Identification of identical TCRs in primary melanoma lesions and tumor free corresponding sentinel lymph nodes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

Per thor Straten, Christina Dahl, David Schrama, Lars Østergaard Pedersen, Mads Hald Andersen, Tina Seremet, Eva-B. Bröcker, Per Guldberg, Jürgen C. Becker

ABSTRACT

It is generally believed that priming of efficient T-cell responses takes place in peripheral lymphoid tissues. Although this notion has been rigidly proven for infectious diseases, direct evidence for lymph node priming of in vivo T-cell responses against tumors is still lacking. In the present study, we conducted a full and nonbiased comparison of T-cell clonotypes in melanoma lesions and corresponding sentinel lymph nodes. Whereas most tumor lesions comprised a high number of T-cell clonotypes, only a small number of clonally expanded T cells were detected in the draining lymph nodes. Comparative clonotype mapping demonstrated the presence of identical T-cell clonotypes in the tumors and the respective sentinel lymph nodes, only when tumor cells were present in the latter. However, taking advantage of clonotype specific PCR amplification, TCR sequences representing clonally expanded T cells at the tumor site could be detected in the lymph nodes draining the tumors even in the absence of tumor cells. Evidence for the tumor-specific characteristics of these cells was obtained by in situ staining with peptide/HLA class I complexes demonstrating the presence of MART-1/HLA-A2- and MAGE-3/HLA-A2-reactive T cells at the tumor site, as well as in the draining lymph node. Our data indicate that T-cell responses to melanoma are primed in the sentinel lymph node by cross presentation of tumor antigens by dendritic cells. More... »

PAGES

495-502

References to SciGraph publications

  • 2001-03. A listing of human tumor antigens recognized by T cells in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1999-09. In situ T cells in melanoma in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1999-11. Natural adjuvants: Endogenous activators of dendritic cells in NATURE MEDICINE
  • 2000-08. CD91: a receptor for heat shock protein gp96 in NATURE IMMUNOLOGY
  • 2002-12. Aggregation of Antigen-Specific T Cells at the Inoculation Site of Mature Dendritic Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-03. A listing of human tumor antigens recognized by T cells: March 2004 update in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1996-09. T-cell recognition of self peptides as tumor rejection antigens in IMMUNOLOGIC RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00262-005-0023-8

    DOI

    http://dx.doi.org/10.1007/s00262-005-0023-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046215006

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16001163


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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0023-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0023-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0023-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-005-0023-8'


     

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