Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus View Full Text


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Article Info

DATE

2016-09

AUTHORS

Mueez u Din, Juho Raiko, Teemu Saari, Nobu Kudomi, Tuula Tolvanen, Vesa Oikonen, Jarmo Teuho, Hannu T Sipilä, Nina Savisto, Riitta Parkkola, Pirjo Nuutila, Kirsi A. Virtanen

ABSTRACT

PURPOSE: Brown adipose tissue (BAT) is considered a potential target for combatting obesity, as it produces heat instead of ATP in cellular respiration due to uncoupling protein-1 (UCP-1) in mitochondria. However, BAT-specific thermogenic capacity, in comparison to whole-body thermogenesis during cold stimulus, is still controversial. In our present study, we aimed to determine human BAT oxygen consumption with [(15)O]O2 positron emission tomography (PET) imaging. Further, we explored whether BAT-specific energy expenditure (EE) is associated with BAT blood flow, non-esterified fatty acid (NEFA) uptake, and whole-body EE. METHODS: Seven healthy study subjects were studied at two different scanning sessions, 1) at room temperature (RT) and 2) with acute cold exposure. Radiotracers [(15)O]O2, [(15)O]H2O, and [(18)F]FTHA were given for the measurements of BAT oxygen consumption, blood flow, and NEFA uptake, respectively, with PET-CT. Indirect calorimetry was performed to assess differences in whole-body EE between RT and cold. RESULTS: BAT-specific EE and oxygen consumption was higher during cold stimulus (approx. 50 %); similarly, whole-body EE was higher during cold stimulus (range 2-47 %). However, there was no association in BAT-specific EE and whole-body EE. BAT-specific EE was found to be a minor contributor in cold induced whole-body thermogenesis (almost 1 % of total whole-body elevation in EE). Certain deep muscles in the cervico-thoracic region made a major contribution to this cold-induced thermogenesis (CIT) without any visual signs or individual perception of shivering. Moreover, BAT-specific EE associated with BAT blood flow and NEFA uptake both at RT and during cold stimulus. CONCLUSION: Our study suggests that BAT is a minor and deep muscles are a major contributor to CIT. In BAT, both in RT and during cold, cellular respiration is linked with circulatory NEFA uptake. More... »

PAGES

1878-1886

References to SciGraph publications

  • 2001-05. Carbon-11 acetate as a tracer of myocardial oxygen consumption in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1987-09. Metabolic monitor in INTERNATIONAL JOURNAL OF CLINICAL MONITORING AND COMPUTING
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    http://scigraph.springernature.com/pub.10.1007/s00259-016-3364-y

    DOI

    http://dx.doi.org/10.1007/s00259-016-3364-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005983033

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26993316


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    RDF/XML is a standard XML format for linked data.

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