18F-FDG PET/CT in paediatric lymphoma: comparison with conventional imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-02

AUTHORS

Kevin London, Siobhan Cross, Ella Onikul, Luciano Dalla-Pozza, Robert Howman-Giles

ABSTRACT

PURPOSE: In children with Hodgkin's disease and non-Hodgkin's lymphoma, the ability of (18)F-fluoro-2-deoxy-D-glucose PET/CT and conventional imaging (CI) to detect malignant lesions and predict poor lesion response to therapy was assessed and compared. METHODS: A retrospective review of findings reported on PET/CT and CI was performed using a lesion-based analysis of 16 lymph node and 8 extra-nodal regions. Lesions were defined by histopathological findings or follow-up > 6 months. RESULTS: The study included 209 PET/CT scans with a valid CI comparator. A total of 5,014 regions (3,342 lymph node, 1,672 extra-nodal) were analysed. PET/CT performed significantly better than CI in the detection of malignant lesions with sensitivity and specificity of 95.9 and 99.7% compared to 70.1 and 99.0%, respectively. For predicting poor lesion response to therapy, PET/CT had fewer false-positive lesions than CI. The specificity for predicting poor lesion response to treatment for PET/CT was 99.2% compared to 96.9% for CI. PET/CT was the correct modality in 86% of lesions with discordant findings. CONCLUSION: PET/CT is more accurate than CI in detecting malignant lesions in childhood lymphoma and in predicting poor lesion response to treatment. In lesions with discordant findings, PET/CT results are more likely to be correct. More... »

PAGES

274-284

References to SciGraph publications

  • 2002-09. [18F]FDG in childhood lymphoma: clinical utility and impact on management in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2010-02. Role of PET/CT in malignant pediatric lymphoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2005-01. 18F-FDG PET in children with lymphomas in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2006-06. F-18 FDG-PET imaging and correlation with CT in staging and follow-up of pediatric lymphomas in PEDIATRIC RADIOLOGY
  • 2008-08. Pulmonary inflammatory myofibroblastic tumor after Hodgkin’s lymphoma and application of PET imaging in PEDIATRIC SURGERY INTERNATIONAL
  • 2005-01. The impact of PET scanning on management of paediatric oncology patients in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2002-01. Whole-body positron emission tomography using 18F-fluorodeoxyglucose for initial staging of patients with Hodgkin's disease in ANNALS OF HEMATOLOGY
  • 2006-09. Comparison of 18F-FDG-PET and standard procedures for the pretreatment staging of children and adolescents with Hodgkin’s disease in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-010-1619-6

    DOI

    http://dx.doi.org/10.1007/s00259-010-1619-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006568604

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20848280


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