Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09-14

AUTHORS

Yoshihiko Kano, Kuniyasu Soda, Takeshi Nakamura, Masaaki Saitoh, Masanobu Kawakami, Fumio Konishi

ABSTRACT

Increased blood polyamine levels, often observed in cancer patients, have negative impacts on patient prognosis and are associated with tumor progression. The purpose of our study was to examine the effects of polyamines on cellular immune function. Peripheral blood mononuclear cells (PBMCs) from healthy volunteers were cultured with the human natural polyamines spermine, spermidine, or putrescine, and the effects on immune cell function were examined. The correlation between post-operative changes in blood polyamine levels and lymphokine-activated killer (LAK) activity was also examined in cancer patients. Spermine decreased the adhesion of non-stimulated PBMCs to tissue culture plastic in a dose- and a time-dependent manner without affecting cell viability or activity. This decrease in adhesion capacity was accompanied by a decrease in the number of CD11a bright-positive and CD56 bright-positive cells. Upon stimulation with interleukin 2 to activate LAK cytotoxicity, PBMCs cultured overnight with 100 or 500 μM spermine showed decreased cytotoxic activity against Daudi cells (91.5 ± 1.7 and 84.9 ± 3.0%, respectively (n = 6) compared to PBMC cultured without polyamines). In a group of 25 cancer patients, changes in blood spermine levels after surgery were negatively correlated with changes in LAK cytotoxicity after surgery (r = −0.510, P = 0.008: n = 25). Increased blood spermine levels may be an important factor in the suppression of anti-tumor immune cell function. More... »

PAGES

771-781

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-006-0229-4

DOI

http://dx.doi.org/10.1007/s00262-006-0229-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016442645

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16972077


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Killer Cells, Lymphokine-Activated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spermidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spermine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Escape", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kano", 
        "givenName": "Yoshihiko", 
        "id": "sg:person.0610356012.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610356012.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soda", 
        "givenName": "Kuniyasu", 
        "id": "sg:person.0730445512.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730445512.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Takeshi", 
        "id": "sg:person.01350064210.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350064210.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saitoh", 
        "givenName": "Masaaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawakami", 
        "givenName": "Masanobu", 
        "id": "sg:person.01143767626.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143767626.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konishi", 
        "givenName": "Fumio", 
        "id": "sg:person.01272216415.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272216415.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00917476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010725949", 
          "https://doi.org/10.1007/bf00917476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00200177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006361138", 
          "https://doi.org/10.1007/bf00200177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2001.1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038794005", 
          "https://doi.org/10.1054/bjoc.2001.1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-004-0555-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007284185", 
          "https://doi.org/10.1007/s00262-004-0555-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.1999.1034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044925984", 
          "https://doi.org/10.1054/bjoc.1999.1034"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-09-14", 
    "datePublishedReg": "2006-09-14", 
    "description": "Increased blood polyamine levels, often observed in cancer patients, have negative impacts on patient prognosis and are associated with tumor progression. The purpose of our study was to examine the effects of polyamines on cellular immune function. Peripheral blood mononuclear cells (PBMCs) from healthy volunteers were cultured with the human natural polyamines spermine, spermidine, or putrescine, and the effects on immune cell function were examined. The correlation between post-operative changes in blood polyamine levels and lymphokine-activated killer (LAK) activity was also examined in cancer patients. Spermine decreased the adhesion of non-stimulated PBMCs to tissue culture plastic in a dose- and a time-dependent manner without affecting cell viability or activity. This decrease in adhesion capacity was accompanied by a decrease in the number of CD11a bright-positive and CD56 bright-positive cells. Upon stimulation with interleukin 2 to activate LAK cytotoxicity, PBMCs cultured overnight with 100 or 500\u00a0\u03bcM spermine showed decreased cytotoxic activity against Daudi cells (91.5\u00a0\u00b1\u00a01.7 and 84.9\u00a0\u00b1\u00a03.0%, respectively (n\u00a0=\u00a06) compared to PBMC cultured without polyamines). In a group of 25 cancer patients, changes in blood spermine levels after surgery were negatively correlated with changes in LAK cytotoxicity after surgery (r\u00a0=\u00a0\u22120.510, P\u00a0=\u00a00.008: n\u00a0=\u00a025). Increased blood spermine levels may be an important factor in the suppression of anti-tumor immune cell function.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00262-006-0229-4", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "keywords": [
      "peripheral blood mononuclear cells", 
      "blood polyamine levels", 
      "immune cell function", 
      "cancer patients", 
      "LAK cytotoxicity", 
      "non-stimulated peripheral blood mononuclear cells", 
      "lymphokine-activated killer activity", 
      "lymphokine-activated killer cells", 
      "cell function", 
      "cellular immune function", 
      "spermine levels", 
      "blood mononuclear cells", 
      "post-operative changes", 
      "cytotoxic activity", 
      "polyamine levels", 
      "time-dependent manner", 
      "killer cells", 
      "mononuclear cells", 
      "patient prognosis", 
      "killer activity", 
      "cancer evasion", 
      "interleukin-2", 
      "healthy volunteers", 
      "immune function", 
      "tumor progression", 
      "Daudi cells", 
      "patients", 
      "surgery", 
      "cell viability", 
      "novel mechanism", 
      "cells", 
      "natural polyamine spermine", 
      "polyamine spermine", 
      "effects of polyamines", 
      "adhesion capacity", 
      "cytotoxicity", 
      "\u03bcM spermine", 
      "levels", 
      "prognosis", 
      "CD11a", 
      "activity", 
      "spermine", 
      "dose", 
      "progression", 
      "volunteers", 
      "stimulation", 
      "decrease", 
      "changes", 
      "important factor", 
      "effect", 
      "evasion", 
      "group", 
      "function", 
      "culture plastic", 
      "suppression", 
      "negative impact", 
      "factors", 
      "viability", 
      "study", 
      "spermidine", 
      "putrescine", 
      "correlation", 
      "polyamines", 
      "manner", 
      "mechanism", 
      "purpose", 
      "adhesion", 
      "number", 
      "impact", 
      "capacity", 
      "plastic"
    ], 
    "name": "Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion", 
    "pagination": "771-781", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016442645"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-006-0229-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16972077"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-006-0229-4", 
      "https://app.dimensions.ai/details/publication/pub.1016442645"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_414.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00262-006-0229-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0229-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0229-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0229-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0229-4'


 

This table displays all metadata directly associated to this object as RDF triples.

221 TRIPLES      22 PREDICATES      110 URIs      97 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-006-0229-4 schema:about N088ae99d1ef14a0d8afcb11587224a2d
2 N471119e419b84090925bdab2b6fafc4b
3 N4fe9bfcddcf044b88dda33dc6e2210e4
4 N6dfaab0347f942609aa16c73ddf82344
5 N7575aaad05e24ff597e22618a7934b2a
6 Naa9f6330599a4661be0535705a4cc5d5
7 Nad9a1916707c45be8d08d977f0eaca79
8 Nbc467f1acb7549fdb1ee04d1447530db
9 anzsrc-for:11
10 anzsrc-for:1107
11 schema:author N6d9c1f01a9b64b1ebb3e2fc94f833f96
12 schema:citation sg:pub.10.1007/bf00200177
13 sg:pub.10.1007/bf00917476
14 sg:pub.10.1007/s00262-004-0555-3
15 sg:pub.10.1054/bjoc.1999.1034
16 sg:pub.10.1054/bjoc.2001.1847
17 schema:datePublished 2006-09-14
18 schema:datePublishedReg 2006-09-14
19 schema:description Increased blood polyamine levels, often observed in cancer patients, have negative impacts on patient prognosis and are associated with tumor progression. The purpose of our study was to examine the effects of polyamines on cellular immune function. Peripheral blood mononuclear cells (PBMCs) from healthy volunteers were cultured with the human natural polyamines spermine, spermidine, or putrescine, and the effects on immune cell function were examined. The correlation between post-operative changes in blood polyamine levels and lymphokine-activated killer (LAK) activity was also examined in cancer patients. Spermine decreased the adhesion of non-stimulated PBMCs to tissue culture plastic in a dose- and a time-dependent manner without affecting cell viability or activity. This decrease in adhesion capacity was accompanied by a decrease in the number of CD11a bright-positive and CD56 bright-positive cells. Upon stimulation with interleukin 2 to activate LAK cytotoxicity, PBMCs cultured overnight with 100 or 500 μM spermine showed decreased cytotoxic activity against Daudi cells (91.5 ± 1.7 and 84.9 ± 3.0%, respectively (n = 6) compared to PBMC cultured without polyamines). In a group of 25 cancer patients, changes in blood spermine levels after surgery were negatively correlated with changes in LAK cytotoxicity after surgery (r = −0.510, P = 0.008: n = 25). Increased blood spermine levels may be an important factor in the suppression of anti-tumor immune cell function.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf N5d581d63e3dd49e58b5f53b834073336
24 N7f093e0f12394803a5db97a1a6941939
25 sg:journal.1096240
26 schema:keywords CD11a
27 Daudi cells
28 LAK cytotoxicity
29 activity
30 adhesion
31 adhesion capacity
32 blood mononuclear cells
33 blood polyamine levels
34 cancer evasion
35 cancer patients
36 capacity
37 cell function
38 cell viability
39 cells
40 cellular immune function
41 changes
42 correlation
43 culture plastic
44 cytotoxic activity
45 cytotoxicity
46 decrease
47 dose
48 effect
49 effects of polyamines
50 evasion
51 factors
52 function
53 group
54 healthy volunteers
55 immune cell function
56 immune function
57 impact
58 important factor
59 interleukin-2
60 killer activity
61 killer cells
62 levels
63 lymphokine-activated killer activity
64 lymphokine-activated killer cells
65 manner
66 mechanism
67 mononuclear cells
68 natural polyamine spermine
69 negative impact
70 non-stimulated peripheral blood mononuclear cells
71 novel mechanism
72 number
73 patient prognosis
74 patients
75 peripheral blood mononuclear cells
76 plastic
77 polyamine levels
78 polyamine spermine
79 polyamines
80 post-operative changes
81 prognosis
82 progression
83 purpose
84 putrescine
85 spermidine
86 spermine
87 spermine levels
88 stimulation
89 study
90 suppression
91 surgery
92 time-dependent manner
93 tumor progression
94 viability
95 volunteers
96 μM spermine
97 schema:name Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion
98 schema:pagination 771-781
99 schema:productId N640da9a70ccf4e4aac592d43b4960850
100 Na709d5071eb74700b258c8910a01b1a7
101 Ne5de2c1bb4464302a076146a20ac4985
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016442645
103 https://doi.org/10.1007/s00262-006-0229-4
104 schema:sdDatePublished 2022-05-20T07:23
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N2dab2908e19344ee8a1099fa65483dc0
107 schema:url https://doi.org/10.1007/s00262-006-0229-4
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N088ae99d1ef14a0d8afcb11587224a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cell Adhesion
113 rdf:type schema:DefinedTerm
114 N20c044b80b5543faadb508aeb053461c rdf:first sg:person.01143767626.39
115 rdf:rest N4fa8dd46bb8c42b784a82cf47fb89dd6
116 N29065aecfbaa498a84dc37970982a81b rdf:first N82dbbb19394742edbd5365977ca895fd
117 rdf:rest N20c044b80b5543faadb508aeb053461c
118 N2dab2908e19344ee8a1099fa65483dc0 schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N471119e419b84090925bdab2b6fafc4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Neoplasms
122 rdf:type schema:DefinedTerm
123 N4fa8dd46bb8c42b784a82cf47fb89dd6 rdf:first sg:person.01272216415.22
124 rdf:rest rdf:nil
125 N4fe9bfcddcf044b88dda33dc6e2210e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Spermidine
127 rdf:type schema:DefinedTerm
128 N5d581d63e3dd49e58b5f53b834073336 schema:volumeNumber 56
129 rdf:type schema:PublicationVolume
130 N640da9a70ccf4e4aac592d43b4960850 schema:name pubmed_id
131 schema:value 16972077
132 rdf:type schema:PropertyValue
133 N6d9c1f01a9b64b1ebb3e2fc94f833f96 rdf:first sg:person.0610356012.56
134 rdf:rest Nf774f610c27946aca357b1b71200aeb7
135 N6dfaab0347f942609aa16c73ddf82344 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 N7575aaad05e24ff597e22618a7934b2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Killer Cells, Lymphokine-Activated
140 rdf:type schema:DefinedTerm
141 N7f093e0f12394803a5db97a1a6941939 schema:issueNumber 6
142 rdf:type schema:PublicationIssue
143 N82dbbb19394742edbd5365977ca895fd schema:affiliation grid-institutes:grid.410804.9
144 schema:familyName Saitoh
145 schema:givenName Masaaki
146 rdf:type schema:Person
147 Na709d5071eb74700b258c8910a01b1a7 schema:name doi
148 schema:value 10.1007/s00262-006-0229-4
149 rdf:type schema:PropertyValue
150 Naa9f6330599a4661be0535705a4cc5d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Spermine
152 rdf:type schema:DefinedTerm
153 Nad9a1916707c45be8d08d977f0eaca79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Tumor Escape
155 rdf:type schema:DefinedTerm
156 Nbc467f1acb7549fdb1ee04d1447530db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Lymphocyte Subsets
158 rdf:type schema:DefinedTerm
159 Ncb9aab6410884813a9ed89d79f989d19 rdf:first sg:person.01350064210.85
160 rdf:rest N29065aecfbaa498a84dc37970982a81b
161 Ne5de2c1bb4464302a076146a20ac4985 schema:name dimensions_id
162 schema:value pub.1016442645
163 rdf:type schema:PropertyValue
164 Nf774f610c27946aca357b1b71200aeb7 rdf:first sg:person.0730445512.27
165 rdf:rest Ncb9aab6410884813a9ed89d79f989d19
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
170 schema:name Immunology
171 rdf:type schema:DefinedTerm
172 sg:journal.1096240 schema:issn 0340-7004
173 1432-0851
174 schema:name Cancer Immunology, Immunotherapy
175 schema:publisher Springer Nature
176 rdf:type schema:Periodical
177 sg:person.01143767626.39 schema:affiliation grid-institutes:grid.410804.9
178 schema:familyName Kawakami
179 schema:givenName Masanobu
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143767626.39
181 rdf:type schema:Person
182 sg:person.01272216415.22 schema:affiliation grid-institutes:grid.410804.9
183 schema:familyName Konishi
184 schema:givenName Fumio
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272216415.22
186 rdf:type schema:Person
187 sg:person.01350064210.85 schema:affiliation grid-institutes:grid.410804.9
188 schema:familyName Nakamura
189 schema:givenName Takeshi
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350064210.85
191 rdf:type schema:Person
192 sg:person.0610356012.56 schema:affiliation grid-institutes:grid.410804.9
193 schema:familyName Kano
194 schema:givenName Yoshihiko
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610356012.56
196 rdf:type schema:Person
197 sg:person.0730445512.27 schema:affiliation grid-institutes:grid.410804.9
198 schema:familyName Soda
199 schema:givenName Kuniyasu
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730445512.27
201 rdf:type schema:Person
202 sg:pub.10.1007/bf00200177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006361138
203 https://doi.org/10.1007/bf00200177
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00917476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010725949
206 https://doi.org/10.1007/bf00917476
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s00262-004-0555-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007284185
209 https://doi.org/10.1007/s00262-004-0555-3
210 rdf:type schema:CreativeWork
211 sg:pub.10.1054/bjoc.1999.1034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044925984
212 https://doi.org/10.1054/bjoc.1999.1034
213 rdf:type schema:CreativeWork
214 sg:pub.10.1054/bjoc.2001.1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038794005
215 https://doi.org/10.1054/bjoc.2001.1847
216 rdf:type schema:CreativeWork
217 grid-institutes:grid.410804.9 schema:alternateName Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan
218 First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan
219 schema:name Department of Surgery, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan
220 First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, 330-0834, Saitama City, Saitama, Japan
221 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...