Angiosomal radiopathologic analysis of transarterial radioembolization for the treatment of hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10-20

AUTHORS

Altan F. Ahmed, Naziya Samreen, Joseph R. Grajo, Ivan Zendejas, Chris L. Sistrom, Amy Collinsworth, Ashwini Esnakula, Jehan L. Shah, Roniel Cabrera, Brian S. Geller, Beau B. Toskich

ABSTRACT

PurposeTo assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response.MethodsTwelve patients with HCC underwent ablative (≥ 190 Gy) and/or non-ablative (< 190 Gy) TARE delivered in a segmental, lobar, or combined fashion as a surgical neoadjuvant or bridge to transplantation. Both targeted tumor and treatment angiosome were analyzed before and after TARE utilizing hepatocyte-specific contrast-enhanced MRI or contrast-enhanced CT. Responses were graded using EASL and mRECIST criteria. Histologic findings including percent tumor necrosis and adjacent hepatic substrate effects were correlated with imaging features.ResultsComplete pathologic necrosis (CPN) was observed in 7/12 tumors post-TARE. Ablative and non-ablative dosing resulted in CPN in 5/6 and 2/6 tumors, respectively. Hyperintensity on T2-weighted imaging, the absence of hepatocyte-specific gadolinium contrast uptake, and plateau or persistent enhancement kinetics in the angiosome correlated with CPN and performed similarly to EASL and mRECIST criteria in predicting CPN.ConclusionsThe absence of hepatocyte-specific contrast uptake, increased signal on T2-weighted sequences, and plateau or persistent enhancement in the angiosome may represent MRI surrogates of CPN following TARE of HCC. These findings correlated with EASL and mRECIST response criteria. Further investigation is needed to determine the role of these findings as possible adjuncts to conventional imaging criteria. More... »

PAGES

1825-1836

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00261-017-1354-6

DOI

http://dx.doi.org/10.1007/s00261-017-1354-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092329691

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29052747


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoembolization, Therapeutic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Yttrium Radioisotopes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahmed", 
        "givenName": "Altan F.", 
        "id": "sg:person.015675456673.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015675456673.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern Memorial Hospital, 676 North St Clair. Ste #800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.416565.5", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
            "Department of Radiology, Northwestern Memorial Hospital, 676 North St Clair. Ste #800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samreen", 
        "givenName": "Naziya", 
        "id": "sg:person.01210147032.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210147032.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grajo", 
        "givenName": "Joseph R.", 
        "id": "sg:person.0744412044.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744412044.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Intermountain Healthcare, 5121 S Cottonwood Street, 84107, Murray, UT, USA", 
          "id": "http://www.grid.ac/institutes/grid.420884.2", 
          "name": [
            "Department of General Surgery, Intermountain Healthcare, 5121 S Cottonwood Street, 84107, Murray, UT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zendejas", 
        "givenName": "Ivan", 
        "id": "sg:person.01051010543.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051010543.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sistrom", 
        "givenName": "Chris L.", 
        "id": "sg:person.01266412102.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266412102.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collinsworth", 
        "givenName": "Amy", 
        "id": "sg:person.010026640021.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010026640021.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Esnakula", 
        "givenName": "Ashwini", 
        "id": "sg:person.0721727052.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721727052.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Jehan L.", 
        "id": "sg:person.01075153134.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075153134.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Gastroenterology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cabrera", 
        "givenName": "Roniel", 
        "id": "sg:person.01164261616.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164261616.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geller", 
        "givenName": "Brian S.", 
        "id": "sg:person.01276561205.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276561205.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.417467.7", 
          "name": [
            "Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA", 
            "Department of Radiology, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toskich", 
        "givenName": "Beau B.", 
        "id": "sg:person.01046104205.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046104205.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00261-016-0639-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026343464", 
          "https://doi.org/10.1007/s00261-016-0639-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00261-014-0127-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022241699", 
          "https://doi.org/10.1007/s00261-014-0127-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00261-008-9454-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053246572", 
          "https://doi.org/10.1007/s00261-008-9454-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6215-15-474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037557459", 
          "https://doi.org/10.1186/1745-6215-15-474"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-10-20", 
    "datePublishedReg": "2017-10-20", 
    "description": "PurposeTo assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response.MethodsTwelve patients with HCC underwent ablative (\u2265\u00a0190\u00a0Gy) and/or non-ablative (<\u00a0190\u00a0Gy) TARE delivered in a segmental, lobar, or combined fashion as a surgical neoadjuvant or bridge to transplantation. Both targeted tumor and treatment angiosome were analyzed before and after TARE utilizing hepatocyte-specific contrast-enhanced MRI or contrast-enhanced CT. Responses were graded using EASL and mRECIST criteria. Histologic findings including percent tumor necrosis and adjacent hepatic substrate effects were correlated with imaging features.ResultsComplete pathologic necrosis (CPN) was observed in 7/12 tumors post-TARE. Ablative and non-ablative dosing resulted in CPN in 5/6 and 2/6 tumors, respectively. Hyperintensity on T2-weighted imaging, the absence of hepatocyte-specific gadolinium contrast uptake, and plateau or persistent enhancement kinetics in the angiosome correlated with CPN and performed similarly to EASL and mRECIST criteria in predicting CPN.ConclusionsThe absence of hepatocyte-specific contrast uptake, increased signal on T2-weighted sequences, and plateau or persistent enhancement in the angiosome may represent MRI surrogates of CPN following TARE of HCC. These findings correlated with EASL and mRECIST response criteria. Further investigation is needed to determine the role of these findings as possible adjuncts to conventional imaging criteria.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00261-017-1354-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297457", 
        "issn": [
          "2366-004X", 
          "2366-0058"
        ], 
        "name": "Abdominal Radiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "keywords": [
      "transarterial radioembolization", 
      "hepatocellular carcinoma", 
      "contrast uptake", 
      "contrast-enhanced CT", 
      "yttrium-90 (90Y) transarterial radioembolization", 
      "percent tumor necrosis", 
      "conventional imaging criteria", 
      "contrast-enhanced MRI", 
      "radiopathologic correlation", 
      "mRECIST criteria", 
      "ConclusionsThe absence", 
      "MRI surrogates", 
      "histologic findings", 
      "imaging features", 
      "histologic response", 
      "pathologic necrosis", 
      "tumor necrosis", 
      "imaging criteria", 
      "MethodsTwelve patients", 
      "possible adjunct", 
      "response criteria", 
      "persistent enhancement", 
      "EASL", 
      "T2-weighted sequences", 
      "angiosomes", 
      "tumors", 
      "enhancement kinetics", 
      "radioembolization", 
      "carcinoma", 
      "necrosis", 
      "further investigation", 
      "findings", 
      "transplantation", 
      "patients", 
      "hyperintensity", 
      "dosing", 
      "criteria", 
      "PurposeTo", 
      "response", 
      "adjunct", 
      "CT", 
      "MRI", 
      "T2-weighted", 
      "uptake", 
      "absence", 
      "treatment", 
      "segmental", 
      "surrogate", 
      "CPN", 
      "role", 
      "correlation", 
      "effect", 
      "fashion", 
      "investigation", 
      "plateau", 
      "features", 
      "analysis", 
      "enhancement", 
      "kinetics", 
      "signals", 
      "sequence", 
      "bridge", 
      "substrate effects", 
      "variable radiodosimetry", 
      "radiodosimetry", 
      "non-ablative (<\u00a0190\u00a0Gy) TARE", 
      "treatment angiosome", 
      "hepatocyte-specific contrast-enhanced MRI", 
      "adjacent hepatic substrate effects", 
      "hepatic substrate effects", 
      "ResultsComplete pathologic necrosis", 
      "non-ablative dosing", 
      "hepatocyte-specific gadolinium contrast uptake", 
      "gadolinium contrast uptake", 
      "persistent enhancement kinetics", 
      "hepatocyte-specific contrast uptake", 
      "TARE of HCC", 
      "Angiosomal radiopathologic analysis", 
      "radiopathologic analysis"
    ], 
    "name": "Angiosomal radiopathologic analysis of transarterial radioembolization for the treatment of hepatocellular carcinoma", 
    "pagination": "1825-1836", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092329691"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00261-017-1354-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29052747"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00261-017-1354-6", 
      "https://app.dimensions.ai/details/publication/pub.1092329691"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_737.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00261-017-1354-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00261-017-1354-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00261-017-1354-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00261-017-1354-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00261-017-1354-6'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      22 PREDICATES      123 URIs      111 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00261-017-1354-6 schema:about N0257cb369abf4c5f8ac81997d7d354a4
2 N0f8a0993ce2f4bb2b8e04af7f2ff80d8
3 N11a7fca677814ec081dbd22b19e6f3d8
4 N189ea29d2fb84154912333790f0f55f0
5 N3821e2bca6d1425491c764c01e3087a3
6 N48aefbb69a1248ccb7cc998747f45f54
7 N8aa48bb9eca341c49b31d2133a46633a
8 N97798559b0a347c3b262d9f707b31e63
9 N9eb13d02818f47f2bbccddc14b50cba4
10 Na576d8b2dbda4ec8a4d9d0b761b075a0
11 Nb2a9229a6a474c94b1e554970105c6b3
12 Nd5ecc9a697f940eea661ab4aabe3cbe6
13 Nfb46a063c0684dff98123473c4af7f3f
14 Nfbb65e59d3e349e38511584ba59ac251
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N8121a934ed6649febf3d0217865814cd
18 schema:citation sg:pub.10.1007/s00261-008-9454-y
19 sg:pub.10.1007/s00261-014-0127-8
20 sg:pub.10.1007/s00261-016-0639-5
21 sg:pub.10.1186/1745-6215-15-474
22 schema:datePublished 2017-10-20
23 schema:datePublishedReg 2017-10-20
24 schema:description PurposeTo assess the radiopathologic correlation following Yttrium-90 transarterial radioembolization (TARE) of hepatocellular carcinoma (HCC) using variable radiodosimetry to identify imaging surrogates of histologic response.MethodsTwelve patients with HCC underwent ablative (≥ 190 Gy) and/or non-ablative (< 190 Gy) TARE delivered in a segmental, lobar, or combined fashion as a surgical neoadjuvant or bridge to transplantation. Both targeted tumor and treatment angiosome were analyzed before and after TARE utilizing hepatocyte-specific contrast-enhanced MRI or contrast-enhanced CT. Responses were graded using EASL and mRECIST criteria. Histologic findings including percent tumor necrosis and adjacent hepatic substrate effects were correlated with imaging features.ResultsComplete pathologic necrosis (CPN) was observed in 7/12 tumors post-TARE. Ablative and non-ablative dosing resulted in CPN in 5/6 and 2/6 tumors, respectively. Hyperintensity on T2-weighted imaging, the absence of hepatocyte-specific gadolinium contrast uptake, and plateau or persistent enhancement kinetics in the angiosome correlated with CPN and performed similarly to EASL and mRECIST criteria in predicting CPN.ConclusionsThe absence of hepatocyte-specific contrast uptake, increased signal on T2-weighted sequences, and plateau or persistent enhancement in the angiosome may represent MRI surrogates of CPN following TARE of HCC. These findings correlated with EASL and mRECIST response criteria. Further investigation is needed to determine the role of these findings as possible adjuncts to conventional imaging criteria.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N27d3e374c2de43589ea1365ceb2de626
29 N31c86fab2858436c89e1a708372b085b
30 sg:journal.1297457
31 schema:keywords Angiosomal radiopathologic analysis
32 CPN
33 CT
34 ConclusionsThe absence
35 EASL
36 MRI
37 MRI surrogates
38 MethodsTwelve patients
39 PurposeTo
40 ResultsComplete pathologic necrosis
41 T2-weighted
42 T2-weighted sequences
43 TARE of HCC
44 absence
45 adjacent hepatic substrate effects
46 adjunct
47 analysis
48 angiosomes
49 bridge
50 carcinoma
51 contrast uptake
52 contrast-enhanced CT
53 contrast-enhanced MRI
54 conventional imaging criteria
55 correlation
56 criteria
57 dosing
58 effect
59 enhancement
60 enhancement kinetics
61 fashion
62 features
63 findings
64 further investigation
65 gadolinium contrast uptake
66 hepatic substrate effects
67 hepatocellular carcinoma
68 hepatocyte-specific contrast uptake
69 hepatocyte-specific contrast-enhanced MRI
70 hepatocyte-specific gadolinium contrast uptake
71 histologic findings
72 histologic response
73 hyperintensity
74 imaging criteria
75 imaging features
76 investigation
77 kinetics
78 mRECIST criteria
79 necrosis
80 non-ablative (< 190 Gy) TARE
81 non-ablative dosing
82 pathologic necrosis
83 patients
84 percent tumor necrosis
85 persistent enhancement
86 persistent enhancement kinetics
87 plateau
88 possible adjunct
89 radiodosimetry
90 radioembolization
91 radiopathologic analysis
92 radiopathologic correlation
93 response
94 response criteria
95 role
96 segmental
97 sequence
98 signals
99 substrate effects
100 surrogate
101 transarterial radioembolization
102 transplantation
103 treatment
104 treatment angiosome
105 tumor necrosis
106 tumors
107 uptake
108 variable radiodosimetry
109 yttrium-90 (90Y) transarterial radioembolization
110 schema:name Angiosomal radiopathologic analysis of transarterial radioembolization for the treatment of hepatocellular carcinoma
111 schema:pagination 1825-1836
112 schema:productId N0175d1afab214ed791cf1ab53e4067bf
113 Nd1370a5dd9db41d7bd374ed673e0cb0a
114 Nfef31a5bd6974242bfdfe1687e639933
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092329691
116 https://doi.org/10.1007/s00261-017-1354-6
117 schema:sdDatePublished 2021-12-01T19:40
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher N31a7bdb055064788bc5c69a654a6796c
120 schema:url https://doi.org/10.1007/s00261-017-1354-6
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N0175d1afab214ed791cf1ab53e4067bf schema:name doi
125 schema:value 10.1007/s00261-017-1354-6
126 rdf:type schema:PropertyValue
127 N0257cb369abf4c5f8ac81997d7d354a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Chemoembolization, Therapeutic
129 rdf:type schema:DefinedTerm
130 N0a831276eef2429cb29cfb446e342603 rdf:first sg:person.01075153134.84
131 rdf:rest Ndc37127ee8f64691bfe89681829e8345
132 N0f8a0993ce2f4bb2b8e04af7f2ff80d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Middle Aged
134 rdf:type schema:DefinedTerm
135 N11a7fca677814ec081dbd22b19e6f3d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Tomography, X-Ray Computed
137 rdf:type schema:DefinedTerm
138 N189ea29d2fb84154912333790f0f55f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Treatment Outcome
140 rdf:type schema:DefinedTerm
141 N27d3e374c2de43589ea1365ceb2de626 schema:issueNumber 7
142 rdf:type schema:PublicationIssue
143 N29b65cc8f52c49c19556cb99bfeb0559 rdf:first sg:person.0721727052.08
144 rdf:rest N0a831276eef2429cb29cfb446e342603
145 N31a7bdb055064788bc5c69a654a6796c schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N31c86fab2858436c89e1a708372b085b schema:volumeNumber 43
148 rdf:type schema:PublicationVolume
149 N3821e2bca6d1425491c764c01e3087a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Liver
151 rdf:type schema:DefinedTerm
152 N3f46cd6dd4e241c19ea167740eb098c3 rdf:first sg:person.01276561205.87
153 rdf:rest Nbbbd9ae537da4358906b8f30a33aff9e
154 N3f4fc161640144f2af3bd7f58af9d145 rdf:first sg:person.010026640021.05
155 rdf:rest N29b65cc8f52c49c19556cb99bfeb0559
156 N48aefbb69a1248ccb7cc998747f45f54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Magnetic Resonance Imaging
158 rdf:type schema:DefinedTerm
159 N8121a934ed6649febf3d0217865814cd rdf:first sg:person.015675456673.17
160 rdf:rest Na7c42becb1034f8d887178de1eaf5f67
161 N830a354e52724ec0a32d2399b0953c70 rdf:first sg:person.01266412102.83
162 rdf:rest N3f4fc161640144f2af3bd7f58af9d145
163 N8aa48bb9eca341c49b31d2133a46633a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Aged
165 rdf:type schema:DefinedTerm
166 N97798559b0a347c3b262d9f707b31e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Retrospective Studies
168 rdf:type schema:DefinedTerm
169 N9eb13d02818f47f2bbccddc14b50cba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Carcinoma, Hepatocellular
171 rdf:type schema:DefinedTerm
172 Na576d8b2dbda4ec8a4d9d0b761b075a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Male
174 rdf:type schema:DefinedTerm
175 Na7c42becb1034f8d887178de1eaf5f67 rdf:first sg:person.01210147032.55
176 rdf:rest Ncbe484eaae494238aaa1eb3d29fd4c02
177 Nb2a9229a6a474c94b1e554970105c6b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Humans
179 rdf:type schema:DefinedTerm
180 Nbbbd9ae537da4358906b8f30a33aff9e rdf:first sg:person.01046104205.49
181 rdf:rest rdf:nil
182 Ncbe484eaae494238aaa1eb3d29fd4c02 rdf:first sg:person.0744412044.35
183 rdf:rest Ne813526e63eb4ab38956119350555e66
184 Nd1370a5dd9db41d7bd374ed673e0cb0a schema:name dimensions_id
185 schema:value pub.1092329691
186 rdf:type schema:PropertyValue
187 Nd5ecc9a697f940eea661ab4aabe3cbe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Female
189 rdf:type schema:DefinedTerm
190 Ndc37127ee8f64691bfe89681829e8345 rdf:first sg:person.01164261616.00
191 rdf:rest N3f46cd6dd4e241c19ea167740eb098c3
192 Ne813526e63eb4ab38956119350555e66 rdf:first sg:person.01051010543.53
193 rdf:rest N830a354e52724ec0a32d2399b0953c70
194 Nfb46a063c0684dff98123473c4af7f3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Liver Neoplasms
196 rdf:type schema:DefinedTerm
197 Nfbb65e59d3e349e38511584ba59ac251 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Yttrium Radioisotopes
199 rdf:type schema:DefinedTerm
200 Nfef31a5bd6974242bfdfe1687e639933 schema:name pubmed_id
201 schema:value 29052747
202 rdf:type schema:PropertyValue
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
207 schema:name Oncology and Carcinogenesis
208 rdf:type schema:DefinedTerm
209 sg:journal.1297457 schema:issn 2366-004X
210 2366-0058
211 schema:name Abdominal Radiology
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.010026640021.05 schema:affiliation grid-institutes:grid.15276.37
215 schema:familyName Collinsworth
216 schema:givenName Amy
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010026640021.05
218 rdf:type schema:Person
219 sg:person.01046104205.49 schema:affiliation grid-institutes:grid.417467.7
220 schema:familyName Toskich
221 schema:givenName Beau B.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046104205.49
223 rdf:type schema:Person
224 sg:person.01051010543.53 schema:affiliation grid-institutes:grid.420884.2
225 schema:familyName Zendejas
226 schema:givenName Ivan
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051010543.53
228 rdf:type schema:Person
229 sg:person.01075153134.84 schema:affiliation grid-institutes:grid.15276.37
230 schema:familyName Shah
231 schema:givenName Jehan L.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075153134.84
233 rdf:type schema:Person
234 sg:person.01164261616.00 schema:affiliation grid-institutes:grid.15276.37
235 schema:familyName Cabrera
236 schema:givenName Roniel
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164261616.00
238 rdf:type schema:Person
239 sg:person.01210147032.55 schema:affiliation grid-institutes:grid.416565.5
240 schema:familyName Samreen
241 schema:givenName Naziya
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210147032.55
243 rdf:type schema:Person
244 sg:person.01266412102.83 schema:affiliation grid-institutes:grid.15276.37
245 schema:familyName Sistrom
246 schema:givenName Chris L.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266412102.83
248 rdf:type schema:Person
249 sg:person.01276561205.87 schema:affiliation grid-institutes:grid.15276.37
250 schema:familyName Geller
251 schema:givenName Brian S.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276561205.87
253 rdf:type schema:Person
254 sg:person.015675456673.17 schema:affiliation grid-institutes:grid.15276.37
255 schema:familyName Ahmed
256 schema:givenName Altan F.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015675456673.17
258 rdf:type schema:Person
259 sg:person.0721727052.08 schema:affiliation grid-institutes:grid.15276.37
260 schema:familyName Esnakula
261 schema:givenName Ashwini
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721727052.08
263 rdf:type schema:Person
264 sg:person.0744412044.35 schema:affiliation grid-institutes:grid.15276.37
265 schema:familyName Grajo
266 schema:givenName Joseph R.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744412044.35
268 rdf:type schema:Person
269 sg:pub.10.1007/s00261-008-9454-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1053246572
270 https://doi.org/10.1007/s00261-008-9454-y
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s00261-014-0127-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022241699
273 https://doi.org/10.1007/s00261-014-0127-8
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s00261-016-0639-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026343464
276 https://doi.org/10.1007/s00261-016-0639-5
277 rdf:type schema:CreativeWork
278 sg:pub.10.1186/1745-6215-15-474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037557459
279 https://doi.org/10.1186/1745-6215-15-474
280 rdf:type schema:CreativeWork
281 grid-institutes:grid.15276.37 schema:alternateName Department of Gastroenterology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
282 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, 32610, Gainesville, FL, USA
283 Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
284 schema:name Department of Gastroenterology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
285 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Box 100275, 32610, Gainesville, FL, USA
286 Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
287 rdf:type schema:Organization
288 grid-institutes:grid.416565.5 schema:alternateName Department of Radiology, Northwestern Memorial Hospital, 676 North St Clair. Ste #800, 60611, Chicago, IL, USA
289 schema:name Department of Radiology, Northwestern Memorial Hospital, 676 North St Clair. Ste #800, 60611, Chicago, IL, USA
290 Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
291 rdf:type schema:Organization
292 grid-institutes:grid.417467.7 schema:alternateName Department of Radiology, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA
293 schema:name Department of Radiology, Mayo Clinic, 4500 San Pablo Road, 32224, Jacksonville, FL, USA
294 Department of Radiology, University of Florida, 1600 SW Archer Road, 32610, Gainesville, FL, USA
295 rdf:type schema:Organization
296 grid-institutes:grid.420884.2 schema:alternateName Department of General Surgery, Intermountain Healthcare, 5121 S Cottonwood Street, 84107, Murray, UT, USA
297 schema:name Department of General Surgery, Intermountain Healthcare, 5121 S Cottonwood Street, 84107, Murray, UT, USA
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...