The effect of right ventricular pacing on myocardial oxidative metabolism and efficiency: relation with left ventricular dyssynchrony View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12

AUTHORS

Heikki Ukkonen, Laurens Tops, Antti Saraste, Alexander Naum, Juhani Koistinen, Jeroen Bax, Juhani Knuuti

ABSTRACT

PURPOSE: Right ventricular (RV) apical pacing induces dyssynchrony by a left bundle branch block type electrical activation sequence in the heart and may impair left ventricular (LV) function. Whether these functional changes are accompanied by changes in myocardial perfusion, oxidative metabolism and efficiency, and the relation with the induction of LV dyssynchrony are unknown. Our study was designed to investigate the acute effects of RV pacing on these parameters. METHODS: Ten patients with normal LV ejection fraction and VVI/DDD pacemaker were studied during AAI pacing/sinus rhythm without RV pacing (pacing-OFF) and with RV pacing (pacing-ON) at the same heart rate. Dynamic [15O]water and [11C]acetate positron emission tomography was used to measure perfusion and oxidative metabolism (kmono) of the LV. An echocardiographic examination was used to assess LV stroke volume (SV) and LV dyssynchrony. Myocardial efficiency of forward work was calculated as systolic blood pressure × cardiac output/LV mass/kmono. RESULTS: RV pacing decreased SV in all subjects (mean decrease 13%, from 76 ± 7 to 66 ± 7 ml, p = 0.004), but global perfusion and kmono were unchanged. The efficiency tended to be lower with pacing-ON (70 ± 20 vs 81 ± 21 mmHg l/g, p = 0.066). In patients with dyssynchrony during pacing (n = 6) efficiency decreased by 23% (from 78 ± 25 to 60 ± 14 mmHg l/g, p = 0.02), but in patients without dyssynchrony no change in efficiency was detected. Accordingly, heterogeneity in myocardial perfusion and oxidative metabolism was detected during pacing in patients with dyssynchrony but not in those without dyssynchrony. CONCLUSION: RV pacing resulted in a significant decrease in SV. However, deleterious effects on LV oxidative metabolism and efficiency were observed only in patients with dyssynchrony during RV pacing. More... »

PAGES

2042-2048

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-009-1200-3

DOI

http://dx.doi.org/10.1007/s00259-009-1200-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028276282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19575197


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiac Pacing, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Ventricles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidation-Reduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Dysfunction, Left", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Department of Medicine, Turku University Hospital, P.O. Box\u00a052, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ukkonen", 
        "givenName": "Heikki", 
        "id": "sg:person.0641403167.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641403167.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Leiden University Medical Center, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tops", 
        "givenName": "Laurens", 
        "id": "sg:person.01124167050.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124167050.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Department of Medicine, Turku University Hospital, P.O. Box\u00a052, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saraste", 
        "givenName": "Antti", 
        "id": "sg:person.0607272607.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607272607.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naum", 
        "givenName": "Alexander", 
        "id": "sg:person.01355403656.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355403656.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Department of Medicine, Turku University Hospital, P.O. Box\u00a052, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koistinen", 
        "givenName": "Juhani", 
        "id": "sg:person.0677511155.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677511155.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Leiden University Medical Center, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bax", 
        "givenName": "Jeroen", 
        "id": "sg:person.01340245251.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340245251.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre", 
          "id": "https://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, University of Turku, Turku, Finland", 
            "Turku PET Centre, Turku University Hospital, P.O. Box\u00a052, 20521, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knuuti", 
        "givenName": "Juhani", 
        "id": "sg:person.01163336756.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.99.23.2993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001506206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.04.099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004305397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(99)00068-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005258006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.81.5.1594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007429417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mje.2002.120202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008966190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2004.08.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009857432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.78.1.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011572434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(00)01096-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014467218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000047068.02226.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-0770(98)90007-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016293929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(86)80140-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016497405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.288.24.3115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019118768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.76.3.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019392161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2003.10.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021103121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehi046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021638959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.05.072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025091297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000072769.17295.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027425327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000138108.68719.c1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028794775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(96)00586-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031881695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.echo.2004.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033020195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.12.1567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035968486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2007.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039798918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.85.3.1125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043981438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/europace/eum234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045533541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.63.3.628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045868256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.echo.2004.06.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049719623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.571455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050664619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eupc.2005.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054734805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076848173", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "PURPOSE: Right ventricular (RV) apical pacing induces dyssynchrony by a left bundle branch block type electrical activation sequence in the heart and may impair left ventricular (LV) function. Whether these functional changes are accompanied by changes in myocardial perfusion, oxidative metabolism and efficiency, and the relation with the induction of LV dyssynchrony are unknown. Our study was designed to investigate the acute effects of RV pacing on these parameters.\nMETHODS: Ten patients with normal LV ejection fraction and VVI/DDD pacemaker were studied during AAI pacing/sinus rhythm without RV pacing (pacing-OFF) and with RV pacing (pacing-ON) at the same heart rate. Dynamic [15O]water and [11C]acetate positron emission tomography was used to measure perfusion and oxidative metabolism (kmono) of the LV. An echocardiographic examination was used to assess LV stroke volume (SV) and LV dyssynchrony. Myocardial efficiency of forward work was calculated as systolic blood pressure \u00d7 cardiac output/LV mass/kmono.\nRESULTS: RV pacing decreased SV in all subjects (mean decrease 13%, from 76 \u00b1 7 to 66 \u00b1 7 ml, p = 0.004), but global perfusion and kmono were unchanged. The efficiency tended to be lower with pacing-ON (70 \u00b1 20 vs 81 \u00b1 21 mmHg l/g, p = 0.066). In patients with dyssynchrony during pacing (n = 6) efficiency decreased by 23% (from 78 \u00b1 25 to 60 \u00b1 14 mmHg l/g, p = 0.02), but in patients without dyssynchrony no change in efficiency was detected. Accordingly, heterogeneity in myocardial perfusion and oxidative metabolism was detected during pacing in patients with dyssynchrony but not in those without dyssynchrony.\nCONCLUSION: RV pacing resulted in a significant decrease in SV. However, deleterious effects on LV oxidative metabolism and efficiency were observed only in patients with dyssynchrony during RV pacing.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00259-009-1200-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "The effect of right ventricular pacing on myocardial oxidative metabolism and efficiency: relation with left ventricular dyssynchrony", 
    "pagination": "2042-2048", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "86b3d59991d97c7b4e34c792234c870676358805da9a536e86629a4457db5faa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19575197"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101140988"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00259-009-1200-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028276282"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00259-009-1200-3", 
      "https://app.dimensions.ai/details/publication/pub.1028276282"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13087_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00259-009-1200-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1200-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1200-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1200-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1200-3'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      70 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00259-009-1200-3 schema:about N0a4408dd6b0a45e9b73a83e28e452dc9
2 N1634c6521e614c68b124222d25bc3d39
3 N2f44daf282e54189a2b8ab64721857ab
4 N6a135d8d374e4dadb45a0b26c15e6b0b
5 N6ff6a7f0eee745b4af0a4cc5e32d81ae
6 Naf28f2b7902c48bbb1560d936fd3f900
7 Nb46c9a63043c410c867ebf8fe85edc65
8 Nbb6f683c21f04d9a8e6f962daee5e88b
9 Nd38e6192f6cb4adeadea21945935551b
10 Ne31a8e33c67a4ef686094a06a97deb5a
11 Nee41e27d65a14bcbb924d436817047e2
12 Nf3b37630252b46d0baaf94b3f37ead1f
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author N1e838c7a85594bacb6494badc1c65ff0
16 schema:citation https://app.dimensions.ai/details/publication/pub.1076848173
17 https://doi.org/10.1001/jama.288.24.3115
18 https://doi.org/10.1016/j.echo.2004.02.011
19 https://doi.org/10.1016/j.echo.2004.06.019
20 https://doi.org/10.1016/j.eupc.2005.06.015
21 https://doi.org/10.1016/j.jacc.2003.10.044
22 https://doi.org/10.1016/j.jacc.2004.08.016
23 https://doi.org/10.1016/j.jacc.2006.04.099
24 https://doi.org/10.1016/j.jacc.2006.05.072
25 https://doi.org/10.1016/j.jacc.2007.06.011
26 https://doi.org/10.1016/s0735-1097(00)01096-2
27 https://doi.org/10.1016/s0735-1097(86)80140-1
28 https://doi.org/10.1016/s0735-1097(96)00586-4
29 https://doi.org/10.1016/s0735-1097(99)00068-6
30 https://doi.org/10.1016/s1053-0770(98)90007-6
31 https://doi.org/10.1067/mje.2002.120202
32 https://doi.org/10.1093/eurheartj/ehi046
33 https://doi.org/10.1093/europace/eum234
34 https://doi.org/10.1161/01.cir.0000047068.02226.95
35 https://doi.org/10.1161/01.cir.0000072769.17295.b1
36 https://doi.org/10.1161/01.cir.0000138108.68719.c1
37 https://doi.org/10.1161/01.cir.76.3.687
38 https://doi.org/10.1161/01.cir.78.1.104
39 https://doi.org/10.1161/01.cir.81.5.1594
40 https://doi.org/10.1161/01.cir.85.3.1125
41 https://doi.org/10.1161/01.cir.99.12.1567
42 https://doi.org/10.1161/01.cir.99.23.2993
43 https://doi.org/10.1161/01.res.63.3.628
44 https://doi.org/10.1161/circulationaha.105.571455
45 schema:datePublished 2009-12
46 schema:datePublishedReg 2009-12-01
47 schema:description PURPOSE: Right ventricular (RV) apical pacing induces dyssynchrony by a left bundle branch block type electrical activation sequence in the heart and may impair left ventricular (LV) function. Whether these functional changes are accompanied by changes in myocardial perfusion, oxidative metabolism and efficiency, and the relation with the induction of LV dyssynchrony are unknown. Our study was designed to investigate the acute effects of RV pacing on these parameters. METHODS: Ten patients with normal LV ejection fraction and VVI/DDD pacemaker were studied during AAI pacing/sinus rhythm without RV pacing (pacing-OFF) and with RV pacing (pacing-ON) at the same heart rate. Dynamic [15O]water and [11C]acetate positron emission tomography was used to measure perfusion and oxidative metabolism (kmono) of the LV. An echocardiographic examination was used to assess LV stroke volume (SV) and LV dyssynchrony. Myocardial efficiency of forward work was calculated as systolic blood pressure × cardiac output/LV mass/kmono. RESULTS: RV pacing decreased SV in all subjects (mean decrease 13%, from 76 ± 7 to 66 ± 7 ml, p = 0.004), but global perfusion and kmono were unchanged. The efficiency tended to be lower with pacing-ON (70 ± 20 vs 81 ± 21 mmHg l/g, p = 0.066). In patients with dyssynchrony during pacing (n = 6) efficiency decreased by 23% (from 78 ± 25 to 60 ± 14 mmHg l/g, p = 0.02), but in patients without dyssynchrony no change in efficiency was detected. Accordingly, heterogeneity in myocardial perfusion and oxidative metabolism was detected during pacing in patients with dyssynchrony but not in those without dyssynchrony. CONCLUSION: RV pacing resulted in a significant decrease in SV. However, deleterious effects on LV oxidative metabolism and efficiency were observed only in patients with dyssynchrony during RV pacing.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N2b17acd6468148f6b0b7b477bdbffa65
52 N5df0ec18862441d08cc15248c4d08bee
53 sg:journal.1297401
54 schema:name The effect of right ventricular pacing on myocardial oxidative metabolism and efficiency: relation with left ventricular dyssynchrony
55 schema:pagination 2042-2048
56 schema:productId N22f1c966f24949b390bb6fdeb1b835dd
57 N5c474a70275e473d86f8ceeb706218bc
58 N7c7d427e873e4b1cbe17279a14799ae4
59 N8589021a4e7e47709f892e0b9f5bb769
60 Ne76d980e2f01460c926e062fbe75b585
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028276282
62 https://doi.org/10.1007/s00259-009-1200-3
63 schema:sdDatePublished 2019-04-11T14:29
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N3b13a340c07d4e93a53b2f366aa0d60e
66 schema:url http://link.springer.com/10.1007%2Fs00259-009-1200-3
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0a4408dd6b0a45e9b73a83e28e452dc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Oxidation-Reduction
72 rdf:type schema:DefinedTerm
73 N0c3df37832804f4a835e2d152311ed96 rdf:first sg:person.01163336756.79
74 rdf:rest rdf:nil
75 N1634c6521e614c68b124222d25bc3d39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Cardiac Pacing, Artificial
77 rdf:type schema:DefinedTerm
78 N1e838c7a85594bacb6494badc1c65ff0 rdf:first sg:person.0641403167.49
79 rdf:rest Nb9f6e1163f7346db94f519bb5ffc7376
80 N22f1c966f24949b390bb6fdeb1b835dd schema:name pubmed_id
81 schema:value 19575197
82 rdf:type schema:PropertyValue
83 N2b17acd6468148f6b0b7b477bdbffa65 schema:issueNumber 12
84 rdf:type schema:PublicationIssue
85 N2f44daf282e54189a2b8ab64721857ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N3b13a340c07d4e93a53b2f366aa0d60e schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N5c474a70275e473d86f8ceeb706218bc schema:name readcube_id
91 schema:value 86b3d59991d97c7b4e34c792234c870676358805da9a536e86629a4457db5faa
92 rdf:type schema:PropertyValue
93 N5df0ec18862441d08cc15248c4d08bee schema:volumeNumber 36
94 rdf:type schema:PublicationVolume
95 N6a135d8d374e4dadb45a0b26c15e6b0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Heart Ventricles
97 rdf:type schema:DefinedTerm
98 N6ff6a7f0eee745b4af0a4cc5e32d81ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Ventricular Dysfunction, Left
100 rdf:type schema:DefinedTerm
101 N7c7d427e873e4b1cbe17279a14799ae4 schema:name doi
102 schema:value 10.1007/s00259-009-1200-3
103 rdf:type schema:PropertyValue
104 N8589021a4e7e47709f892e0b9f5bb769 schema:name dimensions_id
105 schema:value pub.1028276282
106 rdf:type schema:PropertyValue
107 Nacf38e693662476fbfab296d2be29216 rdf:first sg:person.0607272607.61
108 rdf:rest Nb975e390e61c427cba58005f53586f6c
109 Naf28f2b7902c48bbb1560d936fd3f900 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aged, 80 and over
111 rdf:type schema:DefinedTerm
112 Nb46c9a63043c410c867ebf8fe85edc65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Myocardium
114 rdf:type schema:DefinedTerm
115 Nb975e390e61c427cba58005f53586f6c rdf:first sg:person.01355403656.71
116 rdf:rest Nc36f444d5e1f449b9b934856703696e6
117 Nb9f6e1163f7346db94f519bb5ffc7376 rdf:first sg:person.01124167050.40
118 rdf:rest Nacf38e693662476fbfab296d2be29216
119 Nbb6f683c21f04d9a8e6f962daee5e88b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Aged
121 rdf:type schema:DefinedTerm
122 Nbd1de20d0fa447f38e65764bec2d759f rdf:first sg:person.01340245251.83
123 rdf:rest N0c3df37832804f4a835e2d152311ed96
124 Nc36f444d5e1f449b9b934856703696e6 rdf:first sg:person.0677511155.38
125 rdf:rest Nbd1de20d0fa447f38e65764bec2d759f
126 Nd38e6192f6cb4adeadea21945935551b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adult
128 rdf:type schema:DefinedTerm
129 Ne31a8e33c67a4ef686094a06a97deb5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Middle Aged
131 rdf:type schema:DefinedTerm
132 Ne76d980e2f01460c926e062fbe75b585 schema:name nlm_unique_id
133 schema:value 101140988
134 rdf:type schema:PropertyValue
135 Nee41e27d65a14bcbb924d436817047e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Female
137 rdf:type schema:DefinedTerm
138 Nf3b37630252b46d0baaf94b3f37ead1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
145 schema:name Cardiorespiratory Medicine and Haematology
146 rdf:type schema:DefinedTerm
147 sg:journal.1297401 schema:issn 1619-7070
148 1619-7089
149 schema:name European Journal of Nuclear Medicine and Molecular Imaging
150 rdf:type schema:Periodical
151 sg:person.01124167050.40 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
152 schema:familyName Tops
153 schema:givenName Laurens
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124167050.40
155 rdf:type schema:Person
156 sg:person.01163336756.79 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
157 schema:familyName Knuuti
158 schema:givenName Juhani
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163336756.79
160 rdf:type schema:Person
161 sg:person.01340245251.83 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
162 schema:familyName Bax
163 schema:givenName Jeroen
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340245251.83
165 rdf:type schema:Person
166 sg:person.01355403656.71 schema:affiliation https://www.grid.ac/institutes/grid.470895.7
167 schema:familyName Naum
168 schema:givenName Alexander
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355403656.71
170 rdf:type schema:Person
171 sg:person.0607272607.61 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
172 schema:familyName Saraste
173 schema:givenName Antti
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607272607.61
175 rdf:type schema:Person
176 sg:person.0641403167.49 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
177 schema:familyName Ukkonen
178 schema:givenName Heikki
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641403167.49
180 rdf:type schema:Person
181 sg:person.0677511155.38 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
182 schema:familyName Koistinen
183 schema:givenName Juhani
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677511155.38
185 rdf:type schema:Person
186 https://app.dimensions.ai/details/publication/pub.1076848173 schema:CreativeWork
187 https://doi.org/10.1001/jama.288.24.3115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019118768
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.echo.2004.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033020195
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.echo.2004.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049719623
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.eupc.2005.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054734805
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.jacc.2003.10.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021103121
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.jacc.2004.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009857432
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.jacc.2006.04.099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004305397
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.jacc.2006.05.072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025091297
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.jacc.2007.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039798918
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s0735-1097(00)01096-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014467218
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/s0735-1097(86)80140-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016497405
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0735-1097(96)00586-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031881695
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0735-1097(99)00068-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005258006
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s1053-0770(98)90007-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016293929
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1067/mje.2002.120202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008966190
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1093/eurheartj/ehi046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021638959
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/europace/eum234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045533541
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1161/01.cir.0000047068.02226.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015864150
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1161/01.cir.0000072769.17295.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027425327
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1161/01.cir.0000138108.68719.c1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028794775
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1161/01.cir.76.3.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019392161
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1161/01.cir.78.1.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011572434
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1161/01.cir.81.5.1594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007429417
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1161/01.cir.85.3.1125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043981438
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1161/01.cir.99.12.1567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035968486
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1161/01.cir.99.23.2993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001506206
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1161/01.res.63.3.628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045868256
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1161/circulationaha.105.571455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050664619
242 rdf:type schema:CreativeWork
243 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
244 schema:name Leiden University Medical Center, Leiden, The Netherlands
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.410552.7 schema:alternateName Turku University Hospital
247 schema:name Department of Medicine, Turku University Hospital, P.O. Box 52, 20521, Turku, Finland
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.470895.7 schema:alternateName Turku PET Centre
250 schema:name Turku PET Centre, Turku University Hospital, P.O. Box 52, 20521, Turku, Finland
251 Turku PET Centre, University of Turku, Turku, Finland
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...