Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Giorgio Treglia, Arnoldo Piccardo, Alessio Imperiale, Klaus Strobel, Philipp A. Kaufmann, John O. Prior, Luca Giovanella

ABSTRACT

PURPOSE: Hyperparathyroidism (HPT) is a common endocrine disorder caused by hyperfunctioning parathyroid glands (HP). The correct detection and localization of HP is challenging but crucial, as it may guide surgical treatment, particularly in patients with primary HPT. There is a growing body of data regarding the role of radiolabelled choline positron emission tomography (PET) in this setting. Therefore, we performed a systematic review and meta-analysis of the diagnostic performance of this method in detecting HP in patients with HPT. METHODS: This systematic review and meta-analysis was carried out according to PRISMA guidelines. A comprehensive computer literature search of PubMed/MEDLINE, EMBASE and Cochrane Library databases for studies published through May 2018 was performed using the following search algorithm: (a) "choline" or "fluorocholine" or "F-choline" or "C-choline" or "FCH" or "CH" or "FECH" or "FMCH" and (b) "PET" or "positron emission tomography" and (c) "parathyroid" or "hyperparathyroidism". The diagnostic performance of radiolabelled choline PET was expressed as sensitivity and positive predictive value (PPV) on a per-patient and per-lesion basis and as detection rate (DR) on a per-patient basis, with pooled proportion and 95% confidence interval (95% CI) obtained using a random-effects model. RESULTS: Eighteen studies were included in the systematic review. Fourteen articles (517 patients) were selected for the meta-analysis. The meta-analysis provided the following results on a per-patient analysis analysis: sensitivity 95% (95% CI: 92-97%), PPV 97% (95% CI: 95-98%) and DR 91% (95% CI: 87-94%). On a per-lesion analysis, pooled sensitivity and PPV were 92% (95% CI: 88-96) and 92% (95% CI: 89-95%), respectively. No significant heterogeneity was found among the selected studies. CONCLUSIONS: Radiolabelled choline PET demonstrated excellent diagnostic performance in detecting HP in patients with HPT. Large multicentre studies and cost-effectiveness analyses are needed to better define the role of this imaging method in this setting. More... »

PAGES

1-15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-018-4123-z

DOI

http://dx.doi.org/10.1007/s00259-018-4123-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106082340

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30094461


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249 https://www.grid.ac/institutes/grid.463766.6 schema:alternateName Laboratoire des sciences de l'ingénieur de l'informatique et de l'imagerie
250 schema:name Department of Biophysics and Nuclear Medicine, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Strasbourg, France
251 Faculty of Medicine, ICube, University of Strasbourg/CNRS (UMR 7357) and FMTS, Strasbourg, France
252 rdf:type schema:Organization
253 https://www.grid.ac/institutes/grid.8515.9 schema:alternateName University Hospital of Lausanne
254 schema:name Clinic of Nuclear Medicine and PET/CT Center, Ente Ospedaliero Cantonale, Oncology Institute of Southern Switzerland, Via Ospedale 12, 6500, Bellinzona, Switzerland
255 Clinical Trial Unit, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
256 Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland
257 Health Technology Assessment Unit, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
258 rdf:type schema:Organization
 




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