Repeatability of tumour hypoxia imaging using [18F]EF5 PET/CT in head and neck cancer View Full Text


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Article Info

DATE

2017-10-26

AUTHORS

Antti Silvoniemi, Sami Suilamo, Timo Laitinen, Sarita Forsback, Eliisa Löyttyniemi, Samuli Vaittinen, Virva Saunavaara, Olof Solin, Tove J. Grönroos, Heikki Minn

ABSTRACT

PurposeHypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types of cancer. This study was designed to evaluate the repeatability of intratumour uptake of the hypoxia tracer [18F]EF5 in paired PET/CT scans.MethodsTen patients with newly diagnosed head and neck cancer (HNC) received three static PET/CT scans before chemoradiotherapy: two with [18F]EF5 a median of 7 days apart and one with [18F]FDG. Metabolically active primary tumour volumes were defined in [18F]FDG images and transferred to co-registered [18F]EF5 images for repeatability analysis. A tumour-to-muscle uptake ratio (TMR) of 1.5 at 3 h from injection of [18F]EF5 was used as a threshold representing hypoxic tissue.ResultsIn 10 paired [18F]EF5 PET/CT image sets, SUVmean, SUVmax, and TMR showed a good correlation with the intraclass correlation coefficients of 0.81, 0.85, and 0.87, respectively. The relative coefficients of repeatability for these parameters were 15%, 17%, and 10%, respectively. Fractional hypoxic volumes of the tumours in the repeated scans had a high correlation using the Spearman rank correlation test (r = 0.94). In a voxel-by-voxel TMR analysis between the repeated scans, the mean of Pearson correlation coefficients of individual patients was 0.65. The mean (± SD) difference of TMR in the pooled data set was 0.03 ± 0.20.ConclusionPretreatment [18F]EF5 PET/CT within one week shows high repeatability and is feasible for the guiding of hypoxia-targeted treatment interventions in HNC. More... »

PAGES

161-169

References to SciGraph publications

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  • 2011-03-30. Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [18F]EF5 in MOLECULAR IMAGING AND BIOLOGY
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29075831


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    29 schema:description PurposeHypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types of cancer. This study was designed to evaluate the repeatability of intratumour uptake of the hypoxia tracer [18F]EF5 in paired PET/CT scans.MethodsTen patients with newly diagnosed head and neck cancer (HNC) received three static PET/CT scans before chemoradiotherapy: two with [18F]EF5 a median of 7 days apart and one with [18F]FDG. Metabolically active primary tumour volumes were defined in [18F]FDG images and transferred to co-registered [18F]EF5 images for repeatability analysis. A tumour-to-muscle uptake ratio (TMR) of 1.5 at 3 h from injection of [18F]EF5 was used as a threshold representing hypoxic tissue.ResultsIn 10 paired [18F]EF5 PET/CT image sets, SUVmean, SUVmax, and TMR showed a good correlation with the intraclass correlation coefficients of 0.81, 0.85, and 0.87, respectively. The relative coefficients of repeatability for these parameters were 15%, 17%, and 10%, respectively. Fractional hypoxic volumes of the tumours in the repeated scans had a high correlation using the Spearman rank correlation test (r = 0.94). In a voxel-by-voxel TMR analysis between the repeated scans, the mean of Pearson correlation coefficients of individual patients was 0.65. The mean (± SD) difference of TMR in the pooled data set was 0.03 ± 0.20.ConclusionPretreatment [18F]EF5 PET/CT within one week shows high repeatability and is feasible for the guiding of hypoxia-targeted treatment interventions in HNC.
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    40 PET/CT
    41 PET/CT scans
    42 Pearson correlation coefficient
    43 PurposeHypoxia
    44 ResultsIn 10
    45 SUVmax
    46 SUVmean
    47 Spearman rank correlation test
    48 TMR
    49 TMR analysis
    50 aggressive behavior
    51 analysis
    52 behavior
    53 cancer
    54 chemoradiotherapy
    55 coefficient
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    57 correlation coefficient
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    59 data sets
    60 days
    61 differences
    62 fractional hypoxic volume
    63 good correlation
    64 guiding
    65 head
    66 high correlation
    67 high repeatability
    68 hypoxia
    69 hypoxia tracer
    70 hypoxic tissue
    71 hypoxic volume
    72 image sets
    73 images
    74 individual patients
    75 injection
    76 intervention
    77 intraclass correlation coefficient
    78 mean difference
    79 means
    80 median
    81 muscle uptake ratios
    82 neck cancer
    83 parameters
    84 patients
    85 pooled data set
    86 primary tumor volume
    87 radiotherapy resistance
    88 rank correlation test
    89 ratio
    90 relative coefficient
    91 repeatability
    92 repeatability analysis
    93 resistance
    94 scans
    95 set
    96 static PET/CT scan
    97 study
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    100 tissue
    101 tracer
    102 treatment interventions
    103 tumor hypoxia
    104 tumor volume
    105 tumors
    106 types
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    113 schema:name Repeatability of tumour hypoxia imaging using [18F]EF5 PET/CT in head and neck cancer
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