The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08

AUTHORS

Takuya Osada, Gabriel Chong, Robert Tansik, Timothy Hong, Neil Spector, Rakesh Kumar, Herbert I. Hurwitz, Inderjit Dev, Andrew B. Nixon, H. Kim Lyerly, Timothy Clay, Michael A. Morse

ABSTRACT

Impairment of dendritic cells (DC), the most effective activators of anticancer immune responses, is one mechanism for defective antitumor immunity, but the causes of DC impairment are incompletely understood. We evaluated the association of impaired DC differentiation with angiogenesis-associated molecules D-dimer, vascular endothelial growth factor (VEGF), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor (PAI-1) in peripheral blood from 41 patients with lung, breast, and colorectal carcinoma. Subsequently, we studied the effect of administration of the anti-VEGF antibody (bevacizumab) on DC maturation and function in vivo. Compared with healthy volunteers, cancer patients had a bias toward the immunoregulatory DC2, had deficits in DC maturation after overnight in vitro culture, and had a significant increase in immature myeloid cell progenitors of DC (0.50 +/- 0.31% vs. 0.32 +/- 0.16% of peripheral blood mononuclear cells, respectively, P = 0.011). A positive correlation was found between the percentage of DC2 and PAI-1 (R = 0.50) and between immature myeloid cells and VEGF (R = 0.52). Bevacizumab administration to cancer patients was associated with a decrease in the accumulation of immature progenitor cells (0.39 +/- 0.30% vs. 0.27 +/- 0.24%, P = 0.012) and induced a modest increase in the DC population in peripheral blood (0.47 +/- 0.23% vs. 0.53 +/- 0.30%). Moreover, anti-VEGF antibody treatment enhanced allo-stimulatory capacity of DC and T cell proliferation against recall antigens. These data suggest that DC differentiation is negatively associated with VEGF levels and may be one explanation for impaired anticancer immunity, especially in patients with advanced malignancies. More... »

PAGES

1115-1124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-007-0441-x

DOI

http://dx.doi.org/10.1007/s00262-007-0441-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027279526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18193223


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenesis Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bevacizumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dendritic Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin Fibrinogen Degradation Products", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Progenitor Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasminogen Activator Inhibitor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urokinase-Type Plasminogen Activator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osada", 
        "givenName": "Takuya", 
        "id": "sg:person.01114717615.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114717615.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chong", 
        "givenName": "Gabriel", 
        "id": "sg:person.0746125275.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746125275.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tansik", 
        "givenName": "Robert", 
        "id": "sg:person.071332555.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071332555.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hartford Hospital", 
          "id": "https://www.grid.ac/institutes/grid.277313.3", 
          "name": [
            "Hartford Hospital, Hartford, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Timothy", 
        "id": "sg:person.01014371502.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014371502.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spector", 
        "givenName": "Neil", 
        "id": "sg:person.01242656120.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242656120.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumar", 
        "givenName": "Rakesh", 
        "id": "sg:person.0776322164.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776322164.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hurwitz", 
        "givenName": "Herbert I.", 
        "id": "sg:person.01242177577.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177577.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dev", 
        "givenName": "Inderjit", 
        "id": "sg:person.01053272241.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053272241.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nixon", 
        "givenName": "Andrew B.", 
        "id": "sg:person.01055010121.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055010121.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lyerly", 
        "givenName": "H. Kim", 
        "id": "sg:person.012507420117.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012507420117.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clay", 
        "givenName": "Timothy", 
        "id": "sg:person.0706420433.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706420433.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Box 3233, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morse", 
        "givenName": "Michael A.", 
        "id": "sg:person.013700705377.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013700705377.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0198-8859(99)00114-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010487007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-002-0280-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011808310", 
          "https://doi.org/10.1007/s00262-002-0280-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2005.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013295558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.152.4.777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018808773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cimm.1996.0139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020075774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v100.1.230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021195967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.2.233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021644759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1096-1096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021940849", 
          "https://doi.org/10.1038/nm1096-1096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024047427", 
          "https://doi.org/10.1038/sj.bjc.6601114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024047427", 
          "https://doi.org/10.1038/sj.bjc.6601114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2567.2001.01204.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030802985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-1715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031370534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.53.6.307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037011675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/mp.53.6.307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037011675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.06.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038985975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.06.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038985975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0958-1669(95)80111-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040181428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040277429", 
          "https://doi.org/10.1038/sj.bjc.6600069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040277429", 
          "https://doi.org/10.1038/sj.bjc.6600069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040662289", 
          "https://doi.org/10.1038/nrc1971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040662289", 
          "https://doi.org/10.1038/nrc1971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(05)80312-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043849402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044818516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.2.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047094342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-006-0234-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047637705", 
          "https://doi.org/10.1007/s00262-006-0234-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-006-0234-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047637705", 
          "https://doi.org/10.1007/s00262-006-0234-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ir:23:2-3:263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051618180", 
          "https://doi.org/10.1385/ir:23:2-3:263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00313029309090853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052391803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00313029309090853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052391803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074539535", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074581611", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074588307", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074641652", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.1.678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074740039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.72.3.546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075121434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.174.1.215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076982628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082462857", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083254153", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083296811", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347171", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083354382", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-08", 
    "datePublishedReg": "2008-08-01", 
    "description": "Impairment of dendritic cells (DC), the most effective activators of anticancer immune responses, is one mechanism for defective antitumor immunity, but the causes of DC impairment are incompletely understood. We evaluated the association of impaired DC differentiation with angiogenesis-associated molecules D-dimer, vascular endothelial growth factor (VEGF), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor (PAI-1) in peripheral blood from 41 patients with lung, breast, and colorectal carcinoma. Subsequently, we studied the effect of administration of the anti-VEGF antibody (bevacizumab) on DC maturation and function in vivo. Compared with healthy volunteers, cancer patients had a bias toward the immunoregulatory DC2, had deficits in DC maturation after overnight in vitro culture, and had a significant increase in immature myeloid cell progenitors of DC (0.50 +/- 0.31% vs. 0.32 +/- 0.16% of peripheral blood mononuclear cells, respectively, P = 0.011). A positive correlation was found between the percentage of DC2 and PAI-1 (R = 0.50) and between immature myeloid cells and VEGF (R = 0.52). Bevacizumab administration to cancer patients was associated with a decrease in the accumulation of immature progenitor cells (0.39 +/- 0.30% vs. 0.27 +/- 0.24%, P = 0.012) and induced a modest increase in the DC population in peripheral blood (0.47 +/- 0.23% vs. 0.53 +/- 0.30%). Moreover, anti-VEGF antibody treatment enhanced allo-stimulatory capacity of DC and T cell proliferation against recall antigens. These data suggest that DC differentiation is negatively associated with VEGF levels and may be one explanation for impaired anticancer immunity, especially in patients with advanced malignancies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-007-0441-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435718", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2420933", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "57"
      }
    ], 
    "name": "The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients", 
    "pagination": "1115-1124", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "81f362e5636fb2002b002c988631a16ec2ed05ca17de931c09a808c2f995ff80"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18193223"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-007-0441-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027279526"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-007-0441-x", 
      "https://app.dimensions.ai/details/publication/pub.1027279526"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13081_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-007-0441-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-007-0441-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-007-0441-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-007-0441-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-007-0441-x'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      21 PREDICATES      84 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-007-0441-x schema:about N0232d40f6eff42908e4c980cfc5fc4f7
2 N0ded6b03542e4148a26105225d6d22ae
3 N15221c5e5cd2449f994e8276464691d2
4 N1f22deb5ad944ba2a5d590157e61f03d
5 N4bf5a001e82747868a9ff41d59045e63
6 N67e584755ba54c07a932d8dc726a900c
7 N7397e6d9807541cf93b6b81025d86f85
8 N82e3eb1c197b4e38a5a4fba8b43da6a6
9 N90bf64b31697465996479b0cf7cb93c7
10 N93a3888442ed4e26abfc8a6a9240fba0
11 N9a577f0559ae45a0b76fd89190a228d9
12 N9aa0b1d04e004ff18d790db7831f54b3
13 Na66a47a7377f48fe82ea1788426352c3
14 Na904edaa2876466297968f1936cd95a4
15 Nbb37e669683d49d4b37ef2bbce8f1cb1
16 Nbe589278b80540d6a8eed0f8ead46657
17 Nd3ea9d0ddd064c9f9c366a8e78de02f8
18 Ndf0b1b5ae697499fb9274cc660982f2d
19 Nee4d6142275c44a59097a34408d072f2
20 Nfa365bb727e848b8b96cd9166298f99d
21 Nfc9e9544a7b24df7816f3c172f45293b
22 anzsrc-for:11
23 anzsrc-for:1107
24 schema:author Nb647a6dff1974cec983cdcfb1e4263e9
25 schema:citation sg:pub.10.1007/s00262-002-0280-8
26 sg:pub.10.1007/s00262-006-0234-7
27 sg:pub.10.1038/nm1096-1096
28 sg:pub.10.1038/nrc1971
29 sg:pub.10.1038/sj.bjc.6600069
30 sg:pub.10.1038/sj.bjc.6601114
31 sg:pub.10.1385/ir:23:2-3:263
32 https://app.dimensions.ai/details/publication/pub.1074539535
33 https://app.dimensions.ai/details/publication/pub.1074581611
34 https://app.dimensions.ai/details/publication/pub.1074588307
35 https://app.dimensions.ai/details/publication/pub.1074641652
36 https://app.dimensions.ai/details/publication/pub.1082462857
37 https://app.dimensions.ai/details/publication/pub.1083254153
38 https://app.dimensions.ai/details/publication/pub.1083296811
39 https://app.dimensions.ai/details/publication/pub.1083347171
40 https://app.dimensions.ai/details/publication/pub.1083354382
41 https://doi.org/10.1002/cncr.20336
42 https://doi.org/10.1006/cimm.1996.0139
43 https://doi.org/10.1016/0958-1669(95)80111-1
44 https://doi.org/10.1016/j.bbrc.2005.06.065
45 https://doi.org/10.1016/j.semcancer.2005.07.005
46 https://doi.org/10.1016/s0198-8859(99)00114-7
47 https://doi.org/10.1016/s0959-8049(05)80312-0
48 https://doi.org/10.1046/j.1365-2567.2001.01204.x
49 https://doi.org/10.1083/jcb.152.4.777
50 https://doi.org/10.1084/jem.193.2.233
51 https://doi.org/10.1093/jnci/94.2.116
52 https://doi.org/10.1136/mp.53.6.307
53 https://doi.org/10.1158/0008-5472.can-03-1715
54 https://doi.org/10.1182/blood.v100.1.230
55 https://doi.org/10.1189/jlb.72.3.546
56 https://doi.org/10.3109/00313029309090853
57 https://doi.org/10.4049/jimmunol.166.1.678
58 https://doi.org/10.4049/jimmunol.174.1.215
59 schema:datePublished 2008-08
60 schema:datePublishedReg 2008-08-01
61 schema:description Impairment of dendritic cells (DC), the most effective activators of anticancer immune responses, is one mechanism for defective antitumor immunity, but the causes of DC impairment are incompletely understood. We evaluated the association of impaired DC differentiation with angiogenesis-associated molecules D-dimer, vascular endothelial growth factor (VEGF), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor (PAI-1) in peripheral blood from 41 patients with lung, breast, and colorectal carcinoma. Subsequently, we studied the effect of administration of the anti-VEGF antibody (bevacizumab) on DC maturation and function in vivo. Compared with healthy volunteers, cancer patients had a bias toward the immunoregulatory DC2, had deficits in DC maturation after overnight in vitro culture, and had a significant increase in immature myeloid cell progenitors of DC (0.50 +/- 0.31% vs. 0.32 +/- 0.16% of peripheral blood mononuclear cells, respectively, P = 0.011). A positive correlation was found between the percentage of DC2 and PAI-1 (R = 0.50) and between immature myeloid cells and VEGF (R = 0.52). Bevacizumab administration to cancer patients was associated with a decrease in the accumulation of immature progenitor cells (0.39 +/- 0.30% vs. 0.27 +/- 0.24%, P = 0.012) and induced a modest increase in the DC population in peripheral blood (0.47 +/- 0.23% vs. 0.53 +/- 0.30%). Moreover, anti-VEGF antibody treatment enhanced allo-stimulatory capacity of DC and T cell proliferation against recall antigens. These data suggest that DC differentiation is negatively associated with VEGF levels and may be one explanation for impaired anticancer immunity, especially in patients with advanced malignancies.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N060fd7907e614686aaaa6f55c44707f9
66 N9a259807e584492faece1cb7b460f8d5
67 sg:journal.1096240
68 schema:name The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients
69 schema:pagination 1115-1124
70 schema:productId N53ea487a60844366af41b60c34c14a55
71 N85b92d730fe24fc69250947bf6eecd34
72 N9d1958f630bc4bcfa169bc24ce8bebe3
73 Naf8b7e35fd27405b8479eaee7d25b74a
74 Nf50338215ab7467f85cb4d55ab4769f2
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027279526
76 https://doi.org/10.1007/s00262-007-0441-x
77 schema:sdDatePublished 2019-04-11T14:28
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N2ee132f0ebcf43a48e6783fe7cf24bf6
80 schema:url http://link.springer.com/10.1007%2Fs00262-007-0441-x
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0232d40f6eff42908e4c980cfc5fc4f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Humans
86 rdf:type schema:DefinedTerm
87 N060fd7907e614686aaaa6f55c44707f9 schema:volumeNumber 57
88 rdf:type schema:PublicationVolume
89 N0ded6b03542e4148a26105225d6d22ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Cell Differentiation
91 rdf:type schema:DefinedTerm
92 N15221c5e5cd2449f994e8276464691d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Antibodies, Monoclonal, Humanized
94 rdf:type schema:DefinedTerm
95 N1e3fa5a253ee4b09907c5c4777338249 rdf:first sg:person.01055010121.15
96 rdf:rest N5ccaad93ab16495abeee1322e5342cba
97 N1f22deb5ad944ba2a5d590157e61f03d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Bevacizumab
99 rdf:type schema:DefinedTerm
100 N2ee132f0ebcf43a48e6783fe7cf24bf6 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N4bf5a001e82747868a9ff41d59045e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cells, Cultured
104 rdf:type schema:DefinedTerm
105 N4e911450024d4976bce7d668c24ebb66 rdf:first sg:person.071332555.75
106 rdf:rest Ndc5fe16339a44b0796c052e64f7ba67a
107 N53ea487a60844366af41b60c34c14a55 schema:name dimensions_id
108 schema:value pub.1027279526
109 rdf:type schema:PropertyValue
110 N5ccaad93ab16495abeee1322e5342cba rdf:first sg:person.012507420117.48
111 rdf:rest N7095194d39394b9bb5e88bdcff6943dd
112 N67e584755ba54c07a932d8dc726a900c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Colorectal Neoplasms
114 rdf:type schema:DefinedTerm
115 N6a3d7786a7804f3487ddf54b7a984032 rdf:first sg:person.01242656120.60
116 rdf:rest Ndbe78d54fcff4cffbbeb949649c0b6d3
117 N7095194d39394b9bb5e88bdcff6943dd rdf:first sg:person.0706420433.90
118 rdf:rest Nd2c0adf47a1a4f2cb920cec291d5364f
119 N7397e6d9807541cf93b6b81025d86f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Plasminogen Activator Inhibitor 1
121 rdf:type schema:DefinedTerm
122 N82e3eb1c197b4e38a5a4fba8b43da6a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Immunotherapy
124 rdf:type schema:DefinedTerm
125 N85b92d730fe24fc69250947bf6eecd34 schema:name readcube_id
126 schema:value 81f362e5636fb2002b002c988631a16ec2ed05ca17de931c09a808c2f995ff80
127 rdf:type schema:PropertyValue
128 N90bf64b31697465996479b0cf7cb93c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Myeloid Progenitor Cells
130 rdf:type schema:DefinedTerm
131 N93a3888442ed4e26abfc8a6a9240fba0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Antibodies, Monoclonal
133 rdf:type schema:DefinedTerm
134 N9a259807e584492faece1cb7b460f8d5 schema:issueNumber 8
135 rdf:type schema:PublicationIssue
136 N9a577f0559ae45a0b76fd89190a228d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Dendritic Cells
138 rdf:type schema:DefinedTerm
139 N9aa0b1d04e004ff18d790db7831f54b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Fibrin Fibrinogen Degradation Products
141 rdf:type schema:DefinedTerm
142 N9d1958f630bc4bcfa169bc24ce8bebe3 schema:name nlm_unique_id
143 schema:value 8605732
144 rdf:type schema:PropertyValue
145 Na66a47a7377f48fe82ea1788426352c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name T-Lymphocytes
147 rdf:type schema:DefinedTerm
148 Na904edaa2876466297968f1936cd95a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Pilot Projects
150 rdf:type schema:DefinedTerm
151 Naf8b7e35fd27405b8479eaee7d25b74a schema:name pubmed_id
152 schema:value 18193223
153 rdf:type schema:PropertyValue
154 Nb647a6dff1974cec983cdcfb1e4263e9 rdf:first sg:person.01114717615.49
155 rdf:rest Nd00a15bc0f6c4fb4871e718086abcc6e
156 Nbb37e669683d49d4b37ef2bbce8f1cb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Neovascularization, Pathologic
158 rdf:type schema:DefinedTerm
159 Nbe589278b80540d6a8eed0f8ead46657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Breast Neoplasms
161 rdf:type schema:DefinedTerm
162 Nd00a15bc0f6c4fb4871e718086abcc6e rdf:first sg:person.0746125275.86
163 rdf:rest N4e911450024d4976bce7d668c24ebb66
164 Nd2c0adf47a1a4f2cb920cec291d5364f rdf:first sg:person.013700705377.06
165 rdf:rest rdf:nil
166 Nd3ea9d0ddd064c9f9c366a8e78de02f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Lung Neoplasms
168 rdf:type schema:DefinedTerm
169 Ndbe78d54fcff4cffbbeb949649c0b6d3 rdf:first sg:person.0776322164.11
170 rdf:rest Nf1440a752a564ef59f24a6b0fa5be65d
171 Ndc5fe16339a44b0796c052e64f7ba67a rdf:first sg:person.01014371502.88
172 rdf:rest N6a3d7786a7804f3487ddf54b7a984032
173 Ndf0b1b5ae697499fb9274cc660982f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Urokinase-Type Plasminogen Activator
175 rdf:type schema:DefinedTerm
176 Ne2ba7e6699ca44309abe1b20348e68f7 rdf:first sg:person.01053272241.07
177 rdf:rest N1e3fa5a253ee4b09907c5c4777338249
178 Nee4d6142275c44a59097a34408d072f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Cell Proliferation
180 rdf:type schema:DefinedTerm
181 Nf1440a752a564ef59f24a6b0fa5be65d rdf:first sg:person.01242177577.68
182 rdf:rest Ne2ba7e6699ca44309abe1b20348e68f7
183 Nf50338215ab7467f85cb4d55ab4769f2 schema:name doi
184 schema:value 10.1007/s00262-007-0441-x
185 rdf:type schema:PropertyValue
186 Nfa365bb727e848b8b96cd9166298f99d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Angiogenesis Inhibitors
188 rdf:type schema:DefinedTerm
189 Nfc9e9544a7b24df7816f3c172f45293b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Vascular Endothelial Growth Factor A
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
196 schema:name Immunology
197 rdf:type schema:DefinedTerm
198 sg:grant.2420933 http://pending.schema.org/fundedItem sg:pub.10.1007/s00262-007-0441-x
199 rdf:type schema:MonetaryGrant
200 sg:grant.2435718 http://pending.schema.org/fundedItem sg:pub.10.1007/s00262-007-0441-x
201 rdf:type schema:MonetaryGrant
202 sg:journal.1096240 schema:issn 0340-7004
203 1432-0851
204 schema:name Cancer Immunology, Immunotherapy
205 rdf:type schema:Periodical
206 sg:person.01014371502.88 schema:affiliation https://www.grid.ac/institutes/grid.277313.3
207 schema:familyName Hong
208 schema:givenName Timothy
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014371502.88
210 rdf:type schema:Person
211 sg:person.01053272241.07 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
212 schema:familyName Dev
213 schema:givenName Inderjit
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053272241.07
215 rdf:type schema:Person
216 sg:person.01055010121.15 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
217 schema:familyName Nixon
218 schema:givenName Andrew B.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055010121.15
220 rdf:type schema:Person
221 sg:person.01114717615.49 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
222 schema:familyName Osada
223 schema:givenName Takuya
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114717615.49
225 rdf:type schema:Person
226 sg:person.01242177577.68 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
227 schema:familyName Hurwitz
228 schema:givenName Herbert I.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177577.68
230 rdf:type schema:Person
231 sg:person.01242656120.60 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
232 schema:familyName Spector
233 schema:givenName Neil
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242656120.60
235 rdf:type schema:Person
236 sg:person.012507420117.48 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
237 schema:familyName Lyerly
238 schema:givenName H. Kim
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012507420117.48
240 rdf:type schema:Person
241 sg:person.013700705377.06 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
242 schema:familyName Morse
243 schema:givenName Michael A.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013700705377.06
245 rdf:type schema:Person
246 sg:person.0706420433.90 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
247 schema:familyName Clay
248 schema:givenName Timothy
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706420433.90
250 rdf:type schema:Person
251 sg:person.071332555.75 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
252 schema:familyName Tansik
253 schema:givenName Robert
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071332555.75
255 rdf:type schema:Person
256 sg:person.0746125275.86 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
257 schema:familyName Chong
258 schema:givenName Gabriel
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746125275.86
260 rdf:type schema:Person
261 sg:person.0776322164.11 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
262 schema:familyName Kumar
263 schema:givenName Rakesh
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776322164.11
265 rdf:type schema:Person
266 sg:pub.10.1007/s00262-002-0280-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011808310
267 https://doi.org/10.1007/s00262-002-0280-8
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s00262-006-0234-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047637705
270 https://doi.org/10.1007/s00262-006-0234-7
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nm1096-1096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021940849
273 https://doi.org/10.1038/nm1096-1096
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nrc1971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662289
276 https://doi.org/10.1038/nrc1971
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/sj.bjc.6600069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040277429
279 https://doi.org/10.1038/sj.bjc.6600069
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/sj.bjc.6601114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024047427
282 https://doi.org/10.1038/sj.bjc.6601114
283 rdf:type schema:CreativeWork
284 sg:pub.10.1385/ir:23:2-3:263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051618180
285 https://doi.org/10.1385/ir:23:2-3:263
286 rdf:type schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1074539535 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1074581611 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1074588307 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1074641652 schema:CreativeWork
291 https://app.dimensions.ai/details/publication/pub.1082462857 schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1083254153 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1083296811 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1083347171 schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1083354382 schema:CreativeWork
296 https://doi.org/10.1002/cncr.20336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044818516
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1006/cimm.1996.0139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020075774
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/0958-1669(95)80111-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040181428
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.bbrc.2005.06.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038985975
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.semcancer.2005.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013295558
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s0198-8859(99)00114-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010487007
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/s0959-8049(05)80312-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043849402
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1046/j.1365-2567.2001.01204.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030802985
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1083/jcb.152.4.777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018808773
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1084/jem.193.2.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021644759
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/jnci/94.2.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047094342
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1136/mp.53.6.307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037011675
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1158/0008-5472.can-03-1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031370534
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1182/blood.v100.1.230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021195967
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1189/jlb.72.3.546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075121434
325 rdf:type schema:CreativeWork
326 https://doi.org/10.3109/00313029309090853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052391803
327 rdf:type schema:CreativeWork
328 https://doi.org/10.4049/jimmunol.166.1.678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074740039
329 rdf:type schema:CreativeWork
330 https://doi.org/10.4049/jimmunol.174.1.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076982628
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
333 schema:name Duke University Medical Center, Box 3233, 27710, Durham, NC, USA
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.277313.3 schema:alternateName Hartford Hospital
336 schema:name Hartford Hospital, Hartford, CT, USA
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.418019.5 schema:alternateName GlaxoSmithKline (United States)
339 schema:name GlaxoSmithKline, Research Triangle Park, NC, USA
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...