Total lesion glycolysis (TLG) as an imaging biomarker in metastatic colorectal cancer patients treated with regorafenib View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-25

AUTHORS

Yoojoo Lim, Ji-In Bang, Sae-Won Han, Jin Chul Paeng, Kyung-Hun Lee, Jee Hyun Kim, Gyeong Hoon Kang, Seung-Yong Jeong, Kyu Joo Park, Tae-You Kim

ABSTRACT

PurposeThis study was performed to evaluate whether fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) could predict treatment outcome of regorafenib in metastatic colorectal cancer (mCRC).MethodsPreviously treated refractory mCRC patients were enrolled into a prospective biomarker study of regorafenib. For this sub-study, the results of FDG PET/CT scans at baseline and after two cycles of treatment were analyzed. Various metabolic parameters obtained from PET images were analyzed in relation to treatment outcome.ResultsA total of 40 patients were evaluable for PET image analysis. Among various PET parameters, total lesion glycolysis (TLG) measured in the same target lesions for RECIST 1.1 analysis were the most significant in predicting prognosis, with the lowest p-value observed in TLG calculated using the margin threshold of 40 % (TLG40 %). Further analysis using TLG40 % showed significantly longer overall survival (OS) in patients with lower baseline TLG40 % (<151.8) (p = 0.003, median 14.2 vs. 9.1 months in <151.8 and ≥151.8, respectively). Patients showing higher decrease in TLG40 % after treatment showed significantly longer progression-free survival (PFS) (p = 0.001, median 8.0 vs. 2.4 months in %ΔTLG40 % < −9.6 % and ≥ −9.6 %, respectively) and OS (p = 0.002, median 16.4 vs. 9.1 months in %ΔTLG40 % < −9.6 % and ≥ −9.6 %, respectively). The same cutoff could discriminate patients with longer survival among the patients who were under the stable disease category according to RECIST 1.1 (median PFS 8.4 vs. 6.8 months, p = 0.020; median OS 18.3 vs. 11.5 months, p = 0.049).ConclusionMeasurement of TLG can predict treatment outcome of regorafenib in mCRC. More... »

PAGES

757-764

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-016-3577-0

DOI

http://dx.doi.org/10.1007/s00259-016-3577-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021358463

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27888325


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57 cycles of treatment
58 decrease
59 disease categories
60 fluorine-18 fluorodeoxyglucose positron emission tomography/
61 fluorodeoxyglucose positron emission tomography/
62 glycolysis
63 highest decrease
64 image analysis
65 images
66 lesion glycolysis
67 lesions
68 longer overall survival
69 longer progression-free survival
70 longer survival
71 low p-values
72 mCRC patients
73 margin threshold
74 metabolic parameters
75 metastatic colorectal cancer
76 metastatic colorectal cancer patients
77 outcomes
78 overall survival
79 p-value
80 parameters
81 patients
82 positron emission tomography/
83 prognosis
84 progression-free survival
85 prospective biomarker study
86 refractory mCRC patients
87 regorafenib
88 relation
89 results
90 same cutoff
91 same target lesions
92 scans
93 stable disease category
94 study
95 survival
96 target lesions
97 threshold
98 tomography
99 tomography/
100 total
101 total lesion glycolysis
102 treatment
103 treatment outcomes
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