Ontology type: schema:ScholarlyArticle
2003-02
AUTHORSAkira Ito, Masashige Shinkai, Hiroyuki Honda, Kazuhiro Yoshikawa, Shinsuke Saga, Toshihiko Wakabayashi, Jun Yoshida, Takeshi Kobayashi
ABSTRACTIn this study we demonstrated that heat shock protein (HSP) 70 expression by hyperthermia induced antitumor immunity in the T-9 rat glioma. Our hyperthermic system using magnetic nanoparticles induced necrotic cell death that correlated with HSP70 expression. We purified the HSP70-peptide complexes from the tumor after hyperthermia to investigate whether HSP70 was involved in the antitumor immunity, and we found that in the F344 rats immunized with T-9-derived HSP70 the tumor growth of T-9 was significantly suppressed. Tumor rejection assay after hyperthermic treatment of implanted T-9 cells with incorporated magnetite cationic liposomes (MCL) was performed to investigate whether antitumor immunity was induced by release of HSP70 from the necrotic cells in the F344 rat. Tumor growth was strongly suppressed in the rats subjected to hyperthermia of implanted T-9 cells, and 50% of rats were protected from challenge with T-9 cells. Immunogenicity was enhanced when the HSP70-overexpressing T-9 cells were killed via necrosis in rats by hyperthermia, after which all rats were completely protected from challenge with T-9 cells. Our hyperthermic system produces vaccination with HSP70-peptide via necrotic tumor cell death in vivo, resulting in antitumor immunity. This phenomenon, which may be termed in situ vaccination, has important implications for the development of novel antitumor therapies. More... »
PAGES80-88
http://scigraph.springernature.com/pub.10.1007/s00262-002-0335-x
DOIhttp://dx.doi.org/10.1007/s00262-002-0335-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1075240185
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12594571
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cations",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ferrosoferric Oxide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glioma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HSP70 Heat-Shock Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperthermia, Induced",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Iron",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liposomes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Necrosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Inbred F344",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464\u20138603, Japan"
],
"type": "Organization"
},
"familyName": "Ito",
"givenName": "Akira",
"id": "sg:person.01037221040.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037221040.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464\u20138603, Japan"
],
"type": "Organization"
},
"familyName": "Shinkai",
"givenName": "Masashige",
"id": "sg:person.013412320611.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013412320611.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464\u20138603, Japan"
],
"type": "Organization"
},
"familyName": "Honda",
"givenName": "Hiroyuki",
"id": "sg:person.016617716011.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016617716011.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aichi Medical University",
"id": "https://www.grid.ac/institutes/grid.411234.1",
"name": [
"Second Department of Pathology, Aichi Medical University School of Medicine, Yazako, Nagakute, Aichi, 480\u20131195 Japan"
],
"type": "Organization"
},
"familyName": "Yoshikawa",
"givenName": "Kazuhiro",
"id": "sg:person.0766017060.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766017060.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aichi Medical University",
"id": "https://www.grid.ac/institutes/grid.411234.1",
"name": [
"Second Department of Pathology, Aichi Medical University School of Medicine, Yazako, Nagakute, Aichi, 480\u20131195 Japan"
],
"type": "Organization"
},
"familyName": "Saga",
"givenName": "Shinsuke",
"id": "sg:person.01023357016.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023357016.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Neurosurgery, School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466\u20138550 Japan"
],
"type": "Organization"
},
"familyName": "Wakabayashi",
"givenName": "Toshihiko",
"id": "sg:person.01367256160.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367256160.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Neurosurgery, School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466\u20138550 Japan"
],
"type": "Organization"
},
"familyName": "Yoshida",
"givenName": "Jun",
"id": "sg:person.0672510657.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672510657.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nagoya University",
"id": "https://www.grid.ac/institutes/grid.27476.30",
"name": [
"Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464\u20138603, Japan"
],
"type": "Organization"
},
"familyName": "Kobayashi",
"givenName": "Takeshi",
"id": "sg:person.012466626631.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012466626631.65"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1146/annurev.immunol.20.100301.064801",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000020979"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00262-001-0233-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002588042",
"https://doi.org/10.1007/s00262-001-0233-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1996.tb03129.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006842994"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1996.tb03129.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006842994"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.bi.55.070186.005443",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010277610"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0598-581",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014484512",
"https://doi.org/10.1038/nm0598-581"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0598-581",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014484512",
"https://doi.org/10.1038/nm0598-581"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4615-0685-0_16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014782102",
"https://doi.org/10.1007/978-1-4615-0685-0_16"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4615-0685-0_16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014782102",
"https://doi.org/10.1007/978-1-4615-0685-0_16"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-1759(97)00017-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014900291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.20.19.7146-7159.2000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015271744"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0165-2478(00)00246-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016566903"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/smim.1996.0035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022946333"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri749",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024200162",
"https://doi.org/10.1038/nri749"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri749",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024200162",
"https://doi.org/10.1038/nri749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1997.tb00429.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025554129"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1997.tb00429.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025554129"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0215(19960503)66:3<347::aid-ijc14>3.0.co;2-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027454270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/94.11.805",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027717875"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/74697",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028349667",
"https://doi.org/10.1038/74697"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/74697",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028349667",
"https://doi.org/10.1038/74697"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/intimm/10.5.609",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030395240"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.178.4.1391",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030566171"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/02656730110108785",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033660043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/intimm/12.11.1539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037326964"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm0196-52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037938818",
"https://doi.org/10.1038/nm0196-52"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1998.tb03283.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039912197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1998.tb03283.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039912197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1998.tb00586.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044462998"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1349-7006.1998.tb00586.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044462998"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197210)30:4<885::aid-cncr2820300404>3.0.co;2-g",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044828751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.186.5.645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044924423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0167-5699(99)01558-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049431794"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0304-3835(01)00825-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052356161"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.278.5335.117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062558154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.7545313",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062647506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/0007-1285-55-656-579",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064554050"
],
"type": "CreativeWork"
}
],
"datePublished": "2003-02",
"datePublishedReg": "2003-02-01",
"description": "In this study we demonstrated that heat shock protein (HSP) 70 expression by hyperthermia induced antitumor immunity in the T-9 rat glioma. Our hyperthermic system using magnetic nanoparticles induced necrotic cell death that correlated with HSP70 expression. We purified the HSP70-peptide complexes from the tumor after hyperthermia to investigate whether HSP70 was involved in the antitumor immunity, and we found that in the F344 rats immunized with T-9-derived HSP70 the tumor growth of T-9 was significantly suppressed. Tumor rejection assay after hyperthermic treatment of implanted T-9 cells with incorporated magnetite cationic liposomes (MCL) was performed to investigate whether antitumor immunity was induced by release of HSP70 from the necrotic cells in the F344 rat. Tumor growth was strongly suppressed in the rats subjected to hyperthermia of implanted T-9 cells, and 50% of rats were protected from challenge with T-9 cells. Immunogenicity was enhanced when the HSP70-overexpressing T-9 cells were killed via necrosis in rats by hyperthermia, after which all rats were completely protected from challenge with T-9 cells. Our hyperthermic system produces vaccination with HSP70-peptide via necrotic tumor cell death in vivo, resulting in antitumor immunity. This phenomenon, which may be termed in situ vaccination, has important implications for the development of novel antitumor therapies.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00262-002-0335-x",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1096240",
"issn": [
"0340-7004",
"1432-0851"
],
"name": "Cancer Immunology, Immunotherapy",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "52"
}
],
"name": "Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles",
"pagination": "80-88",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e33e2cd584797cf9cc8af44f4d9657e43827b805c7bf303c0229741bd1f6f5ff"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12594571"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8605732"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00262-002-0335-x"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1075240185"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00262-002-0335-x",
"https://app.dimensions.ai/details/publication/pub.1075240185"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:01",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000535.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00262-002-0335-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0335-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0335-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0335-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-002-0335-x'
This table displays all metadata directly associated to this object as RDF triples.
267 TRIPLES
21 PREDICATES
71 URIs
34 LITERALS
22 BLANK NODES