Diagnostic accuracy of F-18 FDG PET/CT for characterization of colorectal focal FDG uptake: a systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08-21

AUTHORS

Gyung Mo Son, Seong-Jang Kim

ABSTRACT

IntroductionWe aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for characterization of incidental colorectal focal FDG uptake through a systematic review and meta-analysis.MethodsThe MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through April 30, 2018, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for characterization of incidental colorectal focal FDG uptake. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR−), and constructed summary receiver operating characteristic curves.ResultsAcross 8 studies (1451 patients), the pooled sensitivity for F-18 FDG PET/CT was 0.87 (95% CI 0.82–0.90) without heterogeneity (χ2 = 10.84, p = 0.37) and a pooled specificity of 0.83 (95% CI 0.76–0.89) with heterogeneity (χ2 = 130.1, p = 0.00). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 5.2 (95% CI 3.6–7.4) and negative likelihood ratio (LR−) of 0.16 (95% CI 0.12–0.22). The pooled DOR was 32 (95% CI 20–51).ConclusionF-18 FDG PET/CT demonstrated good sensitivity and specificity for characterization of incidental colorectal focal FDG uptake. At present, the literature regarding the use of F-18 FDG PET/CT for characterization of incidental colorectal focal FDG uptake remains still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET/CT for characterization of incidental colorectal focal FDG uptake. More... »

PAGES

456-463

References to SciGraph publications

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  • 2014-08-20. Incidental colonic focal FDG uptake on PET/CT: can the maximum standardized uptake value (SUVmax) guide us in the timing of colonoscopy? in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1996-10. Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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    http://dx.doi.org/10.1007/s00261-018-1747-1

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