Correlation of 18F-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the ... View Full Text


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Article Info

DATE

2012-11-15

AUTHORS

Anne Roivainen, Sannamari Hautaniemi, Timo Möttönen, Pirjo Nuutila, Vesa Oikonen, Riitta Parkkola, Luminita Pricop, Rudyard Ress, Nicholas Seneca, Marko Seppänen, Timo Yli-Kerttula

ABSTRACT

PurposeThis study evaluated the potential of functional imaging to monitor disease activity and response to treatment with disease-modifying antirheumatic drugs (DMARD) in DMARD-naive patients with early rheumatoid arthritis (RA).MethodsThe study involved 17 patients with active RA in whom combination therapy was initiated with methotrexate, sulfasalazine, hydroxychloroquine, and low-dose oral prednisolone. Clinical disease activity was assessed at screening, at baseline and after 2, 4, 8 and 12 weeks of therapy. 18F-FDG PET/CT of all joints was performed at baseline and after 2 and 4 weeks of therapy.Results18F-FDG maximum standardized uptake values showed a reduction of 22 ± 13 % in 76 % of patients from baseline to week 2 and a reduction of 29 ± 13 % in 81 % of patients from baseline to week 4. The percentage decrease in 18F-FDG uptake from baseline to week 2 correlated with clinical outcome, as measured by the disease activity score (DAS-28) at week 12. In addition, changes in C-reactive protein levels and erythrocyte sedimentation rate were positively associated with changes shown by PET.Conclusion18F-FDG PET/CT findings after 2 and 4 weeks of triple combination oral DMARD therapy correlated with treatment efficacy and clinical outcome in patients with early RA. 18F-FDG PET/CT may help predict the therapeutic response to novel drug treatments. More... »

PAGES

403-410

References to SciGraph publications

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  • 2011-01-06. Measuring response to therapy using FDG PET: semi-quantitative and full kinetic analysis in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-012-2282-x

    DOI

    http://dx.doi.org/10.1007/s00259-012-2282-x

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    PUBMED

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    39 Disease Activity Score
    40 MethodsThe study
    41 PET
    42 PET/CT
    43 PET/CT findings
    44 PurposeThis study
    45 Results18F-FDG maximum standardized uptake values
    46 active rheumatoid arthritis
    47 activity
    48 activity score
    49 addition
    50 antirheumatic drugs
    51 arthritis
    52 baseline
    53 changes
    54 clinical disease activity
    55 clinical outcomes
    56 combination oral DMARD therapy
    57 combination therapy
    58 correlation
    59 decrease
    60 disease activity
    61 disease-modifying antirheumatic drugs
    62 drug treatment
    63 drugs
    64 early rheumatoid arthritis
    65 efficacy
    66 erythrocyte sedimentation rate
    67 findings
    68 functional imaging
    69 hydroxychloroquine
    70 imaging
    71 inflammation
    72 initiation
    73 joints
    74 levels
    75 low-dose oral prednisolone
    76 markers
    77 markers of inflammation
    78 maximum standardized uptake value
    79 novel drug treatments
    80 oral DMARD therapy
    81 oral antirheumatic drugs
    82 oral prednisolone
    83 outcomes
    84 patients
    85 percentage decrease
    86 potential
    87 prednisolone
    88 protein levels
    89 rate
    90 reactive protein levels
    91 reduction
    92 response
    93 rheumatoid arthritis
    94 scores
    95 sedimentation rate
    96 standardized uptake value
    97 study
    98 sulfasalazine
    99 therapeutic response
    100 therapy
    101 treatment
    102 treatment efficacy
    103 triple combination oral DMARD therapy
    104 triple oral antirheumatic drugs
    105 uptake
    106 uptake value
    107 values
    108 week 12
    109 week 2
    110 week 4
    111 weeks
    112 weeks of therapy
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