Ontology type: schema:ScholarlyArticle Open Access: True
2009-05
AUTHORSChih-Wen Tseng, Cornelia Trimble, Qi Zeng, Archana Monie, Ronald D. Alvarez, Warner K. Huh, Talia Hoory, Mei-Cheng Wang, Chien-Fu Hung, T.-C. Wu
ABSTRACTCurrent therapeutic approaches to treatment of patients with bulky cervical cancer are based on conventional in situ ablative modalities including cisplatin-based chemotherapy and radiation therapy. The 5-year survival of patients with nonresectable disease is dismal. Because over 99% of squamous cervical cancer is caused by persistent infection with an oncogenic strain of human papillomavirus (HPV), particularly type 16 and viral oncoproteins E6 and E7 are functionally required for disease initiation and persistence, HPV-targeted immune strategies present a compelling opportunity in which to demonstrate proof of principle. Sublethal doses of radiation and chemotherapeutic agents have been shown to have synergistic effect in combination with either vaccination against cancer-specific antigens, or with passive transfer of tumor-specific cytotoxic T lymphocytes (CTLs). Here, we explored the combination of low-dose radiation therapy with DNA vaccination with calreticulin (CRT) linked to the mutated form of HPV-16 E7 antigen (E7(detox)), CRT/E7(detox) in the treatment of E7-expressing TC-1 tumors. We observed that TC-1 tumor-bearing mice treated with radiotherapy combined with CRT/E7(detox) DNA vaccination generated significant therapeutic antitumor effects and the highest frequency of E7-specific CD8(+) T cells in the tumors and spleens of treated mice. Furthermore, treatment with radiotherapy was shown to render the TC-1 tumor cells more susceptible to lysis by E7-specific CTLs. In addition, we observed that treatment with radiotherapy during the second DNA vaccination generated the highest frequency of E7-specific CD8(+) T cells in the tumors and spleens of TC-1 tumor-bearing mice. Finally, TC-1 tumor-bearing mice treated with the chemotherapy in combination with radiation and CRT/E7(detox) DNA vaccination generate significantly enhanced therapeutic antitumor effects. The clinical implications of the study are discussed. More... »
PAGES737-748
http://scigraph.springernature.com/pub.10.1007/s00262-008-0596-0
DOIhttp://dx.doi.org/10.1007/s00262-008-0596-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012836779
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18815785
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calreticulin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Transformed",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Transformation, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Combined Modality Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Models, Animal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunotherapy, Active",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oncogene Proteins, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Papillomavirus E7 Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Papillomavirus Vaccines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiotherapy Dosage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recombinant Fusion Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Lymphocytes, Cytotoxic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Uterine Cervical Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vaccines, DNA",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA",
"Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kao-hsiung, Taiwan"
],
"type": "Organization"
},
"familyName": "Tseng",
"givenName": "Chih-Wen",
"id": "sg:person.01111272621.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111272621.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA",
"Department of Obstetrics and Gynecology, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA",
"Department of Oncology, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Trimble",
"givenName": "Cornelia",
"id": "sg:person.015141721307.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015141721307.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Zeng",
"givenName": "Qi",
"id": "sg:person.01057651641.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057651641.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Monie",
"givenName": "Archana",
"id": "sg:person.0761630667.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761630667.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Alabama at Birmingham",
"id": "https://www.grid.ac/institutes/grid.265892.2",
"name": [
"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35249, Birmingham, AL, USA"
],
"type": "Organization"
},
"familyName": "Alvarez",
"givenName": "Ronald D.",
"id": "sg:person.015126310717.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015126310717.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Alabama at Birmingham",
"id": "https://www.grid.ac/institutes/grid.265892.2",
"name": [
"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35249, Birmingham, AL, USA"
],
"type": "Organization"
},
"familyName": "Huh",
"givenName": "Warner K.",
"id": "sg:person.01101274700.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101274700.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hoory",
"givenName": "Talia",
"id": "sg:person.01214504331.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214504331.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Biostatistics, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Mei-Cheng",
"id": "sg:person.01014064641.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014064641.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA",
"Department of Oncology, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Hung",
"givenName": "Chien-Fu",
"id": "sg:person.014470015607.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014470015607.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, The Johns Hopkins University School of Medicine, CRB II Room 309, 1550 Orleans Street, 21231, Baltimore, MD, USA",
"Department of Obstetrics and Gynecology, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA",
"Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA",
"Department of Oncology, Johns Hopkins Medical Institutions, 21231, Baltimore, MD, USA"
],
"type": "Organization"
},
"familyName": "Wu",
"givenName": "T.-C.",
"id": "sg:person.012107260544.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012107260544.50"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s1074-7613(00)80487-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000135136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/095530097143428",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001699878"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.mt.6300149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002081731"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-1525",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003315567"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20062056",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009851357"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-2062",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010341888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pros.20157",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012144573"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-05-1761",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014421462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3816/cbc.2006.n.032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014773882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1586/14760584.2.4.495",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019634092"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.28.17011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020522643"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.189.5.797",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023338763"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20052494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023529444"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024719788",
"https://doi.org/10.1038/sj.gt.3302252"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302252",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024719788",
"https://doi.org/10.1038/sj.gt.3302252"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00925962",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028548811",
"https://doi.org/10.1007/bf00925962"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-2111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032586637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-0037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033081426"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cji.0000154248.74383.5e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038396435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cji.0000154248.74383.5e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038396435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.vaccine.2007.08.036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039233604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-05-2013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039601270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000012192",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040539293"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri2216",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044452926",
"https://doi.org/10.1038/nri2216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/viro.2000.0271",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049165246"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/eji.1830270944",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049405483"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-06-1838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051155229"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/10430349950016474",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059202794"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci12346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063416061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1667/rr1006.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068195134"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074601062",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077528644",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.180.5.3132",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077610815"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082854625",
"type": "CreativeWork"
}
],
"datePublished": "2009-05",
"datePublishedReg": "2009-05-01",
"description": "Current therapeutic approaches to treatment of patients with bulky cervical cancer are based on conventional in situ ablative modalities including cisplatin-based chemotherapy and radiation therapy. The 5-year survival of patients with nonresectable disease is dismal. Because over 99% of squamous cervical cancer is caused by persistent infection with an oncogenic strain of human papillomavirus (HPV), particularly type 16 and viral oncoproteins E6 and E7 are functionally required for disease initiation and persistence, HPV-targeted immune strategies present a compelling opportunity in which to demonstrate proof of principle. Sublethal doses of radiation and chemotherapeutic agents have been shown to have synergistic effect in combination with either vaccination against cancer-specific antigens, or with passive transfer of tumor-specific cytotoxic T lymphocytes (CTLs). Here, we explored the combination of low-dose radiation therapy with DNA vaccination with calreticulin (CRT) linked to the mutated form of HPV-16 E7 antigen (E7(detox)), CRT/E7(detox) in the treatment of E7-expressing TC-1 tumors. We observed that TC-1 tumor-bearing mice treated with radiotherapy combined with CRT/E7(detox) DNA vaccination generated significant therapeutic antitumor effects and the highest frequency of E7-specific CD8(+) T cells in the tumors and spleens of treated mice. Furthermore, treatment with radiotherapy was shown to render the TC-1 tumor cells more susceptible to lysis by E7-specific CTLs. In addition, we observed that treatment with radiotherapy during the second DNA vaccination generated the highest frequency of E7-specific CD8(+) T cells in the tumors and spleens of TC-1 tumor-bearing mice. Finally, TC-1 tumor-bearing mice treated with the chemotherapy in combination with radiation and CRT/E7(detox) DNA vaccination generate significantly enhanced therapeutic antitumor effects. The clinical implications of the study are discussed.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00262-008-0596-0",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2478134",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2440195",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2440185",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1096240",
"issn": [
"0340-7004",
"1432-0851"
],
"name": "Cancer Immunology, Immunotherapy",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "58"
}
],
"name": "Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts",
"pagination": "737-748",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"3d270381dc610853a889cd5e152dbc2e9841fc9d5b88c0c50816b1d4068f7577"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18815785"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8605732"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00262-008-0596-0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012836779"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00262-008-0596-0",
"https://app.dimensions.ai/details/publication/pub.1012836779"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13073_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00262-008-0596-0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0596-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0596-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0596-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-008-0596-0'
This table displays all metadata directly associated to this object as RDF triples.
334 TRIPLES
21 PREDICATES
84 URIs
44 LITERALS
32 BLANK NODES