Visual assessment of [11C]PIB PET in patients with cognitive impairment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02-09

AUTHORS

Timo Suotunen, Jussi Hirvonen, Pirjo Immonen-Räihä, Sargo Aalto, Irina Lisinen, Eveliina Arponen, Mika Teräs, Kari Koski, Raimo Sulkava, Marko Seppänen, Juha O. Rinne

ABSTRACT

PurposeThe aim of this study was to evaluate the visual assessment of positron emission tomography images of N-[methyl-11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) in a patient population with mild to moderate memory impairment or dementia.MethodsWe compared the visual ratings of two readers using kappa statistics and correlated the results of visual and quantitative region of interest (ROI) analyses. The one reader had good experience in evaluating PIB images and the other had little previous experience. The sensitivity and specificity of the visual assessment was determined using quantitative data from 18 healthy controls previously examined: [11C]PIB uptake was considered as abnormal if it was more than 2 SD above the mean of the healthy subjects.ResultsThe evaluation of visual classification as “normal” or “abnormal” showed good interobserver agreement (κ = 0.90). There was a clear correlation between visual and quantitative analysis (r = 0.47–0.79, p < 0.001). The most difficult visually assessed brain area was the putamen (κ = 0.11; correlation with quantitative analysis: reader A r = 0.22; reader B r = 0.60).ConclusionOur study shows that visual evaluation of [11C]PIB images conforms with quantitative analyses also in a clinical patient population supporting the feasibility of visual evaluation in clinical settings. More... »

PAGES

1141-1147

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-010-1382-8

DOI

http://dx.doi.org/10.1007/s00259-010-1382-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028558798

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20143064


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