MR-based attenuation correction for cardiac FDG PET on a hybrid PET/MRI scanner: comparison with standard CT attenuation correction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Jan Vontobel, Riccardo Liga, Mathias Possner, Olivier F. Clerc, Fran Mikulicic, Patrick Veit-Haibach, Edwin E. G. W. ter Voert, Tobias A. Fuchs, Julia Stehli, Aju P. Pazhenkottil, Dominik C. Benz, Christoph Gräni, Oliver Gaemperli, Bernhard Herzog, Ronny R. Buechel, Philipp A. Kaufmann

ABSTRACT

PURPOSE: The aim of this study was to evaluate the feasibility of attenuation correction (AC) for cardiac (18)F-labelled fluorodeoxyglucose (FDG) positron emission tomography (PET) using MR-based attenuation maps. METHODS: We included 23 patients with no known cardiac history undergoing whole-body FDG PET/CT imaging for oncological indications on a PET/CT scanner using time-of-flight (TOF) and subsequent whole-body PET/MR imaging on an investigational hybrid PET/MRI scanner. Data sets from PET/MRI (with and without TOF) were reconstructed using MR AC and semi-quantitative segmental (20-segment model) myocardial tracer uptake (per cent of maximum) and compared to PET/CT which was reconstructed using CT AC and served as standard of reference. RESULTS: Excellent correlations were found for regional uptake values between PET/CT and PET/MRI with TOF (n = 460 segments in 23 patients; r = 0.913; p < 0.0001) with narrow Bland-Altman limits of agreement (-8.5 to +12.6 %). Correlation coefficients were slightly lower between PET/CT and PET/MRI without TOF (n = 460 segments in 23 patients; r = 0.851; p < 0.0001) with broader Bland-Altman limits of agreement (-12.5 to +15.0 %). PET/MRI with and without TOF showed minimal underestimation of tracer uptake (-2.08 and -1.29 %, respectively), compared to PET/CT. CONCLUSION: Relative myocardial FDG uptake obtained from MR-based attenuation corrected FDG PET is highly comparable to standard CT-based attenuation corrected FDG PET, suggesting interchangeability of both AC techniques. More... »

PAGES

1574-1580

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-015-3089-3

DOI

http://dx.doi.org/10.1007/s00259-015-3089-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050739103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26091704


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