Ontology type: schema:ScholarlyArticle
2020-10-23
AUTHORSJi Hun Kang, Do Hyung Kim, So Yeon Kim, Hyo Jeong Kang, Jung Bok Lee, Kyoung Won Kim, Seung Soo Lee, Jonggi Choi, Young-Suk Lim
ABSTRACTPurposeTo differentiate the computed tomography (CT) and magnetic resonance imaging (MRI) features of porto-sinusoidal vascular disease (PSVD) and liver cirrhosis (LC).MethodsIn this retrospective case–control study of patients with PSVD matched in a 1:3 ratio with LC patients according to liver function, initial diagnosis and time to final diagnosis were analyzed. Imaging features on CT and the parenchymal enhancement on hepatobiliary phase of hepatobiliary agent-enhanced MRI (HBA-MRI) were compared using a generalized linear mixed model. Focal hepatic lesions in the PSVD group were analyzed.ResultsIn total, 43 PSVD patients and 129 LC patients were included. Among PSVD patients, 72.1% were initially misdiagnosed with LC. PSVD patients had a longer diagnostic delay than LC patients (32 months vs. 4 months; p < 0.001). Liver surface nodularity was less common in the PSVD group than in the LC group (16.3% vs. 89.2%, p < 0.001). Increased caudate-to-right lobe ratio, heterogeneous parenchymal enhancement, and portal vein abnormalities were more frequently noted in the PSVD group than in the LC group (all p < 0.001). The grade of portal hypertension was significantly higher in the PSVD group than in the LC group (p < 0.001), and they also had brighter parenchymal enhancement during the hepatobiliary phase of HBA-MRI (p < 0.001). In the PSVD group, 14% patients had at least one focal hepatic lesion, primarily a focal nodular hyperplasia (FNH)-like nodule.ConclusionsSome imaging features on CT and HBA-MRI can distinguish PSVD from LC. Benign focal lesions, most commonly FNH-like nodules, can develop in PSVD. More... »
PAGES1891-1903
http://scigraph.springernature.com/pub.10.1007/s00261-020-02831-w
DOIhttp://dx.doi.org/10.1007/s00261-020-02831-w
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33095310
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