18F-Flurodeoxyglucose positron emission tomography with computed tomography (FDG PET/CT) findings in children with encephalitis and comparison to conventional imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-12

AUTHORS

Sophie Turpin, Patrick Martineau, Marc-André Levasseur, Inge Meijer, Jean-Claude Décarie, Julie Barsalou, Christian Renaud, Hélène Decaluwe, Elie Haddad, Raymond Lambert

ABSTRACT

PURPOSE: FDG PET/CT is emerging as a new tool for the evaluation of acute encephalitis (AE). However, to date, there are no exclusively pediatric studies on the use of FDG PET for suspected AE. The objective of this study was to compare qualitative and quantitative brain PET to conventional brain imaging in a cohort of children, and to identify patterns of metabolic abnormalities characteristic of AE. METHODS: This retrospective study included 34 children imaged with PET/CT, CT and magnetic resonance imaging (MRI). The positivity rate of all three imaging modalities was measured. Besides visual assessment, quantification of relative regional brain metabolism (RRBM) was performed and compared to a database of normal pediatric brains. RESULTS: Fourteen subjects had a clinical diagnosis of autoimmune encephalitis (AIE) or encephalitis of unknown origin (EX), six of anti-N-methyl-D-aspartate receptor (anti-NMDAr) encephalitis, three of Hashimoto's encephalopathy, three of neurolupus and eight had other subtypes of encephalitis. Quantitative PET was abnormal in 100% of cases, visually assessed PET in 94.1% of subjects, MRI in 41.2% and CT in 6.9%. RRBM quantification demonstrated multiple hyper and hypo metabolic cortical regions in 82.3% of subjects, exclusively hypermetabolic abnormalities in 3%, and exclusively hypometabolic abnormalities in 14.7%. The basal ganglia were hypermetabolic in 26.5% of cases on visual assessment and in 58.8% of subjects using quantification. CONCLUSION: In our pediatric population FDG PET was more sensitive than conventional imaging for the detection of AE, and basal ganglia hypermetabolism was frequently encountered. More... »

PAGES

1-16

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-019-04302-x

DOI

http://dx.doi.org/10.1007/s00259-019-04302-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112703039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30863933


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