Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Giuseppe Rengo, Gennaro Pagano, Dino Franco Vitale, Roberto Formisano, Klara Komici, Laura Petraglia, Valentina Parisi, Grazia Daniela Femminella, Claudio de Lucia, Stefania Paolillo, Alessandro Cannavo, Emilio Attena, Teresa Pellegrino, Santo Dellegrottaglie, Alessia Memmi, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone Filardi, Dario Leosco, Nicola Ferrara

ABSTRACT

PURPOSE: Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. Importantly, SNS hyperactivity characterizes also physiological ageing, and there is conflicting evidence on cardiac 123I-mIBG uptake in healthy elderly subjects compared to adults. However, little data are available on the impact of ageing on cardiac sympathetic nerve activity assessed by 123I-mIBG scintigraphy, in patients with HF. METHODS AND RESULTS: We studied 180 HF patients (age = 66.1 ± 10.5 years [yrs]), left ventricular ejection fraction (LVEF = 30.6 ± 6.3 %) undergoing cardiac 123I-mIBG imaging. Early and late heart to mediastinum (H/M) ratios and washout rate were calculated in all patients. Demographic, clinical, and echocardiographic data were also collected. Our study population consisted of 53 patients aged >75 years (age = 77.7 ± 4.0 year), 67 patients aged 62-72 years (age = 67.9 ± 3.2 years) and 60 patients aged ≤61 year (age = 53.9 ± 5.6 years). In elderly patients, both early and late H/M ratios were significantly lower compared to younger patients (p < 0.05). By multivariate analysis, H/M ratios (both early and late) and washout rate were significantly correlated with LVEF and age. CONCLUSIONS: Our data indicate that, in a population of HF patients, there is an independent age-related effect on cardiac SNS innervation assessed by 123I-mIBG imaging. This finding suggests that cardiac 123I-mIBG uptake in patients with HF might be affected by patient age. More... »

PAGES

2392-2400

References to SciGraph publications

  • 1995-03. Myocardial iodine-labeled metaiodobenzylguanidine 123 uptake relates to age in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2008-01. Age-related decrease in cardiopulmonary adrenergic neuronal function in children as assessed by I-123 metaiodobenzylguanidine imaging in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2014-09. A prediction model for 5-year cardiac mortality in patients with chronic heart failure using 123I-metaiodobenzylguanidine imaging in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013-03. Decomposition procedures for distributional analysis: a unified framework based on the Shapley value in THE JOURNAL OF ECONOMIC INEQUALITY
  • 2008-12. Dyslipidemia in primary care – prevalence, recognition, treatment and control: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS) in CARDIOVASCULAR DIABETOLOGY
  • 2006-03. Optimized acquisition and processing protocols for I-123 cardiac SPECT imaging in JOURNAL OF NUCLEAR CARDIOLOGY
  • 1976-05. Plasma noradrenaline increases with age in NATURE
  • 2013-06. Impact of age on myocardial uptake of 123I-mIBG in older adult subjects without coronary heart disease in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2013-10. Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2007-06. Neuronal imaging using SPECT in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-08. Future G protein-coupled receptor targets for treatment of heart failure in CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-016-3432-3

    DOI

    http://dx.doi.org/10.1007/s00259-016-3432-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002558431

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27287990


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