123I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Koji Kasanuki, Eizo Iseki, Kazumi Ota, Daizo Kondo, Yosuke Ichimiya, Kiyoshi Sato, Heii Arai

ABSTRACT

PURPOSE: Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the 123I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance. METHODS: We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in 18F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of 123I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups. RESULTS: Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB. CONCLUSION: 123I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway. More... »

PAGES

358-365

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-016-3466-6

DOI

http://dx.doi.org/10.1007/s00259-016-3466-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016061809

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27480759


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lewy Body Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sleep", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Emission-Computed, Single-Photon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tropanes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417467.7", 
          "name": [
            "PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan", 
            "Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan", 
            "Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., 32224, Jacksonville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kasanuki", 
        "givenName": "Koji", 
        "id": "sg:person.0732404355.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732404355.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan", 
            "Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iseki", 
        "givenName": "Eizo", 
        "id": "sg:person.01365445524.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365445524.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan", 
            "Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ota", 
        "givenName": "Kazumi", 
        "id": "sg:person.0730151044.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730151044.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Daizo", 
        "id": "sg:person.01057207634.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057207634.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichimiya", 
        "givenName": "Yosuke", 
        "id": "sg:person.01163057754.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163057754.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Kiyoshi", 
        "id": "sg:person.01136622426.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136622426.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Juntendo University", 
          "id": "https://www.grid.ac/institutes/grid.258269.2", 
          "name": [
            "Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "Heii", 
        "id": "sg:person.01315267046.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315267046.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mds.20844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001614000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006074726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006074726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02988523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006369608", 
          "https://doi.org/10.1007/bf02988523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02988523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006369608", 
          "https://doi.org/10.1007/bf02988523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.114025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006616276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000339363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008724972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.214.1.r00ja43227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011831088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2013-002642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012950958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.05115.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014599944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.05115.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014599944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015460770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2006.111666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018667946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.55.10.967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024417247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jns.2013.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025999083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1212-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026061446", 
          "https://doi.org/10.1007/s00259-009-1212-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1212-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026061446", 
          "https://doi.org/10.1007/s00259-009-1212-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1212-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026061446", 
          "https://doi.org/10.1007/s00259-009-1212-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gps.2346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gps.2346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.21710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031756111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031911840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91006-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033112327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91006-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033112327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.111.089946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033389106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.62.2.133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034125453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.parkreldis.2011.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036073060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gps.2836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037902402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1479-8301.2010.00325.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039061236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1479-8301.2010.00325.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039061236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0155-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039858530", 
          "https://doi.org/10.1007/s00259-006-0155-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0155-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039858530", 
          "https://doi.org/10.1007/s00259-006-0155-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2006.110122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00234-016-1644-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043939600", 
          "https://doi.org/10.1007/s00234-016-1644-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0146-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046126697", 
          "https://doi.org/10.1007/s00401-006-0146-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0146-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046126697", 
          "https://doi.org/10.1007/s00401-006-0146-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.287.13.1653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049579881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2004.01388.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049862084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052350302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rlu.0000000000000602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052765377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rlu.0000000000000602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052765377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000187889.17253.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077911924", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082509074", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03", 
    "datePublishedReg": "2017-03-01", 
    "description": "PURPOSE: Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the 123I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance.\nMETHODS: We enrolled subjects into a prodromal DLB group (PRD-DLB) (n\u2009=\u200920) and clinical DLB group (CLIN-DLB) (n\u2009=\u200918) and compared these groups with an Alzheimer's disease control group (AD) (n\u2009=\u200910). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in 18F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of 123I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups.\nRESULTS: Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB.\nCONCLUSION: 123I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00259-016-3466-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "123I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies", 
    "pagination": "358-365", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4c87fbfb32897ddd841faf8810e896bfa2c9de5af09538d3fee69f6609dc4368"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27480759"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101140988"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00259-016-3466-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016061809"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00259-016-3466-6", 
      "https://app.dimensions.ai/details/publication/pub.1016061809"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87104_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00259-016-3466-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3466-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3466-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3466-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-016-3466-6'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      74 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00259-016-3466-6 schema:about N02881b6c156945e8b8bef705bacd28e6
2 N777727d1557144e1af29bb2660f44650
3 N875a90db81334ed3a7bfb41a22cf587d
4 N941048ed322b47ea8db93e4fdd7e6f24
5 N9753f40754034d1aa4eb198401086c85
6 Na82686b37a264ba7984ba8c11007993e
7 Nabf80dae57cc4e5b8b078db08cb28af7
8 Nbdc1f0658ce84d6b9eb6344a2e4d593a
9 Ndc0659455b1045f39d6b8f423dfa21e0
10 Ne14a0a29f8a04043ac33dbde7a30c8f9
11 Nfe3e0b43c1aa407fb142e1ddc73f08d8
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author Nbcb3c2cdc20c49cb9779d4c3a6ed1838
15 schema:citation sg:pub.10.1007/bf02988523
16 sg:pub.10.1007/s00234-016-1644-7
17 sg:pub.10.1007/s00259-006-0155-x
18 sg:pub.10.1007/s00259-009-1212-z
19 sg:pub.10.1007/s00401-006-0146-9
20 https://app.dimensions.ai/details/publication/pub.1077911924
21 https://app.dimensions.ai/details/publication/pub.1082509074
22 https://doi.org/10.1001/jama.287.13.1653
23 https://doi.org/10.1002/gps.2346
24 https://doi.org/10.1002/gps.2836
25 https://doi.org/10.1002/mds.20844
26 https://doi.org/10.1002/mds.21710
27 https://doi.org/10.1002/mds.22158
28 https://doi.org/10.1002/mds.22702
29 https://doi.org/10.1016/0140-6736(90)91006-v
30 https://doi.org/10.1016/j.jalz.2011.03.005
31 https://doi.org/10.1016/j.jns.2013.07.013
32 https://doi.org/10.1016/j.parkreldis.2011.09.015
33 https://doi.org/10.1016/s0197-4580(02)00065-9
34 https://doi.org/10.1093/brain/awh445
35 https://doi.org/10.1097/rlu.0000000000000602
36 https://doi.org/10.1111/j.1365-2796.2004.01388.x
37 https://doi.org/10.1111/j.1479-8301.2010.00325.x
38 https://doi.org/10.1111/j.1749-6632.2009.05115.x
39 https://doi.org/10.1136/bmjopen-2013-002642
40 https://doi.org/10.1136/jnnp.2006.110122
41 https://doi.org/10.1136/jnnp.2006.111666
42 https://doi.org/10.1136/jnnp.55.10.967
43 https://doi.org/10.1136/jnnp.62.2.133
44 https://doi.org/10.1148/radiology.214.1.r00ja43227
45 https://doi.org/10.1159/000339363
46 https://doi.org/10.1212/01.wnl.0000187889.17253.b1
47 https://doi.org/10.2967/jnumed.111.089946
48 https://doi.org/10.2967/jnumed.112.114025
49 schema:datePublished 2017-03
50 schema:datePublishedReg 2017-03-01
51 schema:description PURPOSE: Evidence for the prodromal stage of dementia with Lewy bodies (DLB) is very limited. To address this issue, we investigate the 123I-FP-CIT SPECT measure of dopamine transporter binding finding and its clinical relevance. METHODS: We enrolled subjects into a prodromal DLB group (PRD-DLB) (n = 20) and clinical DLB group (CLIN-DLB) (n = 18) and compared these groups with an Alzheimer's disease control group (AD) (n = 10). PRD-DLB was defined as patients having the non-motor symptoms associated with Lewy body disease (LBD) [i.e. REM sleep behavior disorder (RBD), olfactory dysfunction, autonomic dysfunction, and depression] and showing characteristic diffuse occipital hypometabolism in 18F-FDG PET. CLIN-DLB was defined as patients fulfilling the established criteria of probable DLB. Striatal specific binding ratio (SBR) of 123I-FP-CIT SPECT was used for objective group comparisons. The correlations between SBR and cognitive function (MMSE), motor symptoms (UPDRS3), and duration of LBD-associated non-motor symptoms were compared between the two DLB groups. RESULTS: Mean SBR scores of both PRD-DLB and CLIN-DLB were significantly lower than those of AD. No correlation was found between SBR and MMSE scores. Both in the CLIN-DLB and total DLB groups, SBR scores were negatively correlated with UPDRS3 scores, whereas no correlation was found in PRD-DLB. Among the LBD-related non-motor symptoms, duration of olfactory dysfunction, and RBD demonstrated negative correlation with SBR scores in PRD-DLB. CONCLUSION: 123I-FP-CIT SPECT may play a role for detecting DLB among the subjects in prodromal stage. During this stage, long-term olfactory dysfunction and/or RBD may indicate more severe degeneration of the nigro-striatal dopaminergic pathway.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N2c76b81d973c4622ad6e76947d29fbfa
56 N91098baab496431c88f0a70a64d6b2b3
57 sg:journal.1297401
58 schema:name 123I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies
59 schema:pagination 358-365
60 schema:productId N1a2d5699b84e4c2884df7f8875618422
61 N426b174981554f2384c6d3c933feb442
62 N6ea9ebbca9b7411bb6bd7f9c8d4670ca
63 Ncb35ec0cd2b54d6898c2e55def0da7f5
64 Ne426ab3c8e2e40fc831c9f2f1e7b8f12
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016061809
66 https://doi.org/10.1007/s00259-016-3466-6
67 schema:sdDatePublished 2019-04-11T12:25
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N90cf5f5022954a6f88a5247cc21f5a72
70 schema:url https://link.springer.com/10.1007%2Fs00259-016-3466-6
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N02881b6c156945e8b8bef705bacd28e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Lewy Body Disease
76 rdf:type schema:DefinedTerm
77 N1a2d5699b84e4c2884df7f8875618422 schema:name dimensions_id
78 schema:value pub.1016061809
79 rdf:type schema:PropertyValue
80 N2c76b81d973c4622ad6e76947d29fbfa schema:issueNumber 3
81 rdf:type schema:PublicationIssue
82 N426b174981554f2384c6d3c933feb442 schema:name readcube_id
83 schema:value 4c87fbfb32897ddd841faf8810e896bfa2c9de5af09538d3fee69f6609dc4368
84 rdf:type schema:PropertyValue
85 N4d90d8fd833c493d83ab5b8dfa158c54 rdf:first sg:person.01136622426.60
86 rdf:rest Nc48292540b284297aac59b1c81ab7c42
87 N6ea9ebbca9b7411bb6bd7f9c8d4670ca schema:name nlm_unique_id
88 schema:value 101140988
89 rdf:type schema:PropertyValue
90 N777727d1557144e1af29bb2660f44650 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Movement
92 rdf:type schema:DefinedTerm
93 N875a90db81334ed3a7bfb41a22cf587d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Male
95 rdf:type schema:DefinedTerm
96 N90cf5f5022954a6f88a5247cc21f5a72 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N91098baab496431c88f0a70a64d6b2b3 schema:volumeNumber 44
99 rdf:type schema:PublicationVolume
100 N9274e00aea6d4e6798decacd0128c8e8 rdf:first sg:person.0730151044.07
101 rdf:rest Nad9ca97d56d941cc8729f83da3d0f7ce
102 N941048ed322b47ea8db93e4fdd7e6f24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Sleep
104 rdf:type schema:DefinedTerm
105 N9753f40754034d1aa4eb198401086c85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N98d71458de7549aba91d0b683e85ec2a rdf:first sg:person.01365445524.58
109 rdf:rest N9274e00aea6d4e6798decacd0128c8e8
110 Na82686b37a264ba7984ba8c11007993e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Tomography, Emission-Computed, Single-Photon
112 rdf:type schema:DefinedTerm
113 Nabf80dae57cc4e5b8b078db08cb28af7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Radiopharmaceuticals
115 rdf:type schema:DefinedTerm
116 Nad9ca97d56d941cc8729f83da3d0f7ce rdf:first sg:person.01057207634.31
117 rdf:rest Ndb37b3c5a3014d80a97def3c6a267b9a
118 Nbcb3c2cdc20c49cb9779d4c3a6ed1838 rdf:first sg:person.0732404355.32
119 rdf:rest N98d71458de7549aba91d0b683e85ec2a
120 Nbdc1f0658ce84d6b9eb6344a2e4d593a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Aged
122 rdf:type schema:DefinedTerm
123 Nc48292540b284297aac59b1c81ab7c42 rdf:first sg:person.01315267046.08
124 rdf:rest rdf:nil
125 Ncb35ec0cd2b54d6898c2e55def0da7f5 schema:name pubmed_id
126 schema:value 27480759
127 rdf:type schema:PropertyValue
128 Ndb37b3c5a3014d80a97def3c6a267b9a rdf:first sg:person.01163057754.61
129 rdf:rest N4d90d8fd833c493d83ab5b8dfa158c54
130 Ndc0659455b1045f39d6b8f423dfa21e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Tropanes
132 rdf:type schema:DefinedTerm
133 Ne14a0a29f8a04043ac33dbde7a30c8f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cognition
135 rdf:type schema:DefinedTerm
136 Ne426ab3c8e2e40fc831c9f2f1e7b8f12 schema:name doi
137 schema:value 10.1007/s00259-016-3466-6
138 rdf:type schema:PropertyValue
139 Nfe3e0b43c1aa407fb142e1ddc73f08d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
146 schema:name Clinical Sciences
147 rdf:type schema:DefinedTerm
148 sg:journal.1297401 schema:issn 1619-7070
149 1619-7089
150 schema:name European Journal of Nuclear Medicine and Molecular Imaging
151 rdf:type schema:Periodical
152 sg:person.01057207634.31 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
153 schema:familyName Kondo
154 schema:givenName Daizo
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057207634.31
156 rdf:type schema:Person
157 sg:person.01136622426.60 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
158 schema:familyName Sato
159 schema:givenName Kiyoshi
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136622426.60
161 rdf:type schema:Person
162 sg:person.01163057754.61 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
163 schema:familyName Ichimiya
164 schema:givenName Yosuke
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163057754.61
166 rdf:type schema:Person
167 sg:person.01315267046.08 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
168 schema:familyName Arai
169 schema:givenName Heii
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315267046.08
171 rdf:type schema:Person
172 sg:person.01365445524.58 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
173 schema:familyName Iseki
174 schema:givenName Eizo
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365445524.58
176 rdf:type schema:Person
177 sg:person.0730151044.07 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
178 schema:familyName Ota
179 schema:givenName Kazumi
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730151044.07
181 rdf:type schema:Person
182 sg:person.0732404355.32 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
183 schema:familyName Kasanuki
184 schema:givenName Koji
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732404355.32
186 rdf:type schema:Person
187 sg:pub.10.1007/bf02988523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006369608
188 https://doi.org/10.1007/bf02988523
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s00234-016-1644-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043939600
191 https://doi.org/10.1007/s00234-016-1644-7
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00259-006-0155-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039858530
194 https://doi.org/10.1007/s00259-006-0155-x
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s00259-009-1212-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1026061446
197 https://doi.org/10.1007/s00259-009-1212-z
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s00401-006-0146-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046126697
200 https://doi.org/10.1007/s00401-006-0146-9
201 rdf:type schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1077911924 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1082509074 schema:CreativeWork
204 https://doi.org/10.1001/jama.287.13.1653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049579881
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/gps.2346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030503610
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/gps.2836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037902402
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1002/mds.20844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001614000
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/mds.21710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031756111
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/mds.22158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052350302
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/mds.22702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006074726
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0140-6736(90)91006-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1033112327
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.jalz.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015460770
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.jns.2013.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025999083
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.parkreldis.2011.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036073060
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0197-4580(02)00065-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016528708
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1093/brain/awh445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031911840
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1097/rlu.0000000000000602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765377
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1365-2796.2004.01388.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049862084
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1479-8301.2010.00325.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039061236
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1749-6632.2009.05115.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014599944
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1136/bmjopen-2013-002642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012950958
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1136/jnnp.2006.110122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043068365
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1136/jnnp.2006.111666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018667946
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1136/jnnp.55.10.967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024417247
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1136/jnnp.62.2.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034125453
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1148/radiology.214.1.r00ja43227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831088
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1159/000339363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008724972
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1212/01.wnl.0000187889.17253.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347654
253 rdf:type schema:CreativeWork
254 https://doi.org/10.2967/jnumed.111.089946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033389106
255 rdf:type schema:CreativeWork
256 https://doi.org/10.2967/jnumed.112.114025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006616276
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.258269.2 schema:alternateName Juntendo University
259 schema:name Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan
260 PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan
261 rdf:type schema:Organization
262 https://www.grid.ac/institutes/grid.417467.7 schema:alternateName Mayo Clinic
263 schema:name Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., 32224, Jacksonville, FL, USA
264 Department of Psychiatry, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan
265 PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, 136-0075, Tokyo, Japan
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...