MR imaging findings of the prostate gland following prostate artery embolization: results from a prospective phase 2 study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-08

AUTHORS

Rehan Ali, Ahmed Gabr, Samdeep K. Mouli, Joseph Ralph Kallini, Ahsun Riaz, Ronald Mora, Robert J. Lewandowski, Elias Hohlastos, David D. Casalino, Matthias D. Hofer, Nabeel Hamoui, Frank H. Miller, John Hairston, Riad Salem

ABSTRACT

PurposeTo assess changes in imaging and volume characteristics of the prostate gland by magnetic resonance (MR) following prostatic artery embolization (PAE) for benign prostate hyperplasia.MethodsWith IRB approval, we analyzed prospectively acquired MR data of PAE patients at baseline and 6-month following treatment from 2015 to 2017. We reviewed prostate MRs looking for sequelae of embolization [changes in signal intensity and/or enhancement, infection/inflammation, infarction, edema, and change in intravesical prostatic protrusion (IPP)]. We calculated the total volume (TV) and central gland volumes (CGV) using DynaCAD® and measured change in volumes. Analyses were performed using SPSS with p < 0.05 considered significant.ResultsForty-three patients (n = 43) met our inclusion criteria. 93% (30/43) and 100% (43/43) showed a decrease in TV and CGV at 6-months respectively. At baseline, median TV was 86 cc (range 29.4–232) and median CGV was 54.4 cc (range 12.9–165.5). Median decrease in TV was 18.2% (CI 13.3–27.2) (p = 0.0001) and median decrease in CGV was 26.7% (CI 20.4–35.9) (p = 0.0001). Thirty-seven percent (16/43) of patients had IPP at baseline; 100% showed a decrease in size of median lobe at follow-up. At 6-month follow-up, 33% (14/43) showed imaging features of infarction, 79% (34/43) had decrease in T2-signal intensity, and 51% (22/43) showed a decrease in enhancement. None had edema, peri-prostatic fat changes or infection/inflammation.ConclusionPAE causes a statistically significant reduction in the TV and CGV. There is also a reduction of the degree of IPP. Non-specific findings of infarction, decrease in T2-signal, and enhancement were also seen. More... »

PAGES

713-722

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00261-018-1757-z

DOI

http://dx.doi.org/10.1007/s00261-018-1757-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106894572

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30196364


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24 schema:description PurposeTo assess changes in imaging and volume characteristics of the prostate gland by magnetic resonance (MR) following prostatic artery embolization (PAE) for benign prostate hyperplasia.MethodsWith IRB approval, we analyzed prospectively acquired MR data of PAE patients at baseline and 6-month following treatment from 2015 to 2017. We reviewed prostate MRs looking for sequelae of embolization [changes in signal intensity and/or enhancement, infection/inflammation, infarction, edema, and change in intravesical prostatic protrusion (IPP)]. We calculated the total volume (TV) and central gland volumes (CGV) using DynaCAD® and measured change in volumes. Analyses were performed using SPSS with p < 0.05 considered significant.ResultsForty-three patients (n = 43) met our inclusion criteria. 93% (30/43) and 100% (43/43) showed a decrease in TV and CGV at 6-months respectively. At baseline, median TV was 86 cc (range 29.4–232) and median CGV was 54.4 cc (range 12.9–165.5). Median decrease in TV was 18.2% (CI 13.3–27.2) (p = 0.0001) and median decrease in CGV was 26.7% (CI 20.4–35.9) (p = 0.0001). Thirty-seven percent (16/43) of patients had IPP at baseline; 100% showed a decrease in size of median lobe at follow-up. At 6-month follow-up, 33% (14/43) showed imaging features of infarction, 79% (34/43) had decrease in T2-signal intensity, and 51% (22/43) showed a decrease in enhancement. None had edema, peri-prostatic fat changes or infection/inflammation.ConclusionPAE causes a statistically significant reduction in the TV and CGV. There is also a reduction of the degree of IPP. Non-specific findings of infarction, decrease in T2-signal, and enhancement were also seen.
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31 schema:keywords CC
32 ConclusionPAE
33 DynaCAD
34 IPP
35 IRB approval
36 MR data
37 MethodsWith IRB approval
38 PAE patients
39 PurposeTo
40 ResultsForty
41 SPSS
42 T2-signal
43 T2-signal intensity
44 analysis
45 approval
46 artery embolization
47 baseline
48 benign prostate hyperplasia
49 central gland volumes
50 changes
51 characteristics
52 criteria
53 data
54 decrease
55 degree
56 degree of IPP
57 edema
58 embolization
59 enhancement
60 fat changes
61 features
62 features of infarction
63 findings
64 gland
65 gland volume
66 hyperplasia
67 imaging
68 inclusion criteria
69 infarction
70 infection/inflammation
71 inflammation
72 intensity
73 lobe
74 magnetic resonance
75 median CGV
76 median decrease
77 median lobe
78 median total volume
79 non-specific findings
80 patients
81 percent
82 percent of patients
83 peri-prostatic fat changes
84 phase 2 study
85 prospective phase 2 study
86 prostate artery embolization
87 prostate gland
88 prostate hyperplasia
89 prostate magnetic resonance
90 prostatic artery embolization
91 reduction
92 resonance
93 results
94 sequelae
95 sequelae of embolization
96 significant reduction
97 size
98 study
99 total volume
100 treatment
101 volume
102 volume characteristics
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