Comparison of the myocardial blood flow response to regadenoson and dipyridamole: a quantitative analysis in patients referred for clinical 82Rb ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10

AUTHORS

Behnaz Goudarzi, Kenji Fukushima, Paco Bravo, Jennifer Merrill, Frank M. Bengel

ABSTRACT

BACKGROUND: Regadenoson is a novel selective A2A adenosine receptor agonist, which is administered as an intravenous bolus at a fixed dose. It is currently not clear if the absolute flow increase in response to this fixed dose is a function of distribution volume in individual patients or if it is generally comparable to the previous standard agents dipyridamole or adenosine, which are dosed based on weight. We used quantitative analysis of clinical 82Rb PET/CT studies to obtain further insights. METHODS: A total of 104 subjects with normal clinical rest/stress 82Rb perfusion PET/CT were included in a retrospective analysis. To rule out confounding factors, none had evidence of prior cardiac disease, ischaemia or infarction, cardiomyopathy, diabetes with insulin use, calcium score>400, renal disease or other significant systemic disease. A group of 52 patients stressed with regadenoson were compared with a group of 52 patients stressed with dipyridamole before regadenoson became available. The groups were matched for clinical characteristics, risk factors and baseline haemodynamics. Myocardial blood flow (MBF) and myocardial flow reserve (MFR) were quantified using a previously validated retention model, after resampling of dynamic studies from list-mode 82Rb datasets. RESULTS: At rest, heart rate, blood pressure and MBF were comparable between the groups. Regadenoson resulted in a significantly higher heart rate (34±14 vs. 23±10 beats per minute increase from baseline; p<0.01) and rate-pressure product. Patients in the regadenoson group reported less severe symptoms and required less aminophylline. Stress MBF and MFR were not different between the groups (2.2±0.6 vs. 2.1±0.6 ml/min/g, p=0.39, and 2.9±0.8 vs. 2.8±0.7, p=0.31, respectively). In the regadenoson group, there was no correlation between stress flow or MFR and body weight or BMI. CONCLUSION: Despite its administration at a fixed dose, regadenoson results in an absolute increase in MBF which is comparable to that following dipyridamole administration and is independent of patient distribution volume. This further supports its usefulness as a clinical stress agent. More... »

PAGES

1908-1916

References to SciGraph publications

  • 2008-05. Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: A randomized, double-blind, placebo-controlled trial in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2008-05. Safety of regadenoson, a selective adenosine A2A agonist, in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled trial (RegCOPD trial) in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2007-07. Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2007-09. Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: Results of the ADVANCE phase 3 multicenter international trial in JOURNAL OF NUCLEAR CARDIOLOGY
  • 1998-09. Reproducibility of polar map generation and assessment of defect severity and extent assessment in myocardial perfusion imaging using positron emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-04. Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: validation in a canine model of coronary artery stenosis in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2008-11. Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2006-01. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: Comparison with ECG-gated Tc-99m sestamibi SPECT in JOURNAL OF NUCLEAR CARDIOLOGY
  • 2008-02. CT-based attenuation correction in 82Rb-myocardial perfusion PET–CT: incidence of misalignment and effect on regional tracer distribution in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-011-1853-6

    DOI

    http://dx.doi.org/10.1007/s00259-011-1853-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044263928

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21656246


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronary Circulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dipyridamole", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemodynamics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Injections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardial Perfusion Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positron-Emission Tomography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Purinergic P1 Receptor Agonists", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Purines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyrazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rubidium Radioisotopes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stress, Physiological", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Johns Hopkins Medicine", 
              "id": "https://www.grid.ac/institutes/grid.469474.c", 
              "name": [
                "Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goudarzi", 
            "givenName": "Behnaz", 
            "id": "sg:person.0625272646.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625272646.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins Medicine", 
              "id": "https://www.grid.ac/institutes/grid.469474.c", 
              "name": [
                "Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukushima", 
            "givenName": "Kenji", 
            "id": "sg:person.01022150250.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022150250.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins Medicine", 
              "id": "https://www.grid.ac/institutes/grid.469474.c", 
              "name": [
                "Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bravo", 
            "givenName": "Paco", 
            "id": "sg:person.01326535277.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326535277.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins Medicine", 
              "id": "https://www.grid.ac/institutes/grid.469474.c", 
              "name": [
                "Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Merrill", 
            "givenName": "Jennifer", 
            "id": "sg:person.01067051554.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067051554.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hannover Medical School", 
              "id": "https://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA", 
                "Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bengel", 
            "givenName": "Frank M.", 
            "id": "sg:person.01225020511.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225020511.95"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00259-008-0972-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005274145", 
              "https://doi.org/10.1007/s00259-008-0972-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-008-0972-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005274145", 
              "https://doi.org/10.1007/s00259-008-0972-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.nuclcard.2007.02.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007288648", 
              "https://doi.org/10.1016/j.nuclcard.2007.02.016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcmg.2009.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008177112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2005.05.097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013126401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.629808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014870616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2009.04.089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015990916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.105.095323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017702331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.88.1.62", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019232396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-007-0607-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019732602", 
              "https://doi.org/10.1007/s00259-007-0607-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-007-0607-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019732602", 
              "https://doi.org/10.1007/s00259-007-0607-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcmg.2008.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021315962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0735-1097(94)90424-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025970600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2007.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026167186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590050301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027870105", 
              "https://doi.org/10.1007/s002590050301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.nuclcard.2008.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030937009", 
              "https://doi.org/10.1016/j.nuclcard.2008.02.013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2006.06.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032478234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.nuclcard.2007.06.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035693866", 
              "https://doi.org/10.1016/j.nuclcard.2007.06.114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03007355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037394649", 
              "https://doi.org/10.1007/bf03007355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03007355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037394649", 
              "https://doi.org/10.1007/bf03007355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2009.02.065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037812548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.nuclcard.2008.02.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037812905", 
              "https://doi.org/10.1016/j.nuclcard.2008.02.009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.109.073858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042456099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1995.03530110056036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044385109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.nuclcard.2005.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049290178", 
              "https://doi.org/10.1016/j.nuclcard.2005.12.004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.108.053819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051958757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.274.11.894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054158753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082979514", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-10", 
        "datePublishedReg": "2011-10-01", 
        "description": "BACKGROUND: Regadenoson is a novel selective A2A adenosine receptor agonist, which is administered as an intravenous bolus at a fixed dose. It is currently not clear if the absolute flow increase in response to this fixed dose is a function of distribution volume in individual patients or if it is generally comparable to the previous standard agents dipyridamole or adenosine, which are dosed based on weight. We used quantitative analysis of clinical 82Rb PET/CT studies to obtain further insights.\nMETHODS: A total of 104 subjects with normal clinical rest/stress 82Rb perfusion PET/CT were included in a retrospective analysis. To rule out confounding factors, none had evidence of prior cardiac disease, ischaemia or infarction, cardiomyopathy, diabetes with insulin use, calcium score>400, renal disease or other significant systemic disease. A group of 52 patients stressed with regadenoson were compared with a group of 52 patients stressed with dipyridamole before regadenoson became available. The groups were matched for clinical characteristics, risk factors and baseline haemodynamics. Myocardial blood flow (MBF) and myocardial flow reserve (MFR) were quantified using a previously validated retention model, after resampling of dynamic studies from list-mode 82Rb datasets.\nRESULTS: At rest, heart rate, blood pressure and MBF were comparable between the groups. Regadenoson resulted in a significantly higher heart rate (34\u00b114 vs. 23\u00b110 beats per minute increase from baseline; p<0.01) and rate-pressure product. Patients in the regadenoson group reported less severe symptoms and required less aminophylline. Stress MBF and MFR were not different between the groups (2.2\u00b10.6 vs. 2.1\u00b10.6 ml/min/g, p=0.39, and 2.9\u00b10.8 vs. 2.8\u00b10.7, p=0.31, respectively). In the regadenoson group, there was no correlation between stress flow or MFR and body weight or BMI.\nCONCLUSION: Despite its administration at a fixed dose, regadenoson results in an absolute increase in MBF which is comparable to that following dipyridamole administration and is independent of patient distribution volume. This further supports its usefulness as a clinical stress agent.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00259-011-1853-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1297401", 
            "issn": [
              "1619-7070", 
              "1619-7089"
            ], 
            "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "38"
          }
        ], 
        "name": "Comparison of the myocardial blood flow response to regadenoson and dipyridamole: a quantitative analysis in patients referred for clinical 82Rb myocardial perfusion PET", 
        "pagination": "1908-1916", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d2d8273c3863f2bf47fd6bda70ed6e2a9b476555a8752ec59581835f3aed2d75"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21656246"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101140988"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00259-011-1853-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044263928"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00259-011-1853-6", 
          "https://app.dimensions.ai/details/publication/pub.1044263928"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:21", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000515.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00259-011-1853-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-011-1853-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-011-1853-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-011-1853-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-011-1853-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    248 TRIPLES      21 PREDICATES      70 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00259-011-1853-6 schema:about N0e17f574888d4e3ca12e9c7398218dfe
    2 N242e2d75e32d4aef97b24abc4e2d510e
    3 N32b647614d4343ed8b9dfb128e6c833e
    4 N3359762030974f9585825a3f3b8b745f
    5 N4da6c0a7adc6449f9220259431494441
    6 N4e4131b232e349bbbdecfbf50d351428
    7 N53ecfc4f9ab44515aec3a634edad8a39
    8 N727b0d3308cb4ba7b994377a190d6ef9
    9 N72b114bccc6940229b67d2ef265966db
    10 N7bff444126b44ebda29a3b5e8b83b45f
    11 N9971af35f16449bba9c06b8cb9d7cb60
    12 Naeabe11d08254a41b57dbc00595e4780
    13 Nb51ab34f32604f38b4b3f9ca231a148e
    14 Nbbc940d8e083490e8efe02f486e99597
    15 Nc7e90cd8d9464b689dc2155d5fba8cea
    16 Nd69f31f558204fc8b9f8d2a78428c7ba
    17 anzsrc-for:11
    18 anzsrc-for:1102
    19 schema:author Nefef3c8d756e4edbb0a1405425f46308
    20 schema:citation sg:pub.10.1007/bf03007355
    21 sg:pub.10.1007/s00259-007-0607-y
    22 sg:pub.10.1007/s00259-008-0972-1
    23 sg:pub.10.1007/s002590050301
    24 sg:pub.10.1016/j.nuclcard.2005.12.004
    25 sg:pub.10.1016/j.nuclcard.2007.02.016
    26 sg:pub.10.1016/j.nuclcard.2007.06.114
    27 sg:pub.10.1016/j.nuclcard.2008.02.009
    28 sg:pub.10.1016/j.nuclcard.2008.02.013
    29 https://app.dimensions.ai/details/publication/pub.1082979514
    30 https://doi.org/10.1001/jama.1995.03530110056036
    31 https://doi.org/10.1001/jama.274.11.894
    32 https://doi.org/10.1016/0735-1097(94)90424-3
    33 https://doi.org/10.1016/j.jacc.2005.05.097
    34 https://doi.org/10.1016/j.jacc.2006.06.025
    35 https://doi.org/10.1016/j.jacc.2007.10.014
    36 https://doi.org/10.1016/j.jacc.2009.02.065
    37 https://doi.org/10.1016/j.jacc.2009.04.089
    38 https://doi.org/10.1016/j.jcmg.2008.02.003
    39 https://doi.org/10.1016/j.jcmg.2009.04.011
    40 https://doi.org/10.1124/jpet.105.095323
    41 https://doi.org/10.1161/01.cir.88.1.62
    42 https://doi.org/10.1161/circulationaha.106.629808
    43 https://doi.org/10.2967/jnumed.108.053819
    44 https://doi.org/10.2967/jnumed.109.073858
    45 schema:datePublished 2011-10
    46 schema:datePublishedReg 2011-10-01
    47 schema:description BACKGROUND: Regadenoson is a novel selective A2A adenosine receptor agonist, which is administered as an intravenous bolus at a fixed dose. It is currently not clear if the absolute flow increase in response to this fixed dose is a function of distribution volume in individual patients or if it is generally comparable to the previous standard agents dipyridamole or adenosine, which are dosed based on weight. We used quantitative analysis of clinical 82Rb PET/CT studies to obtain further insights. METHODS: A total of 104 subjects with normal clinical rest/stress 82Rb perfusion PET/CT were included in a retrospective analysis. To rule out confounding factors, none had evidence of prior cardiac disease, ischaemia or infarction, cardiomyopathy, diabetes with insulin use, calcium score>400, renal disease or other significant systemic disease. A group of 52 patients stressed with regadenoson were compared with a group of 52 patients stressed with dipyridamole before regadenoson became available. The groups were matched for clinical characteristics, risk factors and baseline haemodynamics. Myocardial blood flow (MBF) and myocardial flow reserve (MFR) were quantified using a previously validated retention model, after resampling of dynamic studies from list-mode 82Rb datasets. RESULTS: At rest, heart rate, blood pressure and MBF were comparable between the groups. Regadenoson resulted in a significantly higher heart rate (34±14 vs. 23±10 beats per minute increase from baseline; p<0.01) and rate-pressure product. Patients in the regadenoson group reported less severe symptoms and required less aminophylline. Stress MBF and MFR were not different between the groups (2.2±0.6 vs. 2.1±0.6 ml/min/g, p=0.39, and 2.9±0.8 vs. 2.8±0.7, p=0.31, respectively). In the regadenoson group, there was no correlation between stress flow or MFR and body weight or BMI. CONCLUSION: Despite its administration at a fixed dose, regadenoson results in an absolute increase in MBF which is comparable to that following dipyridamole administration and is independent of patient distribution volume. This further supports its usefulness as a clinical stress agent.
    48 schema:genre research_article
    49 schema:inLanguage en
    50 schema:isAccessibleForFree false
    51 schema:isPartOf N296d8211f3d742e7bc9d659e2d8851fb
    52 N7e4e6bc66dd74344ab646606fcb2423a
    53 sg:journal.1297401
    54 schema:name Comparison of the myocardial blood flow response to regadenoson and dipyridamole: a quantitative analysis in patients referred for clinical 82Rb myocardial perfusion PET
    55 schema:pagination 1908-1916
    56 schema:productId N159d442fc48649d89887a783789eeb53
    57 N19d29200883f4da4b7e06dbf4b2d0b4f
    58 N67c99a0baba44c40bf7a11232e76077a
    59 N74e705c2feaa4a2981d8cdd9351d60b5
    60 Ndc147a68a02843879133fb80ca45589d
    61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044263928
    62 https://doi.org/10.1007/s00259-011-1853-6
    63 schema:sdDatePublished 2019-04-10T18:21
    64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    65 schema:sdPublisher N3563bd349ecf4a24ba584354da504b98
    66 schema:url http://link.springer.com/10.1007%2Fs00259-011-1853-6
    67 sgo:license sg:explorer/license/
    68 sgo:sdDataset articles
    69 rdf:type schema:ScholarlyArticle
    70 N0a07f1640e864fb8b1fa8572d8418e3b rdf:first sg:person.01022150250.39
    71 rdf:rest N3d0d36cc1b924055a2f4f045635d96ee
    72 N0e17f574888d4e3ca12e9c7398218dfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    73 schema:name Purines
    74 rdf:type schema:DefinedTerm
    75 N159d442fc48649d89887a783789eeb53 schema:name doi
    76 schema:value 10.1007/s00259-011-1853-6
    77 rdf:type schema:PropertyValue
    78 N19d29200883f4da4b7e06dbf4b2d0b4f schema:name pubmed_id
    79 schema:value 21656246
    80 rdf:type schema:PropertyValue
    81 N242e2d75e32d4aef97b24abc4e2d510e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    82 schema:name Myocardial Perfusion Imaging
    83 rdf:type schema:DefinedTerm
    84 N296d8211f3d742e7bc9d659e2d8851fb schema:issueNumber 10
    85 rdf:type schema:PublicationIssue
    86 N32b647614d4343ed8b9dfb128e6c833e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Retrospective Studies
    88 rdf:type schema:DefinedTerm
    89 N3359762030974f9585825a3f3b8b745f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Purinergic P1 Receptor Agonists
    91 rdf:type schema:DefinedTerm
    92 N3563bd349ecf4a24ba584354da504b98 schema:name Springer Nature - SN SciGraph project
    93 rdf:type schema:Organization
    94 N3d0d36cc1b924055a2f4f045635d96ee rdf:first sg:person.01326535277.42
    95 rdf:rest Nd44c9cbb2b2346fb8b5f65a7767b31b2
    96 N4da6c0a7adc6449f9220259431494441 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Hemodynamics
    98 rdf:type schema:DefinedTerm
    99 N4e4131b232e349bbbdecfbf50d351428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Dipyridamole
    101 rdf:type schema:DefinedTerm
    102 N53ecfc4f9ab44515aec3a634edad8a39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Injections
    104 rdf:type schema:DefinedTerm
    105 N5844d0706f7c4d5face5d15406c1e78f rdf:first sg:person.01225020511.95
    106 rdf:rest rdf:nil
    107 N67c99a0baba44c40bf7a11232e76077a schema:name nlm_unique_id
    108 schema:value 101140988
    109 rdf:type schema:PropertyValue
    110 N727b0d3308cb4ba7b994377a190d6ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Humans
    112 rdf:type schema:DefinedTerm
    113 N72b114bccc6940229b67d2ef265966db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Middle Aged
    115 rdf:type schema:DefinedTerm
    116 N74e705c2feaa4a2981d8cdd9351d60b5 schema:name readcube_id
    117 schema:value d2d8273c3863f2bf47fd6bda70ed6e2a9b476555a8752ec59581835f3aed2d75
    118 rdf:type schema:PropertyValue
    119 N7bff444126b44ebda29a3b5e8b83b45f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Rubidium Radioisotopes
    121 rdf:type schema:DefinedTerm
    122 N7e4e6bc66dd74344ab646606fcb2423a schema:volumeNumber 38
    123 rdf:type schema:PublicationVolume
    124 N9971af35f16449bba9c06b8cb9d7cb60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Positron-Emission Tomography
    126 rdf:type schema:DefinedTerm
    127 Naeabe11d08254a41b57dbc00595e4780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Male
    129 rdf:type schema:DefinedTerm
    130 Nb51ab34f32604f38b4b3f9ca231a148e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Stress, Physiological
    132 rdf:type schema:DefinedTerm
    133 Nbbc940d8e083490e8efe02f486e99597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Female
    135 rdf:type schema:DefinedTerm
    136 Nc7e90cd8d9464b689dc2155d5fba8cea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Pyrazoles
    138 rdf:type schema:DefinedTerm
    139 Nd44c9cbb2b2346fb8b5f65a7767b31b2 rdf:first sg:person.01067051554.58
    140 rdf:rest N5844d0706f7c4d5face5d15406c1e78f
    141 Nd69f31f558204fc8b9f8d2a78428c7ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Coronary Circulation
    143 rdf:type schema:DefinedTerm
    144 Ndc147a68a02843879133fb80ca45589d schema:name dimensions_id
    145 schema:value pub.1044263928
    146 rdf:type schema:PropertyValue
    147 Nefef3c8d756e4edbb0a1405425f46308 rdf:first sg:person.0625272646.72
    148 rdf:rest N0a07f1640e864fb8b1fa8572d8418e3b
    149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Medical and Health Sciences
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Cardiorespiratory Medicine and Haematology
    154 rdf:type schema:DefinedTerm
    155 sg:journal.1297401 schema:issn 1619-7070
    156 1619-7089
    157 schema:name European Journal of Nuclear Medicine and Molecular Imaging
    158 rdf:type schema:Periodical
    159 sg:person.01022150250.39 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
    160 schema:familyName Fukushima
    161 schema:givenName Kenji
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022150250.39
    163 rdf:type schema:Person
    164 sg:person.01067051554.58 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
    165 schema:familyName Merrill
    166 schema:givenName Jennifer
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067051554.58
    168 rdf:type schema:Person
    169 sg:person.01225020511.95 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
    170 schema:familyName Bengel
    171 schema:givenName Frank M.
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225020511.95
    173 rdf:type schema:Person
    174 sg:person.01326535277.42 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
    175 schema:familyName Bravo
    176 schema:givenName Paco
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326535277.42
    178 rdf:type schema:Person
    179 sg:person.0625272646.72 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
    180 schema:familyName Goudarzi
    181 schema:givenName Behnaz
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625272646.72
    183 rdf:type schema:Person
    184 sg:pub.10.1007/bf03007355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037394649
    185 https://doi.org/10.1007/bf03007355
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s00259-007-0607-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019732602
    188 https://doi.org/10.1007/s00259-007-0607-y
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s00259-008-0972-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274145
    191 https://doi.org/10.1007/s00259-008-0972-1
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s002590050301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027870105
    194 https://doi.org/10.1007/s002590050301
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1016/j.nuclcard.2005.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049290178
    197 https://doi.org/10.1016/j.nuclcard.2005.12.004
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1016/j.nuclcard.2007.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007288648
    200 https://doi.org/10.1016/j.nuclcard.2007.02.016
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1016/j.nuclcard.2007.06.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035693866
    203 https://doi.org/10.1016/j.nuclcard.2007.06.114
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1016/j.nuclcard.2008.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037812905
    206 https://doi.org/10.1016/j.nuclcard.2008.02.009
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1016/j.nuclcard.2008.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030937009
    209 https://doi.org/10.1016/j.nuclcard.2008.02.013
    210 rdf:type schema:CreativeWork
    211 https://app.dimensions.ai/details/publication/pub.1082979514 schema:CreativeWork
    212 https://doi.org/10.1001/jama.1995.03530110056036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044385109
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1001/jama.274.11.894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054158753
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/0735-1097(94)90424-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025970600
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.jacc.2005.05.097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013126401
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.jacc.2006.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032478234
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/j.jacc.2007.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026167186
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/j.jacc.2009.02.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037812548
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/j.jacc.2009.04.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015990916
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/j.jcmg.2008.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021315962
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/j.jcmg.2009.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008177112
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1124/jpet.105.095323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017702331
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1161/01.cir.88.1.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019232396
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1161/circulationaha.106.629808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014870616
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.2967/jnumed.108.053819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051958757
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.2967/jnumed.109.073858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042456099
    241 rdf:type schema:CreativeWork
    242 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
    243 schema:name Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
    244 Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
    245 rdf:type schema:Organization
    246 https://www.grid.ac/institutes/grid.469474.c schema:alternateName Johns Hopkins Medicine
    247 schema:name Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
    248 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...