intratumoral IFN-alpha gene transfer induced strong local tumor control and systemic tumor-specific immunity. In the present study, we examined whether the IFN-alpha gene transfer could enhance recognition of tumor-associated antigens by donor T cells and augment the antitumor activity of alloHSCT. First, when a mouse IFN-alpha adenovirus vector (Ad-mIFN) was injected into subcutaneous xenografts of syngeneic renal and colon cancer cells, tumor growth was significantly suppressed in a dose-dependent manner. A significant tumor cell death and infiltration of immune cells was recognized in the Ad-mIFN-injected tumors, and the dendritic cells isolated from the tumors showed a strong Th1-oriented response. The antitumor effect of Ad-mIFN was then examined in a murine model of minor histocompatibility antigen-mismatched alloHSCT. The intratumoral IFN-alpha gene transfer caused significant tumor suppression in the alloHSCT recipients, and this suppression was evident not only in the gene-transduced tumors but also in simultaneously inoculated distant tumors which did not receive the vector injection. A cytotoxicity assay showed specific tumor cell lysis by donor T cells responding to IFN-alpha. Graft-versus-host disease was not exacerbated serologically or clinically in the mice treated with IFN-alpha. This combination strategy deserves evaluation in future clinical trials for human solid cancers. More... »

PAGES

1007

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-008-0616-0

DOI

http://dx.doi.org/10.1007/s00262-008-0616-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032861981

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18998126


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dendritic Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Transfer Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft vs Host Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Killer Cells, Natural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred DBA", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kyorin University", 
          "id": "https://www.grid.ac/institutes/grid.411205.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan", 
            "Department of Urology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Hidehiko", 
        "id": "sg:person.01066175310.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066175310.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "Akihiko", 
        "id": "sg:person.01125663453.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125663453.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narumi", 
        "givenName": "Kenta", 
        "id": "sg:person.0721471615.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721471615.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondoh", 
        "givenName": "Atsushi", 
        "id": "sg:person.01350047644.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350047644.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Kimiko", 
        "id": "sg:person.01367760473.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367760473.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishimoto", 
        "givenName": "Takeshi", 
        "id": "sg:person.01072157121.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072157121.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohashi", 
        "givenName": "Masaki", 
        "id": "sg:person.0673716475.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673716475.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyorin University", 
          "id": "https://www.grid.ac/institutes/grid.411205.3", 
          "name": [
            "Department of Urology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higashihara", 
        "givenName": "Eiji", 
        "id": "sg:person.01165004202.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165004202.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohnami", 
        "givenName": "Shumpei", 
        "id": "sg:person.01303452420.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303452420.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Teruhiko", 
        "id": "sg:person.014057530702.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014057530702.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Kazunori", 
        "id": "sg:person.01113535615.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113535615.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1146/annurev.immunol.25.022106.141606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000507551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2007.00521.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000633266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588566", 
          "https://doi.org/10.1038/sj.bjc.6602713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588566", 
          "https://doi.org/10.1038/sj.bjc.6602713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588566", 
          "https://doi.org/10.1038/sj.bjc.6602713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-01-0023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002767380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19860415)57:8+<1705::aid-cncr2820571314>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003856393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005760336", 
          "https://doi.org/10.1038/sj.gt.3301036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005760336", 
          "https://doi.org/10.1038/sj.gt.3301036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.9.4513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006104751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008474701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci7111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009497174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.161.2.345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014783930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.191.10.1777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014989411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.9.2886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015365477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2007.00408.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017275248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.9.1451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018322100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018997111", 
          "https://doi.org/10.1038/sj.gt.3301949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018997111", 
          "https://doi.org/10.1038/sj.gt.3301949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.4.1553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019039725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020372062", 
          "https://doi.org/10.1038/sj.cgt.7700364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020372062", 
          "https://doi.org/10.1038/sj.cgt.7700364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.4.1198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020445985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2006.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021221394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(91)90434-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021517814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(91)90434-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021517814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-09-3135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025154555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(01)00022-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034168282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037545494", 
          "https://doi.org/10.1038/nm915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-07-2233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039563454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041692738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041816479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0337543100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041891025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-02-0419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049126406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053137276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200111)31:11<3138::aid-immu3138>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053174226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-11-4495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053398293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jir.1996.16.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059280240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jir.1996.16.759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059280318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5270.1947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03402119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074507569", 
          "https://doi.org/10.1007/bf03402119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074610563", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074721454", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074763325", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075010617", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.177.6.4159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077292295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.2.838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077343852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.10.6242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077412723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082503696", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-07", 
    "datePublishedReg": "2009-07-01", 
    "description": "One of the major challenges in the treatment of solid cancers by allogenic hematopoietic stem cell transfer (alloHSCT) is the specific enhancement of antitumor immunity. Interferon (IFN) is a cytokine with pleiotropic biological functions including an immunomoduration, and our preclinical studies have shown that an intratumoral IFN-alpha gene transfer induced strong local tumor control and systemic tumor-specific immunity. In the present study, we examined whether the IFN-alpha gene transfer could enhance recognition of tumor-associated antigens by donor T cells and augment the antitumor activity of alloHSCT. First, when a mouse IFN-alpha adenovirus vector (Ad-mIFN) was injected into subcutaneous xenografts of syngeneic renal and colon cancer cells, tumor growth was significantly suppressed in a dose-dependent manner. A significant tumor cell death and infiltration of immune cells was recognized in the Ad-mIFN-injected tumors, and the dendritic cells isolated from the tumors showed a strong Th1-oriented response. The antitumor effect of Ad-mIFN was then examined in a murine model of minor histocompatibility antigen-mismatched alloHSCT. The intratumoral IFN-alpha gene transfer caused significant tumor suppression in the alloHSCT recipients, and this suppression was evident not only in the gene-transduced tumors but also in simultaneously inoculated distant tumors which did not receive the vector injection. A cytotoxicity assay showed specific tumor cell lysis by donor T cells responding to IFN-alpha. Graft-versus-host disease was not exacerbated serologically or clinically in the mice treated with IFN-alpha. This combination strategy deserves evaluation in future clinical trials for human solid cancers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-008-0616-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "58"
      }
    ], 
    "name": "Intratumoral interferon-\u03b1 gene transfer enhances tumor immunity after allogeneic hematopoietic stem cell transplantation", 
    "pagination": "1007", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9c8d0dded0c903d99804d909feaba88c9b8fe839a593f4ec871eb8a434fed029"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18998126"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-008-0616-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032861981"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-008-0616-0", 
      "https://app.dimensions.ai/details/publication/pub.1032861981"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13069_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-008-0616-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0616-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0616-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0616-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0616-0'


 

This table displays all metadata directly associated to this object as RDF triples.

350 TRIPLES      21 PREDICATES      91 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-008-0616-0 schema:about N06672dc3163c4ae2bc2685680a157b29
2 N0f08740d406e41a8b921bd037cf7edbc
3 N10cc7649f7c64e35a741668fe9e94061
4 N1febc99dac754cc2b7f83c49c6affdce
5 N201452f4c71047b3bf7ec0e0a1b7132d
6 N20c6421c7a6a4563a6ea16286d5ab838
7 N3cc854fa5c264a0bbaa9394dd29da1ae
8 N3dcdb01c97674993b8a27fd352efd095
9 N49d96d652a144eaf8c2c54faa24109e1
10 N529aeefd5db04d47917e26acd2d602eb
11 N624dfb710818406a94b3fa6a583f711b
12 N8a4dc3d32ce94fef88f496fa28388f99
13 N93186eda97be49ac831e37d28c7c90c7
14 N9935cc383e224cecb9bf4190e666b2cd
15 Nb529b876428d4b419f1fb011695c3f2d
16 Nc351c984edd44fa38cacd8a5787b984e
17 Ne5ae87881b7d4e52a85f6bb4303ded46
18 Necb671c4d6e048459c302f12a9f1f5ce
19 Nfa419beb290e405d8b7a21486f8824a7
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author N6fa92c6c50f548dca278db6debc9dae2
23 schema:citation sg:pub.10.1007/bf03402119
24 sg:pub.10.1038/nm915
25 sg:pub.10.1038/sj.bjc.6602713
26 sg:pub.10.1038/sj.cgt.7700364
27 sg:pub.10.1038/sj.gt.3301036
28 sg:pub.10.1038/sj.gt.3301949
29 https://app.dimensions.ai/details/publication/pub.1074610563
30 https://app.dimensions.ai/details/publication/pub.1074721454
31 https://app.dimensions.ai/details/publication/pub.1074763325
32 https://app.dimensions.ai/details/publication/pub.1075010617
33 https://app.dimensions.ai/details/publication/pub.1082503696
34 https://doi.org/10.1002/1097-0142(19860415)57:8+<1705::aid-cncr2820571314>3.0.co;2-u
35 https://doi.org/10.1002/1521-4141(200111)31:11<3138::aid-immu3138>3.0.co;2-b
36 https://doi.org/10.1002/jgm.602
37 https://doi.org/10.1016/0378-1119(91)90434-d
38 https://doi.org/10.1016/j.bbmt.2006.10.015
39 https://doi.org/10.1016/s1359-6101(01)00022-3
40 https://doi.org/10.1073/pnas.0337543100
41 https://doi.org/10.1073/pnas.91.4.1198
42 https://doi.org/10.1073/pnas.93.9.4513
43 https://doi.org/10.1073/pnas.96.4.1553
44 https://doi.org/10.1084/jem.161.2.345
45 https://doi.org/10.1084/jem.189.9.1451
46 https://doi.org/10.1084/jem.191.10.1777
47 https://doi.org/10.1089/jir.1996.16.275
48 https://doi.org/10.1089/jir.1996.16.759
49 https://doi.org/10.1111/j.1349-7006.2007.00408.x
50 https://doi.org/10.1111/j.1349-7006.2007.00521.x
51 https://doi.org/10.1126/science.272.5270.1947
52 https://doi.org/10.1146/annurev.immunol.25.022106.141606
53 https://doi.org/10.1158/0008-5472.can-06-1615
54 https://doi.org/10.1158/1078-0432.ccr-05-2657
55 https://doi.org/10.1158/1078-0432.ccr-07-1163
56 https://doi.org/10.1172/jci7111
57 https://doi.org/10.1182/blood-2002-01-0023
58 https://doi.org/10.1182/blood-2002-02-0419
59 https://doi.org/10.1182/blood-2002-07-2233
60 https://doi.org/10.1182/blood-2003-09-3135
61 https://doi.org/10.1182/blood-2005-11-4495
62 https://doi.org/10.1182/blood.v97.9.2886
63 https://doi.org/10.4049/jimmunol.177.6.4159
64 https://doi.org/10.4049/jimmunol.178.10.6242
65 https://doi.org/10.4049/jimmunol.178.2.838
66 schema:datePublished 2009-07
67 schema:datePublishedReg 2009-07-01
68 schema:description One of the major challenges in the treatment of solid cancers by allogenic hematopoietic stem cell transfer (alloHSCT) is the specific enhancement of antitumor immunity. Interferon (IFN) is a cytokine with pleiotropic biological functions including an immunomoduration, and our preclinical studies have shown that an intratumoral IFN-alpha gene transfer induced strong local tumor control and systemic tumor-specific immunity. In the present study, we examined whether the IFN-alpha gene transfer could enhance recognition of tumor-associated antigens by donor T cells and augment the antitumor activity of alloHSCT. First, when a mouse IFN-alpha adenovirus vector (Ad-mIFN) was injected into subcutaneous xenografts of syngeneic renal and colon cancer cells, tumor growth was significantly suppressed in a dose-dependent manner. A significant tumor cell death and infiltration of immune cells was recognized in the Ad-mIFN-injected tumors, and the dendritic cells isolated from the tumors showed a strong Th1-oriented response. The antitumor effect of Ad-mIFN was then examined in a murine model of minor histocompatibility antigen-mismatched alloHSCT. The intratumoral IFN-alpha gene transfer caused significant tumor suppression in the alloHSCT recipients, and this suppression was evident not only in the gene-transduced tumors but also in simultaneously inoculated distant tumors which did not receive the vector injection. A cytotoxicity assay showed specific tumor cell lysis by donor T cells responding to IFN-alpha. Graft-versus-host disease was not exacerbated serologically or clinically in the mice treated with IFN-alpha. This combination strategy deserves evaluation in future clinical trials for human solid cancers.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N5e9d7705955647ab9795bb94350927db
73 N983a165237624b399fc98745496a6b5e
74 sg:journal.1096240
75 schema:name Intratumoral interferon-α gene transfer enhances tumor immunity after allogeneic hematopoietic stem cell transplantation
76 schema:pagination 1007
77 schema:productId N073cbb60718b4ec4b238523abed6a63b
78 N1716afc524c34cfb8d9ab09d6b6a645b
79 N4b8a321ccc804e50b196d943c004360d
80 Na2027e8347674f1bb458ecefee3df24d
81 Nf019205817a84a4182614fe9fe164826
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032861981
83 https://doi.org/10.1007/s00262-008-0616-0
84 schema:sdDatePublished 2019-04-11T14:26
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Na352747dafa44c129047ee87a1f281a7
87 schema:url http://link.springer.com/10.1007%2Fs00262-008-0616-0
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N06672dc3163c4ae2bc2685680a157b29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Graft vs Host Disease
93 rdf:type schema:DefinedTerm
94 N073cbb60718b4ec4b238523abed6a63b schema:name nlm_unique_id
95 schema:value 8605732
96 rdf:type schema:PropertyValue
97 N0f08740d406e41a8b921bd037cf7edbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Animals
99 rdf:type schema:DefinedTerm
100 N10cc7649f7c64e35a741668fe9e94061 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Mice, Inbred DBA
102 rdf:type schema:DefinedTerm
103 N1716afc524c34cfb8d9ab09d6b6a645b schema:name pubmed_id
104 schema:value 18998126
105 rdf:type schema:PropertyValue
106 N1febc99dac754cc2b7f83c49c6affdce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Line, Tumor
108 rdf:type schema:DefinedTerm
109 N201452f4c71047b3bf7ec0e0a1b7132d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lymphoma
111 rdf:type schema:DefinedTerm
112 N20c6421c7a6a4563a6ea16286d5ab838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Kidney Neoplasms
114 rdf:type schema:DefinedTerm
115 N37a931bff3574aad9b2cfa4e5cf701ac rdf:first sg:person.01165004202.99
116 rdf:rest Nb1efe635aaf047fcad4f816a2c87f78f
117 N3cc854fa5c264a0bbaa9394dd29da1ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name CD8-Positive T-Lymphocytes
119 rdf:type schema:DefinedTerm
120 N3dcdb01c97674993b8a27fd352efd095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mice
122 rdf:type schema:DefinedTerm
123 N44982c7c653b45beb6275e3efeed0f89 rdf:first sg:person.01125663453.05
124 rdf:rest N8df0795c9ea74a888a3d49570165ef84
125 N49d96d652a144eaf8c2c54faa24109e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Hematopoietic Stem Cells
127 rdf:type schema:DefinedTerm
128 N4b8a321ccc804e50b196d943c004360d schema:name dimensions_id
129 schema:value pub.1032861981
130 rdf:type schema:PropertyValue
131 N529aeefd5db04d47917e26acd2d602eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Colonic Neoplasms
133 rdf:type schema:DefinedTerm
134 N5c59e9ccb7f64b0ca7a29bf7c8eba815 rdf:first sg:person.01072157121.05
135 rdf:rest N77ac9ce329024a0f9af0072ab756c182
136 N5e9d7705955647ab9795bb94350927db schema:issueNumber 7
137 rdf:type schema:PublicationIssue
138 N624dfb710818406a94b3fa6a583f711b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Gene Transfer Techniques
140 rdf:type schema:DefinedTerm
141 N6fa92c6c50f548dca278db6debc9dae2 rdf:first sg:person.01066175310.45
142 rdf:rest N44982c7c653b45beb6275e3efeed0f89
143 N77ac9ce329024a0f9af0072ab756c182 rdf:first sg:person.0673716475.72
144 rdf:rest N37a931bff3574aad9b2cfa4e5cf701ac
145 N87a7d6a40ec345aaa682dbfeb3427256 rdf:first sg:person.01367760473.05
146 rdf:rest N5c59e9ccb7f64b0ca7a29bf7c8eba815
147 N8a4dc3d32ce94fef88f496fa28388f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Killer Cells, Natural
149 rdf:type schema:DefinedTerm
150 N8df0795c9ea74a888a3d49570165ef84 rdf:first sg:person.0721471615.00
151 rdf:rest Naea66579828b432db380c5898e505ee5
152 N93186eda97be49ac831e37d28c7c90c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Hematopoietic Stem Cell Transplantation
154 rdf:type schema:DefinedTerm
155 N983a165237624b399fc98745496a6b5e schema:volumeNumber 58
156 rdf:type schema:PublicationVolume
157 N9935cc383e224cecb9bf4190e666b2cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Genetic Therapy
159 rdf:type schema:DefinedTerm
160 Na2027e8347674f1bb458ecefee3df24d schema:name readcube_id
161 schema:value 9c8d0dded0c903d99804d909feaba88c9b8fe839a593f4ec871eb8a434fed029
162 rdf:type schema:PropertyValue
163 Na352747dafa44c129047ee87a1f281a7 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nae915ef2ec7e4d6a8b24fd9fc2ec4367 rdf:first sg:person.014057530702.35
166 rdf:rest Ne7c2b06fd8114306bb49ec4a3c5b6cf0
167 Naea66579828b432db380c5898e505ee5 rdf:first sg:person.01350047644.84
168 rdf:rest N87a7d6a40ec345aaa682dbfeb3427256
169 Nb1efe635aaf047fcad4f816a2c87f78f rdf:first sg:person.01303452420.38
170 rdf:rest Nae915ef2ec7e4d6a8b24fd9fc2ec4367
171 Nb529b876428d4b419f1fb011695c3f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Dendritic Cells
173 rdf:type schema:DefinedTerm
174 Nc351c984edd44fa38cacd8a5787b984e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mice, Inbred BALB C
176 rdf:type schema:DefinedTerm
177 Ne5ae87881b7d4e52a85f6bb4303ded46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Genetic Vectors
179 rdf:type schema:DefinedTerm
180 Ne7c2b06fd8114306bb49ec4a3c5b6cf0 rdf:first sg:person.01113535615.46
181 rdf:rest rdf:nil
182 Necb671c4d6e048459c302f12a9f1f5ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Interferon-alpha
184 rdf:type schema:DefinedTerm
185 Nf019205817a84a4182614fe9fe164826 schema:name doi
186 schema:value 10.1007/s00262-008-0616-0
187 rdf:type schema:PropertyValue
188 Nfa419beb290e405d8b7a21486f8824a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Female
190 rdf:type schema:DefinedTerm
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
195 schema:name Immunology
196 rdf:type schema:DefinedTerm
197 sg:journal.1096240 schema:issn 0340-7004
198 1432-0851
199 schema:name Cancer Immunology, Immunotherapy
200 rdf:type schema:Periodical
201 sg:person.01066175310.45 schema:affiliation https://www.grid.ac/institutes/grid.411205.3
202 schema:familyName Hara
203 schema:givenName Hidehiko
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066175310.45
205 rdf:type schema:Person
206 sg:person.01072157121.05 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
207 schema:familyName Nishimoto
208 schema:givenName Takeshi
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072157121.05
210 rdf:type schema:Person
211 sg:person.01113535615.46 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
212 schema:familyName Aoki
213 schema:givenName Kazunori
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113535615.46
215 rdf:type schema:Person
216 sg:person.01125663453.05 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
217 schema:familyName Kobayashi
218 schema:givenName Akihiko
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125663453.05
220 rdf:type schema:Person
221 sg:person.01165004202.99 schema:affiliation https://www.grid.ac/institutes/grid.411205.3
222 schema:familyName Higashihara
223 schema:givenName Eiji
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165004202.99
225 rdf:type schema:Person
226 sg:person.01303452420.38 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
227 schema:familyName Ohnami
228 schema:givenName Shumpei
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303452420.38
230 rdf:type schema:Person
231 sg:person.01350047644.84 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
232 schema:familyName Kondoh
233 schema:givenName Atsushi
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350047644.84
235 rdf:type schema:Person
236 sg:person.01367760473.05 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
237 schema:familyName Yoshida
238 schema:givenName Kimiko
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367760473.05
240 rdf:type schema:Person
241 sg:person.014057530702.35 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
242 schema:familyName Yoshida
243 schema:givenName Teruhiko
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014057530702.35
245 rdf:type schema:Person
246 sg:person.0673716475.72 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
247 schema:familyName Ohashi
248 schema:givenName Masaki
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673716475.72
250 rdf:type schema:Person
251 sg:person.0721471615.00 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
252 schema:familyName Narumi
253 schema:givenName Kenta
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721471615.00
255 rdf:type schema:Person
256 sg:pub.10.1007/bf03402119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074507569
257 https://doi.org/10.1007/bf03402119
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nm915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037545494
260 https://doi.org/10.1038/nm915
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/sj.bjc.6602713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002588566
263 https://doi.org/10.1038/sj.bjc.6602713
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sj.cgt.7700364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020372062
266 https://doi.org/10.1038/sj.cgt.7700364
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/sj.gt.3301036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005760336
269 https://doi.org/10.1038/sj.gt.3301036
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/sj.gt.3301949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018997111
272 https://doi.org/10.1038/sj.gt.3301949
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1074610563 schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1074721454 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1074763325 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1075010617 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1082503696 schema:CreativeWork
279 https://doi.org/10.1002/1097-0142(19860415)57:8+<1705::aid-cncr2820571314>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1003856393
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/1521-4141(200111)31:11<3138::aid-immu3138>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1053174226
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/jgm.602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041816479
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0378-1119(91)90434-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1021517814
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.bbmt.2006.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021221394
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s1359-6101(01)00022-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034168282
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.0337543100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041891025
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.91.4.1198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020445985
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.93.9.4513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006104751
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.96.4.1553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019039725
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1084/jem.161.2.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014783930
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1084/jem.189.9.1451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018322100
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1084/jem.191.10.1777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014989411
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1089/jir.1996.16.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059280240
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1089/jir.1996.16.759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059280318
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1111/j.1349-7006.2007.00408.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017275248
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1111/j.1349-7006.2007.00521.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000633266
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1126/science.272.5270.1947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553452
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1146/annurev.immunol.25.022106.141606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000507551
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1158/0008-5472.can-06-1615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041692738
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1158/1078-0432.ccr-05-2657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008474701
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1158/1078-0432.ccr-07-1163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053137276
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1172/jci7111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009497174
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1182/blood-2002-01-0023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002767380
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1182/blood-2002-02-0419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049126406
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1182/blood-2002-07-2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039563454
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1182/blood-2003-09-3135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025154555
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1182/blood-2005-11-4495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053398293
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1182/blood.v97.9.2886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015365477
336 rdf:type schema:CreativeWork
337 https://doi.org/10.4049/jimmunol.177.6.4159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077292295
338 rdf:type schema:CreativeWork
339 https://doi.org/10.4049/jimmunol.178.10.6242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077412723
340 rdf:type schema:CreativeWork
341 https://doi.org/10.4049/jimmunol.178.2.838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077343852
342 rdf:type schema:CreativeWork
343 https://www.grid.ac/institutes/grid.272242.3 schema:alternateName National Cancer Centre
344 schema:name Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan
345 Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan
346 rdf:type schema:Organization
347 https://www.grid.ac/institutes/grid.411205.3 schema:alternateName Kyorin University
348 schema:name Department of Urology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan
349 Section for Studies on Host-Immune Response, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo, 104-0045, Tokyo, Japan
350 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...