Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-03

AUTHORS

Andrew M. Scott, Dishan H. Gunawardana, Joseph Wong, Ian Kirkwood, Rodney J. Hicks, Ivan Ho Shon, Jayne E. Ramshaw, Peter Robins

ABSTRACT

PURPOSE: Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. METHODS: PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented. RESULTS: PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior. CONCLUSION: PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma. More... »

PAGES

347-353

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-008-0958-z

DOI

http://dx.doi.org/10.1007/s00259-008-0958-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007564198

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18931840


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