Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01

AUTHORS

Christos Sachpekidis, J. Hillengass, H. Goldschmidt, B. Wagner, U. Haberkorn, K. Kopka, A. Dimitrakopoulou-Strauss

ABSTRACT

AIM: The aim of this study was to assess the combined use of the radiotracers 18F-FDG and 18F-NaF in treatment response evaluation of a group of multiple myeloma (MM) patients undergoing high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) by means of static (whole-body) and dynamic PET/CT (dPET/CT). PATIENTS AND METHODS: Thirty-four patients with primary, previously untreated MM scheduled for treatment with HDT followed by ASCT were enrolled in the study. All patients underwent PET/CT scanning with 18F-FDG and 18F-NaF before and after therapy. Treatment response by means of PET/CT was assessed according to the European Organization for Research and Treatment of Cancer (EORTC) 1999 criteria. The evaluation of dPET/CT studies was based on qualitative evaluation, semi-quantitative (SUV) calculation, and quantitative analysis based on two-tissue compartment modelling and a non-compartmental approach leading to the extraction of fractal dimension (FD). RESULTS: An analysis was possible in 29 patients: three with clinical complete response (CR) and 26 with non-CR (13 patients near complete response-nCR, four patients very good partial response-VGPR, nine patients partial response-PR). After treatment, 18F-FDG PET/CT was negative in 14/29 patients and positive in 15/29 patients, showing a sensitivity of 57.5 % and a specificity of 100 %. According to the EORTC 1999 criteria, 18F-FDG PET/CT-based treatment response revealed CR in 14 patients (18F-FDG PET/CT CR), PR in 11 patients (18F-FDG PET/CT PR) and progressive disease in four patients (18F-FDG PET/CT PD). In terms of 18F-NaF PET/CT, 4/29 patients (13.8 %) had a negative baseline scan, thus failed to depict MM. Regarding the patients for which a direct lesion-to-lesion comparison was feasible, 18F-NaF PET/CT depicted 56 of the 129 18F-FDG positive lesions (43 %). Follow-up 18F-NaF PET/CT showed persistence of 81.5 % of the baseline 18F-NaF positive MM lesions after treatment, despite the fact that 64.7 % of them had turned to 18F-FDG negative. Treatment response according to 18F-NaF PET/CT revealed CR in one patient (18F-NaF PET/CT CR), PR in five patients (18F-NaF PET/CT PR), SD in 12 patients (18F-NaF PET/CT SD), and PD in seven patients (18F-NaF PET/CT PD). Dynamic 18F-FDG and 18F-NaF PET/CT studies showed that SUVaverage, SUVmax, as well as the kinetic parameters K1, influx and FD from reference bone marrow and skeleton responded to therapy with a significant decrease (p < 0.001). CONCLUSION: F-FDG PET/CT demonstrated a sensitivity of 57.7 % and a specificity of 100 % in treatment response evaluation of MM. Despite its limited sensitivity, the performance of 18F-FDG PET/CT was satisfactory, given that 6/9 false negative patients in follow-up scans (66.7 %) were clinically characterized as nCR, a disease stage with very low tumor mass. On the other hand, 18F-NaF PET/CT does not seem to add significantly to 18F-FDG PET/CT in treatment response evaluation of MM patients undergoing HDT and ASCT, at least shortly after therapy. More... »

PAGES

50-62

References to SciGraph publications

  • 1983. Basic Principles Underlying Radioisotopic Methods for Assay of Biochemical Processes in Vivo in TRACER KINETICS AND PHYSIOLOGIC MODELING
  • 2013-02. Comparative diagnostic performance of 18F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation in EUROPEAN RADIOLOGY
  • 2015-10. 18F-NaF PET/CT: EANM procedure guidelines for bone imaging in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-01. Role of 18F-fluoride PET/CT in the assessment of multiple myeloma: initial experience in ANNALS OF NUCLEAR MEDICINE
  • 2006-09. International uniform response criteria for multiple myeloma in LEUKEMIA
  • 2005-10. Relative roles of bone scintigraphy and positron emission tomography in assessing the treatment response of bone metastases in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2004-08. Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma in LEUKEMIA
  • 2016-02. 18F-FDG PET/CT focal, but not osteolytic, lesions predict the progression of smoldering myeloma to active disease in LEUKEMIA
  • 2012-03. 18F-FDG PET/CT for detection and localization of residual or recurrent disease in patients with multiple myeloma after stem cell transplantation in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2015-09. Is there any complimentary role of F-18 NaF PET/CT in detecting of osseous involvement of multiple myeloma? A comparative study for F-18 FDG PET/CT and F-18 FDG NaF PET/CT in ANNALS OF HEMATOLOGY
  • 1994. Diagnosis of Skeletal Metastases and Assessment of Response to Treatment in METASTATIC BONE DISEASE
  • 2013-06. Evaluation of New Bone Formation in Normal and Osteoporotic Rats with a 3-mm Femur Defect: Functional Assessment with Dynamic PET-CT (dPET-CT) Using 2-Deoxy-2-[18F]Fluoro-d-glucose (18F-FDG) and 18F-Fluoride in MOLECULAR IMAGING AND BIOLOGY
  • 2014-07. PET/CT studies of multiple myeloma using 18 F-FDG and 18 F-NaF: comparison of distribution patterns and tracers’ pharmacokinetics in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-016-3502-6

    DOI

    http://dx.doi.org/10.1007/s00259-016-3502-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012943805

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27573638


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dose-Response Relationship, Drug", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorine Radioisotopes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorodeoxyglucose F18", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melphalan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiple Myeloma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positron Emission Tomography Computed Tomography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiopharmaceuticals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sensitivity and Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sodium Fluoride", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Medical PET Group-Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany", 
                "Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sachpekidis", 
            "givenName": "Christos", 
            "id": "sg:person.01003176044.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003176044.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hillengass", 
            "givenName": "J.", 
            "id": "sg:person.01007410143.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007410143.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany", 
                "National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goldschmidt", 
            "givenName": "H.", 
            "id": "sg:person.014240003617.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014240003617.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wagner", 
            "givenName": "B.", 
            "id": "sg:person.01247511244.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247511244.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Medical PET Group-Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany", 
                "Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haberkorn", 
            "givenName": "U.", 
            "id": "sg:person.01142772466.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142772466.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kopka", 
            "givenName": "K.", 
            "id": "sg:person.01370431444.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370431444.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Medical PET Group-Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dimitrakopoulou-Strauss", 
            "givenName": "A.", 
            "id": "sg:person.01371422644.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371422644.06"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1053/j.semnuclmed.2007.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000079925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.114.150391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001009229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001253478", 
              "https://doi.org/10.1038/sj.leu.2403423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001253478", 
              "https://doi.org/10.1038/sj.leu.2403423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.106.037200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002718393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjh.12007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003383046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.115.163808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004761600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-015-2410-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005842914", 
              "https://doi.org/10.1007/s00277-015-2410-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10428194.2015.1090572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006562828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61424-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008465800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.108.057307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009233958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-012-0592-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013332561", 
              "https://doi.org/10.1007/s11307-012-0592-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-02-297325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014912879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.110.077933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015683207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2013.091918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016702551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-0396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017529383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00330-012-2600-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017782833", 
              "https://doi.org/10.1007/s00330-012-2600-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-005-1843-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019899046", 
              "https://doi.org/10.1007/s00259-005-1843-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-005-1843-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019899046", 
              "https://doi.org/10.1007/s00259-005-1843-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)70442-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021088092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12149-012-0647-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022705686", 
              "https://doi.org/10.1007/s12149-012-0647-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-06-361386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022725801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2015.291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024919571", 
              "https://doi.org/10.1038/leu.2015.291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-08-238196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026079715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/14639239809001400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026297411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-015-3138-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026355076", 
              "https://doi.org/10.1007/s00259-015-3138-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-015-3138-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026355076", 
              "https://doi.org/10.1007/s00259-015-3138-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdn449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026824166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.111.100883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028135940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0001-2998(72)80005-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028365411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc.2001.23527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029155258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.2003.04303.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031765337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0000000000000773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033299158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0000000000000773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033299158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033553106", 
              "https://doi.org/10.1038/sj.leu.2404284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033553106", 
              "https://doi.org/10.1038/sj.leu.2404284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-014-2721-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035640100", 
              "https://doi.org/10.1007/s00259-014-2721-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2013.099358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035802531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0609.2012.01751.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038970353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1011442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039702038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0000000000000908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041700130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0000000000000908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041700130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0b013e3181b06bc5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042523539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0b013e3181b06bc5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042523539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0270(93)90033-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042538159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0270(93)90033-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042538159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0b013e318266cee2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042971887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-011-1993-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043636576", 
              "https://doi.org/10.1007/s00259-011-1993-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clon.2011.03.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043792002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-50036-7_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044754663", 
              "https://doi.org/10.1007/978-3-642-50036-7_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-78596-2_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047897995", 
              "https://doi.org/10.1007/978-3-642-78596-2_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0000000000000285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048431701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0000000000000285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048431701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(99)00229-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049505783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-03-213280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049875975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199607113350204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050074028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2014.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051400827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.2003.04355.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051477607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1998.00930.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051933965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10428194.2011.573036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052159431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077003841", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077122200", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077182477", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078193803", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079177156", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1995.13.5.1123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082403874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082443643", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1148/radiology.192.1.8208938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082702277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083174109", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-01", 
        "datePublishedReg": "2017-01-01", 
        "description": "AIM: The aim of this study was to assess the combined use of the radiotracers 18F-FDG and 18F-NaF in treatment response evaluation of a group of multiple myeloma (MM) patients undergoing high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) by means of static (whole-body) and dynamic PET/CT (dPET/CT).\nPATIENTS AND METHODS: Thirty-four patients with primary, previously untreated MM scheduled for treatment with HDT followed by ASCT were enrolled in the study. All patients underwent PET/CT scanning with 18F-FDG and 18F-NaF before and after therapy. Treatment response by means of PET/CT was assessed according to the European Organization for Research and Treatment of Cancer (EORTC) 1999 criteria. The evaluation of dPET/CT studies was based on qualitative evaluation, semi-quantitative (SUV) calculation, and quantitative analysis based on two-tissue compartment modelling and a non-compartmental approach leading to the extraction of fractal dimension (FD).\nRESULTS: An analysis was possible in 29 patients: three with clinical complete response (CR) and 26 with non-CR (13 patients near complete response-nCR, four patients very good partial response-VGPR, nine patients partial response-PR). After treatment, 18F-FDG PET/CT was negative in 14/29 patients and positive in 15/29 patients, showing a sensitivity of 57.5\u00a0% and a specificity of 100\u00a0%. According to the EORTC 1999 criteria, 18F-FDG PET/CT-based treatment response revealed CR in 14 patients (18F-FDG PET/CT CR), PR in 11 patients (18F-FDG PET/CT PR) and progressive disease in four patients (18F-FDG PET/CT PD). In terms of 18F-NaF PET/CT, 4/29 patients (13.8\u00a0%) had a negative baseline scan, thus failed to depict MM. Regarding the patients for which a direct lesion-to-lesion comparison was feasible, 18F-NaF PET/CT depicted 56 of the 129 18F-FDG positive lesions (43\u00a0%). Follow-up 18F-NaF PET/CT showed persistence of 81.5\u00a0% of the baseline 18F-NaF positive MM lesions after treatment, despite the fact that 64.7\u00a0% of them had turned to 18F-FDG negative. Treatment response according to 18F-NaF PET/CT revealed CR in one patient (18F-NaF PET/CT CR), PR in five patients (18F-NaF PET/CT PR), SD in 12 patients (18F-NaF PET/CT SD), and PD in seven patients (18F-NaF PET/CT PD). Dynamic 18F-FDG and 18F-NaF PET/CT studies showed that SUVaverage, SUVmax, as well as the kinetic parameters K1, influx and FD from reference bone marrow and skeleton responded to therapy with a significant decrease (p\u2009<\u20090.001).\nCONCLUSION: F-FDG PET/CT demonstrated a sensitivity of 57.7\u00a0% and a specificity of 100\u00a0% in treatment response evaluation of MM. Despite its limited sensitivity, the performance of 18F-FDG PET/CT was satisfactory, given that 6/9 false negative patients in follow-up scans (66.7\u00a0%) were clinically characterized as nCR, a disease stage with very low tumor mass. On the other hand, 18F-NaF PET/CT does not seem to add significantly to 18F-FDG PET/CT in treatment response evaluation of MM patients undergoing HDT and ASCT, at least shortly after therapy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00259-016-3502-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1297401", 
            "issn": [
              "1619-7070", 
              "1619-7089"
            ], 
            "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "44"
          }
        ], 
        "name": "Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation", 
        "pagination": "50-62", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3daa6cc167bd1dc76cdbc01fc9c2ccb1bffd806f666f244093e8920820ef9f2c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27573638"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101140988"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00259-016-3502-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1012943805"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00259-016-3502-6", 
          "https://app.dimensions.ai/details/publication/pub.1012943805"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70031_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00259-016-3502-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3502-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3502-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3502-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3502-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    387 TRIPLES      21 PREDICATES      109 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00259-016-3502-6 schema:about N13db3f86b94a4cc4b39d0ccd4f23efbe
    2 N18591c82b8bd44a9bc419f8357994e9f
    3 N1e95ed296f1347299c1c870ca7f50975
    4 N2001d49dbe804f2e9c5f04a777eef2e3
    5 N22fdc6afba154d66993b75926f390e4b
    6 N410767debe71467cbedb9231d049a776
    7 N456ffcb735fe42c8ab1c8d6512053b8d
    8 N47e82c9ee93349cbb180f402c43238ef
    9 N5096c64d68d24d8fab728e186564c4c9
    10 N66897252ff5a40bb872c619391ea3316
    11 N6f8d7e98606f48a4ac34c169609763bb
    12 N84385d6a3f194d6c98ab6ec9273ccb0f
    13 N880c81afb8b44dc1af34d8a220166717
    14 N90f3eb8316a843bf870e5c498bcd7310
    15 Nab0b3b280e6146108f315bd12b6e2487
    16 Nada5099ed1e043aca39fc979915f3792
    17 Ncd8f0f8ca13b45a8a55d64b1f272b77c
    18 Nd97e92e9bd25461ab71b98880918d705
    19 Ndbd8bdc55c72467880ff0ae6e30ac336
    20 Nf7e81c6e0f304b56a5a8c32cb45e7cf6
    21 anzsrc-for:11
    22 anzsrc-for:1103
    23 schema:author N093d65734af34f74aec568d2cd6b86a8
    24 schema:citation sg:pub.10.1007/978-3-642-50036-7_4
    25 sg:pub.10.1007/978-3-642-78596-2_8
    26 sg:pub.10.1007/s00259-005-1843-7
    27 sg:pub.10.1007/s00259-011-1993-8
    28 sg:pub.10.1007/s00259-014-2721-y
    29 sg:pub.10.1007/s00259-015-3138-y
    30 sg:pub.10.1007/s00277-015-2410-3
    31 sg:pub.10.1007/s00330-012-2600-5
    32 sg:pub.10.1007/s11307-012-0592-9
    33 sg:pub.10.1007/s12149-012-0647-7
    34 sg:pub.10.1038/leu.2015.291
    35 sg:pub.10.1038/sj.leu.2403423
    36 sg:pub.10.1038/sj.leu.2404284
    37 https://app.dimensions.ai/details/publication/pub.1077003841
    38 https://app.dimensions.ai/details/publication/pub.1077122200
    39 https://app.dimensions.ai/details/publication/pub.1077182477
    40 https://app.dimensions.ai/details/publication/pub.1078193803
    41 https://app.dimensions.ai/details/publication/pub.1079177156
    42 https://app.dimensions.ai/details/publication/pub.1082443643
    43 https://app.dimensions.ai/details/publication/pub.1083174109
    44 https://doi.org/10.1016/0165-0270(93)90033-n
    45 https://doi.org/10.1016/j.clon.2011.03.010
    46 https://doi.org/10.1016/j.ejca.2014.07.002
    47 https://doi.org/10.1016/s0001-2998(72)80005-9
    48 https://doi.org/10.1016/s0140-6736(10)61424-9
    49 https://doi.org/10.1016/s0959-8049(99)00229-4
    50 https://doi.org/10.1016/s1470-2045(14)70442-5
    51 https://doi.org/10.1046/j.1365-2141.1998.00930.x
    52 https://doi.org/10.1046/j.1365-2141.2003.04303.x
    53 https://doi.org/10.1046/j.1365-2141.2003.04355.x
    54 https://doi.org/10.1053/j.semnuclmed.2007.07.002
    55 https://doi.org/10.1053/snuc.2001.23527
    56 https://doi.org/10.1056/nejm199607113350204
    57 https://doi.org/10.1056/nejmra1011442
    58 https://doi.org/10.1093/annonc/mdn449
    59 https://doi.org/10.1097/rlu.0000000000000285
    60 https://doi.org/10.1097/rlu.0000000000000773
    61 https://doi.org/10.1097/rlu.0000000000000908
    62 https://doi.org/10.1097/rlu.0b013e3181b06bc5
    63 https://doi.org/10.1097/rlu.0b013e318266cee2
    64 https://doi.org/10.1111/bjh.12007
    65 https://doi.org/10.1111/j.1600-0609.2012.01751.x
    66 https://doi.org/10.1148/radiology.192.1.8208938
    67 https://doi.org/10.1158/1078-0432.ccr-15-0396
    68 https://doi.org/10.1182/blood-2009-03-213280
    69 https://doi.org/10.1182/blood-2009-08-238196
    70 https://doi.org/10.1182/blood-2011-02-297325
    71 https://doi.org/10.1182/blood-2011-06-361386
    72 https://doi.org/10.1200/jco.1995.13.5.1123
    73 https://doi.org/10.2967/jnumed.106.037200
    74 https://doi.org/10.2967/jnumed.108.057307
    75 https://doi.org/10.2967/jnumed.110.077933
    76 https://doi.org/10.2967/jnumed.111.100883
    77 https://doi.org/10.2967/jnumed.114.150391
    78 https://doi.org/10.2967/jnumed.115.163808
    79 https://doi.org/10.3109/10428194.2011.573036
    80 https://doi.org/10.3109/10428194.2015.1090572
    81 https://doi.org/10.3109/14639239809001400
    82 https://doi.org/10.3324/haematol.2013.091918
    83 https://doi.org/10.3324/haematol.2013.099358
    84 schema:datePublished 2017-01
    85 schema:datePublishedReg 2017-01-01
    86 schema:description AIM: The aim of this study was to assess the combined use of the radiotracers 18F-FDG and 18F-NaF in treatment response evaluation of a group of multiple myeloma (MM) patients undergoing high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) by means of static (whole-body) and dynamic PET/CT (dPET/CT). PATIENTS AND METHODS: Thirty-four patients with primary, previously untreated MM scheduled for treatment with HDT followed by ASCT were enrolled in the study. All patients underwent PET/CT scanning with 18F-FDG and 18F-NaF before and after therapy. Treatment response by means of PET/CT was assessed according to the European Organization for Research and Treatment of Cancer (EORTC) 1999 criteria. The evaluation of dPET/CT studies was based on qualitative evaluation, semi-quantitative (SUV) calculation, and quantitative analysis based on two-tissue compartment modelling and a non-compartmental approach leading to the extraction of fractal dimension (FD). RESULTS: An analysis was possible in 29 patients: three with clinical complete response (CR) and 26 with non-CR (13 patients near complete response-nCR, four patients very good partial response-VGPR, nine patients partial response-PR). After treatment, 18F-FDG PET/CT was negative in 14/29 patients and positive in 15/29 patients, showing a sensitivity of 57.5 % and a specificity of 100 %. According to the EORTC 1999 criteria, 18F-FDG PET/CT-based treatment response revealed CR in 14 patients (18F-FDG PET/CT CR), PR in 11 patients (18F-FDG PET/CT PR) and progressive disease in four patients (18F-FDG PET/CT PD). In terms of 18F-NaF PET/CT, 4/29 patients (13.8 %) had a negative baseline scan, thus failed to depict MM. Regarding the patients for which a direct lesion-to-lesion comparison was feasible, 18F-NaF PET/CT depicted 56 of the 129 18F-FDG positive lesions (43 %). Follow-up 18F-NaF PET/CT showed persistence of 81.5 % of the baseline 18F-NaF positive MM lesions after treatment, despite the fact that 64.7 % of them had turned to 18F-FDG negative. Treatment response according to 18F-NaF PET/CT revealed CR in one patient (18F-NaF PET/CT CR), PR in five patients (18F-NaF PET/CT PR), SD in 12 patients (18F-NaF PET/CT SD), and PD in seven patients (18F-NaF PET/CT PD). Dynamic 18F-FDG and 18F-NaF PET/CT studies showed that SUVaverage, SUVmax, as well as the kinetic parameters K1, influx and FD from reference bone marrow and skeleton responded to therapy with a significant decrease (p < 0.001). CONCLUSION: F-FDG PET/CT demonstrated a sensitivity of 57.7 % and a specificity of 100 % in treatment response evaluation of MM. Despite its limited sensitivity, the performance of 18F-FDG PET/CT was satisfactory, given that 6/9 false negative patients in follow-up scans (66.7 %) were clinically characterized as nCR, a disease stage with very low tumor mass. On the other hand, 18F-NaF PET/CT does not seem to add significantly to 18F-FDG PET/CT in treatment response evaluation of MM patients undergoing HDT and ASCT, at least shortly after therapy.
    87 schema:genre research_article
    88 schema:inLanguage en
    89 schema:isAccessibleForFree true
    90 schema:isPartOf N32aac46b815343cb8ca8d56e2aba95fc
    91 N43085f1266874c958fcbc4c7849a225e
    92 sg:journal.1297401
    93 schema:name Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation
    94 schema:pagination 50-62
    95 schema:productId N2a7ca9216a514947a99713bd6e640a87
    96 N6fd3d8424da447c2a0b9b9345383daea
    97 N8699c267949346bf90c0ccd984d9689c
    98 N991621652e914ecea9dea8e5660ed84f
    99 Nbc358ca21f3e4cd48549896f64a5a45f
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012943805
    101 https://doi.org/10.1007/s00259-016-3502-6
    102 schema:sdDatePublished 2019-04-11T12:36
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher N7ea7ac34aa254d908f50d95e34a34f0e
    105 schema:url https://link.springer.com/10.1007%2Fs00259-016-3502-6
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N093d65734af34f74aec568d2cd6b86a8 rdf:first sg:person.01003176044.62
    110 rdf:rest Na7a34bcb56a24ec9a059da1f6e958e42
    111 N13db3f86b94a4cc4b39d0ccd4f23efbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Fluorine Radioisotopes
    113 rdf:type schema:DefinedTerm
    114 N18591c82b8bd44a9bc419f8357994e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Radiopharmaceuticals
    116 rdf:type schema:DefinedTerm
    117 N1e95ed296f1347299c1c870ca7f50975 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Sodium Fluoride
    119 rdf:type schema:DefinedTerm
    120 N2001d49dbe804f2e9c5f04a777eef2e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Middle Aged
    122 rdf:type schema:DefinedTerm
    123 N22fdc6afba154d66993b75926f390e4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Melphalan
    125 rdf:type schema:DefinedTerm
    126 N2a7ca9216a514947a99713bd6e640a87 schema:name pubmed_id
    127 schema:value 27573638
    128 rdf:type schema:PropertyValue
    129 N32aac46b815343cb8ca8d56e2aba95fc schema:volumeNumber 44
    130 rdf:type schema:PublicationVolume
    131 N410767debe71467cbedb9231d049a776 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Humans
    133 rdf:type schema:DefinedTerm
    134 N41dd0da584634cc88e8d1233f2568540 rdf:first sg:person.01142772466.17
    135 rdf:rest Nfe3bc79802bf4d68819b594547556836
    136 N43085f1266874c958fcbc4c7849a225e schema:issueNumber 1
    137 rdf:type schema:PublicationIssue
    138 N456ffcb735fe42c8ab1c8d6512053b8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Treatment Outcome
    140 rdf:type schema:DefinedTerm
    141 N47e82c9ee93349cbb180f402c43238ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Male
    143 rdf:type schema:DefinedTerm
    144 N5096c64d68d24d8fab728e186564c4c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Adult
    146 rdf:type schema:DefinedTerm
    147 N66897252ff5a40bb872c619391ea3316 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Sensitivity and Specificity
    149 rdf:type schema:DefinedTerm
    150 N6f8d7e98606f48a4ac34c169609763bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Female
    152 rdf:type schema:DefinedTerm
    153 N6fd3d8424da447c2a0b9b9345383daea schema:name nlm_unique_id
    154 schema:value 101140988
    155 rdf:type schema:PropertyValue
    156 N7d137f6bf5ef4d57921f176380536aaf rdf:first sg:person.01247511244.80
    157 rdf:rest N41dd0da584634cc88e8d1233f2568540
    158 N7ea7ac34aa254d908f50d95e34a34f0e schema:name Springer Nature - SN SciGraph project
    159 rdf:type schema:Organization
    160 N84385d6a3f194d6c98ab6ec9273ccb0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Fluorodeoxyglucose F18
    162 rdf:type schema:DefinedTerm
    163 N8699c267949346bf90c0ccd984d9689c schema:name dimensions_id
    164 schema:value pub.1012943805
    165 rdf:type schema:PropertyValue
    166 N880c81afb8b44dc1af34d8a220166717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Multiple Myeloma
    168 rdf:type schema:DefinedTerm
    169 N8d50c63ee86f4ae8ba76c9fe0db7996b rdf:first sg:person.01371422644.06
    170 rdf:rest rdf:nil
    171 N90f3eb8316a843bf870e5c498bcd7310 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Antineoplastic Agents
    173 rdf:type schema:DefinedTerm
    174 N991621652e914ecea9dea8e5660ed84f schema:name doi
    175 schema:value 10.1007/s00259-016-3502-6
    176 rdf:type schema:PropertyValue
    177 N9fe2be4230594897875ad92839a09bde rdf:first sg:person.014240003617.51
    178 rdf:rest N7d137f6bf5ef4d57921f176380536aaf
    179 Na7a34bcb56a24ec9a059da1f6e958e42 rdf:first sg:person.01007410143.45
    180 rdf:rest N9fe2be4230594897875ad92839a09bde
    181 Nab0b3b280e6146108f315bd12b6e2487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Positron Emission Tomography Computed Tomography
    183 rdf:type schema:DefinedTerm
    184 Nada5099ed1e043aca39fc979915f3792 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Stem Cell Transplantation
    186 rdf:type schema:DefinedTerm
    187 Nbc358ca21f3e4cd48549896f64a5a45f schema:name readcube_id
    188 schema:value 3daa6cc167bd1dc76cdbc01fc9c2ccb1bffd806f666f244093e8920820ef9f2c
    189 rdf:type schema:PropertyValue
    190 Ncd8f0f8ca13b45a8a55d64b1f272b77c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Reproducibility of Results
    192 rdf:type schema:DefinedTerm
    193 Nd97e92e9bd25461ab71b98880918d705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Aged
    195 rdf:type schema:DefinedTerm
    196 Ndbd8bdc55c72467880ff0ae6e30ac336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Dose-Response Relationship, Drug
    198 rdf:type schema:DefinedTerm
    199 Nf7e81c6e0f304b56a5a8c32cb45e7cf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Combined Modality Therapy
    201 rdf:type schema:DefinedTerm
    202 Nfe3bc79802bf4d68819b594547556836 rdf:first sg:person.01370431444.02
    203 rdf:rest N8d50c63ee86f4ae8ba76c9fe0db7996b
    204 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Medical and Health Sciences
    206 rdf:type schema:DefinedTerm
    207 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Clinical Sciences
    209 rdf:type schema:DefinedTerm
    210 sg:journal.1297401 schema:issn 1619-7070
    211 1619-7089
    212 schema:name European Journal of Nuclear Medicine and Molecular Imaging
    213 rdf:type schema:Periodical
    214 sg:person.01003176044.62 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    215 schema:familyName Sachpekidis
    216 schema:givenName Christos
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003176044.62
    218 rdf:type schema:Person
    219 sg:person.01007410143.45 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    220 schema:familyName Hillengass
    221 schema:givenName J.
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007410143.45
    223 rdf:type schema:Person
    224 sg:person.01142772466.17 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    225 schema:familyName Haberkorn
    226 schema:givenName U.
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142772466.17
    228 rdf:type schema:Person
    229 sg:person.01247511244.80 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    230 schema:familyName Wagner
    231 schema:givenName B.
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247511244.80
    233 rdf:type schema:Person
    234 sg:person.01370431444.02 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    235 schema:familyName Kopka
    236 schema:givenName K.
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370431444.02
    238 rdf:type schema:Person
    239 sg:person.01371422644.06 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    240 schema:familyName Dimitrakopoulou-Strauss
    241 schema:givenName A.
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371422644.06
    243 rdf:type schema:Person
    244 sg:person.014240003617.51 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    245 schema:familyName Goldschmidt
    246 schema:givenName H.
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014240003617.51
    248 rdf:type schema:Person
    249 sg:pub.10.1007/978-3-642-50036-7_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044754663
    250 https://doi.org/10.1007/978-3-642-50036-7_4
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/978-3-642-78596-2_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047897995
    253 https://doi.org/10.1007/978-3-642-78596-2_8
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s00259-005-1843-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019899046
    256 https://doi.org/10.1007/s00259-005-1843-7
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1007/s00259-011-1993-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043636576
    259 https://doi.org/10.1007/s00259-011-1993-8
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1007/s00259-014-2721-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1035640100
    262 https://doi.org/10.1007/s00259-014-2721-y
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/s00259-015-3138-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1026355076
    265 https://doi.org/10.1007/s00259-015-3138-y
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/s00277-015-2410-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005842914
    268 https://doi.org/10.1007/s00277-015-2410-3
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s00330-012-2600-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017782833
    271 https://doi.org/10.1007/s00330-012-2600-5
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1007/s11307-012-0592-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013332561
    274 https://doi.org/10.1007/s11307-012-0592-9
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/s12149-012-0647-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022705686
    277 https://doi.org/10.1007/s12149-012-0647-7
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/leu.2015.291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024919571
    280 https://doi.org/10.1038/leu.2015.291
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/sj.leu.2403423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001253478
    283 https://doi.org/10.1038/sj.leu.2403423
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/sj.leu.2404284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033553106
    286 https://doi.org/10.1038/sj.leu.2404284
    287 rdf:type schema:CreativeWork
    288 https://app.dimensions.ai/details/publication/pub.1077003841 schema:CreativeWork
    289 https://app.dimensions.ai/details/publication/pub.1077122200 schema:CreativeWork
    290 https://app.dimensions.ai/details/publication/pub.1077182477 schema:CreativeWork
    291 https://app.dimensions.ai/details/publication/pub.1078193803 schema:CreativeWork
    292 https://app.dimensions.ai/details/publication/pub.1079177156 schema:CreativeWork
    293 https://app.dimensions.ai/details/publication/pub.1082443643 schema:CreativeWork
    294 https://app.dimensions.ai/details/publication/pub.1083174109 schema:CreativeWork
    295 https://doi.org/10.1016/0165-0270(93)90033-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1042538159
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.clon.2011.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043792002
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.ejca.2014.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051400827
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0001-2998(72)80005-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028365411
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0140-6736(10)61424-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008465800
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0959-8049(99)00229-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049505783
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s1470-2045(14)70442-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021088092
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1046/j.1365-2141.1998.00930.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051933965
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1046/j.1365-2141.2003.04303.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031765337
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1046/j.1365-2141.2003.04355.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051477607
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1053/j.semnuclmed.2007.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000079925
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1053/snuc.2001.23527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029155258
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1056/nejm199607113350204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050074028
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1056/nejmra1011442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039702038
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1093/annonc/mdn449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026824166
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1097/rlu.0000000000000285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048431701
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1097/rlu.0000000000000773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033299158
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1097/rlu.0000000000000908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041700130
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1097/rlu.0b013e3181b06bc5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042523539
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1097/rlu.0b013e318266cee2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042971887
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1111/bjh.12007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003383046
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1111/j.1600-0609.2012.01751.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038970353
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1148/radiology.192.1.8208938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082702277
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1158/1078-0432.ccr-15-0396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017529383
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1182/blood-2009-03-213280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049875975
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1182/blood-2009-08-238196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026079715
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1182/blood-2011-02-297325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014912879
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1182/blood-2011-06-361386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022725801
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1200/jco.1995.13.5.1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082403874
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.2967/jnumed.106.037200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002718393
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.2967/jnumed.108.057307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009233958
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.2967/jnumed.110.077933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015683207
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.2967/jnumed.111.100883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028135940
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.2967/jnumed.114.150391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001009229
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.2967/jnumed.115.163808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004761600
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.3109/10428194.2011.573036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052159431
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.3109/10428194.2015.1090572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006562828
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.3109/14639239809001400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026297411
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.3324/haematol.2013.091918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016702551
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.3324/haematol.2013.099358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035802531
    374 rdf:type schema:CreativeWork
    375 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
    376 schema:name Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
    377 National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany
    378 rdf:type schema:Organization
    379 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
    380 schema:name Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
    381 Department of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
    382 Medical PET Group-Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
    385 schema:name Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    386 Medical PET Group-Biological Imaging, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69210, Heidelberg, Germany
    387 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...