CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09

AUTHORS

Koji Kono, Hiromichi Kawaida, Akihiro Takahashi, Hidemitsu Sugai, Kosaku Mimura, Naoto Miyagawa, Hideo Omata, Hideki Fujii

ABSTRACT

PURPOSE: Regulatory T cells (T regs) can inhibit immune responses mediated by T cells. It has been shown that there is an increased proportion of T regs in several different human malignancies, although the actual mechanism remains unclear. In the present study, we evaluated the prevalence of CD4(+)CD25high T regs in PBMCs from patients with gastric and esophageal cancers in relation to the clinical outcome. METHODS: PBMCs in 72 patients with gastric cancer and 42 patients with esophageal cancer were evaluated for the proportion of CD4(+)CD25high T cells, as a percentage of the total CD4(+) cells, by flow cytometric analysis with triple-color staining. Actuarial overall survival rates of the patients were analyzed by the Kaplan-Meier method. RESULTS: The percentages of CD4(+)CD25high T cells for cases of gastric cancer (4.9+/-1.2%) and esophageal cancer (5.2+/-2.1%) were significantly higher than those for healthy donors (1.9+/-1.1%, P<0.01). There were significant differences in the prevalence of CD4(+)CD25high T cells between the early and advanced disease stages, both in gastric cancer (stage I vs. III, P<0.05; stage I vs. IV, P<0.05) and esophageal cancer (stage I vs. IV, P<0.05). The patients with a high proportion of CD4(+)CD25high T cells showed poorer survival rates in comparison to those with a low proportion, in both gastric and esophageal cancers. After patients received curative resections of gastric cancers (n=57), the increased proportions of CD4(+)CD25high T cells were significantly reduced, and the levels were almost equal to those in normal healthy donors. In addition, studies of gastric cancer patients with postoperative recurrent tumors (n=6) revealed that the prevalence of CD4(+)CD25high T cells individually increased compared to 2 months after the operations. CD4(+)CD25high T cells expressed FOXP3 mRNA and had abundant CD45RO and intracellular CTLA-4 molecules. CONCLUSIONS: These results strongly suggest that tumor-related factors induce and expand CD4(+)CD25high T regs. More... »

PAGES

1064-1071

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-005-0092-8

DOI

http://dx.doi.org/10.1007/s00262-005-0092-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042262663

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16328385


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esophageal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes, Mononuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Regulatory", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kono", 
        "givenName": "Koji", 
        "id": "sg:person.01362133435.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362133435.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawaida", 
        "givenName": "Hiromichi", 
        "id": "sg:person.01126035032.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126035032.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Akihiro", 
        "id": "sg:person.0732251172.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732251172.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugai", 
        "givenName": "Hidemitsu", 
        "id": "sg:person.01015045552.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015045552.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mimura", 
        "givenName": "Kosaku", 
        "id": "sg:person.01356512032.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356512032.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyagawa", 
        "givenName": "Naoto", 
        "id": "sg:person.01215561760.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215561760.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omata", 
        "givenName": "Hideo", 
        "id": "sg:person.01123550272.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123550272.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujii", 
        "givenName": "Hideki", 
        "id": "sg:person.014173406752.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014173406752.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.188.2.287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000968180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001462449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.2.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004722043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.2.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004722043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.6.823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006035130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.11.f41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010248812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.2.387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011923735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012208897", 
          "https://doi.org/10.1038/nm1093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012208897", 
          "https://doi.org/10.1038/nm1093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80856-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014611437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.11.1303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015517526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2001.1820102.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021721908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2005.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023471840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2004.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024173149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.9.2736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025461278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.11.1285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029841618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.11.6210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030036323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20021139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033485856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2001.1820117.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043961260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smim.2003.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051748707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053642209", 
          "https://doi.org/10.1038/39614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053642209", 
          "https://doi.org/10.1038/39614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.1.183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074565122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074834935", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.167.3.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074853179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.9.4272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075039316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075068997", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.5.2756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075112145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075189856", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075234166", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075329266", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076580391", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082444072", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-09", 
    "datePublishedReg": "2006-09-01", 
    "description": "PURPOSE: Regulatory T cells (T regs) can inhibit immune responses mediated by T cells. It has been shown that there is an increased proportion of T regs in several different human malignancies, although the actual mechanism remains unclear. In the present study, we evaluated the prevalence of CD4(+)CD25high T regs in PBMCs from patients with gastric and esophageal cancers in relation to the clinical outcome.\nMETHODS: PBMCs in 72 patients with gastric cancer and 42 patients with esophageal cancer were evaluated for the proportion of CD4(+)CD25high T cells, as a percentage of the total CD4(+) cells, by flow cytometric analysis with triple-color staining. Actuarial overall survival rates of the patients were analyzed by the Kaplan-Meier method.\nRESULTS: The percentages of CD4(+)CD25high T cells for cases of gastric cancer (4.9+/-1.2%) and esophageal cancer (5.2+/-2.1%) were significantly higher than those for healthy donors (1.9+/-1.1%, P<0.01). There were significant differences in the prevalence of CD4(+)CD25high T cells between the early and advanced disease stages, both in gastric cancer (stage I vs. III, P<0.05; stage I vs. IV, P<0.05) and esophageal cancer (stage I vs. IV, P<0.05). The patients with a high proportion of CD4(+)CD25high T cells showed poorer survival rates in comparison to those with a low proportion, in both gastric and esophageal cancers. After patients received curative resections of gastric cancers (n=57), the increased proportions of CD4(+)CD25high T cells were significantly reduced, and the levels were almost equal to those in normal healthy donors. In addition, studies of gastric cancer patients with postoperative recurrent tumors (n=6) revealed that the prevalence of CD4(+)CD25high T cells individually increased compared to 2 months after the operations. CD4(+)CD25high T cells expressed FOXP3 mRNA and had abundant CD45RO and intracellular CTLA-4 molecules.\nCONCLUSIONS: These results strongly suggest that tumor-related factors induce and expand CD4(+)CD25high T regs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-005-0092-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers", 
    "pagination": "1064-1071", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c951716a3b74c520bf60d58bb28fe1866543705d4d6e139b10c09c5af2173c7d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16328385"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-005-0092-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042262663"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-005-0092-8", 
      "https://app.dimensions.ai/details/publication/pub.1042262663"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87091_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-005-0092-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0092-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0092-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0092-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0092-8'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      77 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-005-0092-8 schema:about N0409ec7eeffd417ca80f79ae13eed56b
2 N0e8d6b3a699b485eb9e23e9e01f6a49a
3 N1c2f513da2d645099ee2ac48619d79e4
4 N2e96fcc7bfce4dd78accceea6a0e64b1
5 N30087cdc70fd4064b98b334d49231576
6 N3bd9469f7a404c919719ae98a7c6be52
7 N502bf9c13b82465786f8db5d6d35f264
8 N5063c7452c054595a578b9f1b48477dc
9 N541c7c09d2144658826cde75b5101ee1
10 N6ae67f995fe94ab6ad95de7bbd89b98f
11 N9061b7343bfe4fdb9fa43724cd1cfc88
12 N995e0f1c57f84da6904a802dd8eb596c
13 Na36554d5490e49b2a7e9135c059ca4ff
14 Nb00220a0b4054331811d4340560be59f
15 Nb7f13bd0266542f58e41b9100fbe8dd0
16 Nd0c8beec0f714f3494b3890321ab965e
17 Nd30bc576d62846609e9c206a1064be72
18 Nea7dfe52b67d4c839adc88dd7b525d42
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N76eb8296d2d94b028e673d75c1c93bc3
22 schema:citation sg:pub.10.1038/39614
23 sg:pub.10.1038/nm1093
24 https://app.dimensions.ai/details/publication/pub.1074834935
25 https://app.dimensions.ai/details/publication/pub.1075068997
26 https://app.dimensions.ai/details/publication/pub.1075189856
27 https://app.dimensions.ai/details/publication/pub.1075234166
28 https://app.dimensions.ai/details/publication/pub.1075329266
29 https://app.dimensions.ai/details/publication/pub.1076580391
30 https://app.dimensions.ai/details/publication/pub.1082444072
31 https://doi.org/10.1002/cncr.11618
32 https://doi.org/10.1016/j.clim.2005.02.018
33 https://doi.org/10.1016/j.jss.2004.10.004
34 https://doi.org/10.1016/j.smim.2003.12.005
35 https://doi.org/10.1016/s0092-8674(00)80856-9
36 https://doi.org/10.1034/j.1600-065x.2001.1820102.x
37 https://doi.org/10.1034/j.1600-065x.2001.1820117.x
38 https://doi.org/10.1084/jem.184.2.387
39 https://doi.org/10.1084/jem.188.2.287
40 https://doi.org/10.1084/jem.192.2.303
41 https://doi.org/10.1084/jem.193.11.1285
42 https://doi.org/10.1084/jem.193.11.1303
43 https://doi.org/10.1084/jem.193.11.f41
44 https://doi.org/10.1084/jem.194.6.823
45 https://doi.org/10.1084/jem.20021139
46 https://doi.org/10.1182/blood.v98.9.2736
47 https://doi.org/10.4049/jimmunol.164.1.183
48 https://doi.org/10.4049/jimmunol.167.3.1245
49 https://doi.org/10.4049/jimmunol.168.9.4272
50 https://doi.org/10.4049/jimmunol.169.11.6210
51 https://doi.org/10.4049/jimmunol.169.5.2756
52 schema:datePublished 2006-09
53 schema:datePublishedReg 2006-09-01
54 schema:description PURPOSE: Regulatory T cells (T regs) can inhibit immune responses mediated by T cells. It has been shown that there is an increased proportion of T regs in several different human malignancies, although the actual mechanism remains unclear. In the present study, we evaluated the prevalence of CD4(+)CD25high T regs in PBMCs from patients with gastric and esophageal cancers in relation to the clinical outcome. METHODS: PBMCs in 72 patients with gastric cancer and 42 patients with esophageal cancer were evaluated for the proportion of CD4(+)CD25high T cells, as a percentage of the total CD4(+) cells, by flow cytometric analysis with triple-color staining. Actuarial overall survival rates of the patients were analyzed by the Kaplan-Meier method. RESULTS: The percentages of CD4(+)CD25high T cells for cases of gastric cancer (4.9+/-1.2%) and esophageal cancer (5.2+/-2.1%) were significantly higher than those for healthy donors (1.9+/-1.1%, P<0.01). There were significant differences in the prevalence of CD4(+)CD25high T cells between the early and advanced disease stages, both in gastric cancer (stage I vs. III, P<0.05; stage I vs. IV, P<0.05) and esophageal cancer (stage I vs. IV, P<0.05). The patients with a high proportion of CD4(+)CD25high T cells showed poorer survival rates in comparison to those with a low proportion, in both gastric and esophageal cancers. After patients received curative resections of gastric cancers (n=57), the increased proportions of CD4(+)CD25high T cells were significantly reduced, and the levels were almost equal to those in normal healthy donors. In addition, studies of gastric cancer patients with postoperative recurrent tumors (n=6) revealed that the prevalence of CD4(+)CD25high T cells individually increased compared to 2 months after the operations. CD4(+)CD25high T cells expressed FOXP3 mRNA and had abundant CD45RO and intracellular CTLA-4 molecules. CONCLUSIONS: These results strongly suggest that tumor-related factors induce and expand CD4(+)CD25high T regs.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N3cadd60adcd84853a196f5872179a5a8
59 Ne72b14f732374baa9fb1c01f9a1abfe8
60 sg:journal.1096240
61 schema:name CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
62 schema:pagination 1064-1071
63 schema:productId N0264ff0419034d758e1c92604dc2e2e9
64 N69c33c5ee873403d904ef17a8c399b59
65 N94f0211710044635a096dd54b9d0f28e
66 Naf98ee44a76f45a4a9b677b0896a5291
67 Nf39921ac758f41459c0524fec32f1745
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042262663
69 https://doi.org/10.1007/s00262-005-0092-8
70 schema:sdDatePublished 2019-04-11T12:23
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Na7f0dea3040d4f92b9a904ffcf45f617
73 schema:url http://link.springer.com/10.1007%2Fs00262-005-0092-8
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0264ff0419034d758e1c92604dc2e2e9 schema:name dimensions_id
78 schema:value pub.1042262663
79 rdf:type schema:PropertyValue
80 N0409ec7eeffd417ca80f79ae13eed56b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Disease Progression
82 rdf:type schema:DefinedTerm
83 N0ddc38e220f2495b9e54f29ccdf4b2a2 rdf:first sg:person.01123550272.10
84 rdf:rest Ne7cb38414382446cb4277edeeb29f697
85 N0e8d6b3a699b485eb9e23e9e01f6a49a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name CD4-Positive T-Lymphocytes
87 rdf:type schema:DefinedTerm
88 N1c2f513da2d645099ee2ac48619d79e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Female
90 rdf:type schema:DefinedTerm
91 N2e96fcc7bfce4dd78accceea6a0e64b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name T-Lymphocyte Subsets
93 rdf:type schema:DefinedTerm
94 N30087cdc70fd4064b98b334d49231576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Neoplasm Staging
96 rdf:type schema:DefinedTerm
97 N3bd9469f7a404c919719ae98a7c6be52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Aged
99 rdf:type schema:DefinedTerm
100 N3cadd60adcd84853a196f5872179a5a8 schema:volumeNumber 55
101 rdf:type schema:PublicationVolume
102 N45891fd0432a4699913043df99f2d3af rdf:first sg:person.0732251172.76
103 rdf:rest N5f040db80aaf4b98955f24ff5ec78bf5
104 N4ba0273c7c9d4ec896e3a9cc6df54a4d rdf:first sg:person.01126035032.49
105 rdf:rest N45891fd0432a4699913043df99f2d3af
106 N502bf9c13b82465786f8db5d6d35f264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Aged, 80 and over
108 rdf:type schema:DefinedTerm
109 N5063c7452c054595a578b9f1b48477dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Esophageal Neoplasms
111 rdf:type schema:DefinedTerm
112 N541c7c09d2144658826cde75b5101ee1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Middle Aged
114 rdf:type schema:DefinedTerm
115 N5f040db80aaf4b98955f24ff5ec78bf5 rdf:first sg:person.01015045552.72
116 rdf:rest Nd074c1a57e2a40b695938e72ae0765f2
117 N69c33c5ee873403d904ef17a8c399b59 schema:name doi
118 schema:value 10.1007/s00262-005-0092-8
119 rdf:type schema:PropertyValue
120 N6ae67f995fe94ab6ad95de7bbd89b98f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cell Proliferation
122 rdf:type schema:DefinedTerm
123 N76eb8296d2d94b028e673d75c1c93bc3 rdf:first sg:person.01362133435.33
124 rdf:rest N4ba0273c7c9d4ec896e3a9cc6df54a4d
125 N8c34da480c014d4482e12ed3ed92c270 rdf:first sg:person.01215561760.26
126 rdf:rest N0ddc38e220f2495b9e54f29ccdf4b2a2
127 N9061b7343bfe4fdb9fa43724cd1cfc88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Survival Rate
129 rdf:type schema:DefinedTerm
130 N94f0211710044635a096dd54b9d0f28e schema:name readcube_id
131 schema:value c951716a3b74c520bf60d58bb28fe1866543705d4d6e139b10c09c5af2173c7d
132 rdf:type schema:PropertyValue
133 N995e0f1c57f84da6904a802dd8eb596c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Stomach Neoplasms
135 rdf:type schema:DefinedTerm
136 Na36554d5490e49b2a7e9135c059ca4ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name T-Lymphocytes, Regulatory
138 rdf:type schema:DefinedTerm
139 Na7f0dea3040d4f92b9a904ffcf45f617 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 Naf98ee44a76f45a4a9b677b0896a5291 schema:name nlm_unique_id
142 schema:value 8605732
143 rdf:type schema:PropertyValue
144 Nb00220a0b4054331811d4340560be59f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Immunophenotyping
146 rdf:type schema:DefinedTerm
147 Nb7f13bd0266542f58e41b9100fbe8dd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 Nd074c1a57e2a40b695938e72ae0765f2 rdf:first sg:person.01356512032.88
151 rdf:rest N8c34da480c014d4482e12ed3ed92c270
152 Nd0c8beec0f714f3494b3890321ab965e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Receptors, Interleukin-2
154 rdf:type schema:DefinedTerm
155 Nd30bc576d62846609e9c206a1064be72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Leukocytes, Mononuclear
157 rdf:type schema:DefinedTerm
158 Ne72b14f732374baa9fb1c01f9a1abfe8 schema:issueNumber 9
159 rdf:type schema:PublicationIssue
160 Ne7cb38414382446cb4277edeeb29f697 rdf:first sg:person.014173406752.52
161 rdf:rest rdf:nil
162 Nea7dfe52b67d4c839adc88dd7b525d42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 Nf39921ac758f41459c0524fec32f1745 schema:name pubmed_id
166 schema:value 16328385
167 rdf:type schema:PropertyValue
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
172 schema:name Oncology and Carcinogenesis
173 rdf:type schema:DefinedTerm
174 sg:journal.1096240 schema:issn 0340-7004
175 1432-0851
176 schema:name Cancer Immunology, Immunotherapy
177 rdf:type schema:Periodical
178 sg:person.01015045552.72 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
179 schema:familyName Sugai
180 schema:givenName Hidemitsu
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015045552.72
182 rdf:type schema:Person
183 sg:person.01123550272.10 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
184 schema:familyName Omata
185 schema:givenName Hideo
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123550272.10
187 rdf:type schema:Person
188 sg:person.01126035032.49 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
189 schema:familyName Kawaida
190 schema:givenName Hiromichi
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126035032.49
192 rdf:type schema:Person
193 sg:person.01215561760.26 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
194 schema:familyName Miyagawa
195 schema:givenName Naoto
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215561760.26
197 rdf:type schema:Person
198 sg:person.01356512032.88 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
199 schema:familyName Mimura
200 schema:givenName Kosaku
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356512032.88
202 rdf:type schema:Person
203 sg:person.01362133435.33 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
204 schema:familyName Kono
205 schema:givenName Koji
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362133435.33
207 rdf:type schema:Person
208 sg:person.014173406752.52 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
209 schema:familyName Fujii
210 schema:givenName Hideki
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014173406752.52
212 rdf:type schema:Person
213 sg:person.0732251172.76 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
214 schema:familyName Takahashi
215 schema:givenName Akihiro
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732251172.76
217 rdf:type schema:Person
218 sg:pub.10.1038/39614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053642209
219 https://doi.org/10.1038/39614
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nm1093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012208897
222 https://doi.org/10.1038/nm1093
223 rdf:type schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1074834935 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1075068997 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1075189856 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1075234166 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1075329266 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1076580391 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1082444072 schema:CreativeWork
231 https://doi.org/10.1002/cncr.11618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001462449
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.clim.2005.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023471840
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.jss.2004.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024173149
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.smim.2003.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051748707
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0092-8674(00)80856-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014611437
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1034/j.1600-065x.2001.1820102.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021721908
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1034/j.1600-065x.2001.1820117.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043961260
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1084/jem.184.2.387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011923735
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1084/jem.188.2.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000968180
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1084/jem.192.2.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004722043
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1084/jem.193.11.1285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029841618
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1084/jem.193.11.1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015517526
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1084/jem.193.11.f41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010248812
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1084/jem.194.6.823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006035130
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1084/jem.20021139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033485856
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1182/blood.v98.9.2736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025461278
262 rdf:type schema:CreativeWork
263 https://doi.org/10.4049/jimmunol.164.1.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074565122
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4049/jimmunol.167.3.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074853179
266 rdf:type schema:CreativeWork
267 https://doi.org/10.4049/jimmunol.168.9.4272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075039316
268 rdf:type schema:CreativeWork
269 https://doi.org/10.4049/jimmunol.169.11.6210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030036323
270 rdf:type schema:CreativeWork
271 https://doi.org/10.4049/jimmunol.169.5.2756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075112145
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.267500.6 schema:alternateName University of Yamanashi
274 schema:name First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409-3898, Yamanashi, Japan
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...