Volumetric parameters on FDG PET can predict early intrahepatic recurrence-free survival in patients with hepatocellular carcinoma after curative surgical resection View Full Text


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Article Info

DATE

2017-07-11

AUTHORS

Jeong Won Lee, Sang Hyun Hwang, Hyun Jeong Kim, Dongwoo Kim, Arthur Cho, Mijin Yun

ABSTRACT

PurposeThis study assessed the prognostic values of volumetric parameters on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting early intrahepatic recurrence-free survival (RFS) after curative resection in patients with hepatocellular carcinoma (HCC).MethodsA retrospective analysis was performed on 242 patients with HCC who underwent staging FDG PET and subsequent curative surgical resection. The tumor-to-non-tumorous liver uptake ratio, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the HCC lesions on PET were measured. The prognostic values of clinical factors and PET parameters for predicting overall RFS, overall survival (OS), extrahepatic RFS, and early and late intrahepatic RFS were assessed.ResultsThe median follow-up period was 54.7 months, during which 110 patients (45.5%) experienced HCC recurrence and 62 (25.6%) died. Patients with extrahepatic and early intrahepatic recurrence showed worse OS than did those with no recurrence or late intrahepatic recurrence (p < 0.001). Serum bilirubin level, MTV, and TLG were independent prognostic factors for overall RFS and OS (p < 0.05). Only MTV and TLG were prognostic for extrahepatic RFS (p < 0.05). Serum alpha-fetoprotein and bilirubin levels, MTV, and TLG were prognostic for early intrahepatic RFS (p < 0.05) and hepatitis C virus (HCV) positivity and serum albumin level were independently prognostic for late intrahepatic RFS (p < 0.05).ConclusionIntrahepatic recurrence showed different prognoses according to the time interval of recurrence in which early recurrence had as poor survival as extrahepatic recurrence. MTV and TLG on initial staging PET were significant independent factors for predicting early intrahepatic and extrahepatic RFS in patients with HCC after curative resection. Only HCV positivity and serum albumin level were significant for late intrahepatic RFS, which is mainly attributable to the de novo formation of new primary HCC. More... »

PAGES

1984-1994

References to SciGraph publications

  • 2011-09-09. The Role of Preoperative [18F]Fluorodeoxyglucose Positron Emission Tomography in Predicting Early Recurrence After Curative Resection of Hepatocellular Carcinomas in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2013-04-06. Harmonizing SUVs in multicentre trials when using different generation PET systems: prospective validation in non-small cell lung cancer patients in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-07-13. Hepatocellular carcinoma: a global view in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2015-02-05. The predictive value of metabolic tumor volume on FDG PET/CT for transarterial chemoembolization and transarterial chemotherapy infusion in hepatocellular carcinoma patients without extrahepatic metastasis in ANNALS OF NUCLEAR MEDICINE
  • 2016-02-04. A randomised controlled trial of meloxicam, a Cox-2 inhibitor, to prevent hepatocellular carcinoma recurrence after initial curative treatment in HEPATOLOGY INTERNATIONAL
  • 2011-08-18. Preoperative FDG-PET Predicts Recurrence Patterns in Hepatocellular Carcinoma in ANNALS OF SURGICAL ONCOLOGY
  • 2017-03-31. Impact of the EARL harmonization program on automatic delineation of metabolic active tumour volumes (MATVs) in EJNMMI RESEARCH
  • 2016-03-02. Prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with Barcelona Clinic Liver Cancer stages 0 and A hepatocellular carcinomas: a multicenter retrospective cohort study in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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    http://scigraph.springernature.com/pub.10.1007/s00259-017-3764-7

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    http://dx.doi.org/10.1007/s00259-017-3764-7

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28695236


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