18F-FDG-PET/CT based total metabolic tumor volume change during neoadjuvant chemotherapy predicts outcome in advanced epithelial ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Tuulia Vallius, Johanna Hynninen, Jukka Kemppainen, Victor Alves, Kari Auranen, Jaakko Matomäki, Sinikka Oksa, Johanna Virtanen, Seija Grénman, Annika Auranen, Marko Seppänen

ABSTRACT

OBJECTIVE: To evaluate the predictive potential of total metabolic tumor volume (MTV) reduction during neoadjuvant chemotherapy (NACT) with 18F-FDG-PET/CT in an advanced FIGO stage III/IV epithelial ovarian cancer (EOC) patient cohort. METHODS: Twenty-nine primarily inoperable EOC patients underwent 18F-FDG-PET/CT before and after NACT. The pre- and post-NACT total MTV, in addition to the percentage MTV reduction during NACT, were compared with primary therapy outcome and progression-free survival (PFS). ROC-analysis determined an optimal threshold for MTV reduction identifying patients with progressive or stable disease (PD/SD) at the end of primary therapy. A multivariate analysis with residual tumor (0/>0), FIGO stage (III/IV) and MTV reduction compared to PFS was performed. The association between MTV reduction and overall survival (OS) was evaluated. RESULTS: The median pre- and post-NACT total MTV were 352 cm3 (range 150 to 1322 cm3) and 51 cm3 (range 0 to 417 cm3), respectively. The median MTV reduction during NACT was 89% (range 24% to 100%). Post-NACT MTV and MTV reduction associated with primary therapy outcome (MTV post-NACT p = 0.007, MTV reduction p = 0.001) and PFS (MTV post-NACT p = 0.005, MTV reduction p = 0.005). MTV reduction <85% identified the PD/SD patients (sensitivity 70%, specificity 78%, AUC 0.79). In a multivariate analysis, MTV reduction (p = 0.002) and FIGO stage (p = 0.003) were statistically significant variables associated with PFS. MTV reduction during NACT corresponded to OS (p = 0.05). CONCLUSION: 18F-FDG-PET/CT is helpful in NACT response evaluation. Patients with total MTV reduction <85% during NACT might be candidates for second-line chemotherapy and clinical trials, instead of interval debulking surgery. More... »

PAGES

1224-1232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-018-3961-z

DOI

http://dx.doi.org/10.1007/s00259-018-3961-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101199064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29476227


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ovarian Epithelial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multimodal Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron Emission Tomography Computed Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, PL 52, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vallius", 
        "givenName": "Tuulia", 
        "id": "sg:person.0626377410.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626377410.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, PL 52, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hynninen", 
        "givenName": "Johanna", 
        "id": "sg:person.01363205102.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363205102.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Department of Clinical Physiology and Nuclear Medicine, Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kemppainen", 
        "givenName": "Jukka", 
        "id": "sg:person.01215160345.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215160345.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Nuclear Medicine, Sao Joao Hospital Centre, Oporto, Portugal"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alves", 
        "givenName": "Victor", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Center of Statistics and Department of Clinical Medicine, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auranen", 
        "givenName": "Kari", 
        "id": "sg:person.01177605617.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177605617.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Turku University Hospital, Clinical Research Centre, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matom\u00e4ki", 
        "givenName": "Jaakko", 
        "id": "sg:person.01366452271.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366452271.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Satakunta Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415303.0", 
          "name": [
            "Department of Obstetrics and Gynecology, Satakunta Central Hospital, Pori, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oksa", 
        "givenName": "Sinikka", 
        "id": "sg:person.0632667315.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632667315.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Medical Imaging centre of Southwest Finland, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Virtanen", 
        "givenName": "Johanna", 
        "id": "sg:person.01120075255.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120075255.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, PL 52, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00e9nman", 
        "givenName": "Seija", 
        "id": "sg:person.0602404307.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602404307.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tampere University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412330.7", 
          "name": [
            "Department of Obstetrics and Gynecology, University of Tampere and Tampere University Hospital, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auranen", 
        "givenName": "Annika", 
        "id": "sg:person.01322557443.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322557443.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Department of Clinical Physiology and Nuclear Medicine, Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sepp\u00e4nen", 
        "givenName": "Marko", 
        "id": "sg:person.01231750412.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231750412.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.radonc.2008.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000285486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930901)72:5<1631::aid-cncr2820720523>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001937901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-008-0890-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006526925", 
          "https://doi.org/10.1007/s00259-008-0890-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-008-0890-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006526925", 
          "https://doi.org/10.1007/s00259-008-0890-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0020-7292(00)90001-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007428502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.108.057307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009233958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.109.063321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009235744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2015.07.095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010019457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2015.07.095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010019457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2013.09.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011753829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2013.09.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011753829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-2634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012378841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2009.10.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013963412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015684380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019644782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019644782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2012.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022139224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2012.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022139224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2015.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022615269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2015.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022615269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-011-2153-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024196126", 
          "https://doi.org/10.1245/s10434-011-2153-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3802/jgo.2011.22.3.183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024249218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026558254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.06.965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027291987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2008.06.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027626926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2012.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029008529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-010-0354-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030470677", 
          "https://doi.org/10.1007/s11307-010-0354-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2016.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030933544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2016.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030933544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-014-2803-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031024771", 
          "https://doi.org/10.1007/s00259-014-2803-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-014-2553-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036348195", 
          "https://doi.org/10.1007/s13277-014-2553-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-014-2553-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036348195", 
          "https://doi.org/10.1007/s13277-014-2553-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rlu.0000000000000768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036739618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rlu.0000000000000768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036739618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cas.12890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036872322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-016-3315-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039864863", 
          "https://doi.org/10.1007/s00259-016-3315-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-016-3315-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039864863", 
          "https://doi.org/10.1007/s00259-016-3315-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040155088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2014.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043844969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2014.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043844969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e3182070f17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046236183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e3182070f17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046236183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e3182070f17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046236183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046917301", 
          "https://doi.org/10.1038/ng.3573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.7800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047931406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra050276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050685987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0908806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051283014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074551522", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074715786", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078523308", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078523308", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07", 
    "datePublishedReg": "2018-07-01", 
    "description": "OBJECTIVE: To evaluate the predictive potential of total metabolic tumor volume (MTV) reduction during neoadjuvant chemotherapy (NACT) with 18F-FDG-PET/CT in an advanced FIGO stage III/IV epithelial ovarian cancer (EOC) patient cohort.\nMETHODS: Twenty-nine primarily inoperable EOC patients underwent 18F-FDG-PET/CT before and after NACT. The pre- and post-NACT total MTV, in addition to the percentage MTV reduction during NACT, were compared with primary therapy outcome and progression-free survival (PFS). ROC-analysis determined an optimal threshold for MTV reduction identifying patients with progressive or stable disease (PD/SD) at the end of primary therapy. A multivariate analysis with residual tumor (0/>0), FIGO stage (III/IV) and MTV reduction compared to PFS was performed. The association between MTV reduction and overall survival (OS) was evaluated.\nRESULTS: The median pre- and post-NACT total MTV were 352\u00a0cm3 (range 150 to 1322\u00a0cm3) and 51\u00a0cm3 (range 0 to 417\u00a0cm3), respectively. The median MTV reduction during NACT was 89% (range 24% to 100%). Post-NACT MTV and MTV reduction associated with primary therapy outcome (MTV post-NACT p\u2009=\u20090.007, MTV reduction p\u2009=\u20090.001) and PFS (MTV post-NACT p\u2009=\u20090.005, MTV reduction p\u2009=\u20090.005). MTV reduction <85% identified the PD/SD patients (sensitivity 70%, specificity 78%, AUC 0.79). In a multivariate analysis, MTV reduction (p\u2009=\u20090.002) and FIGO stage (p\u2009=\u20090.003) were statistically significant variables associated with PFS. MTV reduction during NACT corresponded to OS (p\u2009=\u20090.05).\nCONCLUSION: 18F-FDG-PET/CT is helpful in NACT response evaluation. Patients with total MTV reduction <85% during NACT might be candidates for second-line chemotherapy and clinical trials, instead of interval debulking surgery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00259-018-3961-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "name": "18F-FDG-PET/CT based total metabolic tumor volume change during neoadjuvant chemotherapy predicts outcome in advanced epithelial ovarian cancer", 
    "pagination": "1224-1232", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "25d10a5c4978d9b3e8811cce1a22a63a3860ccacd84f1ebd5bcf6eaef71268ba"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29476227"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101140988"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00259-018-3961-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101199064"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00259-018-3961-z", 
      "https://app.dimensions.ai/details/publication/pub.1101199064"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99843_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00259-018-3961-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-018-3961-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-018-3961-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-018-3961-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-018-3961-z'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      82 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00259-018-3961-z schema:about N01904366043f4f7faabad0913538d1ed
2 N04db0f9fcbb547589ea8ea169ba0822b
3 N06505b5cbfc8407a954c1ca78849c762
4 N117ff0a7a7774ea2acd697314c3d86fe
5 N18469230e08b4a0aa13d9d6492db94d8
6 N251de878f47c4ac88f86d1b247769229
7 N2b162268e0654780af4279a177194a9e
8 N2df23c29c5d04043b29a333ccf1f0f8f
9 N4f322b4de1c048f4a9135ae55b657f74
10 N58dd1d12045e463b9a35f27ea57526ae
11 N833f84b3d49144f09bc566a7e6d8ecaa
12 N960812189dca40a0a0ba66478a12ae6e
13 Nad3d4e0d39994ee0aac170c781e0335a
14 Nbd633470b2fa471989582232c5b8e344
15 Neaceb1511e3b4d4182b83b283ecfb425
16 Nfe8c9bbe53b34ef6bf272dc3941821b5
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Na589ec9d04174c588b8bb541f2500810
20 schema:citation sg:pub.10.1007/s00259-008-0890-2
21 sg:pub.10.1007/s00259-014-2803-x
22 sg:pub.10.1007/s00259-016-3315-7
23 sg:pub.10.1007/s11307-010-0354-5
24 sg:pub.10.1007/s13277-014-2553-1
25 sg:pub.10.1038/ng.3573
26 sg:pub.10.1245/s10434-011-2153-x
27 https://app.dimensions.ai/details/publication/pub.1074551522
28 https://app.dimensions.ai/details/publication/pub.1074715786
29 https://app.dimensions.ai/details/publication/pub.1078523308
30 https://doi.org/10.1002/1097-0142(19930901)72:5<1631::aid-cncr2820720523>3.0.co;2-i
31 https://doi.org/10.1002/cncr.24149
32 https://doi.org/10.1016/j.ajog.2008.06.052
33 https://doi.org/10.1016/j.ejca.2008.10.026
34 https://doi.org/10.1016/j.radonc.2008.06.014
35 https://doi.org/10.1016/j.ygyno.2009.10.059
36 https://doi.org/10.1016/j.ygyno.2012.04.023
37 https://doi.org/10.1016/j.ygyno.2012.09.013
38 https://doi.org/10.1016/j.ygyno.2013.09.030
39 https://doi.org/10.1016/j.ygyno.2014.11.004
40 https://doi.org/10.1016/j.ygyno.2015.07.095
41 https://doi.org/10.1016/j.ygyno.2015.10.018
42 https://doi.org/10.1016/j.ygyno.2016.05.022
43 https://doi.org/10.1016/s0020-7292(00)90001-8
44 https://doi.org/10.1056/nejmoa0908806
45 https://doi.org/10.1056/nejmra050276
46 https://doi.org/10.1093/annonc/mdt333
47 https://doi.org/10.1097/igc.0b013e3182070f17
48 https://doi.org/10.1097/rlu.0000000000000768
49 https://doi.org/10.1111/cas.12890
50 https://doi.org/10.1158/1078-0432.ccr-08-2030
51 https://doi.org/10.1158/1078-0432.ccr-13-2634
52 https://doi.org/10.1200/jco.2005.06.965
53 https://doi.org/10.1200/jco.2006.07.7800
54 https://doi.org/10.2967/jnumed.108.057307
55 https://doi.org/10.2967/jnumed.109.063321
56 https://doi.org/10.3802/jgo.2011.22.3.183
57 schema:datePublished 2018-07
58 schema:datePublishedReg 2018-07-01
59 schema:description OBJECTIVE: To evaluate the predictive potential of total metabolic tumor volume (MTV) reduction during neoadjuvant chemotherapy (NACT) with 18F-FDG-PET/CT in an advanced FIGO stage III/IV epithelial ovarian cancer (EOC) patient cohort. METHODS: Twenty-nine primarily inoperable EOC patients underwent 18F-FDG-PET/CT before and after NACT. The pre- and post-NACT total MTV, in addition to the percentage MTV reduction during NACT, were compared with primary therapy outcome and progression-free survival (PFS). ROC-analysis determined an optimal threshold for MTV reduction identifying patients with progressive or stable disease (PD/SD) at the end of primary therapy. A multivariate analysis with residual tumor (0/>0), FIGO stage (III/IV) and MTV reduction compared to PFS was performed. The association between MTV reduction and overall survival (OS) was evaluated. RESULTS: The median pre- and post-NACT total MTV were 352 cm3 (range 150 to 1322 cm3) and 51 cm3 (range 0 to 417 cm3), respectively. The median MTV reduction during NACT was 89% (range 24% to 100%). Post-NACT MTV and MTV reduction associated with primary therapy outcome (MTV post-NACT p = 0.007, MTV reduction p = 0.001) and PFS (MTV post-NACT p = 0.005, MTV reduction p = 0.005). MTV reduction <85% identified the PD/SD patients (sensitivity 70%, specificity 78%, AUC 0.79). In a multivariate analysis, MTV reduction (p = 0.002) and FIGO stage (p = 0.003) were statistically significant variables associated with PFS. MTV reduction during NACT corresponded to OS (p = 0.05). CONCLUSION: 18F-FDG-PET/CT is helpful in NACT response evaluation. Patients with total MTV reduction <85% during NACT might be candidates for second-line chemotherapy and clinical trials, instead of interval debulking surgery.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N06a9285715be4856a605f9c65083a12d
64 Nb01a11fd28a64e2caf7f80d26cb9affd
65 sg:journal.1297401
66 schema:name 18F-FDG-PET/CT based total metabolic tumor volume change during neoadjuvant chemotherapy predicts outcome in advanced epithelial ovarian cancer
67 schema:pagination 1224-1232
68 schema:productId Naa79947b9b5d4375b5da0dc498c052c9
69 Nb11c20b29c1147c5a154651733dea9d2
70 Nb1f4d007d3364e34a38cb86b1d0343dc
71 Nc50c7da5f46545e9b226b2d842673b94
72 Nc9cdc6c806f3450e8d3ccc46ec01896d
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101199064
74 https://doi.org/10.1007/s00259-018-3961-z
75 schema:sdDatePublished 2019-04-11T09:42
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N07432a994fc046c0a84247852d11eb35
78 schema:url https://link.springer.com/10.1007%2Fs00259-018-3961-z
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N01904366043f4f7faabad0913538d1ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Prognosis
84 rdf:type schema:DefinedTerm
85 N04db0f9fcbb547589ea8ea169ba0822b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Fluorodeoxyglucose F18
87 rdf:type schema:DefinedTerm
88 N06505b5cbfc8407a954c1ca78849c762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Multimodal Imaging
90 rdf:type schema:DefinedTerm
91 N06a9285715be4856a605f9c65083a12d schema:volumeNumber 45
92 rdf:type schema:PublicationVolume
93 N07432a994fc046c0a84247852d11eb35 schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N117ff0a7a7774ea2acd697314c3d86fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Prospective Studies
97 rdf:type schema:DefinedTerm
98 N18469230e08b4a0aa13d9d6492db94d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Neoadjuvant Therapy
100 rdf:type schema:DefinedTerm
101 N19f42a5c4d2b401b84b8b10d3d9e88c8 rdf:first sg:person.0632667315.72
102 rdf:rest Na20a0897eff04dbcab5148aa0c142229
103 N251de878f47c4ac88f86d1b247769229 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Tomography, X-Ray Computed
105 rdf:type schema:DefinedTerm
106 N2b162268e0654780af4279a177194a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Female
108 rdf:type schema:DefinedTerm
109 N2df23c29c5d04043b29a333ccf1f0f8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Retrospective Studies
111 rdf:type schema:DefinedTerm
112 N4759e9adffce48029376384bb07d2581 schema:affiliation N5985ed7504064e7eaf48866edc1bab51
113 schema:familyName Alves
114 schema:givenName Victor
115 rdf:type schema:Person
116 N4d134839e51541388f99ca09514fe465 rdf:first sg:person.01231750412.31
117 rdf:rest rdf:nil
118 N4f322b4de1c048f4a9135ae55b657f74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Aged
120 rdf:type schema:DefinedTerm
121 N5002e40e01a64dbface8affa05aabbe0 rdf:first sg:person.01366452271.23
122 rdf:rest N19f42a5c4d2b401b84b8b10d3d9e88c8
123 N536b5749f6814450911dae51ecb75f83 rdf:first sg:person.01363205102.98
124 rdf:rest Nf1271a6586484508b45948be39af3b9d
125 N58dd1d12045e463b9a35f27ea57526ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Tumor Burden
127 rdf:type schema:DefinedTerm
128 N5985ed7504064e7eaf48866edc1bab51 schema:name Department of Nuclear Medicine, Sao Joao Hospital Centre, Oporto, Portugal
129 rdf:type schema:Organization
130 N6a0162abd3d943c1b4c174897d529eda schema:name Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, PL 52, 20521, Turku, Finland
131 rdf:type schema:Organization
132 N76bc0f27d42e4bbebf70ca7a30aa3bba rdf:first sg:person.0602404307.00
133 rdf:rest Naadd28bcfef648859a93813c8781ea6c
134 N833f84b3d49144f09bc566a7e6d8ecaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N960812189dca40a0a0ba66478a12ae6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Carcinoma, Ovarian Epithelial
139 rdf:type schema:DefinedTerm
140 N9f3f50ca3be64eacac13b9393146de5f schema:name Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, PL 52, 20521, Turku, Finland
141 rdf:type schema:Organization
142 Na20a0897eff04dbcab5148aa0c142229 rdf:first sg:person.01120075255.69
143 rdf:rest N76bc0f27d42e4bbebf70ca7a30aa3bba
144 Na589ec9d04174c588b8bb541f2500810 rdf:first sg:person.0626377410.48
145 rdf:rest N536b5749f6814450911dae51ecb75f83
146 Naa79947b9b5d4375b5da0dc498c052c9 schema:name dimensions_id
147 schema:value pub.1101199064
148 rdf:type schema:PropertyValue
149 Naadd28bcfef648859a93813c8781ea6c rdf:first sg:person.01322557443.32
150 rdf:rest N4d134839e51541388f99ca09514fe465
151 Nad3d4e0d39994ee0aac170c781e0335a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged, 80 and over
153 rdf:type schema:DefinedTerm
154 Nb01a11fd28a64e2caf7f80d26cb9affd schema:issueNumber 7
155 rdf:type schema:PublicationIssue
156 Nb11c20b29c1147c5a154651733dea9d2 schema:name doi
157 schema:value 10.1007/s00259-018-3961-z
158 rdf:type schema:PropertyValue
159 Nb1f4d007d3364e34a38cb86b1d0343dc schema:name nlm_unique_id
160 schema:value 101140988
161 rdf:type schema:PropertyValue
162 Nbd633470b2fa471989582232c5b8e344 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Positron-Emission Tomography
164 rdf:type schema:DefinedTerm
165 Nc50c7da5f46545e9b226b2d842673b94 schema:name readcube_id
166 schema:value 25d10a5c4978d9b3e8811cce1a22a63a3860ccacd84f1ebd5bcf6eaef71268ba
167 rdf:type schema:PropertyValue
168 Nc6e638ddd0294b61806087eeee1d0441 rdf:first N4759e9adffce48029376384bb07d2581
169 rdf:rest Ndf51012a2e6c4f968d821d12e9d1bc03
170 Nc9cdc6c806f3450e8d3ccc46ec01896d schema:name pubmed_id
171 schema:value 29476227
172 rdf:type schema:PropertyValue
173 Ndbddb5aa3edf46a6b0db7a49db52d5ad schema:name Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, PL 52, 20521, Turku, Finland
174 rdf:type schema:Organization
175 Ndf51012a2e6c4f968d821d12e9d1bc03 rdf:first sg:person.01177605617.64
176 rdf:rest N5002e40e01a64dbface8affa05aabbe0
177 Neaceb1511e3b4d4182b83b283ecfb425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Middle Aged
179 rdf:type schema:DefinedTerm
180 Nf1271a6586484508b45948be39af3b9d rdf:first sg:person.01215160345.52
181 rdf:rest Nc6e638ddd0294b61806087eeee1d0441
182 Nfe8c9bbe53b34ef6bf272dc3941821b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Positron Emission Tomography Computed Tomography
184 rdf:type schema:DefinedTerm
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
189 schema:name Oncology and Carcinogenesis
190 rdf:type schema:DefinedTerm
191 sg:journal.1297401 schema:issn 1619-7070
192 1619-7089
193 schema:name European Journal of Nuclear Medicine and Molecular Imaging
194 rdf:type schema:Periodical
195 sg:person.01120075255.69 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
196 schema:familyName Virtanen
197 schema:givenName Johanna
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120075255.69
199 rdf:type schema:Person
200 sg:person.01177605617.64 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
201 schema:familyName Auranen
202 schema:givenName Kari
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177605617.64
204 rdf:type schema:Person
205 sg:person.01215160345.52 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
206 schema:familyName Kemppainen
207 schema:givenName Jukka
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215160345.52
209 rdf:type schema:Person
210 sg:person.01231750412.31 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
211 schema:familyName Seppänen
212 schema:givenName Marko
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231750412.31
214 rdf:type schema:Person
215 sg:person.01322557443.32 schema:affiliation https://www.grid.ac/institutes/grid.412330.7
216 schema:familyName Auranen
217 schema:givenName Annika
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322557443.32
219 rdf:type schema:Person
220 sg:person.01363205102.98 schema:affiliation N9f3f50ca3be64eacac13b9393146de5f
221 schema:familyName Hynninen
222 schema:givenName Johanna
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363205102.98
224 rdf:type schema:Person
225 sg:person.01366452271.23 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
226 schema:familyName Matomäki
227 schema:givenName Jaakko
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366452271.23
229 rdf:type schema:Person
230 sg:person.0602404307.00 schema:affiliation Ndbddb5aa3edf46a6b0db7a49db52d5ad
231 schema:familyName Grénman
232 schema:givenName Seija
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602404307.00
234 rdf:type schema:Person
235 sg:person.0626377410.48 schema:affiliation N6a0162abd3d943c1b4c174897d529eda
236 schema:familyName Vallius
237 schema:givenName Tuulia
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626377410.48
239 rdf:type schema:Person
240 sg:person.0632667315.72 schema:affiliation https://www.grid.ac/institutes/grid.415303.0
241 schema:familyName Oksa
242 schema:givenName Sinikka
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632667315.72
244 rdf:type schema:Person
245 sg:pub.10.1007/s00259-008-0890-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006526925
246 https://doi.org/10.1007/s00259-008-0890-2
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00259-014-2803-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031024771
249 https://doi.org/10.1007/s00259-014-2803-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s00259-016-3315-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039864863
252 https://doi.org/10.1007/s00259-016-3315-7
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s11307-010-0354-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030470677
255 https://doi.org/10.1007/s11307-010-0354-5
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s13277-014-2553-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036348195
258 https://doi.org/10.1007/s13277-014-2553-1
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/ng.3573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046917301
261 https://doi.org/10.1038/ng.3573
262 rdf:type schema:CreativeWork
263 sg:pub.10.1245/s10434-011-2153-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024196126
264 https://doi.org/10.1245/s10434-011-2153-x
265 rdf:type schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1074551522 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1074715786 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1078523308 schema:CreativeWork
269 https://doi.org/10.1002/1097-0142(19930901)72:5<1631::aid-cncr2820720523>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1001937901
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/cncr.24149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015684380
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.ajog.2008.06.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027626926
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.radonc.2008.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000285486
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.ygyno.2009.10.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013963412
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.ygyno.2012.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022139224
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.ygyno.2012.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029008529
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.ygyno.2013.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011753829
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.ygyno.2014.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043844969
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.ygyno.2015.07.095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010019457
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.ygyno.2015.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022615269
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.ygyno.2016.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030933544
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0020-7292(00)90001-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007428502
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejmoa0908806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051283014
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1056/nejmra050276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050685987
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/annonc/mdt333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019644782
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1097/igc.0b013e3182070f17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046236183
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1097/rlu.0000000000000768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036739618
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1111/cas.12890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036872322
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1158/1078-0432.ccr-08-2030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040155088
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1158/1078-0432.ccr-13-2634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012378841
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1200/jco.2005.06.965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027291987
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1200/jco.2006.07.7800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047931406
316 rdf:type schema:CreativeWork
317 https://doi.org/10.2967/jnumed.108.057307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009233958
318 rdf:type schema:CreativeWork
319 https://doi.org/10.2967/jnumed.109.063321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009235744
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3802/jgo.2011.22.3.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024249218
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.1374.1 schema:alternateName University of Turku
324 schema:name Center of Statistics and Department of Clinical Medicine, University of Turku, Turku, Finland
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.410552.7 schema:alternateName Turku University Hospital
327 schema:name Medical Imaging centre of Southwest Finland, University of Turku and Turku University Hospital, Turku, Finland
328 Turku University Hospital, Clinical Research Centre, Turku, Finland
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.412330.7 schema:alternateName Tampere University Hospital
331 schema:name Department of Obstetrics and Gynecology, University of Tampere and Tampere University Hospital, Tampere, Finland
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.415303.0 schema:alternateName Satakunta Central Hospital
334 schema:name Department of Obstetrics and Gynecology, Satakunta Central Hospital, Pori, Finland
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.470895.7 schema:alternateName Turku PET Centre
337 schema:name Department of Clinical Physiology and Nuclear Medicine, Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...