Computed tomography findings after radiofrequency ablation in locally advanced pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10

AUTHORS

Steffi J. E. Rombouts, Tyche C. Derksen, Chung Y. Nio, Richard van Hillegersberg, Hjalmar C. van Santvoort, Marieke S. Walma, Izaak Q. Molenaar, Maarten S. van Leeuwen

ABSTRACT

PURPOSE: The purpose of the study was to provide a systematic evaluation of the computed tomography(CT) findings after radiofrequency ablation (RFA) in locally advanced pancreatic cancer(LAPC). METHODS: Eighteen patients with intra-operative RFA-treated LAPC were included in a prospective case series. All CT-scans performed prior to RFA and 1 week and 3 months of post-RFA, according to standard regimen, were assessed by two radiologists in consensus, using standardized radiological scoring lists. RESULTS: 51 CT-scans were assessed. One week after RFA, the ablation zone was visible in all patients as a (partially) sharply defined (83%), heterogeneous area (94%). At 3 months of follow-up, the ablation zone was completely invaded by tumor in 67% of patients and still present, but decreased in 33%. In two patients (11%), local thrombosis and/or occlusion of the superior mesenteric vein occurred. The occlusions persisted without clinical consequences and the thrombosis disappeared. A peripancreatic fluid collection was visible 1 week after RFA in 3 patients, wherein the ablation zone extended ventrally outside of the pancreas. CONCLUSIONS: Directly after RFA for LAPC, a well-defined ablation zone is visible on CT-imaging. This ablation zone is usually replaced by tumor ingrowth after 3 months. Moreover, the ablation zone regularly included vascular structures, with rare asymptomatic venous occlusion or thrombosis and without adverse effects on arteries. More... »

PAGES

2702-2711

References to SciGraph publications

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URI

http://scigraph.springernature.com/pub.10.1007/s00261-018-1519-y

DOI

http://dx.doi.org/10.1007/s00261-018-1519-y

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https://app.dimensions.ai/details/publication/pub.1101267194

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29492602


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