Decreased response rates by the combination of histamine and IL-2 in melphalan-based isolated limb perfusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04

AUTHORS

Flavia Brunstein, Saske Hoving, Gisela aan de Wiel-Ambagtsheer, Ernst A. de Bruijn, Gunther Guetens, Alexander M. M. Eggermont, Timo L. M. ten Hagen

ABSTRACT

Histamine (Hi) combined to melphalan in a rat experimental model of isolated limb perfusion (ILP) for lower limb soft tissue sarcoma, resulted in overall response rates (OR) of 66%. Likewise, ILP with interleukin-2 (IL-2) resulted in OR of 67%, when combined to melphalan, in the same experimental model. In systemic immunotherapy, the combination of IL-2 and Hi has been used for solid tumor treatment based on immunomodulatory effects. In this study, we used our well-established ILP experimental model to evaluate whether the synergistic effect between the two drugs seen in the systemic setting, could further improve response rates in a loco-regional setting. Histological evaluation was done directly and 24 h after ILP. Melphalan uptake by tumor and muscle were measured. Hi and IL-2 together, combined to melphalan in the ILP led to OR of only 28%. Histology of tumors demonstrated partial loss of Hi-induced hemorrhagic effect when IL-2 was present. Melphalan accumulation in the tumor when both Hi and IL-2 were added (3.1-fold) was very similar to accumulation with Hi only (2.8-fold), or IL-2 only (3.5-fold) combined to melphalan. In vitro there was no synergy between the drugs. In conclusion there was a negative synergistic effect between IL-2 and Hi in the regional setting. More... »

PAGES

573-580

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-006-0206-y

DOI

http://dx.doi.org/10.1007/s00262-006-0206-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019599708

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16896966


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0206-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0206-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-006-0206-y'


 

This table displays all metadata directly associated to this object as RDF triples.

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