Ontology type: schema:ScholarlyArticle Open Access: True
2018-05
AUTHORSKee H. Wong, Rafal Panek, Alex Dunlop, Dualta Mcquaid, Angela Riddell, Liam C. Welsh, Iain Murray, Dow-Mu Koh, Martin O. Leach, Shreerang A. Bhide, Christopher M. Nutting, Wim J. Oyen, Kevin J. Harrington, Kate L. Newbold
ABSTRACTOBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC). METHODS: Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent 18F-FDG-PET/CT, and diffusion-weighted (DW), dynamic contrast-enhanced (DCE) and susceptibility-weighted MRI at baseline, week 1 and week 2 of chemoradiation. Patients with evidence of persistent or recurrent disease during follow-up were classed as non-responders. Changes in FMI parameters at week 1 and week 2 were compared between responders and non-responders with the Mann-Whitney U test. The significance threshold was set at a p value of <0.05. RESULTS: There were 27 responders and 8 non-responders. Responders showed a greater reduction in PET-derived tumor total lesion glycolysis (TLG40%; p = 0.007) and maximum standardized uptake value (SUVmax; p = 0.034) after week 1 than non-responders but these differences were absent by week 2. In contrast, it was not until week 2 that MRI-derived parameters were able to discriminate between the two groups: larger fractional increases in primary tumor apparent diffusion coefficient (ADC; p < 0.001), volume transfer constant (Ktrans; p = 0.012) and interstitial space volume fraction (Ve; p = 0.047) were observed in responders versus non-responders. ADC was the most powerful predictor (∆ >17%, AUC 0.937). CONCLUSION: Early intra-treatment changes in FDG-PET, DW and DCE MRI-derived parameters are predictive of ultimate response to chemoradiation in HNSCC. However, the optimal timing for assessment with FDG-PET parameters (week 1) differed from MRI parameters (week 2). This highlighted the importance of scanning time points for the design of FMI risk-stratified interventional studies. More... »
PAGES759-767
http://scigraph.springernature.com/pub.10.1007/s00259-017-3890-2
DOIhttp://dx.doi.org/10.1007/s00259-017-3890-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092862496
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29164301
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"name": "pubmed_id",
"type": "PropertyValue",
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},
{
"name": "nlm_unique_id",
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},
{
"name": "doi",
"type": "PropertyValue",
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},
{
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],
"sameAs": [
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"https://app.dimensions.ai/details/publication/pub.1092862496"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T13:25",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
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"type": "ScholarlyArticle",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-017-3890-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-017-3890-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-017-3890-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-017-3890-2'
This table displays all metadata directly associated to this object as RDF triples.
268 TRIPLES
21 PREDICATES
58 URIs
21 LITERALS
9 BLANK NODES