Estimation of deadtime in imaging human subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-09

AUTHORS

Yusuke Inoue, Tohru Ohtake, Kohki Yoshikawa, Junichi Nishikawa, Yasuhito Sasaki

ABSTRACT

Deadtime count loss may cause significant errors in quantitative measurements performed by scintigraphic techniques. Deadtime depends on the scattering condition, and may vary among patients. The aim of this study was to estimate deadtime in imaging a human subject. A cylindrical phantom filled with various concentrations of technetium-99m solution was imaged with a gamma camera, and deadtime was assessed assuming the gamma camera to be a non-paralysable system (multi-dose method). Deadtime for the cylindrical phantom was also estimated using a point source to monitor counting efficiency (reference source method). Radionuclide angiography of the chest was performed in 38 patients with a reference source in the field of view, and temporal changes in count loss were assessed. The deadtime for each patient was calculated by the reference source method. The deadtime for the cylindrical phantom was estimated as 6.96+/-0.09 micros by the reference source method and was almost identical to that obtained by the multi-dose method (6.93 micros). Deadtime ranged from 6.01 to 9.58 micros in radionuclide angiography, and was positively correlated with the ratio of body weight in kg to body height in cm (y=8.566 x+5.611, r=0.869). Count loss was successfully corrected using the deadtime predicted with the regression line. In summary, the deadtime in imaging a human subject has a wide range and is related to the constitution of the subject. Correction for count loss using a deadtime predicted for each patient may be helpful in improving the reliability of quantitative nuclear medicine. More... »

PAGES

1232-1237

References to SciGraph publications

  • 1992-03. A quantitative approach to technetium-99m hexamethylpropylene amine oxime in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1978-09. Dead-time correction in dynamic radionuclide studies by computer in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1993-05. Noninvasive measurements of regional cerebral blood flow using technetium-99m hexamethylprophylene amine oxime in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1997-11. Effect of deadtime loss on quantitative measurement of cerebral blood flow with technetium-99m hexamethylpropylene amine oxime in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s002590050289

    DOI

    http://dx.doi.org/10.1007/s002590050289

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052456274

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9724370


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