Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07

AUTHORS

Bernd Schlereth, Petra Kleindienst, Iduna Fichtner, Grit Lorenczewski, Klaus Brischwein, Sandra Lippold, Antonio da Silva, Mathias Locher, Roman Kischel, Ralf Lutterbüse, Peter Kufer, Patrick A. Baeuerle

ABSTRACT

Bispecific single-chain antibody constructs specific for human CD3 have been extensively studied for antitumor activity in human xenograft models using severe combined immunodeficient mice supplemented with human T cells. High efficacy at low effector-to-target ratios, independence of T cell costimuli and a potent activation of previously unstimulated polyclonal T cells were identified as hallmarks of this class of bispecific antibodies. Here we studied a bispecific single-chain antibody construct (referred to as 'bispecific T cell engager', BiTE) in an immunocompetent mouse model. This was possible by the use of a murine CD3-specific BiTE, and a syngeneic melanoma cell line (B16F10) expressing the human Ep-CAM target. The murine CD3-specific BiTE, called 2C11x4-7 prevented in a dose-dependent fashion the outgrowth of subcutaneously growing B16/Ep-CAM tumors with daily i.v. injections of 5 or 50 microg BiTE which was most effective. Treatment with 2C11x4-7 was effective even when it was started 10 days after tumor cell inoculation but delayed treatments showed a reduction in the number of cured animals. 2C11x4-7 was also highly active in a lung tumor colony model. When treatment was started on the day of intravenous tumor cell injection, seven out of eight animals stayed free of lung tumors, and three out of eight animals when treatment was started on day 5. Our study shows that BiTEs also have a high antitumor activity in immunocompetent mice and that there is no obvious need for costimulation of T cells by secondary agents. More... »

PAGES

785-796

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-005-0082-x

DOI

http://dx.doi.org/10.1007/s00262-005-0082-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036607851

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16187083


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Bispecific", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD3 Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion Molecules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Screening Assays, Antitumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cell Adhesion Molecule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunocompetence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred NOD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor B-Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subcutaneous Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlereth", 
        "givenName": "Bernd", 
        "id": "sg:person.01264417044.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264417044.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleindienst", 
        "givenName": "Petra", 
        "id": "sg:person.01322004264.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322004264.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Experimental Pharmacology and Oncology (EPO), 13122, Berlin-Buch, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fichtner", 
        "givenName": "Iduna", 
        "id": "sg:person.0777701322.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777701322.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lorenczewski", 
        "givenName": "Grit", 
        "id": "sg:person.01137761157.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137761157.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brischwein", 
        "givenName": "Klaus", 
        "id": "sg:person.01254207557.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254207557.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lippold", 
        "givenName": "Sandra", 
        "id": "sg:person.01176560773.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176560773.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Antonio da", 
        "id": "sg:person.01214115315.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214115315.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Locher", 
        "givenName": "Mathias", 
        "id": "sg:person.01073005363.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073005363.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kischel", 
        "givenName": "Roman", 
        "id": "sg:person.01324401137.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324401137.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lutterb\u00fcse", 
        "givenName": "Ralf", 
        "id": "sg:person.01151250011.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151250011.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kufer", 
        "givenName": "Peter", 
        "id": "sg:person.01230240414.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230240414.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420023.7", 
          "name": [
            "Micromet AG, Staffelseestr 2, 81477, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baeuerle", 
        "givenName": "Patrick A.", 
        "id": "sg:person.0665557013.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665557013.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molimm.2005.07.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000050936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2005.07.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000050936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000138204", 
          "https://doi.org/10.1038/sj.leu.2402890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000138204", 
          "https://doi.org/10.1038/sj.leu.2402890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(85)90274-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005181136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(85)90274-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005181136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005681080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibtech.2004.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011253985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011506028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/314628a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011668037", 
          "https://doi.org/10.1038/314628a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.8.2526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015472229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316354a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016066214", 
          "https://doi.org/10.1038/316354a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2003.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016329423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019028157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01517350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019305587", 
          "https://doi.org/10.1007/bf01517350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199856040-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020624095", 
          "https://doi.org/10.2165/00003495-199856040-00011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.15.7021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024032562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990105)80:1<138::aid-ijc25>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027814620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028096782", 
          "https://doi.org/10.1038/sj.bjc.6602310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028096782", 
          "https://doi.org/10.1038/sj.bjc.6602310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029887400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2004.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034114723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(90)85044-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041776878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1990.01410140078012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043535631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.125.2.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046212390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047898896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.170.8.4397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049032729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.5.1374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050572688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2005.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051763905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/7.6.947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059712370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074601318", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074713905", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075286407", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075314273", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076572518", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076893863", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077613147", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077892666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082683285", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082860428", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-07", 
    "datePublishedReg": "2006-07-01", 
    "description": "Bispecific single-chain antibody constructs specific for human CD3 have been extensively studied for antitumor activity in human xenograft models using severe combined immunodeficient mice supplemented with human T cells. High efficacy at low effector-to-target ratios, independence of T cell costimuli and a potent activation of previously unstimulated polyclonal T cells were identified as hallmarks of this class of bispecific antibodies. Here we studied a bispecific single-chain antibody construct (referred to as 'bispecific T cell engager', BiTE) in an immunocompetent mouse model. This was possible by the use of a murine CD3-specific BiTE, and a syngeneic melanoma cell line (B16F10) expressing the human Ep-CAM target. The murine CD3-specific BiTE, called 2C11x4-7 prevented in a dose-dependent fashion the outgrowth of subcutaneously growing B16/Ep-CAM tumors with daily i.v. injections of 5 or 50 microg BiTE which was most effective. Treatment with 2C11x4-7 was effective even when it was started 10 days after tumor cell inoculation but delayed treatments showed a reduction in the number of cured animals. 2C11x4-7 was also highly active in a lung tumor colony model. When treatment was started on the day of intravenous tumor cell injection, seven out of eight animals stayed free of lung tumors, and three out of eight animals when treatment was started on day 5. Our study shows that BiTEs also have a high antitumor activity in immunocompetent mice and that there is no obvious need for costimulation of T cells by secondary agents.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-005-0082-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3", 
    "pagination": "785-796", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ae6328cfd0a32da5c8e91ccf89562f503e2d2c80dd0d738966abbdee0820de66"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16187083"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-005-0082-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036607851"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-005-0082-x", 
      "https://app.dimensions.ai/details/publication/pub.1036607851"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53977_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-005-0082-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0082-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0082-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0082-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0082-x'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      89 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-005-0082-x schema:about N15666441525644968e292da6e6ed973e
2 N15d36c20c905481381c8314ce29a1b33
3 N3c71d0e5dec74218a440dba7d4ff3507
4 N3cc0fecffb32478dbaa55a5df3d6e0e9
5 N3fdd6964969448cc8d289f9b65785b96
6 N46d96a0118554da692b2461564f77df2
7 N48fa07a2dbef4d98b3c597766153aaa9
8 N4be73c970c4a487fbbdbeba558a4ca4d
9 N6ed01cdb51e64e4db58c750492a73eb5
10 N76dae33164cb45e4a7586898ab03e912
11 N80e62c6ddd8e4e1fb6a6ac3dbde24fbb
12 N91e4fd8bf08f414aaab216965376ebaa
13 N963010b4dbbf4362b79bed8d149ab8f0
14 N9cf5abcd95e24cec89fdacf2521e2673
15 Na6a60467018746919f885532b9c8b690
16 Naaa89c8e223c4abdb4822c63ce77a540
17 Nafcbb17d383f42908e95792f6ecaa1c4
18 Nbb4ec530f9a940dfa3e01e653bb4c50f
19 Nc2313457184a45baa6b949646c32a524
20 Nc762fd7b162640b691d074142b3a52e6
21 Nce421fdb32114c1f95555fd8348161eb
22 Ncf5850a128d948499f3d1b7687d9c30d
23 Ndb861b04cbb44fe480744e7803596a55
24 Nfae85a53eacb4c59917d9acc100358fe
25 anzsrc-for:11
26 anzsrc-for:1112
27 schema:author N9dac32bb15224211b80760c12572f9ce
28 schema:citation sg:pub.10.1007/bf01517350
29 sg:pub.10.1038/314628a0
30 sg:pub.10.1038/316354a0
31 sg:pub.10.1038/sj.bjc.6602310
32 sg:pub.10.1038/sj.leu.2402890
33 sg:pub.10.2165/00003495-199856040-00011
34 https://app.dimensions.ai/details/publication/pub.1074601318
35 https://app.dimensions.ai/details/publication/pub.1074713905
36 https://app.dimensions.ai/details/publication/pub.1075286407
37 https://app.dimensions.ai/details/publication/pub.1075314273
38 https://app.dimensions.ai/details/publication/pub.1076572518
39 https://app.dimensions.ai/details/publication/pub.1076893863
40 https://app.dimensions.ai/details/publication/pub.1077613147
41 https://app.dimensions.ai/details/publication/pub.1077892666
42 https://app.dimensions.ai/details/publication/pub.1082683285
43 https://app.dimensions.ai/details/publication/pub.1082860428
44 https://doi.org/10.1001/archsurg.1990.01410140078012
45 https://doi.org/10.1002/(sici)1097-0215(19990105)80:1<138::aid-ijc25>3.0.co;2-j
46 https://doi.org/10.1002/ijc.10443
47 https://doi.org/10.1002/ijc.10557
48 https://doi.org/10.1002/ijc.20908
49 https://doi.org/10.1016/0022-1759(85)90274-1
50 https://doi.org/10.1016/0076-6879(90)85044-o
51 https://doi.org/10.1016/j.humpath.2003.08.026
52 https://doi.org/10.1016/j.molimm.2004.04.002
53 https://doi.org/10.1016/j.molimm.2005.03.007
54 https://doi.org/10.1016/j.molimm.2005.07.034
55 https://doi.org/10.1016/j.tibtech.2004.03.006
56 https://doi.org/10.1073/pnas.84.5.1374
57 https://doi.org/10.1073/pnas.92.15.7021
58 https://doi.org/10.1083/jcb.125.2.437
59 https://doi.org/10.1093/intimm/7.6.947
60 https://doi.org/10.1158/0008-5472.can-04-2637
61 https://doi.org/10.1158/1078-0432.ccr-04-0729
62 https://doi.org/10.1182/blood.v98.8.2526
63 https://doi.org/10.4049/jimmunol.170.8.4397
64 schema:datePublished 2006-07
65 schema:datePublishedReg 2006-07-01
66 schema:description Bispecific single-chain antibody constructs specific for human CD3 have been extensively studied for antitumor activity in human xenograft models using severe combined immunodeficient mice supplemented with human T cells. High efficacy at low effector-to-target ratios, independence of T cell costimuli and a potent activation of previously unstimulated polyclonal T cells were identified as hallmarks of this class of bispecific antibodies. Here we studied a bispecific single-chain antibody construct (referred to as 'bispecific T cell engager', BiTE) in an immunocompetent mouse model. This was possible by the use of a murine CD3-specific BiTE, and a syngeneic melanoma cell line (B16F10) expressing the human Ep-CAM target. The murine CD3-specific BiTE, called 2C11x4-7 prevented in a dose-dependent fashion the outgrowth of subcutaneously growing B16/Ep-CAM tumors with daily i.v. injections of 5 or 50 microg BiTE which was most effective. Treatment with 2C11x4-7 was effective even when it was started 10 days after tumor cell inoculation but delayed treatments showed a reduction in the number of cured animals. 2C11x4-7 was also highly active in a lung tumor colony model. When treatment was started on the day of intravenous tumor cell injection, seven out of eight animals stayed free of lung tumors, and three out of eight animals when treatment was started on day 5. Our study shows that BiTEs also have a high antitumor activity in immunocompetent mice and that there is no obvious need for costimulation of T cells by secondary agents.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N493cef18383b417f8524a34c3fdf1287
71 N87b2f2803c39485395f5627f57548fba
72 sg:journal.1096240
73 schema:name Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
74 schema:pagination 785-796
75 schema:productId N1914358593014c4f88ca07f00a24f7bc
76 N25e2b1a148f84ca5a2b913d9b50fc5a3
77 Na9c8983909ca49d5a34afdaf9efc7503
78 Nc0ef2a7f11ee4906ab9282bb957052eb
79 Nd8a78aecdb70482987f0ae97d86fb854
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036607851
81 https://doi.org/10.1007/s00262-005-0082-x
82 schema:sdDatePublished 2019-04-11T12:10
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nc340938bef56438c8105bd14157159a8
85 schema:url http://link.springer.com/10.1007%2Fs00262-005-0082-x
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N08348973c06a42cab08c822b40878779 rdf:first sg:person.01137761157.17
90 rdf:rest Naeb979981227415cabb5d590ddb07c5d
91 N15666441525644968e292da6e6ed973e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Animals
93 rdf:type schema:DefinedTerm
94 N15d36c20c905481381c8314ce29a1b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Cell Line, Tumor
96 rdf:type schema:DefinedTerm
97 N1914358593014c4f88ca07f00a24f7bc schema:name pubmed_id
98 schema:value 16187083
99 rdf:type schema:PropertyValue
100 N25e2b1a148f84ca5a2b913d9b50fc5a3 schema:name readcube_id
101 schema:value ae6328cfd0a32da5c8e91ccf89562f503e2d2c80dd0d738966abbdee0820de66
102 rdf:type schema:PropertyValue
103 N277f5e3f1daa4b3e8acdcb53dc3fa230 rdf:first sg:person.01322004264.16
104 rdf:rest Nd07c40cfefd64edb9168a2c02a1292be
105 N28518eba3e5f40d39ad054cca423b807 rdf:first sg:person.01073005363.10
106 rdf:rest Nfd9bb1297e524b999238027a6c6ff292
107 N3c71d0e5dec74218a440dba7d4ff3507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Immunocompetence
109 rdf:type schema:DefinedTerm
110 N3cc0fecffb32478dbaa55a5df3d6e0e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mice, SCID
112 rdf:type schema:DefinedTerm
113 N3fdd6964969448cc8d289f9b65785b96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Immunotherapy
115 rdf:type schema:DefinedTerm
116 N46d96a0118554da692b2461564f77df2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Lung Neoplasms
118 rdf:type schema:DefinedTerm
119 N48fa07a2dbef4d98b3c597766153aaa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Melanoma, Experimental
121 rdf:type schema:DefinedTerm
122 N493cef18383b417f8524a34c3fdf1287 schema:volumeNumber 55
123 rdf:type schema:PublicationVolume
124 N4be73c970c4a487fbbdbeba558a4ca4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N5068618b99164add9ccbd2799d804e56 schema:name Experimental Pharmacology and Oncology (EPO), 13122, Berlin-Buch, Germany
128 rdf:type schema:Organization
129 N6ed01cdb51e64e4db58c750492a73eb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Xenograft Model Antitumor Assays
131 rdf:type schema:DefinedTerm
132 N76dae33164cb45e4a7586898ab03e912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cell Adhesion Molecules
134 rdf:type schema:DefinedTerm
135 N80e62c6ddd8e4e1fb6a6ac3dbde24fbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mice, Inbred NOD
137 rdf:type schema:DefinedTerm
138 N87b2f2803c39485395f5627f57548fba schema:issueNumber 7
139 rdf:type schema:PublicationIssue
140 N91e4fd8bf08f414aaab216965376ebaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Epithelial Cell Adhesion Molecule
142 rdf:type schema:DefinedTerm
143 N963010b4dbbf4362b79bed8d149ab8f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name CD3 Complex
145 rdf:type schema:DefinedTerm
146 N9cf5abcd95e24cec89fdacf2521e2673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mice, Inbred C57BL
148 rdf:type schema:DefinedTerm
149 N9dac32bb15224211b80760c12572f9ce rdf:first sg:person.01264417044.24
150 rdf:rest N277f5e3f1daa4b3e8acdcb53dc3fa230
151 Na6a60467018746919f885532b9c8b690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
153 rdf:type schema:DefinedTerm
154 Na9c8983909ca49d5a34afdaf9efc7503 schema:name doi
155 schema:value 10.1007/s00262-005-0082-x
156 rdf:type schema:PropertyValue
157 Naaa89c8e223c4abdb4822c63ce77a540 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Subcutaneous Tissue
159 rdf:type schema:DefinedTerm
160 Naeb979981227415cabb5d590ddb07c5d rdf:first sg:person.01254207557.05
161 rdf:rest Nd1ab9e8751e54c95b3412e97ad1467bf
162 Nafcbb17d383f42908e95792f6ecaa1c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Antibody Specificity
164 rdf:type schema:DefinedTerm
165 Nbb4ec530f9a940dfa3e01e653bb4c50f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Mice
167 rdf:type schema:DefinedTerm
168 Nc0d52506b8b44a18ba99b4a972ef7303 rdf:first sg:person.01230240414.09
169 rdf:rest Nd011167b158a416e9fb89d1811b4801e
170 Nc0ef2a7f11ee4906ab9282bb957052eb schema:name dimensions_id
171 schema:value pub.1036607851
172 rdf:type schema:PropertyValue
173 Nc2313457184a45baa6b949646c32a524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Dose-Response Relationship, Immunologic
175 rdf:type schema:DefinedTerm
176 Nc340938bef56438c8105bd14157159a8 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Nc762fd7b162640b691d074142b3a52e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Antibodies, Bispecific
180 rdf:type schema:DefinedTerm
181 Nce421fdb32114c1f95555fd8348161eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Antigens, Neoplasm
183 rdf:type schema:DefinedTerm
184 Ncf5850a128d948499f3d1b7687d9c30d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Recombinant Fusion Proteins
186 rdf:type schema:DefinedTerm
187 Nd011167b158a416e9fb89d1811b4801e rdf:first sg:person.0665557013.66
188 rdf:rest rdf:nil
189 Nd07c40cfefd64edb9168a2c02a1292be rdf:first sg:person.0777701322.49
190 rdf:rest N08348973c06a42cab08c822b40878779
191 Nd1ab9e8751e54c95b3412e97ad1467bf rdf:first sg:person.01176560773.11
192 rdf:rest Ndda3d32cb4ae4647aa00d9bd60f717ef
193 Nd8a78aecdb70482987f0ae97d86fb854 schema:name nlm_unique_id
194 schema:value 8605732
195 rdf:type schema:PropertyValue
196 Ndb861b04cbb44fe480744e7803596a55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Drug Screening Assays, Antitumor
198 rdf:type schema:DefinedTerm
199 Ndda3d32cb4ae4647aa00d9bd60f717ef rdf:first sg:person.01214115315.64
200 rdf:rest N28518eba3e5f40d39ad054cca423b807
201 Nf3064e48b9df48c9852d72db42718e4b rdf:first sg:person.01151250011.21
202 rdf:rest Nc0d52506b8b44a18ba99b4a972ef7303
203 Nfae85a53eacb4c59917d9acc100358fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Neoplasm Transplantation
205 rdf:type schema:DefinedTerm
206 Nfd9bb1297e524b999238027a6c6ff292 rdf:first sg:person.01324401137.64
207 rdf:rest Nf3064e48b9df48c9852d72db42718e4b
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:journal.1096240 schema:issn 0340-7004
215 1432-0851
216 schema:name Cancer Immunology, Immunotherapy
217 rdf:type schema:Periodical
218 sg:person.01073005363.10 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
219 schema:familyName Locher
220 schema:givenName Mathias
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073005363.10
222 rdf:type schema:Person
223 sg:person.01137761157.17 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
224 schema:familyName Lorenczewski
225 schema:givenName Grit
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137761157.17
227 rdf:type schema:Person
228 sg:person.01151250011.21 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
229 schema:familyName Lutterbüse
230 schema:givenName Ralf
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151250011.21
232 rdf:type schema:Person
233 sg:person.01176560773.11 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
234 schema:familyName Lippold
235 schema:givenName Sandra
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176560773.11
237 rdf:type schema:Person
238 sg:person.01214115315.64 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
239 schema:familyName Silva
240 schema:givenName Antonio da
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214115315.64
242 rdf:type schema:Person
243 sg:person.01230240414.09 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
244 schema:familyName Kufer
245 schema:givenName Peter
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230240414.09
247 rdf:type schema:Person
248 sg:person.01254207557.05 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
249 schema:familyName Brischwein
250 schema:givenName Klaus
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254207557.05
252 rdf:type schema:Person
253 sg:person.01264417044.24 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
254 schema:familyName Schlereth
255 schema:givenName Bernd
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264417044.24
257 rdf:type schema:Person
258 sg:person.01322004264.16 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
259 schema:familyName Kleindienst
260 schema:givenName Petra
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322004264.16
262 rdf:type schema:Person
263 sg:person.01324401137.64 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
264 schema:familyName Kischel
265 schema:givenName Roman
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324401137.64
267 rdf:type schema:Person
268 sg:person.0665557013.66 schema:affiliation https://www.grid.ac/institutes/grid.420023.7
269 schema:familyName Baeuerle
270 schema:givenName Patrick A.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665557013.66
272 rdf:type schema:Person
273 sg:person.0777701322.49 schema:affiliation N5068618b99164add9ccbd2799d804e56
274 schema:familyName Fichtner
275 schema:givenName Iduna
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777701322.49
277 rdf:type schema:Person
278 sg:pub.10.1007/bf01517350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019305587
279 https://doi.org/10.1007/bf01517350
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/314628a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011668037
282 https://doi.org/10.1038/314628a0
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/316354a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016066214
285 https://doi.org/10.1038/316354a0
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/sj.bjc.6602310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028096782
288 https://doi.org/10.1038/sj.bjc.6602310
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/sj.leu.2402890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000138204
291 https://doi.org/10.1038/sj.leu.2402890
292 rdf:type schema:CreativeWork
293 sg:pub.10.2165/00003495-199856040-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020624095
294 https://doi.org/10.2165/00003495-199856040-00011
295 rdf:type schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1074601318 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074713905 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1075286407 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1075314273 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1076572518 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1076893863 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1077613147 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1077892666 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1082683285 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1082860428 schema:CreativeWork
306 https://doi.org/10.1001/archsurg.1990.01410140078012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043535631
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1002/(sici)1097-0215(19990105)80:1<138::aid-ijc25>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1027814620
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/ijc.10443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019028157
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/ijc.10557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005681080
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/ijc.20908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011506028
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/0022-1759(85)90274-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005181136
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/0076-6879(90)85044-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1041776878
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.humpath.2003.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016329423
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.molimm.2004.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034114723
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.molimm.2005.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051763905
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.molimm.2005.07.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000050936
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.tibtech.2004.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011253985
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.84.5.1374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050572688
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.92.15.7021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024032562
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1083/jcb.125.2.437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046212390
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/intimm/7.6.947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059712370
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1158/0008-5472.can-04-2637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047898896
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1158/1078-0432.ccr-04-0729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029887400
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1182/blood.v98.8.2526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015472229
343 rdf:type schema:CreativeWork
344 https://doi.org/10.4049/jimmunol.170.8.4397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049032729
345 rdf:type schema:CreativeWork
346 https://www.grid.ac/institutes/grid.420023.7 schema:alternateName Amgen (Germany)
347 schema:name Micromet AG, Staffelseestr 2, 81477, Munich, Germany
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...