JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chelating Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deferoxamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isotope Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trastuzumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zirconium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vugts", 
        "givenName": "Danielle J.", 
        "id": "sg:person.0665425270.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665425270.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klaver", 
        "givenName": "Chris", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sewing", 
        "givenName": "Claudia", 
        "id": "sg:person.0735067024.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735067024.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poot", 
        "givenName": "Alex J.", 
        "id": "sg:person.01070325626.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070325626.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adamzek", 
        "givenName": "Kevin", 
        "id": "sg:person.016110216521.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016110216521.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of Zurich, Zurich, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Department of Chemistry, University of Zurich, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huegli", 
        "givenName": "Seraina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of Zurich, Zurich, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Department of Chemistry, University of Zurich, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mari", 
        "givenName": "Cristina", 
        "id": "sg:person.01325726600.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325726600.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Visser", 
        "givenName": "Gerard W. M.", 
        "id": "sg:person.013707211632.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013707211632.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Radiopharmaceutical Chemistry, University of Basel Hospital, Basel, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Division of Radiopharmaceutical Chemistry, University of Basel Hospital, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valverde", 
        "givenName": "Ibai E.", 
        "id": "sg:person.01224225567.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224225567.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of Zurich, Zurich, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Department of Chemistry, University of Zurich, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gasser", 
        "givenName": "Gilles", 
        "id": "sg:person.0614137050.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614137050.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Boltzmann Institute for Applied Diagnostics, General Hospital of Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.411904.9", 
          "name": [
            "ETH Zurich, Institute of Pharmaceutical Sciences, Vladimir-Prelog Weg 4, CH-8093, Zurich, Switzerland", 
            "Ludwig Boltzmann Institute for Applied Diagnostics, General Hospital of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mindt", 
        "givenName": "Thomas L.", 
        "id": "sg:person.01361130701.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361130701.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1085, loc. Radionuclide Center, 1081HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dongen", 
        "givenName": "Guus A. M. S.", 
        "id": "sg:person.0732223564.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732223564.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00259-009-1263-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005085942", 
          "https://doi.org/10.1007/s00259-009-1263-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13550-015-0098-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048807169", 
          "https://doi.org/10.1186/s13550-015-0098-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2013.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048328786", 
          "https://doi.org/10.1038/nprot.2013.054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037255057", 
          "https://doi.org/10.1038/nrd4255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2010.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015342974", 
          "https://doi.org/10.1038/nprot.2010.13"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-30", 
    "datePublishedReg": "2016-08-30", 
    "description": "PurposeAll clinical 89Zr-immuno-PET studies are currently performed with the chelator desferrioxamine (DFO). This chelator provides hexadentate coordination to zirconium, leaving two coordination sites available for coordination with, e.g., water molecules, which are relatively labile ligands. The unsaturated coordination of DFO to zirconium has been suggested to result in impaired stability of the complex in vivo and consequently in unwanted bone uptake of 89Zr. Aiming at clinical improvements, we report here on a bifunctional isothiocyanate variant of the octadentate chelator DFO* and the in vitro and in vivo comparison of its 89Zr-DFO*-mAb complex with 89Zr-DFO-mAb.MethodsThe bifunctional chelator DFO*-pPhe-NCS was prepared from previously reported DFO* and p-phenylenediisothiocyanate. Subsequently, trastuzumab was conjugated with either DFO*-pPhe-NCS or commercial DFO-pPhe-NCS and radiolabeled with Zr-89 according to published procedures. In vitro stability experiments were carried out in saline, a histidine/sucrose buffer, and blood serum. The in vivo performance of the chelators was compared in N87 tumor-bearing mice by biodistribution studies and PET imaging.ResultsIn 0.9\u00a0% NaCl 89Zr-DFO*-trastuzumab was more stable than 89Zr-DFO-trastuzumab; after 72\u00a0h incubation at 2-8\u00a0\u00b0C 95\u00a0% and 58\u00a0% intact tracer were left, respectively, while in a histidine-sucrose buffer no difference was observed, both products were\u2009\u2265\u200992\u00a0% intact. In vivo uptake at 144\u00a0h post injection (p.i.) in tumors, blood, and most normal organs was similar for both conjugates, except for skin, liver, spleen, ileum, and bone. Tumor uptake was 32.59\u2009\u00b1\u200911.95 and 29.06\u2009\u00b1\u20098.66\u00a0% ID/g for 89Zr-DFO*-trastuzumab and 89Zr-DFO-trastuzumab, respectively. The bone uptake was significantly lower for 89Zr-DFO*-trastuzumab compared to 89Zr-DFO-trastuzumab. At 144\u00a0h p.i. for 89Zr-DFO*-trastuzumab and 89Zr-DFO-trastuzumab, the uptake in sternum was 0.92\u2009\u00b1\u20090.16 and 3.33\u2009\u00b1\u20090.32\u00a0% ID/g, in femur 0.78\u2009\u00b1\u20090.11 and 3.85,\u2009\u00b1\u20090.80 and in knee 1.38\u2009\u00b1\u20090.23 and 8.20\u2009\u00b1\u20092.94\u00a0% ID/g, respectively. The uptake in bone decreased from 24\u00a0h to 144\u00a0h p.i. about two fold for the DFO* conjugate, while it increased about two fold for the DFO conjugate.ConclusionsZr-DFO*-trastuzumab showed superior in vitro stability and in vivo performance when compared to 89Zr-DFO-trastuzumab. This makes the new octadentate DFO* chelator a candidate successor of DFO for future clinical 89Zr-immuno-PET.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00259-016-3499-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5234086", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "keywords": [
      "ID/", 
      "bone uptake", 
      "chelator desferrioxamine", 
      "tumor-bearing mice", 
      "h post injection", 
      "clinical improvement", 
      "trastuzumab", 
      "tumor uptake", 
      "normal organs", 
      "biodistribution studies", 
      "post injection", 
      "intact tracer", 
      "PET imaging", 
      "desferrioxamine", 
      "vivo comparison", 
      "blood serum", 
      "Zr-89", 
      "impaired stability", 
      "bifunctional chelator", 
      "h incubation", 
      "bone", 
      "vivo", 
      "MAB complexes", 
      "chelators", 
      "uptake", 
      "vivo performance", 
      "PET", 
      "spleen", 
      "ileum", 
      "tumors", 
      "mice", 
      "liver", 
      "blood", 
      "serum", 
      "saline", 
      "mAbs", 
      "p-phenylenediisothiocyanate", 
      "sternum", 
      "skin", 
      "injection", 
      "histidine/", 
      "organs", 
      "study", 
      "imaging", 
      "conjugates", 
      "folds", 
      "incubation", 
      "differences", 
      "variants", 
      "comparison", 
      "procedure", 
      "improvement", 
      "tracer", 
      "sites", 
      "coordination", 
      "ligands", 
      "buffer", 
      "molecules", 
      "NCS", 
      "complexes", 
      "products", 
      "stability experiments", 
      "experiments", 
      "performance", 
      "stability", 
      "hexadentate coordination", 
      "labile ligands", 
      "successor", 
      "unsaturated coordination", 
      "zirconium", 
      "coordination sites", 
      "water molecules"
    ], 
    "name": "Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET", 
    "pagination": "286-295", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045664701"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00259-016-3499-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27573793"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00259-016-3499-x", 
      "https://app.dimensions.ai/details/publication/pub.1045664701"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_702.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00259-016-3499-x"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      22 PREDICATES      122 URIs      109 LITERALS      26 BLANK NODES