Correlation of breast cancer subtypes, based on estrogen receptor, progesterone receptor, and HER2, with functional imaging parameters from 68Ga-RGD PET/CT ... View Full Text


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Article Info

DATE

2014-03-21

AUTHORS

Hai-Jeon Yoon, Keon Wook Kang, In Kook Chun, Nariya Cho, Seock-Ah Im, Sunjoo Jeong, Song Lee, Kyeong Cheon Jung, Yun-Sang Lee, Jae Min Jeong, Dong Soo Lee, June-Key Chung, Woo Kyung Moon

ABSTRACT

PurposeImaging biomarkers from functional imaging modalities were assessed as potential surrogate markers of disease status. Specifically, in this prospective study, we investigated the relationships between functional imaging parameters and histological prognostic factors and breast cancer subtypes.MethodsIn total, 43 patients with large or locally advanced invasive ductal carcinoma (IDC) were analyzed (47.6 ± 7.5 years old). 68Ga-Labeled arginine-glycine-aspartic acid (RGD) and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were performed. The maximum and average standardized uptake values (SUVmax and SUVavg) from RGD PET/CT and SUVmax and SUVavg from FDG PET/CT were the imaging parameters used. For histological prognostic factors, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression was identified using immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH). Four breast cancer subtypes, based on ER/PR and HER2 expression (ER/PR+,Her2−, ER/PR+,Her2+, ER/PR−,Her2+, and ER/PR−,Her2−), were considered.ResultsQuantitative FDG PET parameters were significantly higher in the ER-negative group (15.88 ± 8.73 vs 10.48 ± 6.01, p = 0.02 for SUVmax; 9.40 ± 5.19 vs 5.92 ± 4.09, p = 0.02 for SUVavg) and the PR-negative group (8.37 ± 4.94 vs 4.79 ± 3.93, p = 0.03 for SUVavg). Quantitative RGD PET parameters were significantly higher in the HER2-positive group (2.42 ± 0.59 vs 2.90 ± 0.75, p = 0.04 for SUVmax; 1.60 ± 0.38 vs 1.95 ± 0.53, p = 0.04 for SUVavg) and showed a significant positive correlation with the HER2/CEP17 ratio (r = 0.38, p = 0.03 for SUVmax and r = 0.46, p < 0.01 for SUVavg). FDG PET parameters showed significantly higher values in the ER/PR−,Her2− subgroup versus the ER/PR+,Her2− or ER/PR+,Her2+ subgroups, while RGD PET parameters showed significantly lower values in the ER/PR−,Her2− subgroup versus the other subgroups. There was no correlation between FDG and RGD PET parameters in the overall group. Only the ER/PR−,Her2− subgroup showed a significant positive correlation between FDG and RGD PET parameters (r = 0.59, p = 0.03 for SUVmax).Conclusion68Ga-RGD and 18F-FDG PET/CT are promising functional imaging modalities for predicting biomarkers and molecular phenotypes in breast cancer patients. More... »

PAGES

1534-1543

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-014-2744-4

DOI

http://dx.doi.org/10.1007/s00259-014-2744-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002202136

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24652232


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