In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-06

AUTHORS

Stefanie Dedeurwaerdere, Marie-Claude Gregoire, Lucy Vivash, Peter Roselt, David Binns, Christopher Fookes, Ivan Greguric, Tien Pham, Christian Loc’h, Andrew Katsifis, Rodney J. Hicks, Terence J. O’Brien, Damian E. Myers

ABSTRACT

PURPOSE: [(11)C]Flumazenil shows promise as a clinical and research PET radiotracer to image changes in GABA(A) central benzodiazepine receptor (cBZR), but its widespread use has been limited by practical limitations of [(11)C]. This study evaluated the imaging characteristics of two fluorinated PET radiotracers in rats in vivo: [(18)F]fluoroflumazenil ([(18)F]FFMZ) and [(18)F]flumazenil ([(18)F]FMZ). METHODS: PET acquisitions were performed on a small-animal scanner following injection of [(18)F]FFMZ in nine rats and [(18)F]FMZ in eight rats. The following treatments were investigated: (1) injection of the tracer dose, (2) presaturation then injection of the tracer dose, and (3) injection of the tracer dose followed by a displacement injection. Unchanged tracer was measured in plasma and brain structures in four animals 10 and 30 min after injection, and ex-vivo autoradiography was also performed. RESULTS: For both [(18)F]FFMZ and [(18)F]FMZ maximal brain activity peaked rapidly, and was highest in the hippocampus (1.12+/-0.06 SUV, 1.24+/-0.10 SUV, respectively), and lowest in the pons (1.00+/-0.07 SUV, 1.03+/-0.09 SUV, respectively). By 50 min after injection, maximal uptake for [(18)F]FFMZ and [(18)F]FMZ had decreased in the hippocampus to 18+/-3% and 80+/-1% (p<0.01), respectively. The presaturation and displacement studies showed a higher nonspecific component for [(18)F]FFMZ than for [(18)F]FMZ. Metabolite studies showed that at 30 min only 10% of the signal was from [(18)F]FFMZ in the brain. This nonspecific binding was apparent on autoradiography. In contrast, [(18)F]FMZ accounted for >70% of the signal in the brain, which resulted in well-defined regional binding on autoradiography. CONCLUSION: These results demonstrate that [(18)F]FMZ is a superior radiotracer to [(18)F]FFMZ for in-vivo PET imaging of the GABA(A)/cBZR, having slower metabolism and leading to lower concentrations of metabolites in the brain that results in a substantially better signal-to-noise ratio. More... »

PAGES

958

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-009-1066-4

DOI

http://dx.doi.org/10.1007/s00259-009-1066-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036566941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19205698


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoradiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flumazenil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorine Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioactive Tracers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, GABA-A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Department of Medicine (RMH), University of Melbourne, Royal Parade, 3050, Parkville, VIC, Australia", 
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dedeurwaerdere", 
        "givenName": "Stefanie", 
        "id": "sg:person.01052616147.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052616147.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gregoire", 
        "givenName": "Marie-Claude", 
        "id": "sg:person.01132251641.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132251641.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Medicine (RMH), University of Melbourne, Royal Parade, 3050, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vivash", 
        "givenName": "Lucy", 
        "id": "sg:person.01231620554.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231620554.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roselt", 
        "givenName": "Peter", 
        "id": "sg:person.01360466505.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360466505.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Binns", 
        "givenName": "David", 
        "id": "sg:person.01213140513.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213140513.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fookes", 
        "givenName": "Christopher", 
        "id": "sg:person.015433407225.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015433407225.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greguric", 
        "givenName": "Ivan", 
        "id": "sg:person.01152033424.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152033424.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pham", 
        "givenName": "Tien", 
        "id": "sg:person.01311343723.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311343723.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loc\u2019h", 
        "givenName": "Christian", 
        "id": "sg:person.01126721074.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126721074.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Australian Nuclear Science and Technology Organisation", 
          "id": "https://www.grid.ac/institutes/grid.1089.0", 
          "name": [
            "Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katsifis", 
        "givenName": "Andrew", 
        "id": "sg:person.01200365041.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200365041.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hicks", 
        "givenName": "Rodney J.", 
        "id": "sg:person.01121233254.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121233254.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Medicine (RMH), University of Melbourne, Royal Parade, 3050, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Brien", 
        "givenName": "Terence J.", 
        "id": "sg:person.01214124212.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214124212.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Medicine (RMH), University of Melbourne, Royal Parade, 3050, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Myers", 
        "givenName": "Damian E.", 
        "id": "sg:person.0635145764.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635145764.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0969-8051(00)00125-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004959548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0271-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009284813", 
          "https://doi.org/10.1007/s00259-006-0271-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0271-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009284813", 
          "https://doi.org/10.1007/s00259-006-0271-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-8051(03)00030-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012445136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-8051(03)00030-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012445136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-8051(01)00251-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018053967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(88)90044-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021067449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0883-2889(88)90044-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021067449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002590100594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021323392", 
          "https://doi.org/10.1007/s002590100594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2004.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022513406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02244294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026987376", 
          "https://doi.org/10.1007/bf02244294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02244294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026987376", 
          "https://doi.org/10.1007/bf02244294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2003.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034492925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nucmedbio.2004.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049683398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074684217", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077196648", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081587123", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081950981", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-06", 
    "datePublishedReg": "2009-06-01", 
    "description": "PURPOSE: [(11)C]Flumazenil shows promise as a clinical and research PET radiotracer to image changes in GABA(A) central benzodiazepine receptor (cBZR), but its widespread use has been limited by practical limitations of [(11)C]. This study evaluated the imaging characteristics of two fluorinated PET radiotracers in rats in vivo: [(18)F]fluoroflumazenil ([(18)F]FFMZ) and [(18)F]flumazenil ([(18)F]FMZ).\nMETHODS: PET acquisitions were performed on a small-animal scanner following injection of [(18)F]FFMZ in nine rats and [(18)F]FMZ in eight rats. The following treatments were investigated: (1) injection of the tracer dose, (2) presaturation then injection of the tracer dose, and (3) injection of the tracer dose followed by a displacement injection. Unchanged tracer was measured in plasma and brain structures in four animals 10 and 30 min after injection, and ex-vivo autoradiography was also performed.\nRESULTS: For both [(18)F]FFMZ and [(18)F]FMZ maximal brain activity peaked rapidly, and was highest in the hippocampus (1.12+/-0.06 SUV, 1.24+/-0.10 SUV, respectively), and lowest in the pons (1.00+/-0.07 SUV, 1.03+/-0.09 SUV, respectively). By 50 min after injection, maximal uptake for [(18)F]FFMZ and [(18)F]FMZ had decreased in the hippocampus to 18+/-3% and 80+/-1% (p<0.01), respectively. The presaturation and displacement studies showed a higher nonspecific component for [(18)F]FFMZ than for [(18)F]FMZ. Metabolite studies showed that at 30 min only 10% of the signal was from [(18)F]FFMZ in the brain. This nonspecific binding was apparent on autoradiography. In contrast, [(18)F]FMZ accounted for >70% of the signal in the brain, which resulted in well-defined regional binding on autoradiography.\nCONCLUSION: These results demonstrate that [(18)F]FMZ is a superior radiotracer to [(18)F]FFMZ for in-vivo PET imaging of the GABA(A)/cBZR, having slower metabolism and leading to lower concentrations of metabolites in the brain that results in a substantially better signal-to-noise ratio.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00259-009-1066-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat", 
    "pagination": "958", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ae30e2395cd5ee1c7a5fc1f593b3e19975c56b8d47f80b739606312e2ab5a2dd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19205698"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101140988"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00259-009-1066-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036566941"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00259-009-1066-4", 
      "https://app.dimensions.ai/details/publication/pub.1036566941"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13073_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00259-009-1066-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1066-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1066-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1066-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-009-1066-4'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      55 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00259-009-1066-4 schema:about N180f463085134d4baa816c5e99d55274
2 N1a09c1d19a1e4ad4b6bd669964283e58
3 N325636193a304698a14911f0aba71446
4 N49f96f460d584530a31dae93997289bd
5 N52bb788dff9546fb82272ba05c180c9c
6 Nb8cfc30624b24d048fcde99b2ffd33cb
7 Nc02a24776f254193bb736f5fb1b7c867
8 Nc8ccf448e7db4d4988a8bca4b533454d
9 Ncb74874c44e74da6a484db32ebc36f5f
10 Ndd00879b6d1a46b38ffdc5a4f24805ce
11 Nf62f3869ebc341f1921119030990a296
12 Nfff6eb998dc44951977753d479ba91d9
13 anzsrc-for:11
14 anzsrc-for:1109
15 schema:author N6b9ab9891f354555b8d00e4135129751
16 schema:citation sg:pub.10.1007/bf02244294
17 sg:pub.10.1007/s00259-006-0271-7
18 sg:pub.10.1007/s002590100594
19 https://app.dimensions.ai/details/publication/pub.1074684217
20 https://app.dimensions.ai/details/publication/pub.1077196648
21 https://app.dimensions.ai/details/publication/pub.1081587123
22 https://app.dimensions.ai/details/publication/pub.1081950981
23 https://doi.org/10.1016/0883-2889(88)90044-5
24 https://doi.org/10.1016/j.nucmedbio.2003.09.003
25 https://doi.org/10.1016/j.nucmedbio.2004.11.001
26 https://doi.org/10.1016/j.nucmedbio.2004.12.004
27 https://doi.org/10.1016/s0969-8051(00)00125-6
28 https://doi.org/10.1016/s0969-8051(01)00251-7
29 https://doi.org/10.1016/s0969-8051(03)00030-1
30 schema:datePublished 2009-06
31 schema:datePublishedReg 2009-06-01
32 schema:description PURPOSE: [(11)C]Flumazenil shows promise as a clinical and research PET radiotracer to image changes in GABA(A) central benzodiazepine receptor (cBZR), but its widespread use has been limited by practical limitations of [(11)C]. This study evaluated the imaging characteristics of two fluorinated PET radiotracers in rats in vivo: [(18)F]fluoroflumazenil ([(18)F]FFMZ) and [(18)F]flumazenil ([(18)F]FMZ). METHODS: PET acquisitions were performed on a small-animal scanner following injection of [(18)F]FFMZ in nine rats and [(18)F]FMZ in eight rats. The following treatments were investigated: (1) injection of the tracer dose, (2) presaturation then injection of the tracer dose, and (3) injection of the tracer dose followed by a displacement injection. Unchanged tracer was measured in plasma and brain structures in four animals 10 and 30 min after injection, and ex-vivo autoradiography was also performed. RESULTS: For both [(18)F]FFMZ and [(18)F]FMZ maximal brain activity peaked rapidly, and was highest in the hippocampus (1.12+/-0.06 SUV, 1.24+/-0.10 SUV, respectively), and lowest in the pons (1.00+/-0.07 SUV, 1.03+/-0.09 SUV, respectively). By 50 min after injection, maximal uptake for [(18)F]FFMZ and [(18)F]FMZ had decreased in the hippocampus to 18+/-3% and 80+/-1% (p<0.01), respectively. The presaturation and displacement studies showed a higher nonspecific component for [(18)F]FFMZ than for [(18)F]FMZ. Metabolite studies showed that at 30 min only 10% of the signal was from [(18)F]FFMZ in the brain. This nonspecific binding was apparent on autoradiography. In contrast, [(18)F]FMZ accounted for >70% of the signal in the brain, which resulted in well-defined regional binding on autoradiography. CONCLUSION: These results demonstrate that [(18)F]FMZ is a superior radiotracer to [(18)F]FFMZ for in-vivo PET imaging of the GABA(A)/cBZR, having slower metabolism and leading to lower concentrations of metabolites in the brain that results in a substantially better signal-to-noise ratio.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf N0ebe7fc118244031811129ec5ceddf60
37 N3aff693cefcd451ca6fce0745407e6dc
38 sg:journal.1297401
39 schema:name In-vivo imaging characteristics of two fluorinated flumazenil radiotracers in the rat
40 schema:pagination 958
41 schema:productId N067b441a39be45e4a495cb13e1ec3a19
42 N3736c7e45cd649c2a0ace8d4895ab1ee
43 N62242e2f5ccd4d8caddbb142ef23ba82
44 N85315e9de4bd48c0a10d8b215fae25ab
45 Nababe1b391ee49b1b4cd5add8cf8572a
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036566941
47 https://doi.org/10.1007/s00259-009-1066-4
48 schema:sdDatePublished 2019-04-11T14:27
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher Nf71d5856d14d4a6990b48ebe92cf7c02
51 schema:url http://link.springer.com/10.1007%2Fs00259-009-1066-4
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N06517b55d95345ea9989efe243da723b rdf:first sg:person.015433407225.81
56 rdf:rest N351c20fd11e244b8938472f6147eb235
57 N067b441a39be45e4a495cb13e1ec3a19 schema:name pubmed_id
58 schema:value 19205698
59 rdf:type schema:PropertyValue
60 N0ebe7fc118244031811129ec5ceddf60 schema:volumeNumber 36
61 rdf:type schema:PublicationVolume
62 N180f463085134d4baa816c5e99d55274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Receptors, GABA-A
64 rdf:type schema:DefinedTerm
65 N1a09c1d19a1e4ad4b6bd669964283e58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Male
67 rdf:type schema:DefinedTerm
68 N26e5b23356a94091891650678226b4d9 rdf:first sg:person.01311343723.31
69 rdf:rest N7119f88840ad421eaf3c52b4d1df4756
70 N325636193a304698a14911f0aba71446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Rats, Wistar
72 rdf:type schema:DefinedTerm
73 N351c20fd11e244b8938472f6147eb235 rdf:first sg:person.01152033424.95
74 rdf:rest N26e5b23356a94091891650678226b4d9
75 N3736c7e45cd649c2a0ace8d4895ab1ee schema:name nlm_unique_id
76 schema:value 101140988
77 rdf:type schema:PropertyValue
78 N3aff693cefcd451ca6fce0745407e6dc schema:issueNumber 6
79 rdf:type schema:PublicationIssue
80 N49f96f460d584530a31dae93997289bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Autoradiography
82 rdf:type schema:DefinedTerm
83 N4ed54e95efee47599d3b4b4f35dc281c rdf:first sg:person.01132251641.45
84 rdf:rest N561993c3ff614949987da9000debc0e3
85 N4f3e77c518394f75807fb9c394c3cba3 rdf:first sg:person.0635145764.06
86 rdf:rest rdf:nil
87 N52bb788dff9546fb82272ba05c180c9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Animals
89 rdf:type schema:DefinedTerm
90 N561993c3ff614949987da9000debc0e3 rdf:first sg:person.01231620554.55
91 rdf:rest N907cebdf2d5b4bcda22685a984b2a517
92 N62242e2f5ccd4d8caddbb142ef23ba82 schema:name readcube_id
93 schema:value ae30e2395cd5ee1c7a5fc1f593b3e19975c56b8d47f80b739606312e2ab5a2dd
94 rdf:type schema:PropertyValue
95 N6b9ab9891f354555b8d00e4135129751 rdf:first sg:person.01052616147.76
96 rdf:rest N4ed54e95efee47599d3b4b4f35dc281c
97 N7119f88840ad421eaf3c52b4d1df4756 rdf:first sg:person.01126721074.64
98 rdf:rest Nda8fb55d9c5f4702b54cc1ee99907913
99 N85315e9de4bd48c0a10d8b215fae25ab schema:name dimensions_id
100 schema:value pub.1036566941
101 rdf:type schema:PropertyValue
102 N907cebdf2d5b4bcda22685a984b2a517 rdf:first sg:person.01360466505.63
103 rdf:rest Ndd021a0070f545389b55662867f0fad4
104 Nababe1b391ee49b1b4cd5add8cf8572a schema:name doi
105 schema:value 10.1007/s00259-009-1066-4
106 rdf:type schema:PropertyValue
107 Nb8cfc30624b24d048fcde99b2ffd33cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Rats
109 rdf:type schema:DefinedTerm
110 Nc02a24776f254193bb736f5fb1b7c867 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Flumazenil
112 rdf:type schema:DefinedTerm
113 Nc8ccf448e7db4d4988a8bca4b533454d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Reproducibility of Results
115 rdf:type schema:DefinedTerm
116 Ncb74874c44e74da6a484db32ebc36f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Brain
118 rdf:type schema:DefinedTerm
119 Nd1c2cf2e946942f3a329f8e8f6a9a0be rdf:first sg:person.01214124212.61
120 rdf:rest N4f3e77c518394f75807fb9c394c3cba3
121 Nda8fb55d9c5f4702b54cc1ee99907913 rdf:first sg:person.01200365041.17
122 rdf:rest Nea3320787d624443a322e4e4ad4f0160
123 Ndd00879b6d1a46b38ffdc5a4f24805ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Positron-Emission Tomography
125 rdf:type schema:DefinedTerm
126 Ndd021a0070f545389b55662867f0fad4 rdf:first sg:person.01213140513.69
127 rdf:rest N06517b55d95345ea9989efe243da723b
128 Nea3320787d624443a322e4e4ad4f0160 rdf:first sg:person.01121233254.97
129 rdf:rest Nd1c2cf2e946942f3a329f8e8f6a9a0be
130 Nf62f3869ebc341f1921119030990a296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Fluorine Radioisotopes
132 rdf:type schema:DefinedTerm
133 Nf71d5856d14d4a6990b48ebe92cf7c02 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 Nfff6eb998dc44951977753d479ba91d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Radioactive Tracers
137 rdf:type schema:DefinedTerm
138 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
139 schema:name Medical and Health Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
142 schema:name Neurosciences
143 rdf:type schema:DefinedTerm
144 sg:journal.1297401 schema:issn 1619-7070
145 1619-7089
146 schema:name European Journal of Nuclear Medicine and Molecular Imaging
147 rdf:type schema:Periodical
148 sg:person.01052616147.76 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
149 schema:familyName Dedeurwaerdere
150 schema:givenName Stefanie
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052616147.76
152 rdf:type schema:Person
153 sg:person.01121233254.97 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
154 schema:familyName Hicks
155 schema:givenName Rodney J.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121233254.97
157 rdf:type schema:Person
158 sg:person.01126721074.64 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
159 schema:familyName Loc’h
160 schema:givenName Christian
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126721074.64
162 rdf:type schema:Person
163 sg:person.01132251641.45 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
164 schema:familyName Gregoire
165 schema:givenName Marie-Claude
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132251641.45
167 rdf:type schema:Person
168 sg:person.01152033424.95 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
169 schema:familyName Greguric
170 schema:givenName Ivan
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152033424.95
172 rdf:type schema:Person
173 sg:person.01200365041.17 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
174 schema:familyName Katsifis
175 schema:givenName Andrew
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200365041.17
177 rdf:type schema:Person
178 sg:person.01213140513.69 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
179 schema:familyName Binns
180 schema:givenName David
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213140513.69
182 rdf:type schema:Person
183 sg:person.01214124212.61 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
184 schema:familyName O’Brien
185 schema:givenName Terence J.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214124212.61
187 rdf:type schema:Person
188 sg:person.01231620554.55 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
189 schema:familyName Vivash
190 schema:givenName Lucy
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231620554.55
192 rdf:type schema:Person
193 sg:person.01311343723.31 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
194 schema:familyName Pham
195 schema:givenName Tien
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311343723.31
197 rdf:type schema:Person
198 sg:person.01360466505.63 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
199 schema:familyName Roselt
200 schema:givenName Peter
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360466505.63
202 rdf:type schema:Person
203 sg:person.015433407225.81 schema:affiliation https://www.grid.ac/institutes/grid.1089.0
204 schema:familyName Fookes
205 schema:givenName Christopher
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015433407225.81
207 rdf:type schema:Person
208 sg:person.0635145764.06 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
209 schema:familyName Myers
210 schema:givenName Damian E.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635145764.06
212 rdf:type schema:Person
213 sg:pub.10.1007/bf02244294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026987376
214 https://doi.org/10.1007/bf02244294
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s00259-006-0271-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009284813
217 https://doi.org/10.1007/s00259-006-0271-7
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s002590100594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021323392
220 https://doi.org/10.1007/s002590100594
221 rdf:type schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1074684217 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1077196648 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1081587123 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1081950981 schema:CreativeWork
226 https://doi.org/10.1016/0883-2889(88)90044-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021067449
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.nucmedbio.2003.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034492925
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.nucmedbio.2004.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049683398
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.nucmedbio.2004.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022513406
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0969-8051(00)00125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004959548
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0969-8051(01)00251-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018053967
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0969-8051(03)00030-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012445136
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
241 schema:name Department of Medicine (RMH), University of Melbourne, Royal Parade, 3050, Parkville, VIC, Australia
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
244 schema:name Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.1089.0 schema:alternateName Australian Nuclear Science and Technology Organisation
247 schema:name Department of Medicine (RMH), University of Melbourne, Royal Parade, 3050, Parkville, VIC, Australia
248 Radiopharmaceuticals Research Institute, ANSTO, Sydney, Australia
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...