Effect of deadtime loss on quantitative measurement of cerebral blood flow with technetium-99m hexamethylpropylene amine oxime View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

Yusuke Inoue, Toshimitsu Momose, Tohru Ohtake, Sae Asai, Kohki Yoshikawa, Junichi Nishikawa, Yasuhito Sasaki

ABSTRACT

. Deadtime count loss may cause error in quantitative measurements with a gamma camera. We evaluated the effect of deadtime loss on the measurement of cerebral blood flow (CBF). Radionuclide angiography with technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) was performed in 20 patients. A reference source was placed on the periphery of the detector to monitor deadtime loss, and CBF was calculated based on the data of radionuclide angiography with and without deadtime correction. In ten patients injected with 1110 MBq of the tracer, the CBF value without correction was 9.9%±1.8% higher than that with correction. This shows that deadtime loss may cause significant overestimation. The difference between CBF values obtained with and without correction was smaller in ten patients with an injected dose of 370 MBq (3.0%±1.2%). These results suggest a substantial effect of deadtime loss on CBF as measured by radionuclide angiography and 99mTc-HMPAO. More... »

PAGES

1418-1421

References to SciGraph publications

  • 1992-03. A quantitative approach to technetium-99m hexamethylpropylene amine oxime in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1993-05. Noninvasive measurements of regional cerebral blood flow using technetium-99m hexamethylprophylene amine oxime in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1994-10. A method to quantitate cerebral blood flow using a rotating gamma camera and iodine-123 iodoamphetamine with one blood sampling in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s002590050169

    DOI

    http://dx.doi.org/10.1007/s002590050169

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053097662

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9371876


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