FDG PET during radiochemotherapy is predictive of outcome at 1 year in non-small-cell lung cancer patients: a prospective multicentre study ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-02-22

AUTHORS

Pierre Vera, Sandrine Mezzani-Saillard, Agathe Edet-Sanson, Jean-François Ménard, Romain Modzelewski, Sebastien Thureau, Marc-Etienne Meyer, Khadija Jalali, Stéphane Bardet, Delphine Lerouge, Claire Houzard, Françoise Mornex, Pierre Olivier, Guillaume Faure, Caroline Rousseau, Marc-André Mahé, Philippe Gomez, Isabelle Brenot-Rossi, Naji Salem, Bernard Dubray

ABSTRACT

PurposeTo assess prospectively the prognostic value of FDG PET/CT during curative-intent radiotherapy (RT) with or without concomitant chemotherapy in patients with non-small-cell lung cancer (NSCLC).MethodsPatients with histological proof of invasive localized NSCLC and evaluable tumour, and who were candidates for curative-intent radiochemotherapy (RCT) or RT were preincluded after providing written informed consent. Definitive inclusion was conditional upon significant FDG uptake before RT (PET1). All included patients had a FDG PET/CT scan during RT (PET2, mean dose 43 Gy) and were evaluated by FDG PET/CT at 3 months and 1 year after RT. The main endpoint was death (from whatever cause) or tumour progression at 1 year.ResultsOf 77 patients preincluded, 52 were evaluable. Among the evaluable patients, 77 % received RT with induction chemotherapy and 73 % RT with concomitant chemotherapy. At 1 year, 40 patients (77 %) had died or had tumour progression. No statistically significant association was found between stage (IIIB vs. other), histology (squamous cell carcinoma vs. other), induction or concomitant chemotherapy, and death/tumour progression at 1 year. The SUVmax in the PET2 scan was the single variable predictive of death or tumour progression at 1 year (odds ratio 1.97, 95 % CI 1.25 – 3.09, p = 0.003) in multivariate analysis. The area under the receiver operating characteristic curve was 0.85 (95 % CI 0.73 – 0.94, p < 10−4). A SUVmax value of 5.3 in the PET2 scan yielded a sensitivity of 70 % and a specificity of 92 % for predicting tumour progression or death at 1 year.ConclusionThis prospective multicentre study demonstrated the prognostic value in terms of disease-free survival of SUVmax assessed during the 5th week of curative-intent RT or RCT in NSCLC patients (NCT01261598; RTEP2 study). More... »

PAGES

1057-1065

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-014-2687-9

DOI

http://dx.doi.org/10.1007/s00259-014-2687-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026824663

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24562641


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    "description": "PurposeTo assess prospectively the prognostic value of FDG PET/CT during curative-intent radiotherapy (RT) with or without concomitant chemotherapy in patients with non-small-cell lung cancer (NSCLC).MethodsPatients with histological proof of invasive localized NSCLC and evaluable tumour, and who were candidates for curative-intent radiochemotherapy (RCT) or RT were preincluded after providing written informed consent. Definitive inclusion was conditional upon significant FDG uptake before RT (PET1). All included patients had a FDG PET/CT scan during RT (PET2, mean dose 43\u00a0Gy) and were evaluated by FDG PET/CT at 3\u00a0months and 1\u00a0year after RT. The main endpoint was death (from whatever cause) or tumour progression at 1\u00a0year.ResultsOf 77 patients preincluded, 52 were evaluable. Among the evaluable patients, 77\u00a0% received RT with induction chemotherapy and 73\u00a0% RT with concomitant chemotherapy. At 1\u00a0year, 40 patients (77\u00a0%) had died or had tumour progression. No statistically significant association was found between stage (IIIB vs. other), histology (squamous cell carcinoma vs. other), induction or concomitant chemotherapy, and death/tumour progression at 1\u00a0year. The SUVmax in the PET2 scan was the single variable predictive of death or tumour progression at 1\u00a0year (odds ratio 1.97, 95\u00a0% CI 1.25\u00a0\u2013\u00a03.09, p\u2009=\u20090.003) in multivariate analysis. The area under the receiver operating characteristic curve was 0.85 (95\u00a0% CI 0.73\u00a0\u2013\u00a00.94, p\u2009<\u200910\u22124). A SUVmax value of 5.3 in the PET2 scan yielded a sensitivity of 70\u00a0% and a specificity of 92\u00a0% for predicting tumour progression or death at 1\u00a0year.ConclusionThis prospective multicentre study demonstrated the prognostic value in terms of disease-free survival of SUVmax assessed during the 5th week of curative-intent RT or RCT in NSCLC patients (NCT01261598; RTEP2 study).", 
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365 grid-institutes:grid.410527.5 schema:alternateName Department of Nuclear Medicine, Brabois University Hospital, Nancy, France
366 schema:name Department of Nuclear Medicine, Brabois University Hospital, Nancy, France
367 rdf:type schema:Organization
368 grid-institutes:grid.413852.9 schema:alternateName Department of Nuclear Medicine, Hospices Civils de Lyon, Lyon, France
369 Department of Radiation Oncology, Hospices Civils de Lyon, Lyon, France
370 schema:name Department of Nuclear Medicine, Hospices Civils de Lyon, Lyon, France
371 Department of Radiation Oncology, Hospices Civils de Lyon, Lyon, France
372 rdf:type schema:Organization
373 grid-institutes:grid.41724.34 schema:alternateName Department of Nuclear Medicine, Henri Becquerel Cancer Center, Henri Becquerel Center & QuantIF - Litis [EA (Equipe d’Accueil) 4108] & Rouen University Hospital, Rouen, France
374 Department of Radiation Oncology and Medical Physics, Henri Becquerel Cancer Center, Henri Becquerel Center & QuantIF - Litis [EA (Equipe d’Accueil) 4108] & Rouen University Hospital, Rouen, France
375 schema:name Department of Nuclear Medicine, Henri Becquerel Cancer Center, Henri Becquerel Center & QuantIF - Litis [EA (Equipe d’Accueil) 4108] & Rouen University Hospital, Rouen, France
376 Department of Radiation Oncology and Medical Physics, Henri Becquerel Cancer Center, Henri Becquerel Center & QuantIF - Litis [EA (Equipe d’Accueil) 4108] & Rouen University Hospital, Rouen, France
377 rdf:type schema:Organization
378 grid-institutes:grid.418443.e schema:alternateName Department of Nuclear Medicine, Institut Paoli Calmette, Marseille, France
379 Department of Radiation Oncology, Institut Paoli Calmette, Marseille, France
380 schema:name Department of Nuclear Medicine, Institut Paoli Calmette, Marseille, France
381 Department of Radiation Oncology, Institut Paoli Calmette, Marseille, France
382 rdf:type schema:Organization
 




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