18F-DOPA PET/CT in the diagnosis and localization of persistent medullary thyroid carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06

AUTHORS

Aurélien Archier, Céline Heimburger, Carole Guerin, Isabelle Morange, Fausto F Palazzo, Jean-François Henry, Olivier Schneegans, Olivier Mundler, Ahmad Esmaeel Abdullah, Frédéric Sebag, Alessio Imperiale, David Taïeb

ABSTRACT

PURPOSE: To evaluate the performance of (18)F-L-dihydroxyphenylalanine ((18)F-DOPA) PET/CT in the detection of locoregional and distant medullary thyroid carcinoma (MTC) metastases and to compare imaging findings with histological data. METHODS: We retrospectively evaluated 86 MTC patients with persistently high serum calcitonin levels after initial surgery who had undergone (18)F-DOPA PET/CT between January 2007 and December 2014 in two referral centres. They were followed up for at least 6 months after the PET/CT assessment. The results were compared with histological data or with the findings obtained during follow-up using a complementary imaging modality. RESULTS: (18)F-DOPA PET/CT was positive in 65 of the 86 patients, corresponding to a patient-based sensitivity of 75.6 %. Distant metastatic disease (M1) was seen in 29 patients including 11 with previously unknown metastases revealed only by PET/CT. Among the 36 patients without distant metastatic spread, 25 had nodal involvement limited to the neck, and 10 of these 25 patients underwent reoperation. The lymph node compartment-based sensitivity of (18)F-DOPA PET/CT was 100 % in the two institutions but lesion-based sensitivity was only 24 %. Preoperative and postoperative median calcitonin levels were 405 pg/mL (range 128 - 1,960 pg/mL) and 259 pg/mL (range 33 - 1,516 pg/mL), respectively. None of the patients achieved normalization of serum calcitonin after reoperation. CONCLUSION: (18)F-DOPA PET/CT enables early diagnosis of a significant number of patients with distant metastasis. It has a limited sensitivity in the detection of residual disease but provides high performance for regional analysis. A surgical compartment-oriented approach could be the approach of choice whatever the number of nodes revealed by (18)F-DOPA PET/CT. More... »

PAGES

1027-1033

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-015-3227-y

DOI

http://dx.doi.org/10.1007/s00259-015-3227-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015069434

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26497699


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305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
307 schema:name Department of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, Marseille, France
308 European Center for Research in Medical Imaging, Aix-Marseille University, Marseille, France
309 rdf:type schema:Organization
 




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