A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Jungsik Song, Chang Hee Suh, Yong Beom Park, Seung Hoon Lee, Nae Chun Yoo, Jong Doo Lee, Kyoung Hwan Kim, Soo Kon Lee

ABSTRACT

Previous animal studies have established that the intra-articular injection of holmium-166-chitosan complex (DW-166HC) causes effective necrosis of the inflamed synovium with litle leakage of radioactivity from the injected joint. Based on these findings, we conducted a phase I/IIa study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA). A total of 16 patients [1 man, 15 women; median age 49 (range 36-65) years] who had RA knee synovitis refractory to disease-modifying anti-rheumatic drug treatments of > 3 months' duration were randomly assigned to three treatment groups with different radiation doses of DW-166HC: 370 MBq (n = 6), 555 MBq (n = 5) and 740 MBq (n = 5). In each treatment group, blood and urine radioactivity were analysed by beta counter and biodistribution of the injected DW-166HC was evaluated using a gamma scan camera. Clinical assessment was done according to three variables (evaluation method): knee joint pain (visual analogue scale), range of motion (goniometry) and joint swelling (circumference of knee joint). The duration of follow-up observation was 3 months. Following the intra-articular injection of DW-166HC, the blood radioactivity was little changed from the baseline measurement and the accumulated radioactivity excreted in urine was minimal. Gamma scan study indicated that most of the injected radiochemical was localized within the injected joint cavity, and the extra-articular leakage was negligible at 24 h after the injection: brain, 0.3%; lung, 0.6%; abdomen, 0.7%; and pelvis, 0.8%. Major adverse events were transient post-injection knee joint pain and swelling. These results suggest that DW-166HC might be a safe agent for radiation synovectomy, particularly for the treatment of knee synovitis of RA, and further trials in a larger patient population are warranted to evaluate the therapeutic efficacy of DW-166HC. More... »

PAGES

489-497

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002590000470

DOI

http://dx.doi.org/10.1007/s002590000470

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010089382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11357500


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Area Under Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis, Rheumatoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chitin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intra-Articular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Knee Joint", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organometallic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synovitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Jungsik", 
        "id": "sg:person.01152203361.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152203361.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suh", 
        "givenName": "Chang Hee", 
        "id": "sg:person.01204315642.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204315642.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Yong Beom", 
        "id": "sg:person.01217447220.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217447220.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Seung Hoon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Nae Chun", 
        "id": "sg:person.0755450144.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755450144.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jong Doo", 
        "id": "sg:person.01362567540.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362567540.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Clinical Pharmacology, Yonsei University College of Medicine, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Kyoung Hwan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Soo Kon", 
        "id": "sg:person.01123665751.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123665751.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0883-2889(87)90256-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001361995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(87)90256-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001361995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000637-199405000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003229202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000637-199405000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003229202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.820190406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019858723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780341208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020577263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780341208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020577263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)91072-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020961332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)91072-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020961332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0142-9612(88)90092-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023655978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0142-9612(88)90092-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023655978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.34.1.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024336426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02735372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027484113", 
          "https://doi.org/10.1007/bf02735372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02735372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027484113", 
          "https://doi.org/10.1007/bf02735372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/36.8.861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028304597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4636(199701)34:1<21::aid-jbm4>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031793271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-5994.1993.tb01731.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034220140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1118/1.597491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040189812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(99)00097-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040977382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00256587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043923534", 
          "https://doi.org/10.1007/bf00256587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00256587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043923534", 
          "https://doi.org/10.1007/bf00256587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1949.02900430001001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045536985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03009749709065694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048040686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/00220345970760020701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063640931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/00220345970760020701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063640931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.qjmed.a067341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083495851"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-04", 
    "datePublishedReg": "2001-04-01", 
    "description": "Previous animal studies have established that the intra-articular injection of holmium-166-chitosan complex (DW-166HC) causes effective necrosis of the inflamed synovium with litle leakage of radioactivity from the injected joint. Based on these findings, we conducted a phase I/IIa study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA). A total of 16 patients [1 man, 15 women; median age 49 (range 36-65) years] who had RA knee synovitis refractory to disease-modifying anti-rheumatic drug treatments of > 3 months' duration were randomly assigned to three treatment groups with different radiation doses of DW-166HC: 370 MBq (n = 6), 555 MBq (n = 5) and 740 MBq (n = 5). In each treatment group, blood and urine radioactivity were analysed by beta counter and biodistribution of the injected DW-166HC was evaluated using a gamma scan camera. Clinical assessment was done according to three variables (evaluation method): knee joint pain (visual analogue scale), range of motion (goniometry) and joint swelling (circumference of knee joint). The duration of follow-up observation was 3 months. Following the intra-articular injection of DW-166HC, the blood radioactivity was little changed from the baseline measurement and the accumulated radioactivity excreted in urine was minimal. Gamma scan study indicated that most of the injected radiochemical was localized within the injected joint cavity, and the extra-articular leakage was negligible at 24 h after the injection: brain, 0.3%; lung, 0.6%; abdomen, 0.7%; and pelvis, 0.8%. Major adverse events were transient post-injection knee joint pain and swelling. These results suggest that DW-166HC might be a safe agent for radiation synovectomy, particularly for the treatment of knee synovitis of RA, and further trials in a larger patient population are warranted to evaluate the therapeutic efficacy of DW-166HC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s002590000470", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis", 
    "pagination": "489-497", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3010c5ceff89bae3742e7719db304695a074eeec9b75094be5884c2c3b2efb89"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11357500"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7606882"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002590000470"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010089382"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002590000470", 
      "https://app.dimensions.ai/details/publication/pub.1010089382"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs002590000470"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002590000470'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002590000470'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002590000470'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002590000470'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      63 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002590000470 schema:about N20b0f6416ec144169322c6d227802201
2 N2f1ab242b1e84d1f9bd4d1d02dabd5e3
3 N4bfc9723f2bd4e06b0e2cdd42b6d5fd0
4 N75a8874e5b054dfb87d2586c13832919
5 N7c389a774cb74adabecec85871fab6a8
6 N8973d19ab9f142e09c8e219dcce0086e
7 N9081b2f3d8e443bf931b3d95c0c8530b
8 N9e75f456971b4aee82e2ae5995372b2b
9 N9ec85fd538a4461eaa9df7c60def51b6
10 Na7e7045722a641ac98444bdeaff80ece
11 Nc017eeb9f8aa4f7c8f9901be9d934759
12 Nd7cb9ee7dc934c518151aa4944205835
13 Ne0740cdcb7fe49febd0eeb3731c885a1
14 Ne42d66702cd54f02ba730af3e7b12c4d
15 Ne9dfed956edc4018be45240ad6d26756
16 Nf169081a87c241158eefcc1d9623de34
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N7584a39f17cf412092c7b1b5eb111f46
20 schema:citation sg:pub.10.1007/bf00256587
21 sg:pub.10.1007/bf02735372
22 https://doi.org/10.1001/jama.1949.02900430001001
23 https://doi.org/10.1002/(sici)1097-4636(199701)34:1<21::aid-jbm4>3.0.co;2-p
24 https://doi.org/10.1002/art.1780341208
25 https://doi.org/10.1002/jbm.820190406
26 https://doi.org/10.1016/0142-9612(88)90092-0
27 https://doi.org/10.1016/0883-2889(87)90256-5
28 https://doi.org/10.1016/s0140-6736(78)91072-3
29 https://doi.org/10.1016/s0142-9612(99)00097-6
30 https://doi.org/10.1093/oxfordjournals.qjmed.a067341
31 https://doi.org/10.1093/rheumatology/36.8.861
32 https://doi.org/10.1097/00000637-199405000-00019
33 https://doi.org/10.1111/j.1445-5994.1993.tb01731.x
34 https://doi.org/10.1118/1.597491
35 https://doi.org/10.1136/ard.34.1.62
36 https://doi.org/10.1177/00220345970760020701
37 https://doi.org/10.3109/03009749709065694
38 schema:datePublished 2001-04
39 schema:datePublishedReg 2001-04-01
40 schema:description Previous animal studies have established that the intra-articular injection of holmium-166-chitosan complex (DW-166HC) causes effective necrosis of the inflamed synovium with litle leakage of radioactivity from the injected joint. Based on these findings, we conducted a phase I/IIa study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA). A total of 16 patients [1 man, 15 women; median age 49 (range 36-65) years] who had RA knee synovitis refractory to disease-modifying anti-rheumatic drug treatments of > 3 months' duration were randomly assigned to three treatment groups with different radiation doses of DW-166HC: 370 MBq (n = 6), 555 MBq (n = 5) and 740 MBq (n = 5). In each treatment group, blood and urine radioactivity were analysed by beta counter and biodistribution of the injected DW-166HC was evaluated using a gamma scan camera. Clinical assessment was done according to three variables (evaluation method): knee joint pain (visual analogue scale), range of motion (goniometry) and joint swelling (circumference of knee joint). The duration of follow-up observation was 3 months. Following the intra-articular injection of DW-166HC, the blood radioactivity was little changed from the baseline measurement and the accumulated radioactivity excreted in urine was minimal. Gamma scan study indicated that most of the injected radiochemical was localized within the injected joint cavity, and the extra-articular leakage was negligible at 24 h after the injection: brain, 0.3%; lung, 0.6%; abdomen, 0.7%; and pelvis, 0.8%. Major adverse events were transient post-injection knee joint pain and swelling. These results suggest that DW-166HC might be a safe agent for radiation synovectomy, particularly for the treatment of knee synovitis of RA, and further trials in a larger patient population are warranted to evaluate the therapeutic efficacy of DW-166HC.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N2646b77039f04977b6b396a415453e4c
45 N90af0133dee34404b077707984944fbd
46 sg:journal.1297401
47 schema:name A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis
48 schema:pagination 489-497
49 schema:productId N174851833b314a90921a658ba0686673
50 N2666559a23184f34b16b49eb7c18e22d
51 N2ed3f8c0c34a45799881976533a89cbd
52 N8492342a147e494fb8a154cbcf50faa9
53 Nca8376f5b2cd4d09b6120d7e2d92e2e5
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010089382
55 https://doi.org/10.1007/s002590000470
56 schema:sdDatePublished 2019-04-10T20:46
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N2cedddf8f5cc411a93550f7f34d854b1
59 schema:url http://link.springer.com/10.1007%2Fs002590000470
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N174851833b314a90921a658ba0686673 schema:name pubmed_id
64 schema:value 11357500
65 rdf:type schema:PropertyValue
66 N20b0f6416ec144169322c6d227802201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Aged
68 rdf:type schema:DefinedTerm
69 N2646b77039f04977b6b396a415453e4c schema:issueNumber 4
70 rdf:type schema:PublicationIssue
71 N2666559a23184f34b16b49eb7c18e22d schema:name nlm_unique_id
72 schema:value 7606882
73 rdf:type schema:PropertyValue
74 N2cedddf8f5cc411a93550f7f34d854b1 schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 N2ed3f8c0c34a45799881976533a89cbd schema:name doi
77 schema:value 10.1007/s002590000470
78 rdf:type schema:PropertyValue
79 N2f1ab242b1e84d1f9bd4d1d02dabd5e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Humans
81 rdf:type schema:DefinedTerm
82 N349035ea27e548f0a320320aee19da88 rdf:first sg:person.01217447220.86
83 rdf:rest Nf9093cb514154c1888d71330f1d65e05
84 N4bfc9723f2bd4e06b0e2cdd42b6d5fd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Follow-Up Studies
86 rdf:type schema:DefinedTerm
87 N52595eb13ab446c6ae2ab2078c486bcc rdf:first sg:person.01123665751.14
88 rdf:rest rdf:nil
89 N62469f7d4ab54dc886158f6eee42a5c4 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
90 schema:familyName Lee
91 schema:givenName Seung Hoon
92 rdf:type schema:Person
93 N629447834bc5443cae57eb4b92c8d73a rdf:first sg:person.01362567540.45
94 rdf:rest Nd58438f6a57041ef8403abc052cb06dc
95 N7584a39f17cf412092c7b1b5eb111f46 rdf:first sg:person.01152203361.12
96 rdf:rest Ne72bb2513d6348a1b7af9c4dcb2b0fdf
97 N75a8874e5b054dfb87d2586c13832919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Organometallic Compounds
99 rdf:type schema:DefinedTerm
100 N7c389a774cb74adabecec85871fab6a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Male
102 rdf:type schema:DefinedTerm
103 N8492342a147e494fb8a154cbcf50faa9 schema:name readcube_id
104 schema:value 3010c5ceff89bae3742e7719db304695a074eeec9b75094be5884c2c3b2efb89
105 rdf:type schema:PropertyValue
106 N8973d19ab9f142e09c8e219dcce0086e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Tissue Distribution
108 rdf:type schema:DefinedTerm
109 N9081b2f3d8e443bf931b3d95c0c8530b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Chitin
111 rdf:type schema:DefinedTerm
112 N90af0133dee34404b077707984944fbd schema:volumeNumber 28
113 rdf:type schema:PublicationVolume
114 N9e75f456971b4aee82e2ae5995372b2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Radiopharmaceuticals
116 rdf:type schema:DefinedTerm
117 N9ec85fd538a4461eaa9df7c60def51b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Arthritis, Rheumatoid
119 rdf:type schema:DefinedTerm
120 Na7e7045722a641ac98444bdeaff80ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Injections, Intra-Articular
122 rdf:type schema:DefinedTerm
123 Nb83c16e596324b94a2769b5435ec71c5 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
124 schema:familyName Kim
125 schema:givenName Kyoung Hwan
126 rdf:type schema:Person
127 Nc017eeb9f8aa4f7c8f9901be9d934759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Area Under Curve
129 rdf:type schema:DefinedTerm
130 Nca8376f5b2cd4d09b6120d7e2d92e2e5 schema:name dimensions_id
131 schema:value pub.1010089382
132 rdf:type schema:PropertyValue
133 Nd58438f6a57041ef8403abc052cb06dc rdf:first Nb83c16e596324b94a2769b5435ec71c5
134 rdf:rest N52595eb13ab446c6ae2ab2078c486bcc
135 Nd7cb9ee7dc934c518151aa4944205835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adult
137 rdf:type schema:DefinedTerm
138 Ne0740cdcb7fe49febd0eeb3731c885a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 Ne42d66702cd54f02ba730af3e7b12c4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Synovitis
143 rdf:type schema:DefinedTerm
144 Ne72bb2513d6348a1b7af9c4dcb2b0fdf rdf:first sg:person.01204315642.59
145 rdf:rest N349035ea27e548f0a320320aee19da88
146 Ne9dfed956edc4018be45240ad6d26756 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Knee Joint
148 rdf:type schema:DefinedTerm
149 Nf169081a87c241158eefcc1d9623de34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Middle Aged
151 rdf:type schema:DefinedTerm
152 Nf3799620d48849d39d563923e0dfce29 rdf:first sg:person.0755450144.15
153 rdf:rest N629447834bc5443cae57eb4b92c8d73a
154 Nf9093cb514154c1888d71330f1d65e05 rdf:first N62469f7d4ab54dc886158f6eee42a5c4
155 rdf:rest Nf3799620d48849d39d563923e0dfce29
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
160 schema:name Clinical Sciences
161 rdf:type schema:DefinedTerm
162 sg:journal.1297401 schema:issn 1619-7070
163 1619-7089
164 schema:name European Journal of Nuclear Medicine and Molecular Imaging
165 rdf:type schema:Periodical
166 sg:person.01123665751.14 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
167 schema:familyName Lee
168 schema:givenName Soo Kon
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123665751.14
170 rdf:type schema:Person
171 sg:person.01152203361.12 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
172 schema:familyName Song
173 schema:givenName Jungsik
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152203361.12
175 rdf:type schema:Person
176 sg:person.01204315642.59 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
177 schema:familyName Suh
178 schema:givenName Chang Hee
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204315642.59
180 rdf:type schema:Person
181 sg:person.01217447220.86 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
182 schema:familyName Park
183 schema:givenName Yong Beom
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217447220.86
185 rdf:type schema:Person
186 sg:person.01362567540.45 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
187 schema:familyName Lee
188 schema:givenName Jong Doo
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362567540.45
190 rdf:type schema:Person
191 sg:person.0755450144.15 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
192 schema:familyName Yoo
193 schema:givenName Nae Chun
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755450144.15
195 rdf:type schema:Person
196 sg:pub.10.1007/bf00256587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043923534
197 https://doi.org/10.1007/bf00256587
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf02735372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027484113
200 https://doi.org/10.1007/bf02735372
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1001/jama.1949.02900430001001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045536985
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/(sici)1097-4636(199701)34:1<21::aid-jbm4>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1031793271
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/art.1780341208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020577263
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/jbm.820190406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019858723
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0142-9612(88)90092-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023655978
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0883-2889(87)90256-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001361995
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0140-6736(78)91072-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020961332
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0142-9612(99)00097-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040977382
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/oxfordjournals.qjmed.a067341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083495851
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/rheumatology/36.8.861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028304597
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1097/00000637-199405000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003229202
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1111/j.1445-5994.1993.tb01731.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034220140
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1118/1.597491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040189812
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1136/ard.34.1.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024336426
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1177/00220345970760020701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063640931
231 rdf:type schema:CreativeWork
232 https://doi.org/10.3109/03009749709065694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048040686
233 rdf:type schema:CreativeWork
234 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
235 schema:name Department of Clinical Pharmacology, Yonsei University College of Medicine, Seoul, Korea, Korea
236 Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea, Korea
237 Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea, Korea
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...