Antibody therapy of non-Hodgkin's B-cell lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05

AUTHORS

Paul Chinn, Gary Braslawsky, Christine White, Nabil Hanna

ABSTRACT

Engineering antibodies with reduced immunogenicity and enhanced effector functions, and selecting antigen targets with the appropriate specificity, density, and/or functionality, have contributed to the recent clinical successes in using unconjugated "naked" antibody therapies of B-cell lymphoma (rituximab) and breast carcinoma (Herceptin). The non-overlapping toxicities of naked antibodies and chemotherapy, together with their potential synergy, which is based on unique and complementary mechanisms of action, have contributed to the creation of new standards of care in cancer therapy and management. Clinical trial results supporting these concepts are presented. Furthermore, the exquisite specificity of antibodies renders them ideal vehicles for selective delivery of toxic payloads such as drugs or radionuclides. Although successful in therapy of hematological cancers (Zevalin, Mylotarg), the broader application of these technologies to carcinomas still remains to be proven in clinical testing. Engineering of antibody constructs with optimal blood clearance and tumor-targeting kinetics, and selecting the radionuclide that may deliver sufficient radiation energy to kill the more radio-resistant carcinomas, are discussed. With the advent of genomics and proteomics, new membrane-associated tumor antigens are being discovered and will provide novel targets for future antibody therapy of cancer. More... »

PAGES

257-280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-002-0347-6

DOI

http://dx.doi.org/10.1007/s00262-002-0347-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075271232

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12700943


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Murine-Derived", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, B-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rituximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Biogen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417832.b", 
          "name": [
            "IDEC Pharmaceuticals Corporation, 3010 Science Park Road, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chinn", 
        "givenName": "Paul", 
        "id": "sg:person.01302675442.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302675442.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biogen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417832.b", 
          "name": [
            "IDEC Pharmaceuticals Corporation, 3010 Science Park Road, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braslawsky", 
        "givenName": "Gary", 
        "id": "sg:person.0700106433.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700106433.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biogen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417832.b", 
          "name": [
            "IDEC Pharmaceuticals Corporation, 3010 Science Park Road, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "White", 
        "givenName": "Christine", 
        "id": "sg:person.01025577604.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025577604.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biogen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417832.b", 
          "name": [
            "IDEC Pharmaceuticals Corporation, 3010 Science Park Road, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanna", 
        "givenName": "Nabil", 
        "id": "sg:person.01211103672.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211103672.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0360-3016(92)90980-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000278483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/256495a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001387921", 
          "https://doi.org/10.1038/256495a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002173707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/095530002317577358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002371408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940201)73:3+<958::aid-cncr2820731331>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002911562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0273-1177(89)90439-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004082764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0273-1177(89)90439-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004082764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/srao.2002.31382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006451016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1192-1455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008246899", 
          "https://doi.org/10.1038/nbt1192-1455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-1497-4_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008578243", 
          "https://doi.org/10.1007/978-1-4613-1497-4_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-1497-4_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008578243", 
          "https://doi.org/10.1007/978-1-4613-1497-4_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.61.10.883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008923560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0969-8051(95)02001-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009273638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910570611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009631447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.2.661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011662486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011723935", 
          "https://doi.org/10.1038/sj.leu.2402320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011723935", 
          "https://doi.org/10.1038/sj.leu.2402320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.22.10459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013032297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.1119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013517460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198203043060906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017864257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19971215)80:12+<2567::aid-cncr32>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020623635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020829545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021042726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02786322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022735441", 
          "https://doi.org/10.1007/bf02786322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02786322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022735441", 
          "https://doi.org/10.1007/bf02786322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830221217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024169860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940201)73:3+<816::aid-cncr2820731311>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025423232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940201)73:3+<1049::aid-cncr2820731344>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026697875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830241042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026961082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/0033-7587(2002)157[0633:vtrwta]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027473767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1118/1.597142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027946046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2000.01965.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028957963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.12.3995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029349125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2001.03041.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029744619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.21.6851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030102558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030129209", 
          "https://doi.org/10.1038/9872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030129209", 
          "https://doi.org/10.1038/9872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/095530000139069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030685462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.11.6037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030783670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0969-8051(93)90137-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031594776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(90)90489-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033619279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60486-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034028490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2897(86)90025-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034713586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002620050016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035594402", 
          "https://doi.org/10.1007/s002620050016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940201)73:3+<989::aid-cncr2820731336>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036918556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m009483200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037109599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.1613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040070260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.5.1326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040463948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040987790", 
          "https://doi.org/10.1038/bjc.1992.41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040987790", 
          "https://doi.org/10.1038/bjc.1992.41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.1.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041990794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.4.952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042844221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/mo:18:2:141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043457440", 
          "https://doi.org/10.1385/mo:18:2:141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910530119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044337064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(84)90435-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045400812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(84)90435-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045400812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.3.781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047336037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb00642.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049482002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb00642.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049482002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90078-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051086492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-200105000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051410279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-200105000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051410279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)82501-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051787177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052302729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002590100542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053224635", 
          "https://doi.org/10.1007/s002590100542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.12.4336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053511143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc00009a008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055152657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc000146n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055152758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc000146n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055152758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc010134h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055153237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc010134h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055153237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm980152t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055958796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm980152t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055958796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008389119525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/108497801300189245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/108497802753773847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cbr.1997.12.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059242284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cbr.1997.12.305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059242292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cbr.1998.13.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059242334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cbr.2000.15.547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059242491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/82.1.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059815757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.5.1288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.09.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.11.076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/0033-7587(2001)155[0288:rwapem]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068194502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3570441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070373883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.15.5.1017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.1.268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074511236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074526361", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.4.1244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.6.1851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.12.3793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074556143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.2.317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074577134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.6.1316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074604332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.8.4178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074619234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074638732", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.17.3135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074691573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074701741", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074722402", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074739242", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074750484", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.2.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074768324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074776086", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074797883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.8.2153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.8.2165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074863961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327480200900207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075037305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327480200900207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075037305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075051023", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077374411", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078430586", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078747290", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078948866", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079355979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082275108", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082384747", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082390841", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082402642", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082715436", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082903130", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082918760", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082949122", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083214916", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083243949", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083263138", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083285280", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.8.2825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083306005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083314021", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083339608", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bk-1995-0604.ch003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1089366670"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-05", 
    "datePublishedReg": "2003-05-01", 
    "description": "Engineering antibodies with reduced immunogenicity and enhanced effector functions, and selecting antigen targets with the appropriate specificity, density, and/or functionality, have contributed to the recent clinical successes in using unconjugated \"naked\" antibody therapies of B-cell lymphoma (rituximab) and breast carcinoma (Herceptin). The non-overlapping toxicities of naked antibodies and chemotherapy, together with their potential synergy, which is based on unique and complementary mechanisms of action, have contributed to the creation of new standards of care in cancer therapy and management. Clinical trial results supporting these concepts are presented. Furthermore, the exquisite specificity of antibodies renders them ideal vehicles for selective delivery of toxic payloads such as drugs or radionuclides. Although successful in therapy of hematological cancers (Zevalin, Mylotarg), the broader application of these technologies to carcinomas still remains to be proven in clinical testing. Engineering of antibody constructs with optimal blood clearance and tumor-targeting kinetics, and selecting the radionuclide that may deliver sufficient radiation energy to kill the more radio-resistant carcinomas, are discussed. With the advent of genomics and proteomics, new membrane-associated tumor antigens are being discovered and will provide novel targets for future antibody therapy of cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-002-0347-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "52"
      }
    ], 
    "name": "Antibody therapy of non-Hodgkin's B-cell lymphoma", 
    "pagination": "257-280", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "83f0b0e47eaec6a0c498debfc5cb5cab51f720bdeff68e70808b916e10d6c11a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12700943"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-002-0347-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1075271232"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-002-0347-6", 
      "https://app.dimensions.ai/details/publication/pub.1075271232"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000535.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00262-002-0347-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0347-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0347-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0347-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0347-6'


 

This table displays all metadata directly associated to this object as RDF triples.

480 TRIPLES      21 PREDICATES      161 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-002-0347-6 schema:about N3181aaca9b74480aa4b54f4158303730
2 N44f234886b1842ef9c1b799a2163a54f
3 N5c9eab6eb88740a680155da632bf25af
4 N65116c9e4ee74792b8398300af4a5ea3
5 N6d2af1b986b04deabe1efc6e6874b6be
6 N796c175492994193bbd11c83088a69be
7 N7a564b6d6f704be2948937a10cf06de7
8 N92f4a022f8ba4982a6ca92c1e7cb3498
9 Nc8f1610b40604def98ca95cdeb8a10ee
10 Nd8abb2ec51fa4047aa8010af81d26a38
11 Ne4e2790f93e643ee8fde0dfeb63940a2
12 Neca7929639a14c2285f9d8c74658ef67
13 Nf491af839a8347478b74c5e60a0db18d
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N5dbb7997f27449b0b04318b596b1ae07
17 schema:citation sg:pub.10.1007/978-1-4613-1497-4_16
18 sg:pub.10.1007/bf02786322
19 sg:pub.10.1007/s002590100542
20 sg:pub.10.1007/s002620050016
21 sg:pub.10.1038/256495a0
22 sg:pub.10.1038/9872
23 sg:pub.10.1038/bjc.1992.41
24 sg:pub.10.1038/nbt1192-1455
25 sg:pub.10.1038/sj.leu.2402320
26 sg:pub.10.1385/mo:18:2:141
27 https://app.dimensions.ai/details/publication/pub.1074526361
28 https://app.dimensions.ai/details/publication/pub.1074638732
29 https://app.dimensions.ai/details/publication/pub.1074701741
30 https://app.dimensions.ai/details/publication/pub.1074722402
31 https://app.dimensions.ai/details/publication/pub.1074739242
32 https://app.dimensions.ai/details/publication/pub.1074750484
33 https://app.dimensions.ai/details/publication/pub.1074776086
34 https://app.dimensions.ai/details/publication/pub.1074797883
35 https://app.dimensions.ai/details/publication/pub.1074863961
36 https://app.dimensions.ai/details/publication/pub.1075051023
37 https://app.dimensions.ai/details/publication/pub.1077374411
38 https://app.dimensions.ai/details/publication/pub.1078430586
39 https://app.dimensions.ai/details/publication/pub.1078747290
40 https://app.dimensions.ai/details/publication/pub.1078948866
41 https://app.dimensions.ai/details/publication/pub.1079355979
42 https://app.dimensions.ai/details/publication/pub.1082275108
43 https://app.dimensions.ai/details/publication/pub.1082384747
44 https://app.dimensions.ai/details/publication/pub.1082390841
45 https://app.dimensions.ai/details/publication/pub.1082402642
46 https://app.dimensions.ai/details/publication/pub.1082715436
47 https://app.dimensions.ai/details/publication/pub.1082903130
48 https://app.dimensions.ai/details/publication/pub.1082918760
49 https://app.dimensions.ai/details/publication/pub.1082949122
50 https://app.dimensions.ai/details/publication/pub.1083214916
51 https://app.dimensions.ai/details/publication/pub.1083243949
52 https://app.dimensions.ai/details/publication/pub.1083263138
53 https://app.dimensions.ai/details/publication/pub.1083285280
54 https://app.dimensions.ai/details/publication/pub.1083314021
55 https://app.dimensions.ai/details/publication/pub.1083339608
56 https://doi.org/10.1002/(sici)1097-0142(19971215)80:12+<2567::aid-cncr32>3.0.co;2-8
57 https://doi.org/10.1002/1097-0142(19940201)73:3+<1049::aid-cncr2820731344>3.0.co;2-1
58 https://doi.org/10.1002/1097-0142(19940201)73:3+<816::aid-cncr2820731311>3.0.co;2-t
59 https://doi.org/10.1002/1097-0142(19940201)73:3+<958::aid-cncr2820731331>3.0.co;2-e
60 https://doi.org/10.1002/1097-0142(19940201)73:3+<989::aid-cncr2820731336>3.0.co;2-u
61 https://doi.org/10.1002/bit.1119
62 https://doi.org/10.1002/cncr.10304
63 https://doi.org/10.1002/eji.1830221217
64 https://doi.org/10.1002/eji.1830241042
65 https://doi.org/10.1002/ijc.1613
66 https://doi.org/10.1002/ijc.2910530119
67 https://doi.org/10.1002/ijc.2910570611
68 https://doi.org/10.1002/pros.10029
69 https://doi.org/10.1016/0022-1759(84)90435-6
70 https://doi.org/10.1016/0273-1177(89)90439-0
71 https://doi.org/10.1016/0360-3016(90)90489-7
72 https://doi.org/10.1016/0360-3016(92)90980-v
73 https://doi.org/10.1016/0360-3016(94)90078-7
74 https://doi.org/10.1016/0883-2897(86)90025-5
75 https://doi.org/10.1016/0969-8051(93)90137-j
76 https://doi.org/10.1016/0969-8051(95)02001-2
77 https://doi.org/10.1016/s0065-2776(08)60486-1
78 https://doi.org/10.1016/s0360-3016(97)82501-1
79 https://doi.org/10.1021/bc00009a008
80 https://doi.org/10.1021/bc000146n
81 https://doi.org/10.1021/bc010134h
82 https://doi.org/10.1021/bk-1995-0604.ch003
83 https://doi.org/10.1021/jm980152t
84 https://doi.org/10.1023/a:1008389119525
85 https://doi.org/10.1046/j.1365-2141.2000.01965.x
86 https://doi.org/10.1046/j.1365-2141.2001.03041.x
87 https://doi.org/10.1053/srao.2002.31382
88 https://doi.org/10.1056/nejm198203043060906
89 https://doi.org/10.1056/nejmoa011795
90 https://doi.org/10.1073/pnas.81.21.6851
91 https://doi.org/10.1073/pnas.90.22.10459
92 https://doi.org/10.1073/pnas.95.11.6037
93 https://doi.org/10.1074/jbc.m009483200
94 https://doi.org/10.1080/095530000139069
95 https://doi.org/10.1080/095530002317577358
96 https://doi.org/10.1084/jem.178.2.661
97 https://doi.org/10.1089/108497801300189245
98 https://doi.org/10.1089/108497802753773847
99 https://doi.org/10.1089/cbr.1997.12.177
100 https://doi.org/10.1089/cbr.1997.12.305
101 https://doi.org/10.1089/cbr.1998.13.239
102 https://doi.org/10.1089/cbr.2000.15.547
103 https://doi.org/10.1093/annonc/mdf159
104 https://doi.org/10.1093/jnci/82.1.47
105 https://doi.org/10.1097/00002371-200105000-00012
106 https://doi.org/10.1111/j.1349-7006.1998.tb00642.x
107 https://doi.org/10.1118/1.597142
108 https://doi.org/10.1136/ard.61.10.883
109 https://doi.org/10.1177/107327480200900207
110 https://doi.org/10.1182/blood.v97.1.101
111 https://doi.org/10.1182/blood.v97.12.3995
112 https://doi.org/10.1182/blood.v98.3.781
113 https://doi.org/10.1182/blood.v98.4.952
114 https://doi.org/10.1182/blood.v98.5.1326
115 https://doi.org/10.1182/blood.v99.12.4336
116 https://doi.org/10.1200/jco.1998.16.8.2825
117 https://doi.org/10.1200/jco.1999.17.1.268
118 https://doi.org/10.1200/jco.1999.17.12.3793
119 https://doi.org/10.1200/jco.1999.17.4.1244
120 https://doi.org/10.1200/jco.1999.17.6.1851
121 https://doi.org/10.1200/jco.20.5.1288
122 https://doi.org/10.1200/jco.2000.18.17.3135
123 https://doi.org/10.1200/jco.2000.18.2.317
124 https://doi.org/10.1200/jco.2000.18.6.1316
125 https://doi.org/10.1200/jco.2001.19.2.389
126 https://doi.org/10.1200/jco.2001.19.8.2153
127 https://doi.org/10.1200/jco.2001.19.8.2165
128 https://doi.org/10.1200/jco.2002.09.039
129 https://doi.org/10.1200/jco.2002.11.017
130 https://doi.org/10.1200/jco.2002.11.076
131 https://doi.org/10.1667/0033-7587(2001)155[0288:rwapem]2.0.co;2
132 https://doi.org/10.1667/0033-7587(2002)157[0633:vtrwta]2.0.co;2
133 https://doi.org/10.2307/3570441
134 https://doi.org/10.3892/ijo.15.5.1017
135 https://doi.org/10.4049/jimmunol.164.8.4178
136 schema:datePublished 2003-05
137 schema:datePublishedReg 2003-05-01
138 schema:description Engineering antibodies with reduced immunogenicity and enhanced effector functions, and selecting antigen targets with the appropriate specificity, density, and/or functionality, have contributed to the recent clinical successes in using unconjugated "naked" antibody therapies of B-cell lymphoma (rituximab) and breast carcinoma (Herceptin). The non-overlapping toxicities of naked antibodies and chemotherapy, together with their potential synergy, which is based on unique and complementary mechanisms of action, have contributed to the creation of new standards of care in cancer therapy and management. Clinical trial results supporting these concepts are presented. Furthermore, the exquisite specificity of antibodies renders them ideal vehicles for selective delivery of toxic payloads such as drugs or radionuclides. Although successful in therapy of hematological cancers (Zevalin, Mylotarg), the broader application of these technologies to carcinomas still remains to be proven in clinical testing. Engineering of antibody constructs with optimal blood clearance and tumor-targeting kinetics, and selecting the radionuclide that may deliver sufficient radiation energy to kill the more radio-resistant carcinomas, are discussed. With the advent of genomics and proteomics, new membrane-associated tumor antigens are being discovered and will provide novel targets for future antibody therapy of cancer.
139 schema:genre research_article
140 schema:inLanguage en
141 schema:isAccessibleForFree false
142 schema:isPartOf N841dd9f1a6f8420b90b5fbc999ff348b
143 Nc5a88c583adf4997b1fe32b8c1ae60a7
144 sg:journal.1096240
145 schema:name Antibody therapy of non-Hodgkin's B-cell lymphoma
146 schema:pagination 257-280
147 schema:productId N01188a730cf1414ab2306606abf3eb30
148 N830f424ba67b40bca2dccf2328e3958d
149 N925b9790026e4d7b83353a781ddf05e9
150 Nb3fc10584a9f4777ad102f43af648923
151 Ncb29b64c105243d3bfcf4b3b5464cff9
152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075271232
153 https://doi.org/10.1007/s00262-002-0347-6
154 schema:sdDatePublished 2019-04-10T22:37
155 schema:sdLicense https://scigraph.springernature.com/explorer/license/
156 schema:sdPublisher N05442ef166c24fc58fe29464ff87e478
157 schema:url http://link.springer.com/10.1007%2Fs00262-002-0347-6
158 sgo:license sg:explorer/license/
159 sgo:sdDataset articles
160 rdf:type schema:ScholarlyArticle
161 N01188a730cf1414ab2306606abf3eb30 schema:name nlm_unique_id
162 schema:value 8605732
163 rdf:type schema:PropertyValue
164 N05442ef166c24fc58fe29464ff87e478 schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 N3181aaca9b74480aa4b54f4158303730 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Antineoplastic Agents
168 rdf:type schema:DefinedTerm
169 N44f234886b1842ef9c1b799a2163a54f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Mice
171 rdf:type schema:DefinedTerm
172 N5c9eab6eb88740a680155da632bf25af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Lymphoma, B-Cell
174 rdf:type schema:DefinedTerm
175 N5dbb7997f27449b0b04318b596b1ae07 rdf:first sg:person.01302675442.14
176 rdf:rest Nadbd96f9275b4d0cb104951a995766bf
177 N65116c9e4ee74792b8398300af4a5ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Lymphoma
179 rdf:type schema:DefinedTerm
180 N6d2af1b986b04deabe1efc6e6874b6be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Immunotherapy
182 rdf:type schema:DefinedTerm
183 N796c175492994193bbd11c83088a69be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Animals
185 rdf:type schema:DefinedTerm
186 N7a564b6d6f704be2948937a10cf06de7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Antibodies, Monoclonal, Murine-Derived
188 rdf:type schema:DefinedTerm
189 N830f424ba67b40bca2dccf2328e3958d schema:name readcube_id
190 schema:value 83f0b0e47eaec6a0c498debfc5cb5cab51f720bdeff68e70808b916e10d6c11a
191 rdf:type schema:PropertyValue
192 N841dd9f1a6f8420b90b5fbc999ff348b schema:volumeNumber 52
193 rdf:type schema:PublicationVolume
194 N925b9790026e4d7b83353a781ddf05e9 schema:name doi
195 schema:value 10.1007/s00262-002-0347-6
196 rdf:type schema:PropertyValue
197 N92f4a022f8ba4982a6ca92c1e7cb3498 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Humans
199 rdf:type schema:DefinedTerm
200 Nadbd96f9275b4d0cb104951a995766bf rdf:first sg:person.0700106433.00
201 rdf:rest Nde50ef648aa54b7785a989a4e79151c8
202 Nb3fc10584a9f4777ad102f43af648923 schema:name pubmed_id
203 schema:value 12700943
204 rdf:type schema:PropertyValue
205 Nc48a685effa7487fa97a4c376159407a rdf:first sg:person.01211103672.34
206 rdf:rest rdf:nil
207 Nc5a88c583adf4997b1fe32b8c1ae60a7 schema:issueNumber 5
208 rdf:type schema:PublicationIssue
209 Nc8f1610b40604def98ca95cdeb8a10ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Time Factors
211 rdf:type schema:DefinedTerm
212 Ncb29b64c105243d3bfcf4b3b5464cff9 schema:name dimensions_id
213 schema:value pub.1075271232
214 rdf:type schema:PropertyValue
215 Nd8abb2ec51fa4047aa8010af81d26a38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Rituximab
217 rdf:type schema:DefinedTerm
218 Nde50ef648aa54b7785a989a4e79151c8 rdf:first sg:person.01025577604.73
219 rdf:rest Nc48a685effa7487fa97a4c376159407a
220 Ne4e2790f93e643ee8fde0dfeb63940a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Antigens, Neoplasm
222 rdf:type schema:DefinedTerm
223 Neca7929639a14c2285f9d8c74658ef67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Antineoplastic Combined Chemotherapy Protocols
225 rdf:type schema:DefinedTerm
226 Nf491af839a8347478b74c5e60a0db18d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Antibodies, Monoclonal
228 rdf:type schema:DefinedTerm
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
233 schema:name Oncology and Carcinogenesis
234 rdf:type schema:DefinedTerm
235 sg:journal.1096240 schema:issn 0340-7004
236 1432-0851
237 schema:name Cancer Immunology, Immunotherapy
238 rdf:type schema:Periodical
239 sg:person.01025577604.73 schema:affiliation https://www.grid.ac/institutes/grid.417832.b
240 schema:familyName White
241 schema:givenName Christine
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025577604.73
243 rdf:type schema:Person
244 sg:person.01211103672.34 schema:affiliation https://www.grid.ac/institutes/grid.417832.b
245 schema:familyName Hanna
246 schema:givenName Nabil
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211103672.34
248 rdf:type schema:Person
249 sg:person.01302675442.14 schema:affiliation https://www.grid.ac/institutes/grid.417832.b
250 schema:familyName Chinn
251 schema:givenName Paul
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302675442.14
253 rdf:type schema:Person
254 sg:person.0700106433.00 schema:affiliation https://www.grid.ac/institutes/grid.417832.b
255 schema:familyName Braslawsky
256 schema:givenName Gary
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700106433.00
258 rdf:type schema:Person
259 sg:pub.10.1007/978-1-4613-1497-4_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008578243
260 https://doi.org/10.1007/978-1-4613-1497-4_16
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/bf02786322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022735441
263 https://doi.org/10.1007/bf02786322
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s002590100542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053224635
266 https://doi.org/10.1007/s002590100542
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s002620050016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035594402
269 https://doi.org/10.1007/s002620050016
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/256495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001387921
272 https://doi.org/10.1038/256495a0
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/9872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030129209
275 https://doi.org/10.1038/9872
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/bjc.1992.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040987790
278 https://doi.org/10.1038/bjc.1992.41
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nbt1192-1455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008246899
281 https://doi.org/10.1038/nbt1192-1455
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.leu.2402320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011723935
284 https://doi.org/10.1038/sj.leu.2402320
285 rdf:type schema:CreativeWork
286 sg:pub.10.1385/mo:18:2:141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043457440
287 https://doi.org/10.1385/mo:18:2:141
288 rdf:type schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1074526361 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1074638732 schema:CreativeWork
291 https://app.dimensions.ai/details/publication/pub.1074701741 schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1074722402 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1074739242 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1074750484 schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1074776086 schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1074797883 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074863961 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1075051023 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1077374411 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1078430586 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1078747290 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1078948866 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1079355979 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1082275108 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1082384747 schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1082390841 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1082402642 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1082715436 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1082903130 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1082918760 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1082949122 schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1083214916 schema:CreativeWork
313 https://app.dimensions.ai/details/publication/pub.1083243949 schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1083263138 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1083285280 schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1083314021 schema:CreativeWork
317 https://app.dimensions.ai/details/publication/pub.1083339608 schema:CreativeWork
318 https://doi.org/10.1002/(sici)1097-0142(19971215)80:12+<2567::aid-cncr32>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020623635
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1002/1097-0142(19940201)73:3+<1049::aid-cncr2820731344>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026697875
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1002/1097-0142(19940201)73:3+<816::aid-cncr2820731311>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1025423232
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1002/1097-0142(19940201)73:3+<958::aid-cncr2820731331>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1002911562
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1002/1097-0142(19940201)73:3+<989::aid-cncr2820731336>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1036918556
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1002/bit.1119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013517460
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1002/cncr.10304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020829545
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1002/eji.1830221217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024169860
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1002/eji.1830241042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026961082
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1002/ijc.1613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040070260
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1002/ijc.2910530119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044337064
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1002/ijc.2910570611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009631447
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1002/pros.10029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021042726
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/0022-1759(84)90435-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045400812
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/0273-1177(89)90439-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004082764
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/0360-3016(90)90489-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033619279
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/0360-3016(92)90980-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1000278483
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/0360-3016(94)90078-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051086492
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/0883-2897(86)90025-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034713586
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/0969-8051(93)90137-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1031594776
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/0969-8051(95)02001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009273638
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0065-2776(08)60486-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034028490
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s0360-3016(97)82501-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051787177
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1021/bc00009a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055152657
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1021/bc000146n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055152758
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1021/bc010134h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153237
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1021/bk-1995-0604.ch003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089366670
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1021/jm980152t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055958796
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1023/a:1008389119525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303668
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1046/j.1365-2141.2000.01965.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028957963
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1046/j.1365-2141.2001.03041.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029744619
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1053/srao.2002.31382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006451016
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1056/nejm198203043060906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017864257
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1056/nejmoa011795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052302729
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1073/pnas.81.21.6851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030102558
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1073/pnas.90.22.10459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013032297
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1073/pnas.95.11.6037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030783670
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1074/jbc.m009483200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037109599
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1080/095530000139069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030685462
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1080/095530002317577358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002371408
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1084/jem.178.2.661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011662486
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1089/108497801300189245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207641
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1089/108497802753773847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207739
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1089/cbr.1997.12.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059242284
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1089/cbr.1997.12.305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059242292
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1089/cbr.1998.13.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059242334
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1089/cbr.2000.15.547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059242491
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1093/annonc/mdf159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002173707
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1093/jnci/82.1.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059815757
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1097/00002371-200105000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051410279
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1111/j.1349-7006.1998.tb00642.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049482002
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1118/1.597142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027946046
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1136/ard.61.10.883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008923560
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1177/107327480200900207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075037305
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1182/blood.v97.1.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041990794
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1182/blood.v97.12.3995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029349125
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1182/blood.v98.3.781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047336037
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1182/blood.v98.4.952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042844221
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1182/blood.v98.5.1326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040463948
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1182/blood.v99.12.4336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053511143
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1200/jco.1998.16.8.2825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083306005
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1200/jco.1999.17.1.268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074511236
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1200/jco.1999.17.12.3793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074556143
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1200/jco.1999.17.4.1244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549729
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1200/jco.1999.17.6.1851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549773
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1200/jco.20.5.1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202851
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1200/jco.2000.18.17.3135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074691573
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1200/jco.2000.18.2.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074577134
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1200/jco.2000.18.6.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074604332
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1200/jco.2001.19.2.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074768324
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1200/jco.2001.19.8.2153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800003
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1200/jco.2001.19.8.2165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800004
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1200/jco.2002.09.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203125
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1200/jco.2002.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203164
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1200/jco.2002.11.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203176
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1667/0033-7587(2001)155[0288:rwapem]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068194502
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1667/0033-7587(2002)157[0633:vtrwta]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027473767
471 rdf:type schema:CreativeWork
472 https://doi.org/10.2307/3570441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070373883
473 rdf:type schema:CreativeWork
474 https://doi.org/10.3892/ijo.15.5.1017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511166
475 rdf:type schema:CreativeWork
476 https://doi.org/10.4049/jimmunol.164.8.4178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074619234
477 rdf:type schema:CreativeWork
478 https://www.grid.ac/institutes/grid.417832.b schema:alternateName Biogen (United States)
479 schema:name IDEC Pharmaceuticals Corporation, 3010 Science Park Road, 92121, San Diego, California, USA
480 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...