Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Sally F. Barrington, Wendi Qian, Edward J. Somer, Antonella Franceschetto, Bruno Bagni, Eva Brun, Helén Almquist, Annika Loft, Liselotte Højgaard, Massimo Federico, Andrea Gallamini, Paul Smith, Peter Johnson, John Radford, Michael J. O’Doherty

ABSTRACT

PURPOSE: To determine if PET reporting criteria for the Response Adapted Treatment in Hodgkin Lymphoma (RATHL) trial could enable satisfactory agreement to be reached between 'core' laboratories operating in different countries. METHODS: Four centres reported scans from 50 patients with stage II-IV HL, acquired before and after two cycles of Adriamycin/bleomycin/vinblastine/dacarbazine. A five-point scale was used to score response scans using 'normal' mediastinum and liver as reference levels. Centres read scans independently of each other. The level of agreement between centres was determined assuming (1) that uptake in sites involved at diagnosis that was higher than liver uptake represented disease (conservative reading), and (2) that uptake in sites involved at diagnosis that was higher than mediastinal uptake represented disease (sensitive reading). RESULTS: There was agreement that the response scan was 'positive' or 'negative' for lymphoma in 44 patients with a conservative reading and in 41 patients with a sensitive reading. Kappa was 0.85 (95% CI 0.74-0.96) for conservative reading and 0.79 (95% CI 0.67-0.90) for sensitive reading. Agreement was reached in 46 and 44 patients after discussion for the conservative and sensitive readings, respectively. CONCLUSION: The criteria developed for reporting in the RATHL trial are sufficiently robust to be used in a multicentre setting. More... »

PAGES

1824-1833

References to SciGraph publications

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  • 2003-06. Limitations of PET for imaging lymphoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-010-1490-5

    DOI

    http://dx.doi.org/10.1007/s00259-010-1490-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014574340

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20505930


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-010-1490-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-010-1490-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-010-1490-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-010-1490-5'


     

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